Abstract: Catamaran boat hulls are described having sponsons, an underside tunnel surface between sponsons, two longitudinal steps disposed across each sponson's keel, and two transverse steps disposed lengthwise on opposing sides of each sponson's keel. The longitudinal steps for a sponson have a profile with a curved longitudinal step portion on the opposing outer edges with an outer edge portion of that curved longitudinal step portion being further away from the sponson's aft section, and an inward step edge offset where each of the two longitudinal steps meets a hull side of the sponson. The transverse steps help define variable deadrise inner lifting pad running portion with a lower deadrise aft transitioning to a higher deadrise forward. Spray rails protruding off the aft end of an underside wave spitter and away from the boat hull's centerline help manage undesired spray and use of radiused chines enhances lift and landing performance.

Abstract: Catamaran boat hulls are described having sponsons, an underside tunnel surface between sponsons, two longitudinal steps disposed across each sponson's keel, and two transverse steps disposed lengthwise on opposing sides of each sponson's keel. The longitudinal steps for a sponson have a profile with a curved longitudinal step portion on the opposing outer edges with an outer edge portion of that curved longitudinal step portion being further away from the sponson's aft section, and an inward step edge offset where each of the two longitudinal steps meets a hull side of the sponson. The transverse steps help define variable deadrise inner lifting pad running portion with a lower deadrise aft transitioning to a higher deadrise forward. Spray rails protruding off the aft end of an underside wave spitter and away from the boat hull's centerline help manage undesired spray and use of radiused chines enhances lift and landing performance.

Abstract: Catamaran boat hulls are described having sponsons, an underside tunnel surface between sponsons, two longitudinal steps disposed across each sponson's keel, and two transverse steps disposed lengthwise on opposing sides of each sponson's keel. The longitudinal steps for a sponson have a profile with a curved longitudinal step portion on the opposing outer edges with an outer edge portion of that curved longitudinal step portion being further away from the sponson's aft section, and an inward step edge offset where each of the two longitudinal steps meets a hull side of the sponson. The transverse steps help define variable deadrise inner lifting pad running portion with a lower deadrise aft transitioning to a higher deadrise forward. Spray rails protruding off the aft end of an underside wave splitter and away from the boat hull's centerline help manage undesired spray and use of radiused chines enhances lift and landing performance.

Abstract: Systems and methods for facilitating access to open public records are provided. The system for facilitating access to open public records comprising an open public records computer system for electronically receiving a request for a public record from a requestor computer system of a requestor, and a database in electronic communication with the open public records computer system, the database storing an updatable index of custodians of records thereon, wherein the open public records computer system automatically identifies a custodian appropriate for the request from the index, and transmits the request anonymously on behalf of the requestor to a custodian computer system of the custodian identified thereby preserving an identity of the requestor.

Abstract: Chelator containing compounds are utilized in the delivery of molecules and polymers to animal cells. At least one chelator such as crown ether is attached to a polymer and then associated with another polymer. An ion is then added to the mixture thereby forming condensed polymer. In condensed form and in complex with the chelator, polymer can be delivered to a cell.

Abstract: A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.

Abstract: Disclosed is expression of zeta negative and zeta positive nucleic acids or nucleic acid complexes using a dystrophin gene in a process for providing nucleic acid expression in a striated (skeletal or cardiac) muscle cell for the purpose of providing a change to the endogenous properties of the cell for cells affected by muscular dystrophy.

Abstract: We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.

Abstract: Methods are described for modifying nucleic acids to facilitate delivery of the nucleic acids to cells. Compounds which interact with of modify nucleic acids are interacted with the nucleic acids within reverse micelles.

Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.

Abstract: We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro.

Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.

Abstract: Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo.

Abstract: Compositions and methods for delivery of proteins and peptides to mammalian cells in vitro are described. Specifically, polypeptide-surfactant complexes formed from noncovalent hydrophobation of polypeptides and reversible hydrophobic modification of polypeptides are described. The compositions can be used to delivery positively charged, negatively charged and charge neutral polypeptides to cells.

Abstract: The invention provides for polycations for condensation and delivery of polynucleotides to cells. Processes for forming the polycations by the polymerization of formamide monomers is also described.

Abstract: Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.

Abstract: Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.