Abstract: The present invention relates to a pharmaceutical composition for promoting the healing of wounds, containing lysophosphatidic acid and an adenylyl cyclase inhibitor as active ingredients, and more particularly, to a pharmaceutical composition which contains an adenylyl cyclase inhibitor and which promotes the healing of wounds in senescent cells or aged persons having physiological characteristics different than those of young cells or young persons. In addition, the present invention relates to a method for promoting the healing of wounds involving treating a wounded person with an effective dose of the lysophosphatidic acid and adenylyl cyclase inhibitor.

Abstract: A clutch actuator assembly may include a motor provided with a rotatable worm shaft, a screw thread being formed at an exterior circumference of the worm shaft; a worm wheel having a disk shape, and provided with a worm gear engaged to the screw thread and first and second guiding holes; an operation unit mounted in the first and second guiding holes in order to move toward a radial direction of the worm wheel; and an upper body provided with a fork, and engaging or releasing a clutch by upward and downward movements of the fork corresponding to a movement of the operation unit.

Abstract: Disclosed are a PLC (Programmable Logic Controller) symbol structure for a PLC code for automatically generating an input/output model, and a simulation apparatus and a simulation method for testing the PLC code using the same. In one embodiment, a computer-readable recording medium records a PLC code including a plurality of PLC symbols, wherein each of the PLC symbols includes a plurality of levels identified by an identifier, and a computer automatically generates an input/output model using the structure of each of the PLC symbols, thereby performing a simulation for testing the PLC code. The PLC symbol structure according to one embodiment systematically contains information required for automatically generating the input/output model, making it possible to automatically generate the input/output model for testing the PLC code in an easier manner without knowledge of simulation and modeling, and reducing the time consumed and the labor required for generating the input/output model.

Abstract: A clutch actuator is configured to change operational force applied to a clutch in cases that a worm wheel is rotated by a motor. The clutch actuator may include a motor provided with a rotatable worm shaft, a screw thread formed along an exterior circumference of the worm shaft, a worm wheel provided with a worm gear engaging the screw thread, and a cam recess, an operation rod mounted to the worm wheel, the operation rod configured to engage or release a clutch, and a rotatable operation unit disposed within the cam recess, and configured to apply elastic force to the worm wheel. Methods of using the clutch actuator are also described.

Abstract: The present invention relates to a composition for controlling aging and/or extending lifespan. More specifically, the present invention relates to a composition containing dapsone as an effective component for controlling aging and/or extending lifespan, in which when applying the composition according to the present invention to an object, the effect of controlling aging or extending lifespan is excellent. Specifically, the treatment of dapsone (DDS) increases the lifespan of C. elegans not depending upon daf-16 and delays aging process, and reduces the activity of cytoplasmic dual oxidase 1 (Duox1) and mitochondria complex V protein. In addition, dapsone can maintain the low oxygen uptake rate in C. elegans thereby reducing ROS formation. In addition, ROS production by paraquat that is an inducing material of oxidative stress is reduced by treating dapsone and the sensitivity of paraquat is reduced.

Abstract: The present invention relates to a composition containing an extracellular matrix for controlling aging and a method for controlling aging by using the same. The composition for controlling aging and the method for controlling aging have an effect for recovering the biological function of the aged aging cell, and the amount of the expression of the integrin alpha V that is a cell membrane protein and is reduced if aging is again increased in the aging cell recovered by the young extracellular matrix. However, when the amount of expression of the integrin alpha V is artificially decreased by using siRNA and antibody, the aging cell is not recovered by the extracellular matrix extracted from the young cell.

Abstract: The present invention relates to the molecular mechanism inducing cell proliferation in aged human fibroblasts by inhibiting AMPK using LPA and AC inhibitor. Particularly, the present invention relates to a composition comprising LPA and ACI as active ingredients and the invention proves with the said composition that LPA and ACI regulate different phosphorylation of AMPK? and thus inactivate p53 and induce senescent cell proliferation. This results support the fact that AMPK signal transduction plays an important role in cell proliferation of senescent cells.

Abstract: The present invention relates to a composition for the treatment and improvement of diabetes comprising caveolin as an active ingredient and a method for treating diabetes using the same, more precisely a composition comprising caveolin-1 as an active ingredient for the treatment and improvement of type II diabetes which is age-dependent but not showing obesity symptom and a method for treating diabetes using the same. The treatment method and composition of the present invention is very effective in improving and treating diabetes by regulating insulin sensitivity by increasing caveolin level in muscle tissues of type II diabetes patient which is age-dependent but not showing obesity symptom.

Abstract: The present invention relates to a composition for inhibiting cellular senescence, comprising N-[2-(cyclohexyloxyl)-4-nitrophenyl]-methanesulfonamide. During the progression of cellular senescence, the expression of COX-2 was decreased, whereas the enzymatic activity of COX-2 was increased, and the cellular senescence regulatory effects of the three selective COX-2 inhibitors had no connection with the concentration of intracellular reactive oxygen species, the activity of NF-?B and the amounts of p53 and p21 proteins. Rather, it was found that the three selective COX-2 inhibitors regulated the expression of caveolin-1 at the transcriptional level and regulated the intracellular total cholesterol concentration, and these results were closely connected with the cellular senescence regulatory effects of the three selective COX-2 inhibitors.

Abstract: A clutch actuator assembly may include a motor provided with a rotatable worm shaft, a screw thread being formed at an exterior circumference of the worm shaft; a worm wheel having a disk shape, and provided with a worm gear engaged to the screw thread and first and second guiding holes; an operation unit mounted in the first and second guiding holes in order to move toward a radial direction of the worm wheel; and an upper body provided with a fork, and engaging or releasing a clutch by upward and downward movements of the fork corresponding to a movement of the operation unit.

Abstract: A clutch actuator is configured to change operational force applied to a clutch in cases that a worm wheel is rotated by a motor. The clutch actuator may include a motor provided with a rotatable worm shaft, a screw thread formed along an exterior circumference of the worm shaft, a worm wheel provided with a worm gear engaging the screw thread, and a cam recess, an operation rod mounted to the worm wheel, the operation rod configured to engage or release a clutch, and/or a rotatable operation unit disposed within the cam recess, and configured to apply elastic force to the worm wheel. Methods of using the clutch actuator are also described.

Abstract: The present application discloses a therapeutic antimicrobial composition comprising mucocidin antimicrobial peptides or analogue or fragments thereof having antimicrobial activity.

Abstract: The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the effective amount of an inhibitor of adenylyl cyclase or an inhibitor of protein kinase A.

Abstract: The present invention relates to (a) a method for detecting a senescent cell, which comprises measuring a relative alteration to young cell in a signal or molecular species involved in signal transduction; (b) a method; and (c) a composition for modulating cellular senescence comprising treating a senescent cell with the effective amount of an inhibitor of adenylyl cyclase or an inhibitor of protein kinase A.

Abstract: The present invention relates to nucleic acid sequences and proteins involved in senescence and particularly, to nucleic acid sequences and proteins including amphiphysin and caveolin involved in cellular senescence and their use.

Abstract: The present invention relates to nucleic acid sequences and proteins involved in senescence and particularly, to nucleic acid sequences and proteins including amphiphysin and caveolin involved in cellular senescence and their use.

Abstract: A liquid crystal display device that uses in-plane switching is capable of eliminating a stain generated at an outer area of a thin film transistor array and minimizing a time delay of a common voltage applied to a thin film transistor array. In the device, a plurality of data lines apply data signals to a thin film transistor array. A plurality of gate lines apply gate signals to the thin film transistor array. A plurality of common voltage lines apply a common voltage to the thin film transistor array. The common voltage lines are provided at the outer area of the thin film transistor array and are spaced from the thin film transistor array by a distance of more than 1 to 1.5 mm. A plurality of dummy signal lines are arranged in parallel to the common voltage lines and adjacent to the common voltage lines provided at the outer area of the thin film transistor array to apply alternating current signals.

Abstract: The present invention provides a method and a composition for detecting the levels of a plurality of biomolecular probes in a sample. In particular, the invention relates to a hybridization composition for detecting the presence or levels of different polynucleotide sequences in a sample.

Abstract: The present invention provides a method and a composition for detecting the levels of a plurality of biomolecular probes in a sample. In particular, the invention relates to a hybridization composition for detecting the presence or levels of different polynucleotide sequences in a sample.

Abstract: A liquid crystal display device that uses in-plane switching is capable of eliminating a stain generated at an outer area of a thin film transistor array and minimizing a time delay of a common voltage applied to a thin film transistor array. In the device, a plurality of data lines apply data signals to a thin film transistor array. A plurality of gate lines apply gate signals to the thin film transistor array. A plurality of common voltage lines apply a common voltage to the thin film transistor array. The common voltage lines are provided at the outer area of the thin film transistor array and are spaced from the thin film transistor array by a distance of more than 1 to 1.5 mm. A plurality of dummy signal lines are arranged in parallel to the common voltage lines and adjacent to the common voltage lines provided at the outer area of the thin film transistor array to apply alternating current signals.