Abstract: The present technology relates to intracardiac pressure monitoring devices, and associated systems and methods. In some embodiments, the present technology includes a device for monitoring pressure within a patient's heart. The device can include a pressure sensor configured to reside within a first chamber of a heart of a patient, and a pressure transmission element configured to extend from the first chamber through a septal wall to a second chamber of the heart of the patient. When the device is implanted in the patient's heart, the pressure transmission element is configured to transmit pressure from the second chamber to the pressure sensor residing within the first chamber.

Abstract: The present technology relates to intracardiac sensors and associated systems and methods. In some embodiments, the present technology includes a device for monitoring pressure within a patient's heart. The device can include an implantable capacitor having a capacitance value that is variable based on the pressure within the patients heart and a sensing circuit configured to measure the capacitance value. The device can also include an implantable inductor and a power circuit configured to wirelessly receive power from an external source via the inductor. When the device is in a first configuration, the capacitor can be electrically coupled to the sensing circuit and the inductor can be electrically coupled to the power circuit. When the device is in a second configuration, the capacitor can be electrically coupled to the inductor to form a resonant circuit.

Abstract: Methods for classifying a core cane of an multimode optical fiber are disclosed. In embodiments, the method includes determining a relative refractive index profile ?(r) of the core cane; fitting the relative refractive index profile ?(r) to an alpha profile ?fit(r) defined by: ? fit ( r ) = ? o , fit ( 1 - ( r a fit ) ? fit ) where ?o,fit is a relative refractive index at a longitudinal centerline of the core cane, ?fit is a core shape parameter, and afit is an outer radius of the core cane; generating a non-alpha residual profile ?diff(r)=?(r)??fit(r) for the core cane; computing one or more metrics from ?diff(r), and using the one or metrics in a classification of the core cane, the classification comprising a prediction of whether a bandwidth at a pre-determined wavelength of an optical fiber drawn from a preform comprising the core cane exceeds a pre-determined bandwidth at the pre-determined wavelength.

Abstract: Multicore optical fibers with low bend loss, low cross-talk, and large mode field diameters In some embodiments a circular multicore optical fiber includes a glass matrix; at least 3 cores arranged within the glass matrix, wherein any two cores have a core center to core center spacing of less than 29 microns; and a plurality of trench layers positioned between a corresponding core and the glass matrix, each trench layer having an outer radius of less than or equal to 14 microns and a trench volume of greater than 50% ? micron2; wherein the optical fiber has a mode field diameter of greater than about 8.2 microns at 1310 nm, and wherein the optical fiber has an outer diameter of less than about 130 microns.

Abstract: The present technology relates to intracardiac pressure monitoring devices, and associated systems and methods. In some embodiments, the present technology includes a device for monitoring pressure within a patient's heart. The device can include a pressure sensor configured to reside within a first chamber of a heart of a patient, and a pressure transmission element configured to extend from the first chamber through a septal wall to a second chamber of the heart of the patient. When the device is implanted in the patient's heart, the pressure transmission element is configured to transmit pressure from the second chamber to the pressure sensor residing within the first chamber.

Abstract: A disclosed multimode optical fiber comprises a core and a cladding surrounding the core. The core has an outer radius r1 in between 20 ?m and 30 ?m. The cladding includes a first outer cladding region having an outer radius r4a and a second outer cladding region having an outer radius r4b less than or equal to 45 ?m. The second outer cladding region comprises silica-based glass doped with titania. The optical fiber further includes a primary coating with an outer radius r5 less than or equal to 80 ?m, and a thickness (r5?r4) less than or equal to 30 ?m. The optical fiber further includes a secondary coating with an outer radius r6 less than or equal to 100 ?m. The secondary coating has a thickness (r6?r5) less than or equal to 30 ?m, and a normalized puncture load greater than 3.6×10?3 g/micron2.

Abstract: A system and method for applications of computer vision in linking users with virtual data that can include detecting digital interaction state of a plurality of subjects in an environment using at least one sensor-based monitoring system; detecting a contextual organization of subjects relative to an operator station; at the operator station, augmenting the user interface based on the contextual organization of subjects which comprises of at least: presenting a set of subject indicators in the user interface with the subject indicators arranged in response to contextual organization, and in response to received user interaction with at least one selected subject indicator, accessing the digital interaction state of the subject associated the at least one subject indicator.

Abstract: Methods and systems for removing coatings from optical fibers. A system includes a gas source for providing gas, and a heater configured to heat the gas. The system further includes a holder comprising first and second attachment features, wherein the attachment features secure a coated optical fiber along a removal path. The system further includes at least one nozzle connected to the gas source, wherein the at least on nozzle is aimed in a nozzle direction that is towards the removal path at a pitch, such that the nozzle is non-perpendicular towards the removal path. The nozzle further directs a continuous stream of the heated gas towards the coated optical fiber causing the coating of the coated optical fiber to be removed. The methods and systems may employ a second nozzle that may be offset from the first nozzle angularly and/or laterally with respect to the removal path.

Abstract: A system and method for applications of computer vision in linking users with virtual data that can include detecting digital interaction state of a plurality of subjects in an environment using at least one sensor-based monitoring system; detecting a contextual organization of subjects relative to an operator station; at the operator station, augmenting the user interface based on the contextual organization of subjects which comprises of at least: presenting a set of subject indicators in the user interface with the subject indicators arranged in response to contextual organization, and in response to received user interaction with at least one selected subject indicator, accessing the digital interaction state of the subject associated the at least one subject indicator.

Abstract: A method, system and computer readable medium of: providing feature data of at least one organ at risk or target volume of said patient from a database of non-transitory data stored on a data storage device of prior patients data; generating, using a data processor, a distribution of dose points of the at least one organ at risk or target volume of said patient based on said feature data; calculating, using the data processor, at least one of (i) a probability of toxicity for the at least one organ at risk or (ii) a probability of treatment failure for the at least one target volume, based on said distribution of dose points; assessing, using the data processor, a dosimetric-outcome relationship based on the calculated probability; and automatically formulating, using the data processor, a treatment plan using the dosimetric-outcome relationship to minimize the at least one treatment-related risk.

Abstract: The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4. The present invention further relates to methods for treating patients suffering from diseases associated with increased expression of DUX4 or expression of an aberrant form of DUX4, such as Facioscapulohumeral muscular dystrophy (FSHD).

Abstract: A fiber optic cable includes a cable jacket having an outer surface defined by a cable jacket outer diameter JOD and an inner surface defined by a cable jacket inner diameter JID; a plurality N of optical fibers, where N?4, contained within the cable jacket and positioned a distance away from the cable jacket inner diameter, with each optical fiber having a core, a cladding surrounding the core, and at least one coating surrounding the core with the at least one coating having an outer coating diameter less than or equal to about 200 microns and wherein the cable jacket outer diameter JOD is less than or equal to 1 mm.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: A Raman spectroscopy system is provided. The spectroscopy system includes an optical switch including a pump inlet, a return outlet, a plurality of pump outlets, and a plurality of return inlets. The spectroscopy system includes a plurality of radiation sources optically coupled to the pump inlet of the optical switch, and a detector optically coupled to the return outlet of the optical switch. The spectroscopy system further includes a plurality of probes, each probe optically connected to at least one of the plurality of pump outlets of the optical switch by at least one excitation fiber and optically coupled to one of the return inlets of the optical switch by at least one emission fiber.

Abstract: The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and/or a geometry of a lumen orifice to control the flow of blood through the lumen.

Abstract: The present technology includes systems and methods for invasively adjusting implantable devices for selectively controlling fluid flow between a first body region and a second body region of a patient. For example, in many of the embodiments described herein, a catheter can be used to mechanically and/or electrically engage an implanted medical device. Once the catheter engages the medical device, the catheter can (i) increase a dimension associated with the medical device, such as through mechanical expansion forces, and/or (ii) decrease a dimension associated with the medical device, such as by heating a shape memory component of the medical device above a phase transition temperature.

Abstract: In accordance with some implementations, a method is performed at an electronic device with one or more processors, a non-transitory memory, one or more input devices, and a display. The method includes displaying, on the display, a reader interface including one or more portions of reading content. The method further includes detecting, via the one or more input devices, a first positional change input. The first positional change input is indicative of the electronic device changing from a first position to a second position. The method further includes, in response to detecting the first positional change input, ceasing to display the reader interface including the one or more portions of reading content, and displaying, on the display, one or more computer-generated representations corresponding to the one or more portions of reading content.

Abstract: The present technology includes systems and methods for invasively adjusting implantable devices for selectively controlling fluid flow between a first body region and a second body region of a patient. For example, in many of the embodiments described herein, a catheter can be used to mechanically and/or electrically engage an implanted medical device. Once the catheter engages the medical device, the catheter can (i) increase a dimension associated with the medical device, such as through mechanical expansion forces, and/or (ii) decrease a dimension associated with the medical device, such as by heating a shape memory component of the medical device above a phase transition temperature.

Abstract: The present disclosure relates to a process by which an optical fiber is terminated with a ferrule to form an optical fiber connector assembly. The ferrule is heated at a heating temperature whereby the ferrule bore (and ferrule microhole) expands. The optical fiber is then inserted into the ferrule microhole. The ferrule then contracts when heat is no longer applied resulting in an interference fit between the optical fiber and the ferrule microhole based on the dimensions of the optical fiber and the ferrule microhole. The interference fit yields certain optical fiber characteristics within the optical fiber connector assembly. The present disclosure also relates to an optical fiber having an outer cladding comprising titania-doped silica and the resulting optical fiber characteristics.

Abstract: An illumination system generating light having at least one wavelength within 200 nm a plurality of nano-sized structures (e.g., voids). The optical fiber coupled to the light source. The light diffusing optical fiber has a core and a cladding. The plurality of nano-sized structures is situated either within said core or at a core-cladding boundary. The optical fiber also includes an outer surface. The optical fiber is configured to scatter guided light via the nano-sized structures away from the core and through the outer surface, to form a light-source fiber portion having a length that emits substantially uniform radiation over its length, said fiber having a scattering-induced attenuation greater than 50 dB/km for the wavelength(s) within 200 nm to 2000 nm range.