Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A system for use with a drug delivery device includes a sensor unit and a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, wherein the drug-retaining region contains a drug. The sensor unit is configured to detect a characteristic of a local environment and generate an output corresponding to a value of the detected characteristic. The deactivation unit is configured to render the drug ineffective when the output of the sensor unit satisfies a predetermined condition.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A system for use with a drug delivery device includes a sensor unit and a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, wherein the drug-retaining region contains a drug. The sensor unit is configured to detect a characteristic of a local environment and generate an output corresponding to a value of the detected characteristic. The deactivation unit is configured to render the drug ineffective when the output of the sensor unit satisfies a predetermined condition.

Abstract: A fluid flow control and debris intercepting apparatus for controlling the flow of fluid and the introduction of debris into the entrance of a water diversion system such as a curbside storm drain.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Techniques for stethoscope sanitation are disclosed. In one particular embodiment, the techniques may be realized as a system for stethoscope sanitation including a first dispensing nozzle positioned to dispense a sanitization fluid on a first surface of a stethoscope, a second dispensing nozzle positioned to dispense the sanitization fluid on a second surface of a stethoscope, a first sensor configured to detect the presence of the stethoscope within a close proximity of the first dispensing nozzle and to detect the presence of the stethoscope within a close proximity of the second dispensing nozzle, and a pump configured to receive the sanitization fluid from a sanitization fluid receptacle and to provide the sanitization fluid to the first dispensing nozzle and the second dispensing nozzle. The techniques may include a microcontroller configured to receive a signal from the first sensor and initiating pumping in response to reception of the signal.

Abstract: Techniques for providing a secondary path for sanitization fluid are disclosed. In one particular embodiment, the techniques may be realized as an apparatus providing an additional sanitization fluid dispensing path. The additional sanitization fluid dispensing path may include a sealing housing which may include a sealing ring, the sealing ring having a first opening for holding a first sanitization fluid dispensing path, a perimeter ring wall connected at one end to the sealing ring and arranged substantially perpendicular to the sealing ring, wherein the perimeter ring wall is configured to fasten the sealing ring to a sanitization fluid container, and a sealed cavity configured to accept an adapter to conduct sanitization fluid, wherein acceptance of the adapter opens the sealed cavity to form a second sanitization fluid dispensing path.

Abstract: A remote controller for a mobile device is described. The remote controller includes a communications transceiver configured for bidirectional communications with the mobile device, and a computer processing system communicatively coupled to the communications transceiver. The computer processing system may be configured to execute instructions to remotely control one or more applications associated with the mobile device. Examples of applications include media playback applications, software updating applications, and the like. The remote controller may also include one or more actuators communicatively coupled to the computer processing system, the one or more actuators being configured to receive user input to control or access the one or more applications. Additionally, the remote controller may include a screen.

Abstract: A fluid flow control and debris intercepting apparatus for controlling the flow of fluid and the introduction of debris into the entrance of a water diversion system such as a curbside storm drain.

Abstract: A fluid flow control and debris intercepting apparatus for controlling the flow of fluid and the introduction of debris into the entrance of a water diversion system such as a curbside storm drain.

Abstract: A cable dispensing apparatus for laying cable has a support for a coil, e.g. a drum, of cable. A boom assembly that includes an arm extends from a location fixed relative to the coil support. Cable guides are fixed relative to the arm at an end of the arm remote from the support. In use the cable guides direct cable from the coil into a trench during use.

Abstract: A fluid flow control and debris intercepting apparatus for controlling the flow of fluid and the introduction of debris into the entrance of a water diversion system such as a curbside storm drain.

Abstract: A drug deactivation system according to some embodiments includes at least one drug-retaining region of a drug delivery device and at least one energy source coupled to the at least one drug-retaining region. The at least one drug-retaining region may be configured to retain a drug. The at least one energy source may be configured to transmit energy to the drug. The drug is capable of being rendered ineffective in the presence of the transmitted energy.

Abstract: A fluid flow control and debris intercepting apparatus for controlling the flow of fluid and the introduction of debris into the entrance of a water diversion system such as a curbside storm drain.

Abstract: A method of enabling administration of a drug includes determining, within a drug-transfer device including cells, a location of at least one cell and generating information identifying the determined location. A user may be provided with the drug-transfer device. The drug is retained within the at least one cell when the user is provided with the drug-transfer device. The method also includes encoding a key with the information and providing the user with the key before, after or when the user is provided with the drug-transfer device. Drug retained within the at least one cell is selectively releasable when the key is operably proximate to the drug-transfer device and is encoded with the information. The key can be encoded with the information before and/or after being provided to the user. In some embodiments, the key is encoded based on instructions transmitted over a network.

Abstract: Devices capable of deterring or preventing bulk extraction of drugs from, for example, drug-delivery systems are exemplarily disclosed. In one embodiment, such a device may include a package releasably retaining a drug and an agent. The agent is configured to suppress a physiological effect of the drug when the agent contacts the drug or is coadministered with the drug. The cell package is configured such that an amount of the drug is selectively releasable with respect to the agent when the package is operably proximate to an encoded key. The package, however, may be configured to impose a relatively high likelihood that either the drug will not be accessed or the drug will be contaminated by the agent if access to the contents of the package is sought without the use of an encoded key.

Abstract: A drug deactivation system according to some embodiments includes at least one drug-retaining region of a drug delivery device and at least one energy source coupled to the at least one drug-retaining region. The at least one drug-retaining region may be configured to retain a drug. The at least one energy source may be configured to transmit energy to the drug. The drug is capable of being rendered ineffective in the presence of the transmitted energy.