Abstract: A dome for applying a vacuum to a patient's skin surface is comprised of a generally rigid dome capable of withstanding a pressure differential, with a rim cushion underlying the rim of the dome for supporting a rim from the patient's skin surface. The rim may be generally wider than the dome in order to distribute the attendant forces across a greater surface and avoid tissue damage. A sticky sole underlies the rim cushion and seals the rim cushion to the patient's skin to thereby preserve the vacuum within the dome. The sticky sole may be comprised of any adhesive material or even be achieved through the use of an appropriate material for the rim cushion itself.

Abstract: Disclosed are matrix materials, methods, and devices for manufacture in vivo of autogenous replacement body parts comprising plural distinct tissues. In one embodiment, the replacement body part is a skeletal joint and the new plural distinct tissues include bone and articular cartilage.

Abstract: Disclosed herein is a method for augmentation of soft tissue in an individual comprising administering percutaneously to the individual at a site for soft-tissue augmentation, a growth factor in an amount effective in eliciting a stable, localized growth of autologous vascularized adipose tissue. Applicable growth factors include IGF-I and IGF-II. The method is useful in treating soft tissue contour defects.

Abstract: Disclosed are matrix materials, methods, and devices for manufacture in vivo of autogenous replacement body parts comprising plural distinct tissues. In one embodiment, the replacement body part is a skeletal joint and the new plural distinct tissues include bone and articular cartilage.

Abstract: A method is disclosed for inhibiting intimal hyperplasia in a warm-blooded mammal which comprises administering topically at the site and time of a vascular injury induced by arterial intervention in said mammal a small but inhibitorily effective amount of tissue factor pathway inhibitor (TFPI) sufficient to inhibit said intimal hyperplasia.

Abstract: Disclosed are matrices, devices and methods for the manufacture of live autogenous skeletal replacement parts comprising plural different tissues.

Abstract: An apparatus and method for healing open wounds through enlargement of soft tissue surrounding said wound is comprised of a dome configured to fit over the wound and at least a portion of the surrounding soft tissue. The dome has a rim with a surface area equal to or greater than the normal area of the dome opening to prevent medical complications caused by excessive pressure to the skin. A gasket or other cushioning material may be provided about the periphery of the dome for patient comfort and improved seal. The dome also includes a vacuum pump with a power source, pressure sensor, and servomechanism for regulating the pressure within the dome to any one of several protocols using pressures which might temporarily exceed non-damaging levels.

Abstract: An apparatus and method for enlargement of soft tissue such as breasts or a penis is comprised of a dome configured to fit over the area of desired augmentation. The dome has a rim with a surface area equal to or greater than the normal area of the dome opening to prevent medical complications caused by excessive pressure to the skin. The dome also includes a vacuum pump with a power source, pressure sensor, and servomechanism for regulating the pressure within the dome.

Abstract: An apparatus and method for enlargement of soft tissue such as breasts or a penis is comprised of a dome configured to fit over the area of desired augmentation. The dome has a rim with a surface area sized to prevent excessive contact pressure to the skin when a suction force of sufficient magnitude to cause enlargement of the soft tissue is applied to the soft tissue by the dome.

Abstract: An apparatus for enlarging a patient's soft tissue. The apparatus comprises an adhesive for adhering to said soft tissue and a tensioner connected to the adhesive for applying a tensile stress to the surface of the soft tissue.

Abstract: A temporary stent and method for vascular anastomosis are disclosed. The method comprises placing, in a vessel to be anastomosed, a stent comprising a biocompatible material; applying staples to anastomose the vessel; and converting the stent material into a liquid that is miscible with blood by melting with warmed saline or pulsed radiation. Also disclosed is a method and composition for delivery of a drug that prevents thrombus formation and/or intimal hyperplasia at the anastomosis.

Abstract: An apparatus and method for enlargement of soft tissue such as breasts or a penis is comprised of a dome configured to fit over the area of desired augmentation. The dome has a rim with a surface area equal to or greater than the normal area of the dome opening to prevent medical complications caused by excessive pressure to the skin. The dome also includes a vacuum pump with a power source, pressure sensor, and servomechanism for regulating the pressure within the dome.

Abstract: A method for reducing the thrombogenicity of microvascular anastomoses in a warm blooded mammal comprising administering to said mammal at the site of said microvascular anastomoses contemporaneously with microvascular reconstruction of a small but inhibitory effective amount of TFPI.

Abstract: A novel method is disclosed for the manufacture of live autogenous skeletal replacement parts through muscle flap molding and osteoinduction comprising the steps of:a) forming a mold of physiologically inert support material into the shape of a replacement part for a defective skeletal site,b) placing a muscle flap into the cavity of the mold,c) thoroughly incorporating osteoinductive factor in the muscle flap,d) closing the mold,e) allowing osteogenesis to take place, andf) implanting the resulting newly formed bone into the defective skeletal site.

Abstract: A method for reducing the thrombogenicity of microvascular anastomoses in a warm blooded mammal comprising administering to said mammal at the site of said microvascular anastomoses contemporaneously with microvascular reconstruction of a small but inhibitory effective amount of TFPI.