Abstract: Embodiments relate to a configurable convolution engine that receives configuration information to perform convolution and other deep machine learning operations on streaming input data of various formats. The convolution engine may include a convolution core circuit and a spatial pooling circuit. The convolution core circuit performs convolution operations on input data to generate a first stream including first values of a first channel and second values of a second channel in an interleaved manner. The convolution core circuit may further perform post-processing operations, including inter-channel processing operations. The spatial pooling circuit performs per-channel operations on the output of the convolution core circuit, pooling subsets of the values of the first and second channel separately, and combining the spatially pooled values into an output stream having multiple channels in an interleaved manner.

Abstract: The present invention relates to an insulin analog that has reduced insulin receptor binding affinity for the purpose of increasing the blood half-life of insulin, and long-acting insulin, a conjugate, and a method of preparing long-acting insulin using the same.

Abstract: Disclosed are a novel strain of Bacillus amyloliquefaciens, a method of producing fermented grains using the strain, fermented grains produced using the strain, and a composition for thrombolysis; digestion improvement; prophylaxis, amelioration or treatment of bowel inflammation, serous membrane weakening or intestinal injury; or antioxidation, comprising the fermented grains.

Abstract: Embodiments relate to a configurable convolution engine that receives configuration information to perform convolution and other deep machine learning operations on streaming input data of various formats. The convolution engine may include two convolution circuits that each generate a stream of values by applying convolution kernels to input data. The stream of values may each define one or more channels of image data. A channel merge circuit combines the streams of values from each convolution circuit in accordance with a selected mode of operation. In one mode, the first and second streams from the convolution circuits are merged into an output stream having the combined channels of the first and second streams in an interleaved manner. In another mode, the first stream from the first convolution circuit is fed into the input of the second convolution circuit.

Abstract: Embodiments relate to a configurable convolution engine that receives configuration information to perform convolution and other deep machine learning operations on streaming input data of various formats. The convolution engine may include two convolution circuits that each generate a stream of values by applying convolution kernels to input data. The stream of values may each define one or more channels of image data. A channel merge circuit combines the streams of values from each convolution circuit in accordance with a selected mode of operation. In one mode, the first and second streams from the convolution circuits are merged into an output stream having the combined channels of the first and second streams in an interleaved manner. In another mode, the first stream from the first convolution circuit is fed into the input of the second convolution circuit.

Abstract: Embodiments relate to a configurable convolution engine that receives configuration information to perform convolution and other deep machine learning operations on streaming input data of various formats. The convolution engine may include a convolution core circuit and a spatial pooling circuit. The convolution core circuit performs convolution operations on input data to generate a first stream including first values of a first channel and second values of a second channel in an interleaved manner. The convolution core circuit may further perform post-processing operations, including inter-channel processing operations. The spatial pooling circuit performs per-channel operations on the output of the convolution core circuit, pooling subsets of the values of the first and second channel separately, and combining the spatially pooled values into an output stream having multiple channels in an interleaved manner.

Abstract: Embodiments relate to a configurable convolution engine that receives configuration information to perform convolution and other deep machine learning operations on streaming input data of various formats. The convolution engine may include two convolution circuits that each generate a stream of values by applying convolution kernels to input data. The stream of values may each define multiple channels of image data. A channel merge circuit interleaves the streams of values from the convolution circuits to generate an output stream of output values. The output stream includes the data multiple channels of each input stream arranged in an interleaved manner.

Abstract: Embodiments relate to a configurable convolution engine that receives configuration information to perform convolution and other deep machine learning operations on streaming input data of various formats. The convolution engine may include two convolution circuits that each generate a stream of values by applying convolution kernels to input data. The stream of values may each define one or more channels of image data. A channel merge circuit combines the streams of values from each convolution circuit in accordance with a selected mode of operation. In one mode, the first and second streams from the convolution circuits are merged into an output stream having the combined channels of the first and second streams in an interleaved manner. In another mode, the first stream from the first convolution circuit is fed into the input of the second convolution circuit.

Abstract: Perishable products, such as food products, can be preserved by cooling to temperatures below their freezing point without ice crystallization. In some embodiments, the perishable product is cooled to temperatures below the freezing point of water while a pulsed electric field and oscillating magnetic field are applied to the product. Apparatus for supercooling perishable products are also provided and include a pulsed electric field generator and an oscillating magnetic field generator.

Abstract: The present invention relates to insulin and/or an insulin analogue conjugate, and a use thereof, wherein the insulin and/or insulin analogue have improved in vivo durability and stability by linking the same with an Fe region of immunoglobulin. The insulin and/or an insulin analogue conjugate of the present invention show an in vivo activity similar to that of insulin. In addition, the insulin and/or insulin analogue conjugate of the present invention are long-acting formulations of insulin and/or the analogue thereof, in which serum half-life is remarkably increased, and therefore, the present invention provides remarkable insulin and/or an insulin analogue conjugate, which do not induce hypoglycemia, a drawback of insulin treatment.

Abstract: The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.

Abstract: The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.

Abstract: The present invention relates to an insulinotropic peptide derivative with a modified N-terminal charge and a pharmaceutical composition including the same. Specifically, the insulinotropic peptide derivative is characterized in that the N-terminal positive charge of the insulinotropic peptide is modified to a neutral or net negative charge at neutral pH. The insulinotropic peptide derivative according to the present invention is rapidly dissociated from the GLP-1 receptor owing to the above modification in the N-terminal charge, and exhibits enhanced insulinotropic ability and blood glucose-lowering activity compared to the native insulinotropic peptide while maintaining its stability in blood. Accordingly, the insulinotropic peptide derivative of the present invention is very useful for the treatment of type 2 diabetes.

Abstract: The present invention relates to an insulinotropic peptide derivative with a modified N-terminal charge and a pharmaceutical composition including the same. Specifically, the insulinotropic peptide derivative is characterized in that the N-terminal positive charge of the insulinotropic peptide is modified to a neutral or net negative charge at neutral pH. The insulinotropic peptide derivative according to the present invention is rapidly dissociated from the GLP-1 receptor owing to the above modification in the N-terminal charge, and exhibits enhanced insulinotropic ability and blood glucose-lowering activity compared to the native insulinotropic peptide while maintaining its stability in blood. Accordingly, the insulinotropic peptide derivative of the present invention is very useful for the treatment of type 2 diabetes.

Abstract: Disclosed herein is an OLED (Organic Light Emitting Display) device. A switching thin-film transistor configured to be an oxide semiconductor thin-film transistor is disposed in a first pixel. A second pixel is adjacent to the first pixel in the direction in which data lines are extended. A switching thin-film transistor configured to be an LTPS (Low Temperature Poly-Silicon) thin-film transistor is disposed in the second pixel. The switching thin-film transistor of the first pixel and the switching thin-film transistor of the second pixel are connected to the same gate line. A pixel and another pixel adjacent to the pixel connected to a gate line in common, so that it is possible to provide an OLED device with high aperture ratio and high resolution.