Abstract: The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans.

Abstract: In an electrophotographic printer or copier, toner images of images to be printed onto a printing substrate are generated and fixed, causing sliding characteristics to be worsened. In order to remedy this problem, a moistening device is provided that applies on the printing substrate a moistening agent made from a moistening fluid and a lubricant dissolved therein. Two problems are thus solved: the printing substrate is moistened and simultaneously lubricated.

Abstract: In an electrophotographic printer or copier, toner images of images to be printed onto a printing substrate are generated and fixed, causing sliding characteristics to be worsened. In order to remedy this problem, a moistening device is provided that applies on the printing substrate a moistening agent made from a moistening fluid and a lubricant dissolved therein. Two problems are thus solved: the printing substrate is moistened and simultaneously lubricated.

Abstract: In an electrophotographic printer or copier, toner images of images to be printed onto a printing substrate are generated and fixed, causing sliding characteristics to be worsened. In order to remedy this problem, a moistening device is provided that applies on the printing substrate a moistening agent made from a moistening fluid and a lubricant dissolved therein. Two problems are thus solved: the printing substrate is moistened and simultaneously lubricated.

Abstract: A device for post-processing of printed print substrate webs comprises a smoothing device that is arranged immediately after the fixing device. The toner (still hot and doughy in terms of its consistency) is compressed with a predetermined pressure over a width of the print substrate web. It is thus achieved that less abrasion of the toner occurs in the further process and a specifically altered print image is generated.

Abstract: In order to already be able to acceptably affix toner images applied on a print substrate at a beginning of a printing, it is necessary that the heat capacity requirement necessary for this is known. This is dependent on the properties of the print substrate such as its weight, dampness, heat conductivity, etc. A measurement arrangement made up of a reference radiation source and a temperature sensor is provided to determine the heat capacity requirement. The print substrate is irradiated with the reference radiation source. The heat emitted by the print substrate is measured with the temperature sensor. The heat requirement of the print substrate can be determined from the measurement result, for example at a beginning of the printing event.

Abstract: The invention relates to a method for automatically generating several electrical pulses using numeric default values, in particular for simulating an incremental encoder for a sequential, digital counting of linear or angular displacement values using said pulses. The method incorporates a value generator that outputs the default values repeatedly within each first cycle time, calculation and control means that detect the default values in a cyclic manner and a pulse switching interface that has one or more outputs for the pulses.

Abstract: Changes of properties (for example, dampness, sliding characteristic, gloss) of a printing substrate web caused by a printing of a printing substrate web are corrected by a multifunction device that is arranged at an output of the printing device. In the multifunction device, arranged in succession in the transport direction of the printing substrate web are devices for buffering, for smoothing, for moistening, for cooling, for lubrication and for discharge of the printing substrate web. The devices are executed and adapted to one another such that they can be optionally deactivated by the uses without affecting the functions of the remaining devices.

Abstract: In an electrophotographic printer or copier, toner images of images to be printed onto a printing substrate are generated and fixed, causing sliding characteristics to be worsened. In order to remedy this problem, a moistening device is provided that applies on the printing substrate a moistening agent made from a moistening fluid and a lubricant dissolved therein. Two problems are thus solved: the printing substrate is moistened and simultaneously lubricated.

Abstract: The invention relates to a method for automatically generating several electrical pulses using numeric default values, in particular for simulating an incremental encoder for a sequential, digital counting of linear or angular displacement values using said pulses. The method incorporates a value generator that outputs the default values repeatedly within each first cycle time, calculation and control means that detect the default values in a cyclic manner and a pulse switching interface that has one or more outputs for the pulses.

Abstract: The invention relates to a method for automatically generating several electrical pulses using numeric default values, in particular for simulating an incremental encoder for a sequential, digital counting of linear or angular displacement values using said pulses. The method incorporates a value generator that outputs the default values repeatedly within each first cycle time, calculation and control means that detect the default values in a cyclic manner and a pulse switching interface that has one or more outputs for the pulses.

Abstract: The present invention relates to non-human transgenic animals, tissues and/or cells derived therefrom having depleted or ablated cytochrome P450 reductase (CPR) expression, methods of producing such animals, tissues and/or cells, and methods of using such animals, tissues and/or cells. Non-human transgenic animals, tissues and or cells derived therefrom of the present invention may be used for, but non exclusively, in both in vivo and in vitro screening of therapeutic agents, drug development, drug metabolism/disposition studies and studying disease states, pregnancy, fetal development, modulation of hormone function and hormone levels, and other pathways and/or substrate metabolism in which cytochrome P450 plays a role.

Abstract: A bacterial cell containing a functional cytochrome P450 monooxygenase system, said cell comprising a genetic construct capable of expressing a cytochrome P450 and a genetic construct capable of expressing, separately from said cytochrome P450, a cytochrome P450 reductase wherein the N-terminus of the cytochrome P450 and the N-terminus of the cytochrome P450 reductase are each adapted to allow functional coupling of said cytochrome P450 and said cytochrome P450 reductase within said cell. A bacterial cell containing a cytochrome P450 comprising a genetic construct encoding, and capable of expressing, said cytochrome P450 wherein the cytochrome P450 comprises an N-terminal portion which directs the cytochrome P450 to a cellular compartment of membrane of the bacterial cell. The bacterial cells are useful as, for example, bioreactors, in drug testing and mutagenicity testing and as a source of cytochrome P450.

Abstract: A bacterial cell containing a functional cytochrome P450 monooxygenase system, said cell comprising a genetic construct capable of expressing a cytochrome P450 and genetic construct capable of expressing, separately from said cytochrome P450, a cytochrome P450 reductase, wherein each of the cytochrome P450 and the cytochrome P450 reductase have at their N-terminus a bacterial signal peptide. The cytochrome P450 and the cytochrome P450 reductase may be encoded by different constructs or the same construct. A bacterial cell containing a cytochrome P450 comprising a genetic construct encoding, and capable of expressing, said cytochrome P450 wherein the cytochrome P450 has, at is N-terminal, a bacterial signal peptide. The bacterial cells are useful as, for example, bioreactors, in drug testing and mutagenicity testing and as a source of cytochrome P450.

Abstract: An electrical plug-like connector, in particular a socket or cigar(ette) lighter in motor vehicles having a sleeve-like guide part for axially accepting a cigar(ette) lighter or a connector plug of an electrical device. A first fixed contact is arranged in the sleeve base region on an insulation carrier. The fixed first contact is acted upon by a counter contact, and the electrically conductive guide part forms a second fixed contact that acts upon other counter contacts. Thermal overload protection is also provided. Parallel to the thermal overload protection and at a distance from the insulation carrier, a sheet metal insert is provided, extending in the sleeve base section. On the underside of the sheet metal insert, an electrically-conductive bimetal-switch spring is fixed such that such that in the non-operative condition the bimetal switch spring acts upon the first fixed contact or upon a side contact connected with the side contact.

Abstract: The present invention relates to a recombinant genetic material which can be operably linked to protein encoding sequence comprising an expression control sequence having at least one promoter region and at least one repressor region such that basal expression in a tissue where the protein is required to be expressed is reduced whilst allowing induction of expression of the protein encoding sequence. Suitably the promoter is a p450 type promoter whilst suitably it is the p450 CYP1A1 promoter of the rat. The invention further provides a method of manufacturing proteins for polypeptides in the method of manufacturing or recombinant construct for transgene induction.

Abstract: The invention relates to a control device, especially a temperature control device, comprising a sensor, a setpoint sensor, an electronic or electromechanical switch, an electricity supply unit, a control electronics unit and a casing encompassing said components. Said control device (1) is constructed by MID technology and the electronic and/or electromechanical components which make up the control device (1) are supported by walls of sections (7, 8, 9, 10) inside the casing and/or supporting elements (2) connected thereto. Said control device (1) has connecting contacts (3, 3′) leading outwards. The electronic and/or electromechanical components are interconnected by means of strip conductors (16) located directly on the casing floor (15) and/or casing walls and/or interior casing sections (7, 8, 9, 10).

Abstract: Polymorphisms at positions 100, 271, 281, 294, 408, 506 or 1432 of the cytochrome P450 enzyme bufuralol-1'-hydroxylase are indicative of the extensive metaboliser/poor metaboliser phenotypes and can be detected using known methods such as amplification of the DNA with the polymerase chain reaction, followed by digestion with a suitable restriction enzyme and analysis by gel electrophoresis. The EM/PM phenotype is relevant to calculating safe or effective drug doses for individuals.

Abstract: The invention relates to an assembly rack with two side walls (10, 11) and with honeycomb plates (20) which are arranged between the side walls and connected to transverse profiled rails (15, 16). In such an assembly rack, a reliable shielding against electromagnetic interference should be safeguarded at low cost. This achieved according to the invention in that two transverse profiled rails (15, 16) together with one honeycomb plate and with two lateral profiled rails form an EMI-shielded, self-contained sub-assembly which can be previously assembled, and in that the assembly rack comprises at least two such sub-assemblies (12, 13) which are connected to the side walls with fastening elements in an EMI-shielded manner.

Abstract: The security tag (10) has a housing (11) and a clasp (12), which can move longitudinally therein, in the manner of a padlock. In its closed position, a piston (20), which is prestressed by a spring (21), engages into a gap or interruption (15) in the clasp (12). In order to open the clasp (12), a reduced-pressure source, which raises the piston (20), is placed onto a projection (28), so that the said piston releases the clasp (12). The use of a reduced-pressure source exacerbates the unauthorized opening of the security tag.