Patents by Inventor Sriram Padmanabhan
Sriram Padmanabhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9064047Abstract: Techniques for running an Extract Transform Load (ETL) job in parallel on one or more processors wherein the ETL job comprises use of an extensible markup language (XML) document are provided. The techniques include receiving an XML document input, identifying a node in the XML document at which partitioning of the XML document is to begin, sending partition information to each respective processor, performing a shallow parsing of the XML document in parallel on the one or more processors, wherein each processor performs shallow parsing using the identified partition node until it reaches its identified partition, using the shallow parsing to generate the partition of the input XML document, wherein each processor generates a different partition of the same XML document, and sending each partition in streaming format to an ETL job instance.Type: GrantFiled: September 24, 2009Date of Patent: June 23, 2015Assignee: International Business Machines CorporationInventors: Manoj K. Agarwal, Manish A. Bhide, Srilakshmi Kotwal, Srinivas Kiran Mittapalli, Sriram Padmanabhan
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Patent number: 9002131Abstract: The present disclosure relates to image filtering techniques for enhancing image quality. In one embodiment, two filtering techniques are applied on an image. Firstly, an adaptive weighted median filtering operation is performed on an acquired low contrast image corrupted by impulsive noise. Subsequently, a guided image filtering on the image obtained from adaptive weighted median filtering operation to de-blur and enhance the contrast that ultimately assures to preserve the edges of the images. In addition, the image filtering for enhancing image quality is enhanced by several variations of data adaptive guided image filtering and adaptive window sizes for guided image filtering techniques.Type: GrantFiled: September 11, 2012Date of Patent: April 7, 2015Assignee: Forus Health Pvt. Ltd.Inventors: Shyam Vasudeva Rao, Chandrasekhar Kuppuswamy, Mahabaleswara Ram Bhatt, Sriram Padmanabhan
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Publication number: 20150010944Abstract: The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant heterologous proteins from bacterial inclusion bodies using modified SAK.Type: ApplicationFiled: August 28, 2014Publication date: January 8, 2015Inventors: Shardul SALUNKHE, Bhaskarjyoti PRASAD, Praveen MUNESHWAR, Anjali Apte DESHPANDE, Sriram PADMANABHAN
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Publication number: 20140369986Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.Type: ApplicationFiled: May 15, 2014Publication date: December 18, 2014Applicant: GangaGen, Inc.Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R.Sanjeev Saravanan, Bharathi Sriram
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Patent number: 8853380Abstract: The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant heterologous proteins from bacterial inclusion bodies using modified SAK.Type: GrantFiled: June 3, 2011Date of Patent: October 7, 2014Assignee: Lupin LimitedInventors: Shardul Salunkhe, Bhaskarjyoti Prasad, Praveen Muneshwar, Anjali Apte Deshpande, Sriram Padmanabhan
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Publication number: 20140297583Abstract: Techniques, systems, and articles of manufacture for determining statistics for cost-based optimization of a workflow. A method includes generating individual sets of statistics for each intermediate relation of a workflow, wherein said intermediate relations comprise results of stages of any plan of the workflow, and wherein each individual set of statistics computes cardinality of the corresponding intermediate relation; determining a global set of statistics for the workflow, wherein said global set of statistics comprises at least one of the individual sets of statistics for each of the intermediate relations; instrumenting a given plan of the workflow to collect the global set of statistics during execution; executing the given plan to collect the global set of statistics; and determining a plan of the workflow with the lowest cost by comparing the cost of multiple plans, wherein the cost of each plan is derived from the global set of statistics.Type: ApplicationFiled: March 29, 2013Publication date: October 2, 2014Applicant: International Business Machines CorporationInventors: Ramanujam S. Halasipuram, Prasad M. Deshpande, Sriram Padmanabhan
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Publication number: 20140193093Abstract: The present disclosure relates to image filtering techniques for enhancing image quality. In one embodiment, two filtering techniques are applied on an image. Firstly, an adaptive weighted median filtering operation is performed on an acquired low contrast image corrupted by impulsive noise. Subsequently, a guided image filtering on the image obtained from adaptive weighted median filtering operation to de-blur and enhance the contrast that ultimately assures to preserve the edges of the images. In addition, the image filtering for enhancing image quality is enhanced by several variations of data adaptive guided image filtering and adaptive window sizes for guided image filtering techniques.Type: ApplicationFiled: September 11, 2012Publication date: July 10, 2014Applicant: FORUS HEALTH PVT. LTD.Inventors: Shyam Vasudeva Rao, Chandrasekhar Kuppuswamy, Mahabaleswara Ram Bhatt, Sriram Padmanabhan
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Publication number: 20140160323Abstract: The present disclosure relates to method and apparatus for image recovery and image correction. In an embodiment, the present disclosure relates to recovering images that are occluded due to some material in the optical path while capturing the images. The detection of noisy region is performed by taking the residual image between the images yielded by large sized and small sized Gaussian window smoothening filters on red, green and blue channels. The recovery of the image that alleviates the noise is obtained by point-wise multiplication of the above said residue image with a suitably synthesized Gaussian distributed co-efficient of same size.Type: ApplicationFiled: December 12, 2013Publication date: June 12, 2014Applicant: Forus Health Pvt. Ltd.Inventors: Shyam Vasudeva RAO, Mahabaleswara Ram BHATT, Sriram PADMANABHAN
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Patent number: 8748150Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.Type: GrantFiled: May 21, 2012Date of Patent: June 10, 2014Assignee: GangaGen, Inc.Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
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Publication number: 20140050713Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.Type: ApplicationFiled: April 12, 2012Publication date: February 20, 2014Inventors: C.B. Appaiah, Sriram Padmanabhan, R. Sanjeev Saravanan, Bharathi Sriram
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Publication number: 20130273585Abstract: Soluble variants of recombinant proteins produced in a prokaryotic host cell, where the high expression levels often cause the original proteins to aggregate into insoluble inclusion body aggregates. The variant polypeptides retain biological function while increasing protein solubility with comparable or higher recoverable levels of biologically active protein when expressed in a suitable expression host. Methods of identifying critical residues and substituting them are provided to produce the variants.Type: ApplicationFiled: April 11, 2013Publication date: October 17, 2013Applicant: GangaGen, Inc.Inventors: C. B. Appaiah, Sriram Padmanabhan, R. Sanjeev Saravanan
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Publication number: 20130122542Abstract: The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant heterologous proteins from bacterial inclusion bodies using modified SAK.Type: ApplicationFiled: June 3, 2011Publication date: May 16, 2013Applicant: LUPIN LIMITEDInventors: Shardul Salunkhe, Bhaskarjyoti Prasad, Praveen Muneshwar, Anjali Apte Deshpande, Sriram Padmanabhan
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Publication number: 20130124454Abstract: A computer-implemented method, computer program product and a system for identifying and handling slowly changing dimension (SCD) attributes for use with an Extract, Transform, Load (ETL) process, comprising importing a data model for dimensional data into a data integration system, where the dimensional data comprises a plurality of attributes, identifying via a data discovery analyzer one or more attributes in the data model as SCD attributes, importing the identified SCD attributes into the data integration system, selecting a data source comprising dimensional data, automatically generating an ETL job for the dimensional data utilizing the imported SCD attributes, and executing the automatically generated ETL to extract the dimensional data from the data source and loading the dimensional data into the imported SCD attributes in a target data system.Type: ApplicationFiled: September 14, 2012Publication date: May 16, 2013Applicant: INTERNATIONAL BUSINESS MACHINES COPORATIONInventors: Manish A. Bhide, Srinivas Kiran Mittapalli, Sriram Padmanabhan
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Publication number: 20130117216Abstract: A computer-implemented method, computer program product and a system for supporting star and snowflake data schemas for use with an Extract, Transform, Load (ETL) process, comprising selecting a data source comprising dimensional data, where the dimensional data comprises at least one source table comprising at least one source column, importing a data model for the dimensional data into a data integration system, analyzing the imported data model to select a star or snowflake target data schema comprising target dimensions and target facts, generating a meta-model representation by mapping at least one source table or source column to each target fact and target dimension, automatically converting the meta-model representation into one or more ETL jobs, and executing the ETL jobs to extract the dimensional data from the data source and loading the dimensional data into the selected target data schema in a target data system.Type: ApplicationFiled: November 9, 2011Publication date: May 9, 2013Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Manish A. Bhide, Srinivas Kiran Mittapalli, Sriram Padmanabhan
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Publication number: 20130117217Abstract: A computer-implemented method, computer program product and a system for supporting star and snowflake data schemas for use with an Extract, Transform, Load (ETL) process, comprising selecting a data source comprising dimensional data, where the dimensional data comprises at least one source table comprising at least one source column, importing a data model for the dimensional data into a data integration system, analyzing the imported data model to select a star or snowflake target data schema comprising target dimensions and target facts, generating a meta-model representation by mapping at least one source table or source column to each target fact and target dimension, automatically converting the meta-model representation into one or more ETL jobs, and executing the ETL jobs to extract the dimensional data from the data source and loading the dimensional data into the selected target data schema in a target data system.Type: ApplicationFiled: September 14, 2012Publication date: May 9, 2013Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Manish A. Bhide, Srinivas Kiran Mittapalli, Sriram Padmanabhan
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Publication number: 20120328576Abstract: The invention provides therapeutic, defined-dose anti-bacterial phage preparations, methods to make such preparations, methods to treat bacterial infections using such preparations and methods to diagnose bacterial infections using such preparations.Type: ApplicationFiled: June 29, 2012Publication date: December 27, 2012Applicant: GangaGen, Inc.Inventors: Manur Jayasheela, Bharathi Sriram, Sriram Padmanabhan
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Publication number: 20120237491Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.Type: ApplicationFiled: May 21, 2012Publication date: September 20, 2012Applicant: GangaGen, Inc.Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
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Patent number: 8202516Abstract: The present invention provides methods and compositions to reduce growth of microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions.Type: GrantFiled: May 4, 2007Date of Patent: June 19, 2012Assignee: GangaGen, Inc.Inventors: Sriram Padmanabhan, Vivek Daniel Paul, R. Sanjeev Saravanan, Bharathi Sriram
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Publication number: 20120107876Abstract: The invention relates to a fusion tag comprising Serine-aspartic acid repeats of the well conserved region of the Staphylococcus aureus Sdr C gene superfamily. A START codon and an enterokinase cleavage site has been incorporated into this repeat region to make a novel fusion tag that is responsible for expressing soluble proteins in bacterial system.Type: ApplicationFiled: April 29, 2010Publication date: May 3, 2012Applicant: LUPIN LIMITEDInventors: Sampali Banerjee, Sriram Padmanabhan
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Publication number: 20120093765Abstract: The present invention describes a novel process for large-scale purification of therapeutic grade quality of recombinant human GCSF from microbial cells, wherein the protein is expressed as inclusion bodies. The Inclusion bodies are solubilized and refolded under redox condition. The Redox condition is provided by using ascorbic acid, dehydroascorbic acid and reduced gluthathione. The process involves the novel use of aqueous two phase extraction step to purify refolded GCSF after removal of denaturant. After this step GCSF is further purified using chromatography techniques for removal of related impurities. The GCSF obtained has good purity and yields which are essential for a production scale process. The host cell related contaminants like proteins, DNA and endotoxins are reduced using the purification processes of the invention.Type: ApplicationFiled: June 7, 2010Publication date: April 19, 2012Applicant: LUPIN LIMITEDInventors: Sandeep Somani, Sriram Padmanabhan