Abstract: In some embodiments, the instant invention includes a computer-implemented method that includes: specifically programming at least one computer system to perform: automatically obtaining input financial data; automatically determining units of work that the input financial data can be organized into; automatically importing the input financial data into a database based on the units of work; automatically validating the imported input financial data, by: identifying deficient units of work based on predefined rules, where each deficient unit of work has a current data error; analyzing, based on research information, the current data error to determine a current corrective action to remedy the current data error; and verifying that the current corrective action does not result in: an additional deficient unit of work, an additional data error, and a change in at least one predefined data report; and automatically executing the current corrective action to remedy the current data error.

Abstract: Disclosed are methods, apparatuses and systems for collecting transactional and dimensional data. One implementation includes a configuration management database, a first data collection agent operating on a first monitored server to collect metadata associated with the first monitored server from the configuration management database using the first data collection agent, collect metric data from the first monitored server regarding operation of the first monitored server, wherein the metric data includes at least one metric collected from at least one application executing on the first monitored server; and assemble the collected metric data and at least part of the collected metadata into a packet for transmission from the first monitored server to a message bus; and a distributed database configured to receive the packet from the message bus and to store the collected metric data and metadata included in the packet.

Abstract: A breakaway support configured to selectively release an actuator from a fitting and a method of providing the breakaway support. The breakaway support includes a race positioned between the actuator and the fitting. The second end of the actuator is connected to the fitting via a ball joint is positioned within the race. The ball joint permits the actuator to pivot about the ball joint in a vertical plane between a first position and a second position. The breakaway support includes a first knuckle that causes the actuator to release from the fitting when the actuator moves in a first direction beyond the first position. A portion of the fitting or a second knuckle may cause the actuator to release from the fitting when the actuator moves in a second direction beyond the second position. A portion of the actuator may break to release the actuator from the fitting.

Abstract: A method for rate adapting a constant bit rate (CBR) client signal into a signal stream in a telecom signal communication link includes at a source node encoding into a control block a control block header, and an ordered set block-designator, encoding into a plurality of path overhead data blocks a data block header and a count of data blocks to be encoded in a signal block, encoding into each of a plurality of signal blocks a data block header, the data blocks from the CBR signal equal to the count and pad blocks, assembling the blocks into a path signal frame, appending a set of idle character blocks following the end of the path signal frame to match a link bit rate of a first link segment, and transmitting the path signal frame and idle character blocks into the first link segment at the link bit rate.

Abstract: A system for differential recording connectable to an electrical lead with at least two electrodes, including: the lead having a distal end; at least one amplifier electrically connectable to the at least two electrodes, wherein the at least one amplifier subtracts a signal recorded by one of the at least two electrodes, from a signal recorded by the other one of the at least two electrodes to generate a differential signal; a memory configured for storing said differential signal and reference indications of electrical signals associated with neural tissue; a processing circuitry for detection of an anatomical position, wherein the processing circuitry calculates an anatomical position of the electrical lead based on processing of the differential signal and the reference indications of electrical signals associated with the neural tissue.

Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.

Abstract: Systems, devices, kits, and methods are provided herein in the form of example embodiments that relate to calibration of medical devices. The medical devices can be sensors adapted to sense a biochemical attribute. The embodiments can be used to determine calibration information specific to an individual medical device. The embodiments can determine the calibration information by reference to one or more parameters obtained during manufacturing of the medical device. The embodiments can also determine the calibration information by reference to in vitro testing of the medical devices. The embodiments also apply to systems incorporating those medical devices in their use in the field. Also described are embodiments of modifications to surfaces of sensor substrates, such as through applied radiation and/or the creation of a well, to aid in the placement and/or sizing of a sensor element on the substrate.

Abstract: A method for extracting path overhead (POH) data blocks from a data stream in a 64B/66B-block communication link, the method includes receiving at a sink node a data stream in a 64B/66B-block communication link, detecting within the data stream at a PCS sublayer a micro-packet starting with an /S/ control block, including K POH data blocks, and ending with a /T/ control block, extracting the micro-packet from the data stream, and extracting the POH data blocks from the micro-packet.

Abstract: The UTILITY RESOURCE ASSET MANAGEMENT SYSTEM APPARATUSES, METHODS AND SYSTEMS (“URAMS”) transform weather, terrain, and utility asset parameter data via URAMS components into damage predictions with confidence metrics, alerts, and asset allocation and response plans.

Abstract: Ligand-ion channel interactions are analyzed via electrophysiological methods having rapid temporal response and high sensitivity, thereby reducing the collection time and enabling monitoring of dynamic processes. This protocol allows quantification of ligand concentrations in the sub-millisecond to ms range, as compared to s-min for traditional approaches. Moreover, the method can be easily integrated into existing patch clamp analysis packages and allow for monitoring of rapid, dynamic chemical processes in a feasible manner.

Abstract: A method for forming a retroreflective prism in a substrate includes inserting and retracting a single point diamond tool through a surface of the substrate while moving the single point diamond tool, the substrate, or both the single point diamond tool and the substrate in a direction of travel along at least one axis to generate a facet in the substrate having a facet face parallel to the direction of travel of at least one of the single diamond point tool or the substrate. The facet face has an angle defined by a chiseling edge of the single point diamond tool. The inserting and retracting is repeated at a plurality of locations on the substrate to form an array of retroreflective microstructures on the surface of the substrate. At least one of the array of retroreflective microstructures is a retroreflective prism having a polygonal projected aperture.

Abstract: A system for differential recording connectable to an electrical lead with at least two electrodes, including: the lead having a distal end; at least one amplifier electrically connectable to the at least two electrodes, wherein the at least one amplifier subtracts a signal recorded by one of the at least two electrodes, from a signal recorded by the other one of the at least two electrodes to generate a differential signal; a memory configured for storing said differential signal and reference indications of electrical signals associated with neural tissue; a processing circuitry for detection of an anatomical position, wherein the processing circuitry calculates an anatomical position of the electrical lead based on processing of the differential signal and the reference indications of electrical signals associated with the neural tissue.

Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.

Abstract: An access device may be implemented to provide one or more access channels to non-volatile memory. Memory mapping implemented at the access device may direct a memory controller of the access device to perform access requests, replacing an initial storage location with a different storage location to access in the non-volatile memory device. Address scrambling, encryption, and other modifications to performing an access request may be implemented at the access device, in some embodiments, in addition to the memory mapping techniques.

Abstract: Arthroplasty components include an articular surface and a bone-facing surface. The bone-facing surface includes a concave arrangement of planar surfaces which converge as they approach a middle portion of the articular surface. Instruments and implantation methods are also disclosed.

Abstract: An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.

Abstract: The UTILITY RESOURCE ASSET MANAGEMENT SYSTEM APPARATUSES, METHODS AND SYSTEMS (“URAMS”) transform weather, terrain, and utility asset parameter data via URAMS components into damage predictions with confidence metrics, alerts, and asset allocation and response plans.

Abstract: Systems, devices, kits, and methods are provided herein in the form of example embodiments that relate to calibration of medical devices. The medical devices can be sensors adapted to sense a biochemical attribute. The embodiments can be used to determine calibration information specific to an individual medical device. The embodiments can determine the calibration information by reference to one or more parameters obtained during manufacturing of the medical device. The embodiments can also determine the calibration information by reference to in vitro testing of the medical devices. The embodiments also apply to systems incorporating those medical devices in their use in the field. Also described are embodiments of modifications to surfaces of sensor substrates, such as through applied radiation and/or the creation of a well, to aid in the placement and/or sizing of a sensor element on the substrate.

Abstract: Surface-modified silica microparticles that are functionalized with stabilized phospholipid vesicles are described herein. These stabilized vesicles can be functionalized with either transmembrane receptors or membrane associated receptors and used for affinity pull-down assays or other chromatographic separation modalities to provide affinity capture/concentration of low abundance ligands in complex mixtures with minimal sample preparation. Further described are methods and apparatus for forming polymer frits in a fused silica capillary. The capillary containing a monomer solution is placed between one or more heat sources connected to each other via a jig and operatively coupled to a temperature controller. The polymer frits are synthesized via thermal polymerization of the monomer solution using the heat sources, which allows for placement of the polymer frits at a spatially-defined location in the capillary.