Abstract: There is provided a composition for separating blood serum or blood plasma that can inhibit bubbling during sterilization, and can inhibit the occurrence of phase separation during storage. The composition for separating blood serum or blood plasma according to the present invention comprises a (meth)acrylic acid ester-based polymer, a silica fine powder, and a silicone oil, wherein the (meth)acrylic acid ester-based polymer has fluidity at room temperature, and has a weight average molecular weight of 15000 or more and 100000 or less.

Abstract: To provide a device for concentration and separation of circulating tumor cells, capable of recovering circulating tumor cells in a blood-derived specimen simply, at a high recovery rate, and with low invasion of the tumor cells. A device for concentration and separation of circulating tumor cells present in a blood-derived specimen, in which a cell separating agent with thixotropic property having a specific gravity ranging from 1.050 to 1.080 and enabling the separation of tumor cells and blood cells other than the tumor cells by a centrifugal operation is housed in a bottomed tube-shaped container closed at one end and opened at the other end.

Abstract: There is provided a composition for separating blood serum or blood plasma that can inhibit bubbling during sterilization, and can inhibit the occurrence of phase separation during storage. The composition for separating blood serum or blood plasma according to the present invention comprises a (meth)acrylic acid ester-based polymer, a silica fine powder, and a silicone oil, wherein the (meth)acrylic acid ester-based polymer has fluidity at room temperature, and has a weight average molecular weight of 15000 or more and 100000 or less.

Abstract: There is provided a serum- or plasma-separating composition less likely to cause separation between a liquid organic compound and a thixotropy imparting component and capable of maintaining a homogeneous blended state for a prolonged period. The serum- or plasma-separating composition comprises a liquid organic compound, a thixotropy imparting component, and a thermoplastic elastomer.

Abstract: There is provided a serum- or plasma-separating composition capable of maintaining stable blood separation performance over a prolonged period even if subjected to a sterilization step during production or to prolonged storage. The serum- or plasma-separating composition comprises a resin composition having fluidity at normal temperature, a silica fine powder, and an amide-based compound represented by the following formula (1): wherein R3 is an alkyl group having 1 to 4 carbon atoms; and R1 and R2 are independently a hydrogen atom or a linear or branched alkyl group having 1 to 8 carbon atoms.

Abstract: A plug that allows the plug body to be easily and reliably pierced through by a hollow bodily fluid collection needle, makes the bodily fluid collection needle difficult to draw back out of the plug body owing to a resilience of a sheath after the start of bodily fluid collection, and enables easy and reliable collection of the bodily fluid.

Abstract: There is provided a serum- or plasma-separating composition less likely to cause separation between a liquid organic compound and a thixotropy imparting component and capable of maintaining a homogeneous blended state for a prolonged period. The serum- or plasma-separating composition comprises a liquid organic compound, a thixotropy imparting component, and a thermoplastic elastomer.

Abstract: There is provided a serum- or plasma-separating composition capable of maintaining stable blood separation performance over a prolonged period even if subjected to a sterilization step during production or to prolonged storage. The serum- or plasma-separating composition comprises a resin composition having fluidity at normal temperature, a silica fine powder, and an amide-based compound represented by the following formula (1): wherein R3 is an alkyl group having 1 to 4 carbon atoms; and R1 and R2 are independently a hydrogen atom or a linear or branched alkyl group having 1 to 8 carbon atoms.

Abstract: Provided is a plug that enables reliable and easy removal of a plug body together with a cover member from a tubular container without increasing an outwardly-bulging flange portion of a grip part of the plug body and is superior in productivity. A plug 1 for closing an open end of an open-ended tubular container 4. A cover member 3 is fitted on a plug body 2 including a press-fit part 2a and a grip part 2b. An engagement portion 3d is extended from a head plate 3a of the cover member 3 into a recess 2d in the upper surface of the plug body 2 to face an inside wall 2e surrounding the recess 2d. When an external force is applied to incline the head plate 3a with respect to the upper surface of the plug body 2, the engagement portion 3d is engaged to the inside wall 2e.

Abstract: To provide a device for concentration and separation of circulating tumor cells, capable of recovering circulating tumor cells in a blood-derived specimen simply, at a high recovery rate, and with low invasion of the tumor cells. A device for concentration and separation of circulating tumor cells present in a blood-derived specimen, in which a cell separating agent with thixotropic property having a specific gravity ranging from 1.050 to 1.080 and enabling the separation of tumor cells and blood cells other than the tumor cells by a centrifugal operation is housed in a bottomed tube-shaped container closed at one end and opened at the other end.

Abstract: Blood separation material which separates blood collected in a blood-sampling container, into blood cells and plasma or serum within a short period of time. An apparatus for separating blood with the blood separation material. An instrument for separating blood having a first hollow needle extending toward one end, a second hollow needle extending toward the other end, a tubular container with an inner space in which the blood flows, and a blood separation material. A container with a first channel for supplying blood into an inner space through which blood flows from the needlepoint of the first hollow needle into the inner space, a second channel for blood to flow out from the inner space toward the needlepoint of the second hollow needle, and a third channel which allows air to flow from the outer space toward the needlepoint of the first hollow needle.

Abstract: The present invention provides a blood collection container capable of allowing blood to coagulate in a short time and preventing blood from coagulating with bubbles contained therein and thus preventing formation of bubbly clots when used to collect blood therein. A blood collection container 1 stores a blood coagulation promoting agent 4 for promoting blood coagulation and an antifoaming agent 5, which is a polyoxyalkylene or a derivative thereof. The amount of the antifoaming agent 5 is 2.0×10?3 to 0.2 mg per mL of blood to be collected in the blood collection container 1.

Abstract: Provided is a blood separating agent that can form an excellent partition wall in an intermediate layer between clot and serum or between blood cell components and plasma even under low-temperature centrifugation conditions, is less likely to form crevices in the partition wall, is less likely to have any effect on test values, and offers stable performance even after long-term storage. The blood separating agent contains: a polymer for the blood separating agent which is composed of a (meth)acrylic acid ester-based polymer and has a viscosity of 10 to 200 Pa·s at 25° C. and a ratio of viscosity at 15° C. to viscosity at 25° C. of below 4.6; an inorganic powder; and a polyalkylene glycol having a number average molecular weight of 700 or more, wherein the polyalkylene glycol is mixed at a concentration of 5% by weight or less of the total weight of the blood separating agent.

Abstract: The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability; and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom.

Abstract: Provided is a plug that enables reliable and easy removal of a plug body together with a cover member from a tubular container without increasing an outwardly-bulging flange portion of a grip part of the plug body and is superior in productivity. A plug 1 for closing an open end of an open-ended tubular container 4. A cover member 3 is fitted on a plug body 2 including a press-fit part 2a and a grip part 2b. An engagement portion 3d is extended from a head plate 3a of the cover member 3 into a recess 2d in the upper surface of the plug body 2 to face an inside wall 2e surrounding the recess 2d. When an external force is applied to incline the head plate 3a with respect to the upper surface of the plug body 2, the engagement portion 3d is engaged to the inside wall 2e.

Abstract: Provided is a blood separating agent that can form an excellent partition wall in an intermediate layer between clot and serum or between blood cell components and plasma even under low-temperature centrifugation conditions, is less likely to form crevices in the partition wall, is less likely to have any effect on test values, and offers stable performance even after long-term storage. The blood separating agent contains: a polymer for the blood separating agent which is composed of a (meth)acrylic acid ester-based polymer and has a viscosity of 10 to 200 Pa·s at 25° C. and a ratio of viscosity at 15° C. to viscosity at 25° C. of below 4.6; an inorganic powder; and a polyalkylene glycol having a number average molecular weight of 700 or more, wherein the polyalkylene glycol is mixed at a concentration of 5% by weight or less of the total weight of the blood separating agent.

Abstract: A plug that allows the plug body to be easily and reliably pierced through by a hollow bodily fluid collection needle, makes the bodily fluid collection needle difficult to draw back out of the plug body owing to a resilience of a sheath after the start of bodily fluid collection, and enables easy and reliable collection of the bodily fluid.

Abstract: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.