Patents by Inventor Ronghui Lin

Ronghui Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives
    Patent number: 8299082
    Abstract: 1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives are disclosed: The 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I) possess cell cycle inhibitory activity and are accordingly useful for their anti cell proliferation (such as anti cancer) activity.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: October 30, 2012
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Shenlin Huang, Ronghui Lin, Peter J. Connolly, Stuart L. Emanuel, Steven A. Middleton, Robert H. Gruninger, Steven K. Wetter
  • 1,2,4-TRIAZOLYLAMINOARYL (HETEROARYL) SULFONAMIDE DERIVATIVES
    Publication number: 20110077249
    Abstract: 1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives are disclosed: The 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I) possess cell cycle inhibitory activity and are accordingly useful for their anti cell proliferation (such as anti cancer) activity.
    Type: Application
    Filed: September 29, 2010
    Publication date: March 31, 2011
    Applicant: Janssen Pharmaceutica N.V.
    Inventors: Shenlin Huang, Ronghui Lin, Peter J. Connolly, Stuart L. Emanuel, Steven A. Middleton, Robert H. Gruninger, Steven K. Wetter
  • 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives
    Patent number: 7888380
    Abstract: 1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives are disclosed: The 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I) possess cell cycle inhibitory activity and are accordingly useful for their anti cell proliferation (such as anti cancer) activity.
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: February 15, 2011
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Shenlin Huang, Ronghui Lin, Peter J. Connolly, Stuart L. Emanuel, Steven A. Middleton, Robert H. Gruninger, Steven K. Wetter
  • Substituted pyrazole kinase inhibitors
    Patent number: 7638518
    Abstract: The present invention is directed to novel substituted pyrazole compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: December 29, 2009
    Assignee: Janssen Pharmaceutica
    Inventors: George Chiu, Yang Yu, Ronghui Lin, Shengjian Li, Peter J. Connolly
  • Imidazole substituted pyrazole kinase inhibitors
    Patent number: 7635703
    Abstract: The present invention is directed to novel substituted pyrazole compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: December 22, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Yang Yu, Ronghui Lin, Peter J. Connolly
  • Substituted Thiazolo [4,5-d]pyrimidines as protein kinase inhibitors
    Patent number: 7605154
    Abstract: The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: October 20, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Eva Binnun, Peter J. Connolly, Sigmond G. Johnson, Ronghui Lin, Steven A. Middleton, Sandra J. Moreno-Mazza, Niranjan B. Pandey, Steven K. Wetter
  • Thia-tetraazaacenaphthylene kinase inhibitors
    Patent number: 7579356
    Abstract: The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: August 25, 2009
    Assignee: Janssen Pharmaceutica NV
    Inventors: Kathleen A. Battista, Gilles C. Bignan, Peter J. Connolly, Stuart Hayden, Sigmond G. Johnson, Ronghui Lin, Niranjan B. Pandey, Mark T. Powell
  • 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
    Patent number: 7541367
    Abstract: The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: June 2, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: George Chiu, Peter J. Connolly, Stuart Emanuel, Shenlin Huang, Shengjian Li, Ronghui Lin, Yanhua Lu, Steven A. Middleton
  • BICYCLIC PYRIMIDINE KINASE INHIBITORS
    Publication number: 20090076037
    Abstract: The present invention is directed to novel bicyclic pyrimidine compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.
    Type: Application
    Filed: September 20, 2007
    Publication date: March 19, 2009
    Inventors: Peter J. Connolly, Stuart Emanuel, Ronghui Lin, Yanhua Lu, Steven A. Middleton
  • 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
    Publication number: 20090048249
    Abstract: The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.
    Type: Application
    Filed: May 31, 2006
    Publication date: February 19, 2009
    Inventors: George Chiu, Peter J. Connolly, Stuart Emanuel, Shenlin Huang, Shengjian Li, Ronghui Lin, Yanhua Lu, Steven A. Middleton
  • SUBSTITUTED PYRAZOLE KINASE INHIBITORS
    Publication number: 20080153844
    Abstract: The present invention is directed to novel substituted pyrazole compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.
    Type: Application
    Filed: October 12, 2007
    Publication date: June 26, 2008
    Inventors: George Chiu, Yang Yu, Ronghui Lin, Shengjian Li, Peter J. Connolly
  • SUBSTITUTED THIENOPYRIMIDINE KINASE INHIBITORS
    Publication number: 20080108611
    Abstract: The present invention is directed to thienopyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
    Type: Application
    Filed: January 10, 2007
    Publication date: May 8, 2008
    Inventors: Kathleen A. Battista, Gilles C. Bignan, Peter J. Connolly, Stuart L. Emanuel, Stuart Hayden, Sigmond G. Johnson, Ronghui Lin, Steven A. Middleton, Niranjan B. Pandey, Mark T. Powell
  • IMIDAZOLE SUBSTITUTED PYRAZOLE KINASE INHIBITORS
    Publication number: 20080103172
    Abstract: The present invention is directed to novel substituted pyrazole compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.
    Type: Application
    Filed: October 12, 2007
    Publication date: May 1, 2008
    Inventors: Yang YU, Ronghui Lin, Peter Connolly
  • Substituted triazole diamine derivatives as kinase inhibitors
    Patent number: 7317031
    Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.
    Type: Grant
    Filed: February 1, 2005
    Date of Patent: January 8, 2008
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ronghui Lin, Shenlin Huang, Steven K. Wetter, Peter J. Connolly, Stuart L. Emanuel, Robert H. Gruninger, Steven A. Middleton
  • Thia-tetraazaacenaphthylene kinase inhibitors
    Publication number: 20070265264
    Abstract: The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.
    Type: Application
    Filed: April 10, 2006
    Publication date: November 15, 2007
    Inventors: Kathleen Battista, Gilles Bignan, Peter Connolly, Stuart Hayden, Sigmond Johnson, Ronghui Lin, Niranjan Pandey, Mark Powell
  • Thiazolopyrimidine kinase inhibitors
    Publication number: 20070185139
    Abstract: The present invention is directed to novel thiazolopyrimidine compounds of Formula (I) or a form or composition thereof and the thereof as inhibitors of ATP-protein kinase interactions.
    Type: Application
    Filed: August 2, 2006
    Publication date: August 9, 2007
    Inventors: Eva Binnun, Peter Connolly, Sigmond Johnson, Ronghui Lin, Steven Middleton, Sandra Moreno-Mazza, Niranjan Pandey, Steven Wetter
  • Amino substituted pyridinyl methanone compounds useful in treating kinase disorders
    Patent number: 7109220
    Abstract: The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliorate CDK mediated disorders. The invention thus also provides the therapeutic or prophylactic use of the compounds and/or pharmaceutical compositions to treat such disorders.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: September 19, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ronghui Lin, Steven K. Wetter, Yanhua Lu, Peter J. Connolly, Stuart Emanuel, Robert H. Gruninger, Steven A. Middleton
  • Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
    Publication number: 20060183900
    Abstract: The present invention provides pyrimidinyl substituted fused-pyrrolyl compounds of Formula (I) and pharmaceutical compositions comprising the compounds and methods of synthesis and use thereof. The compounds are kinase inhibitors useful in treating or ameliorating a kinase mediated, angiogenesis-mediated or hyperproliferative disorder. The invention thus also provides a therapeutic or prophylactic method of use for the compounds and/or pharmaceutical compositions to treat such disorders.
    Type: Application
    Filed: October 28, 2005
    Publication date: August 17, 2006
    Inventors: Shenlin Huang, Ronghui Lin, Peter Connolly, Stuart Emanuel, Steven Middleton
  • 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives
    Publication number: 20060173020
    Abstract: 1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives are disclosed: The 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I) possess cell cycle inhibitory activity and are accordingly useful for their anti cell proliferation (such as anti cancer) activity.
    Type: Application
    Filed: October 6, 2005
    Publication date: August 3, 2006
    Inventors: Shenlin Huang, Ronghui Lin, Peter Connolly, Stuart Emanuel, Steven Middleton, Robert Gruninger, Steven Wetter
  • Substituted triazole diamine derivatives as kinase inhibitors
    Publication number: 20050182116
    Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.
    Type: Application
    Filed: February 1, 2005
    Publication date: August 18, 2005
    Inventors: Ronghui Lin, Shenlin Huang, Steven Wetter, Peter Connolly, Stuart Emanuel, Robert Gruninger, Steven Middleton