Abstract: An information processing apparatus (10) includes a display (110), a housing (120), and a wireless relay apparatus (130). A control unit is provided inside the housing (120). The control unit includes, for example, a central processing unit (CPU), and performs various pieces of arithmetic processing and control processing. One example of the control processing is control of the display (110). The display (110) is mounted to the housing (120). The wireless relay apparatus (130) is mounted to any surface in surfaces of the housing (120). As one example, the display (110) and the wireless relay apparatus (130) are each mounted to a side surface of the housing (120).

Abstract: A painting target surface of a resin bumper is painted by discharging a paint mist from a spray gun toward the painting target surface with a charged conductor arranged in contact with an opposite side to the painting target surface. The paint mist is uncharged or is charged with electric charges having an opposite polarity to that of the conductor and at a potential having a lower absolute value than that of the conductor.

Abstract: Crystals of the compound represented by formula (1), a method for the production thereof, and a method for producing an antibody-drug conjugate using the crystals.

Abstract: Aqueous pharmaceutical compositions containing a fusion protein of an antibody and a lysosomal enzyme as an active ingredient, which are stable enough to be marketed, are disclosed. The aqueous pharmaceutical composition, for example, comprises the fusion protein of the antibody and the lysosomal enzyme at a concentration of 0.5 to 20 mg/mL, sodium chloride at a concentration of 0.3 to 1.2 mg/mL, sucrose at a concentration of 50 to 100 mg/mL, a nonionic surfactant at a concentration of 0.15 to 3 mg/mL, a buffer at a concentration of 3 to 30 mM, and is adjusted to pH 5.0 to 7.5.

Abstract: A vehicle travel control device is equipped with a target vehicle speed setting part which outputs a set up target vehicle speed, a constant speed travel controller which outputs a first acceleration instruction for constant speed travel from the speed of a host vehicle and the target vehicle speed, a target inter vehicle distance setting part which outputs a target inter vehicle distance between a preceding vehicle and the host vehicle, an inter vehicle distance controller which outputs a second acceleration instruction for controlling to the target inter vehicle distance, and a control selection part which selects either the first acceleration instruction or the second acceleration instruction, to make an acceleration instruction. The control selection part has a predetermined switching acceleration, and is configured to select the second acceleration instruction of the inter vehicle distance controller, when it is judged that the second acceleration instruction exceeds the switching acceleration.

Abstract: SPINK2 mutant peptide conjugates are provided that inhibit KLK5. The KLK5 inhibitory peptide conjugates are Fc fusion peptides in which, in certain embodiments, the Fc region of the fusion peptides are the Fc region of human IgG1 or a fragment thereof. The KLK5 inhibitory peptide conjugates include an amino acid sequence of one of SEQ ID NOs: 34, 36, 38, 40, 42, 44, 46, 48, 96, 50, 52, 54, 56, 58, or 60. Pharmaceutical compositions that include the KLK5 inhibitory peptide conjugates useful for treating KLK5-related diseases are also provided.

Abstract: An image display element, provided with a pixel region and a connection region, includes a light-emitting unit and a driving circuit substrate. The light-emitting unit includes a semiconductor layer obtained by layering a second conductive layer, a light-emitting layer, and a first conductive layer, mesa shapes formed by dividing the semiconductor layer, and a step portion separated from the mesa shapes by a groove. A first electrode is connected to the first conductive layer and a first driving electrode. The light-emitting unit further includes, between the mesa shapes adjacent to each other, a wiring line layer forming a conductive path, the wiring line layer being thinner than a layer thickness of a portion of each of the mesa shapes in the semiconductor layer. The wiring line layer extends to a top of the step portion and is connected to a common second electrode provided on the step portion.

Abstract: SPINK2 mutant peptide conjugates are provided that inhibit KLK5. The KLK5 inhibitory peptide conjugates are Fc fusion peptides in which, in certain embodiments, the Fc region of the fusion peptides are the Fc region of human IgG1 or a fragment thereof. The KLK5 inhibitory peptide conjugates include an amino acid sequence of one of SEQ ID NOs: 34, 36, 38, 40, 42, 44, 46, 48, 96, 50, 52, 54, 56, 58, or 60. Pharmaceutical compositions that include the KLK5 inhibitory peptide conjugates useful for treating KLK5-related diseases are also provided.

Abstract: A vehicle control device disclosed in the present disclosure includes: a first control unit configured to control a speed of the vehicle in accordance with the route distance and the set speed until the detection unit determines that the vehicle has passed through the ETC toll gate, while the vehicle is performing the constant-speed traveling by the cruise control unit; a vehicle frontward detecting unit configured to detect road information about a road frontward of the vehicle; and a second control unit configured to change control content in the cruise control unit on the basis of a detection result from the vehicle frontward detecting unit, when the detection unit determines that the vehicle has passed through the ETC toll gate, while the vehicle is performing the constant-speed traveling by the cruise control unit.

Abstract: SPINK2 mutant peptide conjugates are provided that inhibit KLK5. The KLK5 inhibitory peptide conjugates are Fc fusion peptides in which, in certain embodiments, the Fc region of the fusion peptides are the Fc region of human IgG1 or a fragment thereof. The KLK5 inhibitory peptide conjugates include an amino acid sequence of one of SEQ ID NOs: 34, 36, 38, 40, 42, 44, 46, 48, 96, 50, 52, 54, 56, 58, or 60. Pharmaceutical compositions that include the KLK5 inhibitory peptide conjugates useful for treating KLK5-related diseases are also provided.

Abstract: Provided is a novel peptide. The peptide contains the amino acid sequence set forth in SEQ ID NO: 61 and inhibits a protease.

Abstract: A vehicle control device disclosed in the present disclosure includes: a first control unit configured to control a speed of the vehicle in accordance with the route distance and the set speed until the detection unit determines that the vehicle has passed through the ETC toll gate, while the vehicle is performing the constant-speed traveling by the cruise control unit; a vehicle frontward detecting unit configured to detect road information about a road frontward of the vehicle; and a second control unit configured to change control content in the cruise control unit on the basis of a detection result from the vehicle frontward detecting unit, when the detection unit determines that the vehicle has passed through the ETC toll gate, while the vehicle is performing the constant-speed traveling by the cruise control unit.

Abstract: A manipulator includes an operation portion, wherein forceps are opened and closed, when a first forceps pulley of a first forceps piece and a second forceps pulley of a second forceps piece rotate in opposite directions to each other, a direction of the forceps is changed when both pulleys rotate in the same direction, and a direction of the forceps can be changed about a P axis (pitch axis); a first driving portion comprising a left driving pulley and a right driving pulley slidably movable along a Z axis (main axis) direction; and an endless loop-shaped wire rope.

Abstract: Provided is a rotary knob rotational structure being less susceptible to the influence of variation in the dimensions of a rotary knob and reducing backlash of the rotary knob while providing a suitable magnitude of rotational resistance to the rotary knob. The rotary knob rotational structure includes an annular sheet 22 interposed between a device body and the rotary knob 14, an attachment member 24 configured to attach a fixed portion 22a of the annular sheet 22 to the device body with the fixed portion 22a being interposed between the attachment member 24 and the device body, and a body-side protrusion 26 contacting the annular sheet 22 on the outside of the fixed portion 22a in the radial direction of the annular sheet 22 to warp the annular sheet 22 toward the rotary knob 14.

Abstract: The invention provides a tilt angle measuring device, which comprises a discoid container for including a liquid forming a free liquid surface, a light emitting source for allowing a detection light to enter the free liquid surface, a photodetector for receiving the detection light reflected on the free liquid surface and a signal processing unit for detecting a tilt of the free liquid surface based on a detection signal from the photodetector, wherein the signal processing unit sets a detection light storage time of the photodetector so that an error incidence rate of the detection signal is a predetermined value.

Abstract: The present invention provides a measuring device, which comprises a leveling unit, a measuring device main body provided on the leveling unit, a control unit, a first tilt angle measuring device for detecting a horizontality with high accuracy, and a second tilt angle measuring device for detecting a tilt angle in a wider range than a range of the first tilt angle measuring device and having a higher responsiveness than a responsiveness of the first tilt angle measuring device, wherein the control unit, the first tilt angle measuring device and the second tilt angle measuring device are provided in the measuring device main body and wherein the control unit drives the leveling unit based on a detection result of the second tilt angle measuring device, performs a rough leveling until a tilt angle detected by the second tilt angle measuring device reaches within a range in which the first tilt angle measuring device is capable of detecting and levels the measuring device main body horizontally based on a detec

Abstract: An inspection apparatus includes beam generation means, a primary optical system, a secondary optical system and an image processing system. Irradiation energy of the beam is set in an energy region where mirror electrons are emitted from the inspection object as the secondary charged particles due to the beam irradiation. The secondary optical system includes a camera for detecting the secondary charged particles, a numerical aperture whose position is adjustable along an optical axis direction and a lens that forms an image of the secondary charged particles that have passed through the numerical aperture on an image surface of the camera. In the image processing system, the image is formed under an aperture imaging condition where the position of the numerical aperture is located on an object surface to acquire an image.

Abstract: The present disclosure relates to novel lipocalin muteins which bind to PCSK9. The disclosure also provides corresponding nucleic acid molecules encoding lipocalin muteins and methods for producing lipocalin muteins as well as their encoding nucleic acid molecules.

Abstract: According to an embodiment, at first, a template is put into a cleaning bath containing a cleaning liquid inside a first process chamber. Then, an inactive gas is supplied into the first process chamber and the cleaning liquid is heated, so as to set temperature and pressure conditions that turn the cleaning liquid into a supercritical fluid state or subcritical fluid state. Then, the template is immersed in the cleaning liquid in the supercritical fluid state or subcritical fluid state for a predetermined time period.

Abstract: The present invention provides a measuring device, which comprises a leveling unit, a measuring device main body provided on the leveling unit, a control unit, a first tilt angle measuring device for detecting a horizontality with high accuracy, and a second tilt angle measuring device for detecting a tilt angle in a wider range than a range of the first tilt angle measuring device and having a higher responsiveness than a responsiveness of the first tilt angle measuring device, wherein the control unit, the first tilt angle measuring device and the second tilt angle measuring device are provided in the measuring device main body and wherein the control unit drives the leveling unit based on a detection result of the second tilt angle measuring device, performs a rough leveling until a tilt angle detected by the second tilt angle measuring device reaches within a range in which the first tilt angle measuring device is capable of detecting and levels the measuring device main body horizontally based on a detec