Patents by Inventor Steven L. Goodman
Steven L. Goodman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8999273Abstract: A system for preparing and holding specimens for microscopic analysis including a capsule having an open end, an opposite end including at least one aperture and a reservoir. The system also includes an insert with a base including at least one aperture. The insert fits within and engages an inner wall of the reservoir to secure the insert within the reservoir. The system also includes an insertion tool configured to engage the insert. The insertion tool is sized to position the insert within the reservoir at a variety of positions within the reservoir. The insertion tool will disengage the insert once the insert is positioned within the reservoir. A method of positioning a specimen within a capsule for processing the specimen in preparation for microscopic analysis. A tray for holding a plurality of pipette tips in such a way that a lower end of each pipette tip is sealed.Type: GrantFiled: August 2, 2011Date of Patent: April 7, 2015Assignee: Microscopy Innovations, LLCInventors: Steven L. Goodman, Mark T. Nelson, Jack C. LaSee
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Patent number: 8507876Abstract: A device for holding a specimen holder, the device including a body with a slot formed therein. The slot includes an interior for receiving the specimen holder which may be a flat disk with edges and a pair of opposing sides. The disk may be made of a resilient deformable material. The slot may be sized to receive the specimen holder through an open top end and may taper from top bottom, such that the bottom end of the slot is smaller than the specimen holder. The slot further configured to contact the specimen holder along edges of the specimen holder and to allow some sideways deformation of the specimen holder without either side of the specimen holder distant from the edges coming into contact with the interior of the slot.Type: GrantFiled: March 8, 2011Date of Patent: August 13, 2013Assignee: Microscopy Innovations, LLCInventors: Steven L. Goodman, Jack LaSee, Mark T. Nelson
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Publication number: 20120027650Abstract: A system for preparing and holding specimens for microscopic analysis including a capsule having an open end, an opposite end including at least one aperture and a reservoir. The system also includes an insert with a base including at least one aperture. The insert fits within and engages an inner wall of the reservoir to secure the insert within the reservoir. The system also includes an insertion tool configured to engage the insert. The insertion tool is sized to position the insert within the reservoir at a variety of positions within the reservoir. The insertion tool will disengage the insert once the insert is positioned within the reservoir. A method of positioning a specimen within a capsule for processing the specimen in preparation for microscopic analysis. A tray for holding a plurality of pipette tips in such a way that a lower end of each pipette tip is sealed.Type: ApplicationFiled: August 2, 2011Publication date: February 2, 2012Inventors: Steven L. Goodman, Mark T. Nelson, Jack C. LaSee
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Publication number: 20120006711Abstract: A device for holding a specimen holder, the device including a body with a slot formed therein. The slot includes an interior for receiving the specimen holder which may be a flat disk with edges and a pair of opposing sides. The disk may be made of a resilient deformable material. The slot may be sized to receive the specimen holder through an open top end and may taper from top bottom, such that the bottom end of the slot is smaller than the specimen holder. The slot further configured to contact the specimen holder along edges of the specimen holder and to allow some sideways deformation of the specimen holder without either side of the specimen holder distant from the edges coming into contact with the interior of the slot.Type: ApplicationFiled: March 8, 2011Publication date: January 12, 2012Inventors: Steven L. Goodman, Jack LaSee, Mark T. Nelson
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Publication number: 20100152052Abstract: The present invention relates to specimens for use in microanalysis processes. One aspect of the invention is directed toward using a mold to form specimens for a microanalysis process (e.g., including an atom probe and/or transmission electron microscope processes). Other aspects of the invention are directed towards embedding specimen material (e.g., including nanoparticles) in an embedment material to produce a specimen suitable for use in a microanalysis process. Still other aspects include combining specimen material with an embedment material to enhance a microanalysis process. Yet other embodiments of the invention are directed toward combining a specimen material with multiple embedment materials to produce specimens suitable for a microanalysis process. Further aspects of the invention are directed toward analyzing at least a portion of a specimen produced by one or more of the processes discussed above.Type: ApplicationFiled: July 28, 2006Publication date: June 17, 2010Inventors: Steven L. Goodman, Thomas F. Kelly, Terri J. Tomicki
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Patent number: 7663101Abstract: A device, method and system for preparing and storing samples for microscopic analysis is disclosed. The device provides a reservoir that can be attached to a displacement pipette thereby filling the reservoir with reagents desired for preparing the samples for microscopic analysis. In some embodiments, the specimen may be contained on a transmission electron microscope (TEM) grid. In other embodiments, the sample may be a light microscope (LM) specimen or a scanning electron microscope (SEM) specimen. In yet another embodiment, the invention provides a method of preparing samples for microscopic examination including a device for preparing TEM grids with, a device for preparing TEM, SEM or LM specimens with and a device for storing both grids and specimens in. In yet another embodiment, the invention provides a system for tracking the preparation, analysis and histological evaluation of multiple samples while also providing for their long term storage.Type: GrantFiled: May 22, 2007Date of Patent: February 16, 2010Assignee: Microscopy InnovationsInventor: Steven L. Goodman
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Patent number: 7544953Abstract: A device, method and system for preparing and storing samples for microscopic analysis is disclosed. The device provides a reservoir that can be attached to a displacement pipette thereby filling the reservoir with reagents desired for preparing the samples for microscopic analysis. In some embodiments, the specimen may be contained on a transmission electron microscope (TEM) grid. In other embodiments, the sample may be a light microscope (LM) specimen or a scanning electron microscope (SEM) specimen. In yet another embodiment, the invention provides a method of preparing samples for microscopic examination including a device for preparing TEM grids with, a device for preparing TEM, SEM or LM specimens with and a device for storing both grids and specimens in. In yet another embodiment, the invention provides a system for tracking the preparation, analysis and histological evaluation of multiple samples while also providing for their long term storage.Type: GrantFiled: May 23, 2007Date of Patent: June 9, 2009Assignee: Microscopy Innovations, LLCInventor: Steven L. Goodman
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Publication number: 20080068706Abstract: A device, method and system for preparing and storing samples for microscopic analysis is disclosed. The device provides a reservoir that can be attached to a displacement pipette thereby filling the reservoir with reagents desired for preparing the samples for microscopic analysis. In some embodiments, the specimen may be contained on a transmission electron microscope (TEM) grid. In other embodiments, the sample may be a light microscope (LM) specimen or a scanning electron microscope (SEM) specimen. In yet another embodiment, the invention provides a method of preparing samples for microscopic examination including a device for preparing TEM grids with, a device for preparing TEM, SEM or LM specimens with and a device for storing both grids and specimens in. In yet another embodiment, the invention provides a system for tracking the preparation, analysis and histological evaluation of multiple samples while also providing for their long term storage.Type: ApplicationFiled: May 22, 2007Publication date: March 20, 2008Applicant: 10H, Inc.Inventor: Steven L. Goodman
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Publication number: 20080068707Abstract: A device, method and system for preparing and storing samples for microscopic analysis is disclosed. The device provides a reservoir that can be attached to a displacement pipette thereby filling the reservoir with reagents desired for preparing the samples for microscopic analysis. In some embodiments, the specimen may be contained on a transmission electron microscope (TEM) grid. In other embodiments, the sample may be a light microscope (LM) specimen or a scanning electron microscope (SEM) specimen. In yet another embodiment, the invention provides a method of preparing samples for microscopic examination including a device for preparing TEM grids with, a device for preparing TEM, SEM or LM specimens with and a device for storing both grids and specimens in. In yet another embodiment, the invention provides a system for tracking the preparation, analysis and histological evaluation of multiple samples while also providing for their long term storage.Type: ApplicationFiled: May 23, 2007Publication date: March 20, 2008Applicant: 10H, INC.Inventor: Steven L. Goodman
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Patent number: 7285363Abstract: A method for crosslinking one or more molecules comprises crosslinking the one or more molecules with a photactivatable crosslinker by one-photon or multi-photon excitation, wherein the crosslinker comprises at least two photoactive groups linked by a bridging moiety, and further wherein the point volume of the activation has at least one dimension of less than about 1 micron. The method is of particular utility for water-soluble molecules, particularly biologically active water-soluble molecules.Type: GrantFiled: November 10, 2003Date of Patent: October 23, 2007Assignee: The University of ConnecticutInventors: Paul J. Campagnola, Amy R. Howell, Jun Wang, Steven L. Goodman
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Publication number: 20040259023Abstract: A method for crosslinking one or more molecules comprises crosslinking the one or more molecules with a photactivatable crosslinker by one-photon or multi-photon excitation, wherein the crosslinker comprises at least two photoactive groups linked by a bridging moiety, and further wherein the point volume of the activation has at least one dimension of less than about 1 micron. The method is of particular utility for water-soluble molecules, particularly biologically active water-soluble molecules.Type: ApplicationFiled: November 10, 2003Publication date: December 23, 2004Inventors: Paul J. Campagnola, Amy R. Howell, Jun Wang, Steven L. Goodman
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Patent number: 6713772Abstract: A method wherein small, two- or three-dimensional structures are formed by multiple-photon-absorbed photopolymerization and/or cross-linking of a precursor composition. Use of multi-photon excitation allows fabrication of structures and structural features having at least one dimension of less than about one micron, preferably less than about 500 nm, more preferably less than about 250 nm, and most preferably of less than about 100 nm, in bulk phase as well as in solution, and from a wide variety of organic and inorganic precursor subunits, including synthetic polymers and biological polymers such as proteins, lipids, oligonucleotides, and the like. In one embodiment, use of two-photon far field optics allows the formation of structures having X-Y dimensions of less than about 300 nm and a Z dimension of less than about 500 nm, while use of three-photon far field optics allows the formation of structures having X-Y dimensions of less than about 250 nm and a Z dimension of less than about 300 nm.Type: GrantFiled: September 5, 2001Date of Patent: March 30, 2004Assignee: The University of ConnecticutInventors: Steven L. Goodman, Paul Campagnola
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Patent number: 6700121Abstract: Methods of sampling specimens for microanalysis, particularly microanalysis by atom probe microscopy, include steps of forming a study specimen in a first study object (as by use of focused ion beam milling); removing the study specimen from the study object; situating the study specimen on a second study object; and microanalyzing the study specimen. Where the first study object is of particular interest for study, the study specimen may be taken from a functional portion of the first study object so that microanalysis will provide information regarding this functional portion. Where the second study object is of particular interest for study, the second study object may be subjected to manufacturing processes (e.g., deposition of layers of materials) after the study specimen is situated thereon so that the study specimen will provide information regarding the results of the manufacturing process.Type: GrantFiled: May 1, 2003Date of Patent: March 2, 2004Assignee: Imago Scientific InstrumentsInventors: Thomas F. Kelly, Richard L. Martens, Steven L. Goodman
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Patent number: 6576900Abstract: Methods of sampling specimens for microanalysis, particularly microanalysis by atom probe microscopy, include steps of forming a study specimen in a first study object (as by use of focused ion beam milling); removing the study specimen from the study object; situating the study specimen on a second study object; and microanalyzing the study specimen. Where the first study object is of particular interest for study, the study specimen may be taken from a functional portion of the first study object so that microanalysis will provide information regarding this functional portion. Where the second study object is of particular interest for study, the second study object may be subjected to manufacturing processes (e.g., deposition of layers of materials) after the study specimen is situated thereon so that the study specimen will provide information regarding the results of the manufacturing process.Type: GrantFiled: May 18, 2001Date of Patent: June 10, 2003Assignee: Imago Scientific InstrumentsInventors: Thomas F. Kelly, Richard L. Martens, Steven L. Goodman
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Publication number: 20020006648Abstract: A method wherein small, two- or three-dimensional structures are formed by multiple-photon-absorbed photopolymerization and/or cross-linking of a precursor composition. Use of multi-photon excitation allows fabrication of structures and structural features having at least one dimension of less than about one micron, preferably less than about 500 nm, more preferably less than about 250 nm, and most preferably of less than about 100 nm, in bulk phase as well as in solution, and from a wide variety of organic and inorganic precursor subunits, including synthetic polymers and biological polymers such as proteins, lipids, oligonucleotides, and the like. In one embodiment, use of two-photon far field optics allows the formation of structures having X-Y dimensions of less than about 300 nm and a Z dimension of less than about 500 nm, while use of three-photon far field optics allows the formation of structures having X-Y dimensions of less than about 250 nm and a Z dimension of less than about 300 nm.Type: ApplicationFiled: September 5, 2001Publication date: January 17, 2002Inventors: Steven L. Goodman, Paul Campagnola
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Publication number: 20010044156Abstract: Methods of sampling specimens for microanalysis, particularly microanalysis by atom probe microscopy, include steps of forming a study specimen in a first study object (as by use of focused ion beam milling); removing the study specimen from the study object; situating the study specimen on a second study object; and microanalyzing the study specimen. Where the first study object is of particular interest for study, the study specimen may be taken from a functional portion of the first study object so that microanalysis will provide information regarding this functional portion. Where the second study object is of particular interest for study, the second study object may be subjected to manufacturing processes (e.g., deposition of layers of materials) after the study specimen is situated thereon so that the study specimen will provide information regarding the results of the manufacturing process.Type: ApplicationFiled: May 18, 2001Publication date: November 22, 2001Inventors: Thomas F. Kelly, Richard L. Martens, Steven L. Goodman
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Patent number: 6316153Abstract: A method wherein small, two- or three- dimensional structures are formed by multiple-photon-absorbed photopolymerization and/or cross-linking of a precursor composition. Use of multi-photon excitation allows fabrication of structures and structural features having at least one dimension of less than about one micron, preferably less than about 500 nm, more preferably less than about 250 nm, and most preferably of less than about 100 nm, in bulk phase as well as in solution, and from a wide variety of organic and inorganic precursor subunits, including synthetic polymers and biological polymers such as proteins, lipids, oligonucleotides, and the like. In one embodiment, use of two-photon far field optics allows the formation of structures having X-Y dimensions of less than about 300 mn and a Z dimension of less than about 500 nm, while use of three-photon far field optics allows the formation of structures having X-Y dimensions of less than about 250 mn and a Z dimension of less than about 300 nm.Type: GrantFiled: April 21, 1999Date of Patent: November 13, 2001Assignee: The University of ConnecticutInventors: Steven L. Goodman, Paul Campagnola
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Patent number: 5700241Abstract: Medical devices, such as percutaneous access devices and other implants, are disclosed which have synthetic biotextured surfaces. The peripheral outer surfaces of these items are provided with either a positive or an inverse representation of transverse surfaces using microcasting techniques.Type: GrantFiled: April 4, 1996Date of Patent: December 23, 1997Assignee: Wisconsin Alumni Research FoundationInventor: Steven L. Goodman
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Patent number: 5591298Abstract: An apparatus (10) of the type for laminating two elastomeric fibrous web materials (14,16) together by ultrasonic bonding includes a continuously moving web transport support (12) for transporting at least two overlaid webs (14,16) through the apparatus (10). An ultrasonic horn (18) transmits ultrasonic energy to bond the webs (14,16) together into a laminate. An anvil underlies the ultrasonic horn (18). A vacuum mechanism (24) draws the webs (14,16) against the web transport support (12) for perfecting bonding and to prevent rippling and tearing of the webs (14,16) against the horn (18) and the web transport support (12) during the ultrasonic bonding.Type: GrantFiled: December 11, 1992Date of Patent: January 7, 1997Assignee: Kimberly-Clark CorporationInventors: Steven L. Goodman, Robert E. Vogt
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Patent number: 5551326Abstract: A boat for use with microtomes eliminates the needs for adhesives and provides reusability by use of an elastomeric gasket compressed between contacting surfaces of the knife and boat. The compression is provided by a clamping action of components of the boat for ultramicrotome applications or in the case of histological knives, where the knife base is much broader, by means of a separate leaf spring encircling the unobstructed lower edge of the knife.Type: GrantFiled: December 15, 1994Date of Patent: September 3, 1996Assignee: Wisconsin Alumni Research FoundationInventor: Steven L. Goodman