Abstract: Microchip devices are provided that include a substrate; a plurality of reservoirs in the substrate, each reservoir defining an internal volume; and a reservoir cap positioned on or in each of the reservoirs bounding the internal volume from an external environment, the reservoir cap being formed of a material that undergoes a phase change upon heating, wherein the internal volume can communicate with the external environment upon heating said reservoir cap to cause said reservoir cap to undergo a phase change and rupture.

Abstract: This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of A? related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

Abstract: The invention relates to 2-aza-bicyclo[2.2.2]octane compounds and uses thereof. Particularly the invention relates to such compounds and their uses as pharmaceuticals in treating pyshoses such as schizophrenia and other diseases, disorders, or conditions.

Abstract: Methods are provided for controlled reservoir opening, including the steps of (a) providing a biocompatible implantable device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir. In another embodiment, the method steps include (a) implanting into a patient a biocompatible device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir.

Abstract: This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

Abstract: The present application relates to internally cyclized naphthamide compounds of the formula Ia (wherein R1a, R1b, R1c, R2, R3, R4, R5, R6, R7, R8, X1, X2, Y, Z, and n are as defined herein), which are useful, for example, for antagonizing the pharmacological actions of the neurokinin 1 (NK1) receptor.

Abstract: A method for teaching an individual to speak correctly using novel visual displays and supporting descriptive material. The visual display comprises a string of discreet visual segments illustrating volume, pace, pitch, melody and tone that guide the individual in creating specific sounds and speech patterns. The visual displays can be published in a book or pamphlet from or in electronic media such as CD, CD-Rom, DVD, or video.

Abstract: Compounds having the general formula wherein R1a, R1b, R1c, R2, R3, R4, R5, R6, R7, R8, X1, X2, Y, Z and n are as defined in the specification, methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.

Abstract: Methods are provided for controlled reservoir opening, including the steps of (a) providing a biocompatible implantable device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir. In another embodiment, the method steps include (a) implanting into a patient a biocompatible device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir.

Abstract: Microchip delivery devices are provided that control both the rate and time of release of molecules. In one embodiment, an implantable microchip device is provided for the controlled delivery of drug molecules into a patient comprising at least one substrate; a plurality of reservoirs in the substrate; a release system which includes drug molecules for release, the release system being provided in each of the reservoirs; a reservoir cap positioned on or in each of the reservoirs over the release system, the reservoir cap comprising a material that undergoes a phase change in response to a change in temperature; and a heating means capable of selectively causing the phase change independently in each reservoir cap, to release the molecules from the reservoirs. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

Abstract: A compound having the general formula (I) and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.

Abstract: Microchip delivery devices are provided that control both the rate and time of release of molecules. In one embodiment, an implantable microchip device is provided for the controlled delivery of drug molecules into a patient comprising at least one substrate; a plurality of reservoirs in the substrate; a release system which includes drug molecules for release, the release system being provided in each of the reservoirs; a reservoir cap positioned on or in each of the reservoirs over the release system, the reservoir cap comprising a material that undergoes a phase change in response to a change in temperature; and a heating means capable of selectively causing the phase change independently in each reservoir cap, to release the molecules from the reservoirs. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

Abstract: The invention is a method of teaching an individual how to correctly sing a song by using visual display that is displayed to the individual synchronously with the playing of the audio portion of the song. A plurality of visual cues included in the visual display guides the individual in following the musical tones in the song that is played along with the display of the visual cues. The visual display can be made available for use in a variety of ways such as on CDs, on the Internet, and the like. Alternatively, the visual display can be published in a printed publication for use with an audio recording of the song.

Abstract: Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress.

Abstract: A rotor assembly for a gas turbine engine including a bearing assembly and a damper sub-assembly that facilitate reducing dynamic motion to the rotor assembly is described. The bearing assembly includes rolling elements positioned between a paired race. The rotor assembly includes a rotor shaft supported by the bearing assembly. The damper sub-assembly is radially outward from the bearing assembly adjacent a sump housing, and includes a damper insert. A predetermined preload force is applied to the rolling elements. An outer race of the bearing assembly distorts to substantially match a distortion pattern of the damper insert.

Abstract: A rotor assembly for a gas turbine engine including a bearing assembly and a damper sub-assembly that facilitate reducing dynamic motion to the rotor assembly is described. The bearing assembly includes rolling elements positioned between a paired race. The rotor assembly includes a rotor shaft supported by the bearing assembly. The damper sub-assembly is radially outward from the bearing assembly adjacent a sump housing, and includes a damper insert. A predetermined preload force is applied to the rolling elements. An outer race of the bearing assembly distorts to substantially match a distortion pattern of the damper insert.

Abstract: A bottle assembly for use in the convenient storage and dispensing of beverages of the character used in restaurants and bars to make mixed drinks. The bottle assembly is compact, easy to use, and permits the smooth dispensing of the beverage contained within the container portion of the assembly in a rapid and efficient manner. Additionally, the bottle assembly embodies a unique handle design for gripping by the user which enables beverages to be poured from the container in an ergonomically sound manner so that undue stresses on the hand and wrist of the user are substantially avoided.

Abstract: A key locking indicator device usable with a key of conventional design for tactile and visual indication of whether the device was last used to look or unlock the look operated by the key. The device is of simple construction, embodies a minimum number of moving parts, and is easy to use.

Abstract: An improved ice cream scoop for scooping ice cream from bulk containers of the character having a spring biased ejection mechanism for ejecting the ice cream from the scoop in which, upon a failure of the ejection mechanism, a new mechanism can be easily and quickly installed without the use of tools and without the need for removal of fasteners of any kind.

Abstract: A securement apparatus for locking together remotely located objects, as for example locking a boat to a dock clete or a light airplane to a tiedown. The apparatus includes spaced apart locking mechanisms which are interconnected by an elongated connector having a flotation cover over a length of steel cable.