Patents by Inventor Seiga Itoh
Seiga Itoh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6027720Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: July 13, 1994Date of Patent: February 22, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 6018037Abstract: A novel motilin analog peptide containing leucine instead of the usual 13th amino acid methionine, as in the naturally occurring motilin, is produced by gene recombination techniques in which several or identical genes, each coding for the novel peptide, are joined in series into a vector. The resultant recombinant DNA is introduced into Escherichia coli and the resultant transformant is cultivated. The resulting polymeric peptide can be cleaved to give the desired peptide.Type: GrantFiled: November 20, 1997Date of Patent: January 25, 2000Assignee: Kyowa Hakko Kogyo Co., LtdInventors: Shinkichi Honda, Tatsunari Nishi, Seiga Itoh, Moriyuki Sato
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Patent number: 5994518Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: July 9, 1997Date of Patent: November 30, 1999Assignee: Kyowa Hakko Co., LtdInventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5795968Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: January 10, 1997Date of Patent: August 18, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5721353Abstract: A novel motilin analog peptide containing leucine instead of the usual 13th amino acid methionine, as in the naturally occurring motilin, is produced by gene recombination techniques in which several or identical genes, each coding for the novel peptide, are joined in series into a vector. The resultant recombinant DNA is introduced into Escherichia coli and the resultant transformant is cultivated. The resulting polymeric peptide can be cleaved to give the desired peptide.Type: GrantFiled: February 13, 1995Date of Patent: February 24, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shinkichi Honda, Tatsunari Nishi, Seiga Itoh, Moriyuki Sato
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Patent number: 5714581Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: May 3, 1995Date of Patent: February 3, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5695952Abstract: A novel motilin analog peptide containing leucine instead of the usual 13th amino acid methionine, as in the naturally occurring motilin, is produced by gene recombination techniques in which several or identical genes, each coding for the novel peptide, are joined in series into a vector. The resultant recombinant DNA is introduced into Escherichia coli and the resultant transformant is cultivated. The resulting polymeric peptide can be cleaved to give the desired peptide.Type: GrantFiled: May 25, 1995Date of Patent: December 9, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shinkichi Honda, Tatsunari Nishi, Seiga Itoh, Moriyuki Sato
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Patent number: 5681720Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: May 3, 1995Date of Patent: October 28, 1997Assignee: Kyowa Hakko Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5420113Abstract: A novel motilin analog peptide containing leucine instead of the usual 13th amino acid methionine, as in the naturally occurring motilin, is produced by gene recombination techniques in which several or identical genes, each coding for the novel peptide, are joined in series into a vector. The resultant recombinant DNA is introduced into Escherichia coli and the resultant transformant is cultivated. The resulting polymeric peptide can be cleaved to give the desired peptide.Type: GrantFiled: July 22, 1993Date of Patent: May 30, 1995Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shinkichi Honda, Tatsunari Nishi, Seiga Itoh, Moriyuki Sato
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Patent number: 5362853Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: December 22, 1992Date of Patent: November 8, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Yoshinori Komatsu
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Patent number: 5236831Abstract: Disclosed is a process for expressing a gene and producing a metabolic product formed by the gene by culturing a transformant microorganism carrying a recombinant DNA constructed of a DNA fragment having at least one gene to be expressed and a vector DNA, at least one of which is foreign to the host microorganism.Type: GrantFiled: February 2, 1990Date of Patent: August 17, 1993Assignee: Kiowa Hakko Kogyo Co., Ltd.Inventors: Ryoichi Katsumata, Akio Ozaki, Toru Mizukami, Motoko Kageyama, Morimasa Yagisawa, Tamio Mizukami, Seiga Itoh, Tetsuo Oka, Akira Furuya
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Patent number: 5218092Abstract: A polypeptide or glycosylated polypeptide with at least one new carbohydrate chain produced by means of recombinant DNA technique, which has protease resistance and thermal stability and is expected to have longer lifetime in blood than those of a naturally-occurring form.Type: GrantFiled: September 27, 1989Date of Patent: June 8, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Katsutoshi Sasaki, Tatsunari Nishi, Shigeyoshi Yasumura, Moriyuki Sato, Seiga Itoh
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Patent number: 5214132Abstract: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.Type: GrantFiled: April 12, 1989Date of Patent: May 25, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Hiromasa Miyaji, Moriyuki Sato, Masami Okabe, Makoto Morimoto, Seiga Itoh, Motoo Yamasaki, Yoshiharu Yokoo, Kazuo Yamaguchi, Hajime Yoshida, Yoshinori Komatsu
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Patent number: 5082776Abstract: The present invention provides a hybrid antigen polypeptide having both antigenicity of the ATLA encoded by gag gene and that of the ATLA encoded by env gene. The hybrid antigen can be produced in a large amount and it is applicable to serum diagnosis of patients infected with antigen polypeptides such as ATLV.Type: GrantFiled: January 31, 1990Date of Patent: January 21, 1992Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Susumu Sekine, Seiga Itoh
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Patent number: 4939094Abstract: The present invention provides a hybrid antigen polypeptide having both antigenicity of the ATLA encoded by gag gene and that of the ATLA encoded by env gene. The hybrid antigen can be produced in a large amount and it is applicable to serum diagnosis of patients infected with antigen polypeptides such as ATLV.Type: GrantFiled: August 15, 1986Date of Patent: July 3, 1990Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tetsuro Kuga, Susumu Sekine, Seiga Itoh
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Patent number: 4898931Abstract: Disclosed is a novel derivative of human IFN-.gamma. polypeptide wherein certain amino acids of human IFN-.gamma. polypeptide are removed and certain amino acids other than said amino acids are replaced with other amino acids. The derivatives have high IFN-.gamma. activity and are expected to be useful as drugs such as anti-viral and anti-tumor agents.Type: GrantFiled: July 10, 1985Date of Patent: February 6, 1990Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Seiga Itoh, Yasutoshi Takeichi, Moriyuki Sato
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Patent number: 4894362Abstract: According to the present invention, a fish growth hormone was isolated from an organ culture broth of the pituitary gland of eels, and further a recombinant DNA incorporated with a DNA coding for the eel growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained. They can be used for mass production of an eel growth hormone.Type: GrantFiled: July 8, 1986Date of Patent: January 16, 1990Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Kazuo Yamaguchi, Akiko Saito, Susumu Sekine, Moriyuki Sato, Seiga Itoh, Kunikatsu Shirahata, Tetsuya Hirano, Hiroshi Kawauchi
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Patent number: 4868125Abstract: Disclosed is a novel promoter wherein a 5' flanking region of a promoter (referred to as promoter A hereinafter) is replaced with a 5' flanking region of another promoter (referred to as promoter B hereinafter) or a chemically synthesized DNA fragment. The promoter is constructed by replacing a region existing upstream from the "-35" region of promoter A with the "-35" region of promoter B or a chemically synthesized DNA fragment.Type: GrantFiled: October 28, 1987Date of Patent: September 19, 1989Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tatsunari Nishi, Akiko Saito, Seiga Itoh
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Patent number: 4851512Abstract: Novel human IL-2 polypeptide derivatives characterized by deletion of at least one amino acid from the amino acid sequence of the human IL-2 polypeptide, recombinant plasmids containing DNAs coding for the above derivatives, microorganisms harboring these plasmids and methods of producing the above derivatives in these microorganisms are provided.Type: GrantFiled: September 26, 1986Date of Patent: July 25, 1989Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hiromasa Miyaji, Seiga Itoh
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Patent number: 4849359Abstract: According to the present invention, a recombinant DNA incorporated with a DNA coding for a fish growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained and they can be used for mass production of the fish growth hormone polypeptide.Type: GrantFiled: April 14, 1987Date of Patent: July 18, 1989Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Susumu Sekine, Tamio Mizukami, Moriyuki Sato, Seiga Itoh, Akiko Saito