Abstract: The present invention relates to spectacles comprising a spectacle frame and a spectacle glass. The spectacle frame, in turn, comprises a frame which defines a receiving opening for the spectacle glass and essentially completely borders the spectacle glass. The spectacle glass is fixed in the receiving opening by means of a thread inserted between the frame defining the receiving opening and the edge of the spectacle glass.

Abstract: In a fixer unit system and method to detect a fire in a fixer unit of an electrographic image generation device, at least one portion of a fixer region of the fixing unit is monitored with a photoelectric sensor arranged adjacent to a substrate material having a toner image to be fixed, at least one portion of radiation generated by at least one heat radiator of the fixer unit is not detected by the photoelectric sensor by not passing said at least one portion of the radiation generated by the at least one heat radiator through to the photoelectric sensor by use of an optical filter associated with the photoelectric sensor. An error signal is output when a fire in the fixer region is detected with the photoelectric sensor.

Abstract: The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and chemicals for therapeutic use or for other purposes is extremely complex. Of particular importance is the understanding of how these chemical agents are handled in the body, whether they have appropriate pharmacokinetics and whether, as a consequence of metabolism, any safety issues arise. Many of the proteins that are involved in the metabolism, disposition and elimination of drugs are members of multigene families that exhibit very marked species differences in gene number, function and regulation. For these reasons, experiments carried out in laboratory animals to establish routes of metabolism or toxicity can be severely compromised and, as a consequence, do not faithfully represent the human situation.

Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.

Abstract: A perfluoroctanoic acid or a salt or an ester thereof; perfluorosuberic acid, perfluoroheptanoic acid, perfluorohexanoic acid, perfluoropentanoic acid, perfluorobutanoic acid or perfluoropropionic acid or a salt or an ester any thereof; or perfluoroctane are useful in treating diabetes, obesity, hypercholesterolaemia, hyperlipidaemia, cancer, inflammation or other conditions in which modulation of lipid or eicosanoid status or function may be desirable.

Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.

Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.

Abstract: An error logging method for a coating plant is disclosed. The error logging method generally includes capturing an error during running of process data records for the coating plant, wherein the individual process data records are ordered according to the given time of operation of the coating plant and each of which contain various process data of the coating plant. The method may further include storage of the captured process data records, detection of a possible error condition of the coating plant, and/or production of an error code when detection of an error condition of the coating plant occurs. The various examples may also relate to storage of the error code in chronological order with the stored process data records.

Abstract: We provide reporter gene constructs incorporating nucleic acid sequences from a promoter region of a gene or set of genes whose expression is modified in response to external or internal changes in the cellular environment such as biochemical stress or toxic conditions. The promoters are operatively linked to nucleic acid sequences chosen on the basis of the ease with which their transcription and/or translation products may be assayed so that the reporter gene constructs can provide a system capable of detecting intracellular conditions. Also described are transfected cell lines including the constructs and transgenic non-human animal models including the constructs.

Abstract: The present invention relates to non-human transgenic animals, tissues and/or cells derived therefrom having depleted or ablated cytochrome P450 reductase (CPR) expression, methods of producing such animals, tissues and/or cells, and methods of using such animals, tissues and/or cells. Non-human transgenic animals, tissues and or cells derived therefrom of the present invention may be used for, but non exclusively, in both in vivo and in vitro screening of therapeutic agents, drug development, drug metabolism/disposition studies and studying disease states, pregnancy, fetal development, modulation of hormone function and hormone levels, and other pathways and/or substrate metabolism in which cytochrome P450 plays a role.

Abstract: The present invention provides cell lines that have been transfected with adenovirus expression vectors so that they express at least one metabolically competent or functional cytochrome P450 enzyme. The invention also includes methods of their use, especially in toxicology screens.

Abstract: The present invention relates to an improved assay for identifying compounds that may be of use in conjunction with cancer chemotherapeutic agents and anti-proliferative agents, to improve efficacy of such agents and/or render effective compounds with relatively little therapeutic activity. There is also provided a class of compounds of formula (I) and retinoids identified by said assay which may be used in a combination therapy, with current and novel agents, to treat cancers and other diseases associated with abnormal host cell proliferation, such as psoriasis.

Abstract: In a fixer unit system and method to detect a fire in a fixer unit of an electrographic image generation device, at least one portion of a fixer region of the fixing unit is monitored with a photoelectric sensor arranged adjacent to a substrate material having a toner image to be fixed, at least one portion of radiation generated by at least one heat radiator of the fixer unit is not detected by the photoelectric sensor by not passing said at least one portion of the radiation generated by the at least one heat radiator through to the photoelectric sensor by use of an optical filter associated with the photoelectric sensor. An error signal is output when a fire in the fixer region is detected with the photoelectric sensor.

Abstract: A lift apparatus is provided for loading relatively items into the bed of a truck or van which initially lifts the item to the level of the truck bed and then is simultaneously loaded with the item onto the truck bed so that it can be used for unloading at the destination.

Abstract: The invention relates to a thermal link (1) for electrical appliances, comprises an insulating part (10) with electrical terminals (11) and contact springs (12) for providing electrical contact between said terminals (11), a fusible material insert (15) that acts as the thermal trip element and a transmission pin (13), which is displaceably mounted in the insulting part (10), one end of which engaging with the fusible material insert (15) and the other end with the contact springs (12). Said link is characterised in that the fusible material insert (15) is situated in a casing (141) that is configured as one piece with the heat transfer plate (14).

Abstract: The invention provides a method of enhancing the effectiveness of pesticides, as well as pesticidal formulations. Furthermore, it also provides the means for the de novo rational design of pesticides. The present invention also relates to a method of screening agents for potential use in insecticides, particularly against mosquitoes.

Abstract: A method of introducing at least one human cytochrome P450 into a non-human animal c ell in which corresponding endogenous P450 enzyme activities have been disabled, thus the method provides a way of using a non-human animal cell to make predictions regarding P450-mediated metabolism in a human. The present invention also provides transgenic non-human animals produced by the method of the invention and uses therefor, especially in assessing xenobiotic/drug metabolism and toxicity.

Abstract: Changes of properties (for example, dampness, sliding characteristic, gloss) of a printing substrate web caused by a printing of a printing substrate web are corrected by a multifunction device that is arranged at an output of the printing device. In the multifunction device, arranged in succession in the transport direction of the printing substrate web are devices for buffering, for smoothing, for moistening, for cooling, for lubrication and for discharge of the printing substrate web. The devices are executed and adapted to one another such that they can be optionally deactivated by the uses without affecting the functions of the remaining devices.

Abstract: A device for post-processing of printed print substrate webs comprises a smoothing device that is arranged immediately after the fixing device. The toner (still hot and doughy in terms of its consistency) is compressed with a predetermined pressure over a width of the print substrate web. It is thus achieved that less abrasion of the toner occurs in the further process and a specifically altered print image is generated.

Abstract: This invention provides a system for rapid determination of pharmacologic effects on target tissue types in cell populations cultured in vitro. The cells contain a promoter-reporter construct that reflects a toxicologic or metabolic change caused by the agent being screened. The promoter is taken from a gene known to be up- or down-regulated according to the metabolic state of the cell, and linked to a reporter gene that provides an external signal for monitoring promoter activity. The promoter-reporter cells may be produced by placing these genetic alterations into a line of human embryonic stem cells, bulking up the cells to any extent desired, and then differentiating the cells into the desired tissue type. This disclosure explains some of the powerful features of the promoter-reporter cells of this invention, and shows various ways the skilled reader can use the invention for pharmaceutical development and testing, or to monitor graft survival.