Abstract: A switch mode power supply and its start-up circuit produce a controlled output voltage from an input voltage. A power supply control circuit is powered by the output voltage and is responsive to the output voltage to control the power supply. The control circuit responds to differences between a fraction of the output voltage and a reference voltage to control the start-up circuit. This control is inhibited at low values of the output voltage to ensure that the power supply starts up correctly despite the reference voltage being indefinite or unstable at such low values of the output voltage.

Abstract: A knitted screen cloth fabric including a polymer coated, fiber-reinforced, flexible, foil-like web and method for making same are disclosed, the web including a lattice material of filaments and a polyester binding thread.

Abstract: A power supply controller controls power supplies for power-up and/or shut-down in a desired sequence. An input voltage for the power supplies powers, and is monitored by, a first control unit having outputs for enabling the power supplies. A second control unit monitors output voltages of the power supplies, and an isolating signal coupler couples signals in both directions between the first and second control units. The second control unit is powered in an isolated manner from the input voltage, conveniently via a transformer constituting the signal coupler. The control units together respond to the monitored voltages for enabling the power supplies in accordance with the desired sequence, information for which can be stored in a non-volatile store. The second control unit can also include enable outputs isolated from the input voltage, and trim outputs for adjusting the monitored voltages.

Abstract: A switch mode power supply and its start-up circuit produce a controlled output voltage from an input voltage. A power supply control circuit is powered by the output voltage and is responsive to the output voltage to control the power supply. The control circuit responds to differences between a fraction of the output voltage and a reference voltage to control the start-up circuit. This control is inhibited at low values of the output voltage to ensure that the power supply starts up correctly despite the reference voltage being indefinite or unstable at such low values of the output voltage.

Abstract: A power supply controller controls power supplies for power-up and/or shut-down in a desired sequence. An input voltage for the power supplies powers, and is monitored by, a first control unit having outputs for enabling the power supplies. A second control unit monitors output voltages of the power supplies, and an isolating signal coupler couples signals in both directions between the first and second control units. The second control unit is powered in an isolated manner from the input voltage, conveniently via a transformer constituting the signal coupler. The control units together respond to the monitored voltages for enabling the power supplies in accordance with the desired sequence, information for which can be stored in a non-volatile store. The second control unit can also include enable outputs isolated from the input voltage, and trim outputs for adjusting the monitored voltages.

Abstract: A reset circuit produces a composite reset signal, in dependence upon a supply voltage, from reset signals produced by three reset units. A first unit produces its reset signal in dependence upon a precise voltage comparison. A second unit, operable at lower values of the supply voltage than the first unit, produces its reset signal in dependence upon the forward voltage drop of a diode. A third unit produces its reset signal in dependence upon charging of a capacitor from the supply voltage via a resistance, to maintain the composite reset signal for at least a predetermined period.

Abstract: A knitted screen cloth fabric including a polymer coated, fiber-reinforced, flexible, foil-like web and method for making same are disclosed, the web including a lattice material of filaments and a polyester binding thread.

Abstract: A knitted screen cloth fabric including a polymer coated, fiber-reinforced, flexible, foil-like web and method for making same are disclosed, the web including a lattice material of filaments and a polyester binding thread.

Abstract: Compounds of formula (I): or a pharmaceutically acceptable salt thereof, or solvate of either entity, wherein R4 is a guanidinyl moiety and the other substituents are as defined in the text, are urokinase inhibitors.

Abstract: Compounds of formula (I):- 1

Abstract: Compounds of formula (I): or a pharmaceutically acceptable salt thereof, or solvate of either entity, wherein R4 is a guanidinyl moiety and the other substituents are as defined in the text, are urokinase inhibitors.

Abstract: A knitted screen cloth fabric including a polymer coated, fiber-reinforced, flexible, foil- like web and method for making same are disclosed, the web including a lattice material of filaments and a polyester binding thread.

Abstract: Compounds of formula (I), and their pharmaceutically acceptable derivatives, wherein R1 and R2 are optional substituents and independently represent C1-6 alkyl, C2-6 alkenyl, optionally substituted by CO2H or CO2(C1-6 alkyl), C2-6 alkynyl, halogen, C1-3 perfluoroalkyl, (CH2)mAr1, (CH2)mHet1, (CH2)mCONR7R8, (CH2)mCO2R8, O(CH2)qCO2R8, (CH2)mCOR8, (CH2)mOR8, O(CH2)pOR8, (CH2)mNR7R8, CO2(CH2)qNR7R8, (CH2)mCN, S(O)nR8, SO2NR7R8, CONH(CH2)mAr1 or CONH(CH2)mHet1; R3 represents H, C1-6 alkyl, (CH2)pNR9R10, SO2R10, SO2NR9R10, (CH2)mCO2R10, C2-6 alkenyl, C2-6 alkynyl, (CH2)mCONR9R10, (CH2)mCO2R10, (CH2)pCN, (CH2)pR10 or (CH2)pOR10; R4 represents H or C1-6 alkyl; R5 represents H or OH; R6 represents phenyl optionally fused to a heterocyclic ring, the group as a whole being optionally substituted; R7-10 are fully defined herein and may independently represent Ar2 or Het2; Z represents CO2H, CONH(tetrazol-5-yl), CONHSO2O(C1-4 alkyl), CO2Ar3, CO2(C1-6 alkyl), tetrazol-5-yl, CONHSO2Ar3, CONHSO2(CH2)qAr3 or

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, or solvates of either entity, wherein the substituents have the values described herein, are useful as matrix metalloprotease (MMP) inhibitors

Abstract: Compounds of formula (I), and their pharmaceutically acceptable derivatives, wherein R1 and R2 are optional substituents and independently represent C1-6 alkyl, C2-6 alkenyl, optionally substituted by CO2H or CO2(C1-6 alkyl), C2-6 alkynyl, halogen, C1-3 perfluoroalkyl, (CH2)mAr1, (CH2)mHet1, (CH2)mCONR7R8, (CH2)mCO2R8, O(CH2)qCO2R8, (CH2)mCOR8, (CH2)mOR8, O(CH2)pOR8, (CH2)mNR7R8, CO2(CH2)qNR7R8, (CH2)mCN, S(O)nR8, SO2NR7R8, CONH(CH2)mAr1 or CONH(CH2)mHet1; R3 represents H, C1-6 alkyl, (CH2)pNR9R10, SO2R10, SO2NR9R10, (CH2)mCO2R10, C2-6 alkenyl, C2-6 alkynyl, (CH2)mCONR9R10, (CH2)mCO2R10, (CH2)pCN, (CH2)pR10 or (CH2)pOR10; R4 represents H or C1-6 alkyl; R5 represents H or OH; R6 represents phenyl optionally fused to a herterocyclic ring, the group as a whole being optionally substituted; R7-10 are fully defined herein and may independently represent Ar2 or Het2; Z represents CO2H, CONH(tetrazol-5-yl), CONHSO2O(C1-4 alkyl), CO2Ar3, CO2(C1-6 alkyl), tetrazol-5-yl, CONHSO2Ar3, CONHSO2(CH2)qAr3 o

Abstract: 1

Abstract: Compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is H and the other is N═C(NH2)2 or NHC(═NH)NH2, and the other substituents are as defined herein, are urokinase (uPA) inhibitors.

Abstract: The invention provides S-(+)-3-{1-(1,3-benzodioxol-5-yl)-2-[(2-methoxy-4-methylphenyl)sulfonylamino]-2-oxoethyl}-1-methyl-1H-indole-6-carboxylic acid, which is substantially free from its (R)-(−)-enantiomer, and pharmaceutically acceptable derivatives thereof. The compounds are useful in the treatment of inter alia acute renal failure, restenosis and pulmonary hypertension.

Abstract: Isoquinolinylguanidine compounds of formula (I): ##STR1## wherein the substituents are as defined herein, and salts thereof, are disclosed as urokinase inhibitors.