Abstract: A system and method of dynamic search result permission checking. A system that provides end users the ability to search an index (i.e., Shinydocs Index) built from content from one or multiple source repositories, and only display results for which the user has sufficient permissions at source to view. User credentials are validated “on the fly”, such that these checks are performant across a multiple of possible back-end repositories sequentially or simultaneously. The resultant search results from the Index may be sourced from many disparate repositories, each of which have their own unique permission structure (to view individual items). A method for handling permissions in multiple repositories in a secure (yet performant) fashion in order to only display search results that the end-user is allowed to view based on source system permissions.

Abstract: The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: Compounds and methods of using said compounds, alone or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Abstract: A reusable container for transporting, inspecting, and/or storing a fuel cell or other item may include a crate or box lined with plurality of cushioning inserts to protect a fuel cell placed within the container, and a plurality of straps that extend inwardly from walls of the container and couplable to the fuel cell. The straps are tensionable to suspend at least a portion of the weight of the fuel cell from the walls of the container while a portion of the fuel cell may rest on top of cushioning inserts at the floor of the container.

Abstract: A compound having the following formula is disclosed. The compound is useful as an emitter in OLED applications.

Abstract: A liquid dispensing system for dispensing two or more liquids of different composition, viscosity, solubility and/or miscibility at high filling speeds into a container through a unitary dispensing nozzle to improve homogeneous mixing of such liquids, while said nozzle is an integral piece free of any movable parts.

Abstract: A flexible packaging laminate has built-in opening/reclose and tamper-evidence features by forming the laminate from an outer structure joined in face-to-face relation to an inner structure. Score lines are formed in both structures to enable an opening to be formed through the laminate by lifting a flap or the like out of the plane of the laminate. The score line through the outer structure defines a larger opening than the score line through the inner structure, such that a marginal region of the outer structure extends beyond the edge of the opening portion of the inner structure. A pressure-sensitive adhesive is used to re-adhere the marginal region to an underlying surface of the inner structure adjacent the opening through the laminate. The outer score line includes at least one tear portion that is torn through upon initial opening, thus indicating the package has been at least partially opened.

Abstract: An environmentally friendly insulated packing system is provided. The insulated packing system may include a base layer and an insulating layer disposed on the base layer in one or more areas. The insulating layer may be a plurality of block-shaped pockets having a substantially rectangular or cube form in each of the one or more areas. The base layer may be folded to join the substantially rectangular forms and align with the inner surface of all or part of a shipping container, e.g., a box. In an alternate embodiment, the insulating packing system may be in the form of a bag/pliable box.

Abstract: The invention relates to imidazopyridines of Formula (I) and pharmaceutically acceptable salts thereof, wherein R0 to R5 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: This document describes a single-layer air waveguide antenna integrated on a circuit board. The waveguide guides electromagnetic energy through channels filled with air. It is formed from a single layer of material, such as a sheet of metal, metal-coated plastic, or other material with conductive surfaces that is attached to a circuit board. A portion of a surface of the circuit board is configured as a floor of the channels filled with air. This floor is an electrical interface between the circuit board and the channels filled with air. The single layer of material is positioned atop this electrical interface to define walls and a ceiling of the channels filled with air. The single layer of material can be secured to the circuit board in various ways. The cost of integrating an air waveguide antenna on to a circuit board this way may be less expensive than other waveguide-manufacturing techniques.

Abstract: The present disclosure describes ultrasound imaging systems and methods for ultrasonically inspecting biological tissue. An ultrasound imaging system according to the present disclosure may be configured to automatically apply tissue-specific imaging parameter settings (312, 314) based upon the automatic identification of the type of tissue being scanned. Tissue type identification (315) may be performed automatically for the images in the live image stream (304) and thus adjustments to the imaging settings may be applied automatically by using a neural network (320) and thus dynamically during the exam obviating the need for the sonographer to manually switch presets or adjust the imaging settings when moving to different portion of the anatomy.

Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: A system may provide a plurality of communication modes to a remote server system and provide remote control and monitoring of the system via two-way communication. The system may communicate with an alarm processor of an alarm system. The system may determine a communication mode to provide communication between the alarm system and the remote server. The system may send status and alarm conditions to the remote server, and the system may send control signals to the alarm system. The remote server may provide a pre-determined response to information received from the alarm system, for example the alarm system may provide alarm system condition information to a user or a monitoring station for response.

Abstract: A passive circuit component includes an edge having a low line edge roughness (LER). A method for manufacturing the passive circuit component includes a self-aligned double patterning (SADP) etch process using a tri-layer process flow. The tri-layer process flow includes use of an underlayer, hard mask, and photoresist. The passive circuit component made by this method achieves improved mismatch between like components due to the low LER.

Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.

Abstract: A needle bending assembly configured to at least temporarily contain a needle can include a first housing section, a second housing section, and a coupling element coupled between the first housing section and the second housing section. The first housing section defines a first cavity configured to at least temporarily contain a first section of the needle. The second housing section defines a second cavity configured to at least temporarily contain a second section of the needle forming a distal tip. The coupling element is configured such that when the needle is contained within the housing sections, movement of the second housing section relative to the first housing section results in a bending of the needle at a location corresponding to the coupling element.

Abstract: A Heating, Ventilation, and Air Conditioning (HVAC) system that is configured to receive a refrigerant from a condenser at a fixed expansion device and a variable expansion device. The system is further configured to output a first portion of the refrigerant to a first downstream HVAC component at a fixed flow rate using the fixed expansion device. The system is further configured to apply a first force to a pin of the variable expansion device based on a sensed temperature. The system is further configured to apply a second force to a valve of the variable expansion device via the force applied to the pin and to output a second portion of the refrigerant to a second downstream HVAC component at a variable flow rate based on the second force using the valve of the variable expansion device.

Abstract: A hemodynamic monitoring system comprising an ultrasound system comprising a transesophageal ultrasound probe and a computer system coupled to the ultrasound system. The computer system can be configured to calculate an image quality parameter and/or a hemodynamic parameter by segmenting images obtained via the hemodynamic monitoring system to identify a selected anatomical structure therein. The image quality and hemodynamic parameters can be displayed to users, such as medical staff, in connection with the ultrasound images.

Abstract: A network node in a peer-to-peer network of nodes includes at least one processor, at least one memory, and at least one network interface. The at least one processor is configured to receive a request to transfer a security token and execute a plurality of compliance rules associated with the security token. At least one of the compliance rules is implemented using at least one smart contract. The at least one smart contract references a global registry. The at least one processor is also configured to transfer the security token based on the execution of the compliance rules. The global registry includes personally identifiable information (PII) hash(es) for each of at least one investor associated with the transfer of the security token. The hashes are committed to the distributed ledger and updated when PII of a respective one of the at least one investor changes.