Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: A optical fiber comprising a central core region having an outer radius r1 of 3 ?m to 7 ?m, and a maximum refractive index ?1 of 0.25% to 0.5% and an alpha (a) profile of 1 to 20; a cladding region comprising (i) a first inner cladding region surrounding the core, having a refractive index ?2 of ?0.25% to 0.05% and a radius r2 of 6 ?m to 15 ?m, (ii) a second inner cladding region, surrounding the first inner cladding region, having a refractive index ?3 of ?0.1% to 0.2% and a radius r3 of 7 ?m to 15 ?m, and (iii) an outer cladding region, surrounding the second inner cladding region, having a refractive index ?4 between ?0.05% to 0.1%; wherein the optical fiber exhibits a cable cutoff of less than 1260 nm, a mode field diameter at 1310 nm of greater than 8.2 microns.

Abstract: The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

Abstract: Optical fibers having a large effective area and a low cutoff wavelength are disclosed. Three main embodiments of the optical fiber allow for single-mode operation at wavelengths greater than 980 nm, and have a large effective area with low bend losses and low dispersion at 1310 nm. The large effective area optical fiber is expected to be particularly useful for data center applications due to its ability to efficiently optically couple with VCSELs and photonic integrated devices. Integrated systems and optical communication systems that employ the optical fibers are also disclosed.

Abstract: A method is used to select a multimode fiber meeting requirements of a first minimum bandwidth at a first wavelength and a second minimum bandwidth at a second wavelength different from the first wavelength. Differential mode delay (DMD) data is measured for the multimode fiber at the first wavelength. The DMD data comprises output laser pulse data as a function of the radial position of an input laser pulse having the first wavelength. The DMD data is transformed into mode group space, to obtain relative mode group delay data as a function of mode group. The multimode fiber is selected based on meeting requirements of the first minimum bandwidth at the first wavelength based on a first set of criteria, comprising a first criterion using as input the measured differential mode delay (DMD) data for the multimode fiber measured at the first wavelength.

Abstract: A coupled-core multicore optical fiber has a plurality of cores that are doped with alkali metals or chlorine to achieve low attenuation and a large effective area. The cores may be embedded in a common cladding region that may be fluorine doped. The cores may also be doped with chlorine, either with the alkali metals described above or without the alkali metals.

Abstract: Multicore optical fibers with low bend loss, low cross-talk, and large mode field diameters In some embodiments a circular multicore optical fiber includes a glass matrix; at least 3 cores arranged within the glass matrix, wherein any two cores have a core center to core center spacing of less than 29 microns; and a plurality of trench layers positioned between a corresponding core and the glass matrix, each trench layer having an outer radius of less than or equal to 14 microns and a trench volume of greater than 50% ? micron2; wherein the optical fiber has a mode field diameter of greater than about 8.2 microns at 1310 nm, and wherein the optical fiber has an outer diameter of less than about 130 microns.

Abstract: An optical fiber is provided that includes a core region, a cladding region having a radius less than about 62.5 microns; a polymer coating comprising a high-modulus layer and a low-modulus layer, wherein a thickness of the low-modulus inner coating layer is in a range of 4 microns to 20 microns, the modulus of the low-modulus inner coating layer is less than or equal to about 0.35 MPa, a thickness of the high-modulus coating layer is in a range of 4 microns to 20 microns, the modulus of the high-modulus inner coating layer is greater than or equal to about 1.6 GPa, and wherein a puncture resistance of the optical fiber is greater than 20 g, and wherein a microbend attenuation penalty of the optical fiber is less than 0.

Abstract: First content may be obtained in response to identifying a first physical element of a first object type. The first content may be associated with the first object type. Second content may be obtained in response to identifying a second physical element of a second object type. The second content may be associated with the second object type. The second physical element may be detected as being within a threshold distance of the first physical element. Third content may be generated based on a combination of the first content and the second content. The third content may be associated with a third object type that is different from the first object type and the second object type. The third content may be displayed on the display.

Abstract: The high-density FAU comprises a support substrate having a grooved front-end section that supports glass end sections of the small diameter low-attenuation optical fibers. A cover is disposed on the front-end section and secured thereto to hold the glass end sections in place. The substrate and the cover can be made of the same glass or glasses having about the same CTE. The glass end sections have a diameter d4 so that the pitch P2 of the fibers at the front end of the FAU can be equal to or greater than d4, wherein d4=2r4, with r4 being the radius of the glass end section as defined by the optical fiber cladding. The glass end section has a radius r4 less than 45 microns, allowing for a high-density FAU and a high-density optical interconnection device.

Abstract: The present disclosure relates to a process by which an optical fiber array or a single optical fiber is cleaved with a laser-cleaving apparatus. The coating material is stripped or removed from a section of an optical fiber array or single optical fiber; a coated or ribbonized section of the optical fiber array or the single optical fiber is secured in a holder; the holder is aligned inside the laser-cleaving apparatus; the laser cleaves the stripped ends of the fibers in the optical fiber array or the single optical fiber; the laser-cleaved ends of the optical fiber(s) are then mechanically separated to remove the free ends from the optical fibers in the optical fiber array or the single optical fiber, leaving a cleaved array of optical fibers or a single cleaved optical fiber. The cleaving process enables the optical fiber array or single optical fiber to be cleaved at flexible locations along an optical fiber ribbon, optical fiber, or optical fiber apparatus (e.g.

Abstract: The present disclosure relates to a process by which an optical fiber array is cleaved with a laser-cleaving apparatus. The coating material is stripped or removed from a section of an optical fiber array; a coated or ribbonized section of the optical fiber array is secured in a holder; the holder is aligned inside the laser-cleaving apparatus; the laser cleaves the stripped ends of the fibers in the optical fiber array; the laser-cleaved ends of the optical fibers are then mechanically separated to remove the free ends from the optical fibers in the optical fiber array, leaving a cleaved array of optical fibers. The cleaving process enables the optical fiber array to be cleaved at flexible locations along an optical fiber ribbon or optical fiber cable with no swelling, minimal cleave angle variation across the cores of the optical fibers, a controlled surface roughness of the optical fiber end-faces, and high process yield.

Abstract: An optical fiber comprising: (a) a core having an outer radius r1; (b) a cladding having an outer radius r4<32.5 microns; (c) a primary coating surrounding the cladding having an outer radius r5, a thickness tP>8 microns, in situ modulus EP?0.35 MPa and a spring constant ?P<2.0 MPa, where ?P=2EP r4/tP; and (d) a secondary coating surrounding said primary coating, the secondary coating having an outer radius r6 and a thickness tS=r6?r5, and in situ modulus ES of 1200 MPa or greater; tS>8 microns, r6?56 microns. The fiber has a mode field diameter MFD greater than 8.2 microns at 1310 nm; a fiber cutoff wavelength of less than 1310 nm; and a bend loss at a wavelength of 1550 nm, when wrapped around a mandrel having a diameter of 10 mm, of less than 1.0 dB/turn.

Abstract: The present disclosure provides optical fibers with an impact-resistant coating system. The fibers feature low microbending and high mechanical reliability. The coating system includes a primary coating and a secondary coating. The primary coating and secondary coating have reduced thickness to provide reduced radius fibers without sacrificing protection. The primary coating has a low spring constant and sufficient thickness to resist transmission of force to the glass fiber. The secondary coating has high puncture resistance. The outer diameter of the optical fiber is less than or equal to 200 ?m.

Abstract: An optical fiber comprising: a core having an outer radius r1; a cladding having an outer radius r4?31 microns; a primary coating surrounding the cladding having an outer radius r5, a thickness tp>10 microns, in situ modulus EP of 0.5 MPa or less, and a spring constant ?P<1 MPa, where ?P=2EP r4/tP; and a secondary coating surrounding said primary coating, the secondary coating having an outer radius r6, a thickness tS=r6-r5, in situ modulus ES of 1200 MPa or greater; tS greater than 9.5 microns, wherein r6 is 50 to 67.5 microns. The fiber has a mode field diameter MFD greater than 8.2 microns at 1310 nm; a fiber cutoff wavelength of less than 1310 nm; and a bend loss at a wavelength of 1550 nm, when wrapped around a mandrel having a diameter of 10 mm, of less than 1.0 dB/turn.

Abstract: An optical fiber comprising: a core having an outer radius r1; a cladding having an outer radius r4<45 microns; a primary coating surrounding the cladding and having an outer radius r5 and a thickness tp>8 microns, the primary coating having in situ modulus EP of 0.35 MPa or less and a spring constant ?P<1.6 MPa, where ?P=2EP r4/tP; and a secondary coating surrounding said primary coating, the secondary coating having an outer radius r6, a thickness tS=r6?r5, in situ modulus ES of 1200 MPa or greater, wherein >10 microns and r6?85 microns. The fiber has a mode field diameter MFD greater than 8.2 microns at 1310 nm; a cutoff wavelength of less than 1310 nm; and a bend loss at a wavelength of 1550 nm, when wrapped around a mandrel having a diameter of 10 mm, of less than 1.0 dB/turn.

Abstract: The optical fibers disclosed is a single mode optical fiber comprising a core region and a cladding region surrounding and directly adjacent to the core region. The core region can have a radius r1 in a range from 3 ?m to 7 ?m and a relative refractive index profile ?1 having a maximum relative refractive index ?1max in the range from 0.25% to 0.50%. The cladding region can include a first outer cladding region and a second outer cladding region surrounding and directly adjacent to the first outer cladding region. The first outer cladding region can have a radius r4a. The second outer cladding region can have a radius rob less than or equal to 45 ?m and comprising silica based glass doped with titania.

Abstract: A disclosed multimode optical fiber comprises a core and a cladding surrounding the core. The core has an outer radius r1 in between 20 ?m and 30 ?m. The cladding includes a first outer cladding region having an outer radius r4a and a second outer cladding region having an outer radius r4b less than or equal to 45 ?m. The second outer cladding region comprises silica-based glass doped with titania. The optical fiber further includes a primary coating with an outer radius r5 less than or equal to 80 ?m, and a thickness (r5?r4) less than or equal to 30 ?m. The optical fiber further includes a secondary coating with an outer radius r6 less than or equal to 100 ?m. The secondary coating has a thickness (r6?r5) less than or equal to 30 ?m, and a normalized puncture load greater than 3.6×10?3 g/micron2.

Abstract: The optical fibers disclosed is a single mode optical fiber having a core region and a cladding region surrounding and directly adjacent to the core region. The core region can have a radius r1 in a range from 3.0 microns to 6.0 microns and a core volume V1 less than 6.0%-micron2. The cladding region can include a first outer cladding region and a second outer cladding region surrounding and directly adjacent to the first outer cladding region. The first outer cladding region can have a radius r4a, the second outer cladding region can have a radius r4b less than or equal to 65 microns and comprising silica based glass doped with titania. The disclosed single mode optical fiber can have a fiber cutoff wavelength ?CF less than 1530 nm.

Abstract: The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and/or a geometry of a lumen orifice to control the flow of blood through the lumen.