Abstract: The present invention is related to agents capable of binding to and inhibiting or antagonizing the action of IL-11 and/or or IL-11RA for the treatment and/or prevention of abnormal uterine bleeding, which comprises heavy menstrual bleeding, prolonged bleeding, altered bleeding pattern, dysmenorrhea, as well as of the underlying diseases leiomyoma and endometriosis and the use of the agent to inhibit menstruation. Furthermore, the invention provides novel IL-11 antibodies.

Abstract: The circulation assist devices disclosed herein can be used, for example, in methods of decreasing venous pressure in the Fontan circulation. The devices can include an inlet, an outlet, a stator, a rotor, and an impeller driven by rotation of the rotor. In some embodiments, the impeller blade (or blades) can at least partially define a central lumen extending through the device. The device can be coupled to the inferior vena cava and the pulmonary artery. Rotating the impeller blade(s) increases blood velocity through the lumen and causes the outlet pressure to be higher than the inlet pressure. The impeller can be configured such that, when it is stationary, the forward static pressure drop between the inlet and the outlet is minimized. That is, the forward static pressure drop of the device approximates the pressure drop between the inferior vena cava and central pulmonary artery of the unassisted Fontan circulation.

Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).

Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).

Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).

Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).

Abstract: A system, method, and computer program product for efficiently finding the best Monte Carlo simulation samples for use as design corners for all design specifications to substitute for a full circuit design verification. Embodiments calculate a corner target value matching an input variation level by modeling the circuit performance with verified accuracy, estimate the corner based on a response surface model such that the corner has the highest probability density (or extrapolation from the worst sample if the model is inaccurate), and verify and/or adjust the corner by performing a small number of additional simulations. Embodiments also estimate the probability that a design already meets the design specifications at a specified variation level. Composite multimodal and non-Gaussian probability distribution functions enhance model accuracy. The extracted design corners may be of particular utility during circuit design iterations.

Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).

Abstract: An electric fluid pump may include a wet section having a pump wheel and a permanently excited rotor of an electric motor arranged therein. The electric fluid pump may include a dry section having a stator of the electric motor arranged therein. A containment shell may be included configured to separate the wet section from the dry section. The dry section may include control electronics for controlling the fluid pump. The control electronics may connect in a heat-transferring manner to the containment shell and the wet section via the containment shell.

Abstract: A blood pump (26) includes a stator assembly (122) that includes a motor stator, a fluid inlet (24), and a fluid outlet (26). A rotor assembly (120) includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). A permanent magnet radial bearing (100) supports the rotor assembly for rotation about the axis (44). The radial bearing (100) includes a permanent magnet radial bearing stator (106) fixed to the stator assembly (122) and a permanent magnet radial bearing rotor (108) fixed to the rotor assembly (120). The radial bearing (100) is configured such that the radial bearing stator magnets (106) and the radial bearing rotor magnets (108) are axially offset from each other when the pump is at rest.

Abstract: An electric fluid pump may include a wet section having a pump wheel and a permanently excited rotor of an electric motor arranged therein. The electric fluid pump may include a dry section having a stator of the electric motor arranged therein. A containment shell may be included configured to separate the wet section from the dry section. The dry section may include control electronics for controlling the fluid pump. The control electronics may connect in a heat-transferring manner to the containment shell and the wet section via the containment shell.

Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).

Abstract: A blood pump (26) includes a stator assembly (122) that includes a motor stator, a fluid inlet (24), and a fluid outlet (26). A rotor assembly (120) includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). A permanent magnet radial bearing (100) supports the rotor assembly for rotation about the axis (44). The radial bearing (100) includes a permanent magnet radial bearing stator (106) fixed to the stator assembly (122) and a permanent magnet radial bearing rotor (108) fixed to the rotor assembly (120). The radial bearing (100) is configured such that the radial bearing stator magnets (106) and the radial bearing rotor magnets (108) are axially offset from each other when the pump is at rest.

Abstract: A silencer is described for damping the outflow noise of compressed air from compressed air appliances, in particular compressed air appliances of vehicles, with an inlet port, with at least one outlet port and with a pot-like housing which is arranged between these ports and which has a pot casing and a pot bottom, a sound-absorbing material in the form of a cartridge of a filter knit, serving for noise damping, being arranged in the inner space of the pot-like housing, characterized in that a layer of fibrous material is arranged between the cartridge and the pot casing.

Abstract: A blood pump (26) includes a stator assembly including a fluid inlet (24) and a fluid outlet (26). A rotor assembly (120) includes an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). A motor (50) imparts rotation of the impeller (40) about the axis (44). The motor (50) includes a motor stator (52) fixed to the stator assembly (122), a motor rotor (54) fixed to the rotor assembly (120), and a radial motor gap (34) between the stator (52) and the rotor (54). The pump (20) is configured to direct a mixed blood flow from the fluid inlet (24) to the fluid outlet (26) and a wash flow through the motor gap (34).

Abstract: A method is described that involves locking a capacity demand profile of a resource for the use of a transaction. The method also involves obtaining a portion of the locked capacity demand profile. The portion describes the capacity demand profile over a time interval in which a locked out transaction desired to implement a change to the capacity demand profile prior to the locking. The method involves implementing the change to the portion to form a changed portion. The method also involves, after the implementing, implementing a second change to the changed portion. The second change is desired by the transaction.

Abstract: A silencer is described for damping the outflow noise of compressed air from compressed air appliances, in particular compressed air appliances of vehicles, with an inlet port, with at least one outlet port and with a pot-like housing which is arranged between these ports and which has a pot casing and a pot bottom, a sound-absorbing material in the form of a cartridge of a filter knit, serving for noise damping, being arranged in the inner space of the pot-like housing, characterized in that a layer of fibrous material is arranged between the cartridge and the pot casing.

Abstract: A blood pump (26) includes a stator assembly including a fluid inlet (24) and a fluid outlet (26). A rotor assembly (120) includes an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). A motor (50) imparts rotation of the impeller (40) about the axis (44). The motor (50) includes a motor stator (52) fixed to the stator assembly (122), a motor rotor (54) fixed to the rotor assembly (120), and a radial motor gap (34) between the stator (52) and the rotor (54). The pump (20) is configured to direct a mixed blood flow from the fluid inlet (24) to the fluid outlet (26) and a wash flow through the motor gap (34).

Abstract: A circuit for providing a base operating voltage for a bipolar transistor includes a UBE multiplier providing, in response to a working-point control current, a working voltage fed to a circuit for reducing the working voltage in order to generate a base operating voltage smaller than a base-emitter voltage drop of a bipolar power transistor. With this, the bipolar power transistor may be maintained in the class C operation in a flexible and robust manner, so that an amplifier with high efficiency is obtained.

Abstract: A method for modeling a plurality of quantities continuously accumulating over time by performing for each quantity of the plurality of quantities the following steps: determining separate time intervals and further determining the quantity accumulated in each time interval, and representing the separate time intervals and the quantity accumulated in each time interval in a table comprising a plurality of related data elements corresponding to the separate time intervals, each data element comprising a point in time in predetermined relation to the time interval and the quantity accumulated in the time interval.