Patents by Inventor Sriram Padmanabhan

Sriram Padmanabhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9064047
    Abstract: Techniques for running an Extract Transform Load (ETL) job in parallel on one or more processors wherein the ETL job comprises use of an extensible markup language (XML) document are provided. The techniques include receiving an XML document input, identifying a node in the XML document at which partitioning of the XML document is to begin, sending partition information to each respective processor, performing a shallow parsing of the XML document in parallel on the one or more processors, wherein each processor performs shallow parsing using the identified partition node until it reaches its identified partition, using the shallow parsing to generate the partition of the input XML document, wherein each processor generates a different partition of the same XML document, and sending each partition in streaming format to an ETL job instance.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: June 23, 2015
    Assignee: International Business Machines Corporation
    Inventors: Manoj K. Agarwal, Manish A. Bhide, Srilakshmi Kotwal, Srinivas Kiran Mittapalli, Sriram Padmanabhan
  • Patent number: 9002131
    Abstract: The present disclosure relates to image filtering techniques for enhancing image quality. In one embodiment, two filtering techniques are applied on an image. Firstly, an adaptive weighted median filtering operation is performed on an acquired low contrast image corrupted by impulsive noise. Subsequently, a guided image filtering on the image obtained from adaptive weighted median filtering operation to de-blur and enhance the contrast that ultimately assures to preserve the edges of the images. In addition, the image filtering for enhancing image quality is enhanced by several variations of data adaptive guided image filtering and adaptive window sizes for guided image filtering techniques.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: April 7, 2015
    Assignee: Forus Health Pvt. Ltd.
    Inventors: Shyam Vasudeva Rao, Chandrasekhar Kuppuswamy, Mahabaleswara Ram Bhatt, Sriram Padmanabhan
  • Publication number: 20150010944
    Abstract: The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant heterologous proteins from bacterial inclusion bodies using modified SAK.
    Type: Application
    Filed: August 28, 2014
    Publication date: January 8, 2015
    Inventors: Shardul SALUNKHE, Bhaskarjyoti PRASAD, Praveen MUNESHWAR, Anjali Apte DESHPANDE, Sriram PADMANABHAN
  • Publication number: 20140369986
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Application
    Filed: May 15, 2014
    Publication date: December 18, 2014
    Applicant: GangaGen, Inc.
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R.Sanjeev Saravanan, Bharathi Sriram
  • Patent number: 8853380
    Abstract: The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant heterologous proteins from bacterial inclusion bodies using modified SAK.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: October 7, 2014
    Assignee: Lupin Limited
    Inventors: Shardul Salunkhe, Bhaskarjyoti Prasad, Praveen Muneshwar, Anjali Apte Deshpande, Sriram Padmanabhan
  • Publication number: 20140297583
    Abstract: Techniques, systems, and articles of manufacture for determining statistics for cost-based optimization of a workflow. A method includes generating individual sets of statistics for each intermediate relation of a workflow, wherein said intermediate relations comprise results of stages of any plan of the workflow, and wherein each individual set of statistics computes cardinality of the corresponding intermediate relation; determining a global set of statistics for the workflow, wherein said global set of statistics comprises at least one of the individual sets of statistics for each of the intermediate relations; instrumenting a given plan of the workflow to collect the global set of statistics during execution; executing the given plan to collect the global set of statistics; and determining a plan of the workflow with the lowest cost by comparing the cost of multiple plans, wherein the cost of each plan is derived from the global set of statistics.
    Type: Application
    Filed: March 29, 2013
    Publication date: October 2, 2014
    Applicant: International Business Machines Corporation
    Inventors: Ramanujam S. Halasipuram, Prasad M. Deshpande, Sriram Padmanabhan
  • Publication number: 20140193093
    Abstract: The present disclosure relates to image filtering techniques for enhancing image quality. In one embodiment, two filtering techniques are applied on an image. Firstly, an adaptive weighted median filtering operation is performed on an acquired low contrast image corrupted by impulsive noise. Subsequently, a guided image filtering on the image obtained from adaptive weighted median filtering operation to de-blur and enhance the contrast that ultimately assures to preserve the edges of the images. In addition, the image filtering for enhancing image quality is enhanced by several variations of data adaptive guided image filtering and adaptive window sizes for guided image filtering techniques.
    Type: Application
    Filed: September 11, 2012
    Publication date: July 10, 2014
    Applicant: FORUS HEALTH PVT. LTD.
    Inventors: Shyam Vasudeva Rao, Chandrasekhar Kuppuswamy, Mahabaleswara Ram Bhatt, Sriram Padmanabhan
  • Publication number: 20140160323
    Abstract: The present disclosure relates to method and apparatus for image recovery and image correction. In an embodiment, the present disclosure relates to recovering images that are occluded due to some material in the optical path while capturing the images. The detection of noisy region is performed by taking the residual image between the images yielded by large sized and small sized Gaussian window smoothening filters on red, green and blue channels. The recovery of the image that alleviates the noise is obtained by point-wise multiplication of the above said residue image with a suitably synthesized Gaussian distributed co-efficient of same size.
    Type: Application
    Filed: December 12, 2013
    Publication date: June 12, 2014
    Applicant: Forus Health Pvt. Ltd.
    Inventors: Shyam Vasudeva RAO, Mahabaleswara Ram BHATT, Sriram PADMANABHAN
  • Patent number: 8748150
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: June 10, 2014
    Assignee: GangaGen, Inc.
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
  • Publication number: 20140050713
    Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.
    Type: Application
    Filed: April 12, 2012
    Publication date: February 20, 2014
    Inventors: C.B. Appaiah, Sriram Padmanabhan, R. Sanjeev Saravanan, Bharathi Sriram
  • Publication number: 20130273585
    Abstract: Soluble variants of recombinant proteins produced in a prokaryotic host cell, where the high expression levels often cause the original proteins to aggregate into insoluble inclusion body aggregates. The variant polypeptides retain biological function while increasing protein solubility with comparable or higher recoverable levels of biologically active protein when expressed in a suitable expression host. Methods of identifying critical residues and substituting them are provided to produce the variants.
    Type: Application
    Filed: April 11, 2013
    Publication date: October 17, 2013
    Applicant: GangaGen, Inc.
    Inventors: C. B. Appaiah, Sriram Padmanabhan, R. Sanjeev Saravanan
  • Publication number: 20130122542
    Abstract: The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant heterologous proteins from bacterial inclusion bodies using modified SAK.
    Type: Application
    Filed: June 3, 2011
    Publication date: May 16, 2013
    Applicant: LUPIN LIMITED
    Inventors: Shardul Salunkhe, Bhaskarjyoti Prasad, Praveen Muneshwar, Anjali Apte Deshpande, Sriram Padmanabhan
  • Publication number: 20130124454
    Abstract: A computer-implemented method, computer program product and a system for identifying and handling slowly changing dimension (SCD) attributes for use with an Extract, Transform, Load (ETL) process, comprising importing a data model for dimensional data into a data integration system, where the dimensional data comprises a plurality of attributes, identifying via a data discovery analyzer one or more attributes in the data model as SCD attributes, importing the identified SCD attributes into the data integration system, selecting a data source comprising dimensional data, automatically generating an ETL job for the dimensional data utilizing the imported SCD attributes, and executing the automatically generated ETL to extract the dimensional data from the data source and loading the dimensional data into the imported SCD attributes in a target data system.
    Type: Application
    Filed: September 14, 2012
    Publication date: May 16, 2013
    Applicant: INTERNATIONAL BUSINESS MACHINES COPORATION
    Inventors: Manish A. Bhide, Srinivas Kiran Mittapalli, Sriram Padmanabhan
  • Publication number: 20130117216
    Abstract: A computer-implemented method, computer program product and a system for supporting star and snowflake data schemas for use with an Extract, Transform, Load (ETL) process, comprising selecting a data source comprising dimensional data, where the dimensional data comprises at least one source table comprising at least one source column, importing a data model for the dimensional data into a data integration system, analyzing the imported data model to select a star or snowflake target data schema comprising target dimensions and target facts, generating a meta-model representation by mapping at least one source table or source column to each target fact and target dimension, automatically converting the meta-model representation into one or more ETL jobs, and executing the ETL jobs to extract the dimensional data from the data source and loading the dimensional data into the selected target data schema in a target data system.
    Type: Application
    Filed: November 9, 2011
    Publication date: May 9, 2013
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Manish A. Bhide, Srinivas Kiran Mittapalli, Sriram Padmanabhan
  • Publication number: 20130117217
    Abstract: A computer-implemented method, computer program product and a system for supporting star and snowflake data schemas for use with an Extract, Transform, Load (ETL) process, comprising selecting a data source comprising dimensional data, where the dimensional data comprises at least one source table comprising at least one source column, importing a data model for the dimensional data into a data integration system, analyzing the imported data model to select a star or snowflake target data schema comprising target dimensions and target facts, generating a meta-model representation by mapping at least one source table or source column to each target fact and target dimension, automatically converting the meta-model representation into one or more ETL jobs, and executing the ETL jobs to extract the dimensional data from the data source and loading the dimensional data into the selected target data schema in a target data system.
    Type: Application
    Filed: September 14, 2012
    Publication date: May 9, 2013
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Manish A. Bhide, Srinivas Kiran Mittapalli, Sriram Padmanabhan
  • Publication number: 20120328576
    Abstract: The invention provides therapeutic, defined-dose anti-bacterial phage preparations, methods to make such preparations, methods to treat bacterial infections using such preparations and methods to diagnose bacterial infections using such preparations.
    Type: Application
    Filed: June 29, 2012
    Publication date: December 27, 2012
    Applicant: GangaGen, Inc.
    Inventors: Manur Jayasheela, Bharathi Sriram, Sriram Padmanabhan
  • Publication number: 20120237491
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Application
    Filed: May 21, 2012
    Publication date: September 20, 2012
    Applicant: GangaGen, Inc.
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
  • Patent number: 8202516
    Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: June 19, 2012
    Assignee: GangaGen, Inc.
    Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
  • Publication number: 20120107876
    Abstract: The invention relates to a fusion tag comprising Serine-aspartic acid repeats of the well conserved region of the Staphylococcus aureus Sdr C gene superfamily. A START codon and an enterokinase cleavage site has been incorporated into this repeat region to make a novel fusion tag that is responsible for expressing soluble proteins in bacterial system.
    Type: Application
    Filed: April 29, 2010
    Publication date: May 3, 2012
    Applicant: LUPIN LIMITED
    Inventors: Sampali Banerjee, Sriram Padmanabhan
  • Publication number: 20120093765
    Abstract: The present invention describes a novel process for large-scale purification of therapeutic grade quality of recombinant human GCSF from microbial cells, wherein the protein is expressed as inclusion bodies. The Inclusion bodies are solubilized and refolded under redox condition. The Redox condition is provided by using ascorbic acid, dehydroascorbic acid and reduced gluthathione. The process involves the novel use of aqueous two phase extraction step to purify refolded GCSF after removal of denaturant. After this step GCSF is further purified using chromatography techniques for removal of related impurities. The GCSF obtained has good purity and yields which are essential for a production scale process. The host cell related contaminants like proteins, DNA and endotoxins are reduced using the purification processes of the invention.
    Type: Application
    Filed: June 7, 2010
    Publication date: April 19, 2012
    Applicant: LUPIN LIMITED
    Inventors: Sandeep Somani, Sriram Padmanabhan