Abstract: The present disclosure relates to use of Sodium 3,5-dichloro-2,4,6-trioxo-1,3,5-triazinan-1-ide having a chemical structure: for the treatment and/or prevention of COVID-19 infection. The present disclosure further relates to a pharmaceutical formulation that is administered in the form of dry powder inhalation (DPI) to the subject. The dry powder inhalation formulation comprises a micronized Sodium 3,5-dichloro-2,4,6-trioxo-1,3,5-triazinan-1-ide, a first lactose, a second lactose, and at least one excipient. The pharmaceutical formulation of the present disclosure increases the bioavailability of the NaDCC, has patient compliance, and reduced adverse effects.

Abstract: The present invention discloses a pharmaceutical composition comprising picroside isolated from Picrorhiza kurroa. The composition contains Picroside I as an active ingredient for treating drug-induced immunopathy such as neutropenia. Methods of isolating Picroside I and Picroside II, and preparing the compositions have also been disclosed herein. The said composition of Picroside I can be a solid oral or an injectable composition of a pre-determined dose. The said composition of Picroside I exhibited reversal of drug-induced immunopathy such as neutropenia through in vivo tests as well as in vitro tests. Therefore, it can be used as a herbal therapeutic agent for treating drug-induced immunopathy such as neutropenia.

Abstract: The present disclosure relates to use of Sodium 3,5-dichloro-2,4,6-trioxo-1,3,5-triazinan-1-ide having a chemical structure: for the treatment and/or prevention of COVID-19 infection. The present disclosure further relates to a pharmaceutical formulation that is administered in the form of dry powder inhalation (DPI) to the subject. The dry powder inhalation formulation comprises a micronized Sodium 3,5-dichloro-2,4,6-trioxo-1,3,5-triazinan-1-ide, a first lactose, a second lactose, and at least one excipient. The pharmaceutical formulation of the present disclosure increases the bioavailability of the NaDCC, has patient compliance, and reduced adverse effects.

Abstract: A system for community monitoring is disclosed. The system includes a community processing subsystem. The community processing subsystem includes an entity control module, configured to control each of plurality of tasks corresponding to one of a plurality of entities. The community processing subsystem also includes a task monitoring module, configured to monitor each of the plurality of tasks corresponding to one of the plurality of entities by entity associated techniques. The community processing subsystem also includes an information exchange module, configured to exchange information within the plurality of entities. A community memory subsystem is configured to store details regarding monitored plurality of tasks corresponding to one of the plurality of entities in real time. Present disclosure enables proper monitoring of every possible entity in a society through a common platform.

Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.

Abstract: A computer implemented method of determining the cultural style of a participant of an organization by accessing records of organizational data and participant data to generate an instance of simulation, and initiating a game simulation session. It includes receiving inputs from the participant to automatically calculate and generate a first set of simulation events, and presents to the participant a first set of events, and receives a response as textual or spoken inputs in an unstructured form. It further performs text analytics on the inputs, identifies themes and clusters based on frequency and meaning of inputs, and calculates probabilities and generates a further set of simulation events for a changed state of organizational model. It further includes presenting a further set of simulation events to the participant for inputs. These method steps are iterated until a state marker is reached. The semantic relationships are then analyzed and reports generated on culture styles.

Abstract: The present invention allows organizations to set up, and its users to experience, dynamic, realistic gamified simulations in a cost- and time-efficient manner, as a means of iteratively assessing and developing individuals' work-focused decision making. It also enables measurement of user attributes and the process of decision making involved at work, through the process of experiencing such simulations. By closely mirroring, or realistically simulating the way data changes with users' decisions or with events external or internal to the organization, the invention is able to faithfully reconstruct the work environment of the user, generate true-to-life responses and unobtrusively measure behavior under various simulated situations.

Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.

Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.

Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.

Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.

Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.

Abstract: The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant heterologous proteins from bacterial inclusion bodies using modified SAK.

Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.

Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.

Abstract: Techniques, systems, and articles of manufacture for determining statistics for cost-based optimization of a workflow. A method includes generating individual sets of statistics for each intermediate relation of a workflow, wherein said intermediate relations comprise results of stages of any plan of the workflow, and wherein each individual set of statistics computes cardinality of the corresponding intermediate relation; determining a global set of statistics for the workflow, wherein said global set of statistics comprises at least one of the individual sets of statistics for each of the intermediate relations; instrumenting a given plan of the workflow to collect the global set of statistics during execution; executing the given plan to collect the global set of statistics; and determining a plan of the workflow with the lowest cost by comparing the cost of multiple plans, wherein the cost of each plan is derived from the global set of statistics.

Abstract: A computer-implemented method, computer program product and a system for supporting star and snowflake data schemas for use with an Extract, Transform, Load (ETL) process, comprising selecting a data source comprising dimensional data, where the dimensional data comprises at least one source table comprising at least one source column, importing a data model for the dimensional data into a data integration system, analyzing the imported data model to select a star or snowflake target data schema comprising target dimensions and target facts, generating a meta-model representation by mapping at least one source table or source column to each target fact and target dimension, automatically converting the meta-model representation into one or more ETL jobs, and executing the ETL jobs to extract the dimensional data from the data source and loading the dimensional data into the selected target data schema in a target data system.

Abstract: A computer-implemented method, computer program product and a system for identifying and handling slowly changing dimension (SCD) attributes for use with an Extract, Transform, Load (ETL) process, comprising importing a data model for dimensional data into a data integration system, where the dimensional data comprises a plurality of attributes, identifying via a data discovery analyzer one or more attributes in the data model as SCD attributes, importing the identified SCD attributes into the data integration system, selecting a data source comprising dimensional data, automatically generating an ETL job for the dimensional data utilizing the imported SCD attributes, and executing the automatically generated ETL to extract the dimensional data from the data source and loading the dimensional data into the imported SCD attributes in a target data system.

Abstract: A computer-implemented method, computer program product and a system for supporting star and snowflake data schemas for use with an Extract, Transform, Load (ETL) process, comprising selecting a data source comprising dimensional data, where the dimensional data comprises at least one source table comprising at least one source column, importing a data model for the dimensional data into a data integration system, analyzing the imported data model to select a star or snowflake target data schema comprising target dimensions and target facts, generating a meta-model representation by mapping at least one source table or source column to each target fact and target dimension, automatically converting the meta-model representation into one or more ETL jobs, and executing the ETL jobs to extract the dimensional data from the data source and loading the dimensional data into the selected target data schema in a target data system.

Abstract: The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to deliver antigens in a manner resembling the live infectious organism in terms of elicitation of a robust immune response, but with reduced risk or no risk of disease. The compositions of the invention are produced by rendering a bacterium bacteriostatic through expression of a recombinant promoter in the bacterial cell, which promoter can be operably linked to a polynucleotide encoding a recombinant gene product. In one embodiment, where the bacterium is a gram negative host, the recombinant gene product provides for reduced toxicity of LPS. In one embodiment, the gene product is a bacteriophage protein, such as endolysin, holin, or ndd.