Abstract: There is provided a spring steel including predetermined chemical composition, in which ([Ti mass %]?3.43×[N mass %])/[S mass %]>4.0, and [Ni mass %]+[Cu mass %]<0.75 are satisfied, and an appearance frequency of MnS is less than 20% among inclusions having an equivalent circle diameter of 1 ?m or more which are observed at a 1/4 position of a diameter from a surface.

Abstract: A soft nitrided induction hardened steel part which is excellent in bearing fatigue strength comprised of a predetermined chemical composition wherein a dissolved N concentration from the surface to 0.2 mm depth is 0.05 to 1.50%, a Vicker's hardness from the surface to 0.2 mm depth after tempering at 300° C. is HV 600 or more, and t/r?0.35 when an effective hardened layer depth “t” is 0.5 mm or more and a radius of a breakage risk site or half of the thickness is “r” (mm).

Abstract: Disclosed is a lip seal for water pump made of a rubber-like elastic material, fixed to a housing as a fixed side and in sliding contact with a shaft rotating relative to the housing; the lip seal having sliding surface with a surface roughness Ra (according to JIS B0601 corresponding to ISO 4287) of 1 to 30 ?m, being obtained by vulcanization-molding of a rubber composition comprising 100 parts by weight of the rubber-like elastic material, 1 to 150 parts by weight of a reinforcing filler, 5 to 90 parts by weight of a non-reinforcing filler having an average particle diameter of 1 ?m or more, 0.1 to 5 parts by weight of a coupling agent, 1 to 15 parts by weight of a co-crosslinking agent, and 0.5 to 10 parts by weight of an organic peroxide. The lip seal effects to prevent softening and volume swelling of the rubber-like elastic material and furthermore the generation of deposits in the rotating shaft, which are problematic for rotation torque and LLC resistance.

Abstract: Steel for forging having high strength and superior machinability due to controlled cooling immediately after shaping by hot forging followed by tempering and having a lower specific gravity than ordinary steel for forging use, the steel containing C: 0.05 to 0.50%, Si: 0.01 to 1.50%, Mn: 3.0 to 7.0%, P: 0.001 to 0.050%, S: 0.020 to 0.200%, Al: 3.0 to 6.0%, Cr: 0.01 to 1.00%, and N: 0.0040 to 0.0200% and having a balance of Fe and unavoidable impurities.

Abstract: There is a hot-rolled steel according to one aspect of the invention including predetermined chemical compositions including 0.0001 to 0.0050 mass % of Bi, in which 90 area % or more of a metallographic structure is configured with a ferrite and a pearlite, and an average number density of Mn sulfides extending along a rolling direction and having an aspect ratio exceeding 10 and equal to or smaller than 30, which is measured on a cross section parallel to the rolling direction, is 50 to 200 number/mm2.

Abstract: Provided is a composition that can be used for an organ preservation solution or perfusate. Alternatively, provided is a composition for prolonging the survival of normal cells and/or a composition for inhibiting the survival of cancer cells. In one or more embodiments, a composition containing, as an active component, a compound that enhances phosphorylation of AMPK (AMP-activated protein kinase). Said composition is one that can prolong the survival of cells (especially, normal cells). Furthermore, said composition is one that can inhibit the survival of cancer cells.

Abstract: There is provided a hot forging steel including, by mass %, C: more than 0.30% and less than 0.60%, Si: 0.10% to 0.90%, Mn: 0.50% to 2.00%, S: 0.010% to 0.100%, Cr: 0.01% to 1.00%, Al: more than 0.005% and 0.100% or less, N: 0.0030% to 0.0200%, Bi: more than 0.0001% and 0.0050% or less, Ti: 0% or more and less than 0.040%, V: 0% to 0.30%, Ca: 0% to 0.0040%, Pb: 0% to 0.40%, and a remainder including Fe and impurities, in which P and O in the impurities are respectively P: 0.050% or less and O: 0.0050% or less, an expression d+3?<20 is satisfied, and a presence density of MnS having an equivalent circle diameter of smaller than 2.0 ?m is 300 pieces/mm2 or more in a cross section parallel to a rolling direction of a steel.

Abstract: A Roughly shaped material for induction hardened components including: a. steel as a base metal including, as a chemical composition, by mass %, C: 0.35% to 0.6%, Si: 0.02% to 2.0%, Mn: 0.35% to 1.5%, Al: 0.001% to 0.5%, Cr: 0.05% to 2.0%, S: 0.0001% to 0.05%, N: 0.003% to 0.0120%, P: 0.03% or less, O: 0.0050% or less, an iron nitride layer having a thickness of 0.1 ?m to 50 ?m in a depth direction is formed at a surface, and a volume fraction of a ?? phase, which is a Fe nitride, in the iron nitride layer, is 80% or more.

Abstract: A compound and a pharmaceutical composition for disease associated with an abnormal splice variant, use of the compound and the pharmaceutical composition, or a screening method of the compound and the pharmaceutical composition are provided. One or more embodiments disclose a compound expressed by the following formula (I) or (I?) or prodrugs or pharmaceutically acceptable salts thereof.

Abstract: Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.

Abstract: A pharmaceutical composition for neovascular diseases, a pharmaceutical composition for inhibiting an angiogenic growth factor, and use of these pharmaceutical compositions are provided. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a low molecular weight compound that is able to suppress the expression of VEGF gene in cells or to reduce the production of VEGF protein from cells. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a compound expressed by the following formula (I) or a prodrug thereof or pharmaceutically acceptable salts thereof.

Abstract: A steel for induction hardening according to an aspect includes, as a chemical composition, predetermined amounts of alloy elements and a remainder including Fe and impurities, in which Al×N is 0.000330 to 0.000825, Mn/S is 4.6 to 14.0, a machinability index M is 15.5 to 25.65, an area fraction of AlN having an equivalent circle diameter of more than 200 nm at a ¼ position of a diameter of the steel is 20% or less of an area fraction of all AlN having an equivalent circle diameter of 40 nm or more, and a number density of Mn sulfide-based inclusions having a maximum diameter of 0.3 ?m or more and 10 ?m or less at the ¼ position of the diameter is 100 pieces/mm2 or more and 2500 pieces/mm2 or less.

Abstract: Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same.

Abstract: The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.

Abstract: A compound and a pharmaceutical composition for disease associated with an abnormal splice variant, use of the compound and the pharmaceutical composition, or a screening method of the compound and the pharmaceutical composition are provided. One or more embodiments disclose a compound expressed by the following formula (I) or (I?) or prodrugs or pharmaceutically acceptable salts thereof.

Abstract: Described include (1) a substituted pyrazine compound of general formula (VIII): and (2) a process for producing the substituted pyrazine compound of general formula (VIII), where R1 is hydrogen, a halogen, a substituted or unsubstituted hydrocarbon group, or a substituted or unsubstituted heterocyclic group, and R4 is a protecting group. The process comprises (1) the step of reacting 2-amino-3,5-dibromo-6-chloropyrazine with R1MgX and ZnCl2 in the presence of a palladium catalyst to produce a compound of general formula (V); (2) the step of reacting the compound of general formula (V) with a compound of general formula (VI) to produce a compound of general formula (VII); and (3) the step of reacting the compound of formula (VII) with tributyl(vinyl)tin in the presence or a palladium catalyst to given the compound of general formula (VIII).

Abstract: A soft nitrided induction hardened steel part which is excellent in bearing fatigue strength comprised of a predetermined chemical composition wherein a dissolved N concentration from the surface to 0.2 mm depth is 0.05 to 1.50%, a Vicker's hardness from the surface to 0.2 mm depth after tempering at 300° C. is Hv600 or more, and t/r?0.35 when an effective hardened layer depth “t” is 0.5 mm or more and a radius of a breakage risk site or half of the thickness is “r” (mm).

Abstract: A Roughly Shaped material for induction hardened components including: a. steel as a base metal including, as a chemical composition, by mass %, C: 0.35% to 0.6%, Si: 0.02% to 2.0%, Mn: 0.30% to 1.5%, Al: 0.001% to 0.5%, Cr: 0.05% to 2.0%. S: 0.0001% to 0.05%, N: 0.003% to 0.0120%, P: 0.03% or less. 0: 0.0050% or less, an iron nitride layer having a thickness of 0.1 ?m to 50 ?m in a. depth direction is formed at a surface, and a volume fraction of a ?? phase, which is a Fe nitride, in the iron nitride layer, is 80% or more.

Abstract: Disclosed is a lip seal for water pump made of a rubber-like elastic material, fixed to a housing as a fixed side and in sliding contact with a shaft rotating relative to the housing; the lip seal having sliding surface with a surface roughness Ra (according to JIS B0601 corresponding to ISO 4287) of 1 to 30 ?m, being obtained by vulcanization-molding of a rubber composition comprising 100 parts by weight of the rubber-like elastic material, 1 to 150 parts by weight of a reinforcing filler, 5 to 90 parts by weight of a non-reinforcing filler having an average particle diameter of 1 ?m or more, 0.1 to 5 parts by weight of a coupling agent, 1 to 15 parts by weight of a co-crosslinking agent, and 0.5 to 10 parts by weight of an organic peroxide. The lip seal effects to prevent softening and volume swelling of the rubber-like elastic material and furthermore the generation of deposits in the rotating shaft, which are problematic for rotation torque and LLC resistance.

Abstract: In the method of cutting steel for machine structural use, steel for machine structural use, in which chemical components contain, by mass %, 0.01% to 1.2% of C, 0.005% to 3.0% of Si, 0.05% to 3.0% of Mn, 0.001% to 0.2% of P, 0.001% to 0.35% of S, 0.002% to 0.035% of N and 0.05% to 1.0% of Al, in a case in which [Al%] and [N%] represent the mass % of Al and N in the steel respectively, [Al%]?(27/14)×[N%]?0.05% is satisfied, is the other elements are included as necessary, and a balance consisting of Fe and inevitable impurities, is used, and a cutting process is carried out on the steel for machine structural use using water-insoluble cutting oil in which the amount of dissolved oxygen is 4 volume % to 16 volume %.