Patents by Inventor Steffen Ernst
Steffen Ernst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20110045572Abstract: The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids situated within 5 ? from the epitope amino acids constituting the epitope sequence, changing one or more of the amino acids defining the epitope area of the parent protein by genetical engineering mutations of a DNA sequence encoding the parent protein, introducing the mutated DNA sequence into a suitable host, culturing said host and expressing the protein variant, and evaluating the immunogenicity of the protein variant using the parent protein as reference. The invention further relates to the protein variant and use thereof, as well as to a method for producing said protein variant.Type: ApplicationFiled: February 4, 2010Publication date: February 24, 2011Applicant: NOVOZYMES A/SInventors: Erwin Ludo Roggen, Steffen Ernst, Allan Svendsen, Esben Peter Friis, Claus Von Der Osten
-
Publication number: 20110027842Abstract: A process for producing a glyceride product which is enriched in monounsaturated fatty acids relative to the starting glyceride comprising the steps: (a) alcoholysis of triglycerides employing lipolytic enzymes selective for saturated fatty acids and/or lipolytic enzymes selective for the 1-position, the 3-position or both positions in a glyceride; and (b) separation of fraction A which is enriched in saturated fatty acid esters from fraction B which is enriched in monounsaturated glycerides.Type: ApplicationFiled: March 25, 2009Publication date: February 3, 2011Applicant: Novozymes A/SInventors: Per Munk Nielsen, Steffen Ernst, Kim Borch, Hans Christian Holm, Yee Hon Seng, David William Cowan
-
Publication number: 20100285175Abstract: The present invention relates to a method for producing a dairy product using an enzyme having lactase activity.Type: ApplicationFiled: December 2, 2008Publication date: November 11, 2010Applicants: Novozymes A/S, Chr. Hansen A/SInventors: Hanne Vang Hendriksen, Steffen Ernst, Reinhard Wilting, Jeppe Wegener Tams, Mette Oerhrstroem Runge, Helle Skov Guldager
-
Publication number: 20100279383Abstract: The present invention relates to subtilase variants and subtilases with an altered immunogenicity, particularly subtilase variants and subtilases with a reduced allergenecity. Furthermore, the invention relates to expression of said subtilase variants and subtilases and to their use, such as in detergents and oral care products.Type: ApplicationFiled: July 7, 2010Publication date: November 4, 2010Applicant: Novozymes A/SInventors: Erwin Ludo Roggen, Nina Teeres Herne, Steffen Ernst, Carsten Andersen, Ninna Willestofte Berg
-
Publication number: 20100255153Abstract: The present invention relates to an enzymatic process for making a milk-based protein hydrolysate and use of such hydrolysate, e.g., in an infant formula composition.Type: ApplicationFiled: April 1, 2010Publication date: October 7, 2010Applicant: Novozymes A/SInventors: Peter Rahbek Oestergaard, Steffen Ernst, Gitte B. Lynglev
-
Publication number: 20090087405Abstract: The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.Type: ApplicationFiled: December 12, 2008Publication date: April 2, 2009Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Gerald Juergen ROTH, Armin HECKEL, Rainer WALTER, Frank HILBERG, Rudolf HAUPTMANN, Martin Friedrich STEFANIC, Florian COLBATZKY, Steffen ERNST
-
Publication number: 20090074915Abstract: The present invention relates to a process for production of cooked vegetable food materials having reduced levels of acrylamide.Type: ApplicationFiled: November 17, 2005Publication date: March 19, 2009Applicants: Novozymes A/S, Procter & Gamble, Inc.Inventors: Hanne Vang Hendriksen, Mary Ann Stringer, Steffen Ernst, Hans Peter Heldt-Hansen, Richard Gerard Schafermeyer, Patrick Joseph Corrigan
-
Publication number: 20090061046Abstract: The present invention relates to a method for producing an acidified milk drink using an enzyme having transglutaminase activity.Type: ApplicationFiled: July 30, 2008Publication date: March 5, 2009Applicant: Novozymes A/SInventors: Jeppe Wegener Tams, Christel Thea Joergensen, Steffen Ernst, Per Munk Nielsen
-
Publication number: 20080279984Abstract: The present invention relates to methods for increasing the content of resistant starch in a potato product by enzymatic treatment. The invention further relates to potato products having an increased content of resistant starch.Type: ApplicationFiled: January 17, 2008Publication date: November 13, 2008Applicant: Novozymes A/SInventors: Lisbeth Kalum, Steffen Ernst
-
Publication number: 20080254041Abstract: The present invention relates to a method for selecting one or more immunotherapeutic preparation having improved properties as a vaccine against a target antigen, said method comprising raising antibodies against a group of candidate preparations and selecting one or more preparations which produces antibodies having higher affinity against the target antigen than does anti-bodies raised against at least one other preparation from the group. More particularly it relates to the need to provide recombinant allergens (Bet V 1) for SIT which have been modified by protein engineering.Type: ApplicationFiled: September 10, 2004Publication date: October 16, 2008Applicant: Novozymes A/SInventors: Steffen Ernst, Charlotte Georgi Jakobsen, Erwin Ludo Roggen
-
Publication number: 20070292938Abstract: The present invention relates to a method for extracting components from yeast cells with a purified phospholipase.Type: ApplicationFiled: May 8, 2007Publication date: December 20, 2007Applicant: Novozymes A/SInventors: Lisbeth Kalum, Per Nielsen, Steffen Ernst
-
Publication number: 20070225207Abstract: This invention concerns variants of a group 1 mite polypeptide, wherein the mature polypeptide of the variants comprise one or more mutations in the positions or corresponding to positions consisting of P11, I14, D15, L16, M19-P24, Q28, F37, S38, T43, A46-A49, Q53-L57, V63, A66-H69, H72, D74-R77, I80, Y82, Q84, H85, S92, I113, S114, P121, V124, K126, R128-A130, A132-S136, A139, L147, A149-H152, T157, Q160, N163, H170, A171, S178, V183, D184, R189, D193, F204, A206, N207, P217, L222 of SEQ ID NO: 1 or alternatively 11, 14, 15, 16, 19-24, 28, 37, 38, 43, 46-49, 53-57, 63, 66-69, 72, 74-77, 80, 82, 84, 85, 92, 113, 114, 121, 124, 126, 128-130, 132-136, 139, 147, 149-152, 157, 160, 163, 170, 178, 183, 189, 193, 204, 206, 207, 217, 222 of the mature Der p 1 polypeptide.Type: ApplicationFiled: April 21, 2005Publication date: September 27, 2007Applicant: Novozymes A/SInventors: Vincent Batori, Erwin Roggen, Steffen Ernst, Stina Lyngstrand
-
Publication number: 20060228791Abstract: The present invention relates to subtilase variants and subtilases with an altered immunogenicity, particularly subtilase variants and subtilases with a reduced allergenecity. Furthermore, the invention relates to expression of said subtilase variants and subtilases and to their use, such as in detergents and oral care products.Type: ApplicationFiled: June 25, 2003Publication date: October 12, 2006Applicant: Novozymes A/SInventors: Erwin Roggen, Nina Nilsson, Steffen Ernst, Carsten Andersen, Ninna Berg
-
Publication number: 20050181446Abstract: The present invention relates to a method of selecting a protein variant having modified immunogenicity as compared to the parent protein comprising the steps obtaining antibody binding peptide sequences, using the sequences to localise epitope sequences on the 3-dimensional structure of parent protein, defining an epitope area including amino acids situated within 5 ? from the epitope amino acids constituting the epitope sequence, changing one or more of the amino acids defining the epitope area of the parent protein by genetical engineering mutations of a DNA sequence encoding the parent protein, introducing the mutated DNA sequence into a suitable host, culturing said host and expressing the protein variant, and evaluating the immunogenicity of the protein variant using the parent protein as reference. The invention further relates to the protein variant and use thereof, as well as to a method for producing said protein variant.Type: ApplicationFiled: September 21, 2001Publication date: August 18, 2005Applicant: Novozymes A/SInventors: Erwin Roggen, Steffen Ernst, Allan Svendsen, Esben Friis, Claus Osten
-
Publication number: 20040204458Abstract: The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.Type: ApplicationFiled: August 14, 2003Publication date: October 14, 2004Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Gerald Juergen Roth, Armin Heckel, Rainer Walter, Frank Hilberg, Rudolf Hauptmann, Martin Friedrich Stefanic, Florian Colbatzky, Steffen Ernst
-
Publication number: 20040175757Abstract: The present invention relates to a method of selecting a protein variant having reduced immunogenicity as compared with the parent protein.Type: ApplicationFiled: December 8, 2003Publication date: September 9, 2004Applicant: Novozymes A/SInventors: Arne Agerlin Olsen, Erwin Lugo Roggen, Steffen Ernst
-
Patent number: 6734310Abstract: The invention relates to cyanine dyes, which have alkyl substituents in the meso position of the methine chain, sulphoaryl groups as well as at least one reactive group which permits the binding to a target substance.Type: GrantFiled: October 21, 2002Date of Patent: May 11, 2004Assignee: FEW Chemicals GmbHInventors: Knut Reiner, Steffen Ernst, Heinz Mustroph
-
Patent number: 6686164Abstract: The present invention relates to a method of selecting a protein variant having reduced immunogenicity as compared with the parent protein.Type: GrantFiled: October 13, 1999Date of Patent: February 3, 2004Assignee: Novozymes A/SInventors: Arne Agerlin Olsen, Erwin Lugo Roggen, Steffen Ernst
-
Patent number: 6613528Abstract: The invention relates to a ellulose film comprising microfibrillated cellulose and to the use of it for screening of a biological compound and nucleic acids encoding a biological compound.Type: GrantFiled: May 20, 2002Date of Patent: September 2, 2003Assignee: Novozymes A/SInventors: William Helbert, Henri Dominique Chanzy, Steffen Ernst, Martin Schulein, Tommy Lykke Husum, Lars Kongsbak
-
Publication number: 20030135058Abstract: The invention relates to cyanine dyes, which have alkyl substituents in the meso position of the methine chain, sulphoaryl groups as well as at least one reactive group which permits the binding to a target substance.Type: ApplicationFiled: October 21, 2002Publication date: July 17, 2003Inventors: Knut Reiner, Steffen Ernst, Heinz Mustroph