Patents by Inventor Sean Monahan

Sean Monahan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for drug delivery using pH sensitive molecules
    Publication number: 20050123600
    Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Application
    Filed: January 28, 2005
    Publication date: June 9, 2005
    Inventors: Vladimir Trubetskoy, James Hagstrom, Vladimir Budker, Jon Wolff, David Rozema, Sean Monahan
  • Delivery by labile hydrophobic modification of drugs
    Publication number: 20050054612
    Abstract: Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytic ally labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells is described. Hydrophobic modification increases drug delivery, while lability minimizes entry of the drug into non-target cells.
    Type: Application
    Filed: August 30, 2004
    Publication date: March 10, 2005
    Inventors: Sean Monahan, Vladimir Budker, Zane Neal, Vladimir Subbotin
  • Polyampholytes for delivering polyions to a cell
    Publication number: 20050037496
    Abstract: An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
    Type: Application
    Filed: July 26, 2004
    Publication date: February 17, 2005
    Inventors: David Rozema, Vladimir Budker, James Hagstrom, Vladimir Trubetskoy, Jon Wolff, Sean Monahan, Paul Slattum
  • Genetic vaccines for cancer therapy
    Publication number: 20050036995
    Abstract: The present invention relates to methods for delivering a genetic immunogen comprising a polynucleotide capable of expressing an antigen. The polynucleotide is delivered to the host via an intravascular route resulting in delivery to extravascular cells, expression of an encoded antigen and induction of an antigen-specific immune response. The methods may be used to enhance an immune response against a cancer cell related antigen.
    Type: Application
    Filed: July 16, 2004
    Publication date: February 17, 2005
    Inventors: Hans Herweijer, Mary Bates, Vladimir Budker, James Hagstrom, Sean Monahan, David Rozema, Paul Slattum, John Wolff
  • Compound containing a labile disulfide bond
    Publication number: 20050020518
    Abstract: A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal.
    Type: Application
    Filed: February 8, 2001
    Publication date: January 27, 2005
    Inventors: Jon Wolff, Sean Monahan, Vladimir Budker, Paul Slattum, David Rozema