Abstract: The present invention provides a polynucleotide vector system used during polypeptide display that can be used to facilitate transfer of pools of polynucleotides encoding antigen binding proteins of interest. The present invention also provides methods that allow seamless conversion of pools of polynucleotides encoding antigen binding proteins using a restriction enzyme digestion and ligation strategy.

Abstract: The present invention provides a polynucleotide vector system used during polypeptide display that can be used to facilitate transfer of pools of polynucleotides encoding antigen binding proteins of interest. The present invention also provides methods that allow seamless conversion of pools of polynucleotides encoding antigen binding proteins using a restriction enzyme digestion and ligation strategy.

Abstract: An injection device comprises a housing (101) to (104) containing a syringe (24). The contents of the syringe (24) are viewable through a window (14) in the mid-section (102) of the housing. The window (14) is concealed by a slideable shutter (12). The slideable shutter (12) is biased by a bias spring (22) which also biases an internal syringe carrier. Also disclosed is a reversible needle cap which operates initially to cap the front end of the housing and, upon removal thereof, pulls a needle sheath (30) off the syringe needle (26). The cap is designed to be reversible so that, after use, it can be reversed and reconnected to the housing to cover the exposed needle.

Abstract: The present application relates to the treatment and diagnosis of mood disorders, including bipolar disorder, major depression disorder and schizophrenia. The invention provides novel diagnostic markers and assays, as well as research tools for the development and discovery of agents and compounds which are useful for treating patients who suffer from mental illness.

Abstract: A data warehouse solution system comprises a metadata model, a user interface and an engine. The metadata model has an information needs model including metadata regarding information needs for building reports by users, and a data information model including metadata describing data that is available for building reports. The user interface has a customer user interface for presenting the information needs model to the users for report generation, and a modeling user interface for presenting the data information model to the users for manipulating data warehouse objects. The engine has a report management service unit for providing report management service using the information needs model, and a data management service unit for providing data management service including generation of a data warehouse using the data information model.

Abstract: A corneal reshaping by means of a soft contact lens to manipulate tear pressure gradient to produce a dimensional change to the surface profile of the cornea of the wearer to provide at least a temporary change in the refractive state of the eye eliminating the need for other refractive corrections. The contact lens has mechanical properties and/or a geometric shape such that when the lens is fitted to the eye the pressure applied to the eye via the lens will vary in a radial direction between at least one zone of higher pressure and at least one zone of lower pressure so that wearing the lens will over time cause a dimensional change to the surface layer of the cornea.

Abstract: A contact lens having near vision and distance vision portions, the lens being movable on the eye between first and second positions, those positions corresponding with aligning the wearer's vision through the near vision and distance vision portions respectively. The lens is positionally stable on the eye in each of the two positions, and requires a force to be applied to the lens to move between the first and second positions. Preferably the lens has a back surface and a front surface, and said back surface has either one or two major back curve zones occupying a major portion of the lens back surface.

Abstract: A locking arrangement for a door system of a transit vehicle includes a combination of a lock mechanism and an electromagnetic brake. The lock mechanism enables positive locking of at least one door but does not require substantial contact between moving and stationary lock elements. The lock mechanism is connected with the manual release means for door opening during an emergency. The electromagnetic brake maintains door seal compression in the closed and locked condition which improves sealing capabilities and provides for reliable lock mechanism operation. Such combination provides locking redundancy and meets various requirements regarding annunciation and manual release operation.

Abstract: A transmission including a first input member which in use is rotatably driven by a first prime mover, a second input member which in use is rotatably driven by a second prime mover, a rotatable output member from which drive is provided to a driven structure, the first input member driving a driven member and there being a drivable member drivable by the second input member, the driven member and the drivable member being coupled though an intermediate structure which carries the output member, drive being transmitted from the first input member to the output member when torque is input to the second input member from the second prime mover, and wherein the second prime mover is an electrically driven switched reluctance motor.

Abstract: The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia and mood disorders such as major depression disorder and bipolar disorder). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.

Abstract: The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.

Abstract: A locking arrangement for a door system of a transit vehicle includes a combination of a lock mechanism and an electromagnetic brake. The lock mechanism enables positive locking of at least one door but does not require substantial contact between moving and stationary lock elements. The lock mechanism is connected with the manual release means for door opening during an emergency. The electromagnetic brake maintains door seal compression in the closed and locked condition which improves sealing capabilities and provides for reliable lock mechanism operation. Such combination provides locking redundancy and meets various requirements regarding annunciation and manual release operation.

Abstract: The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.

Abstract: The present invention provides methods for diagnosing mental disorders.