Abstract: Provided is a separation and recovery apparatus for continuously separating and recovering, from a resin mixture containing a resin containing a hydrolyzable polymer and a resin containing a nonhydrolyzable polymer, a hydrolytic component a of the hydrolyzable polymer A and the nonhydrolyzable polymer B, the apparatus including: a crushing unit that crushes the resin mixture a melting/discharging unit that melts a crushed product obtained by the crushing unit to form a fluid and discharges the fluid at a high pressure; and a hydrothermal reaction treatment unit that continuously subjects the fluid discharged from the melting/discharging unit to a hydrothermal reaction treatment, wherein, in the melting/discharging unit, the hydrolyzable polymer A is hydrolyzed, and the hydrolytic component a thereof is dissolved and transferred into water permeating a sintered alloy diaphragm, thereby separating the nonhydrolyzable polymer B.

Abstract: An object of the present invention is to provide a wheel drive device capable of suppressing a temperature increase in an electric motor and a power conversion device and suppressing occurrence of a failure of an electric component. Provided are: an electric motor having a stator 60 and a rotor 40; a stator holder 80 that holds the stator 60; a power conversion device 100 that converts power supplied to the electric motor; and a wheel which accommodates the electric motor, the stator holder 80, and the power conversion device 100 on the inner peripheral side. The stator holder 80 includes a flow path 90 through which a cooling medium flows. The flow path 90 is arranged between the stator 60 and the power conversion device 100.

Abstract: A decrease in event detection efficiency is suppressed. A solid-state imaging device according to an embodiment includes a pixel array unit (101) in which a plurality of pixels each detecting a change in luminance of incident light is disposed in a two-dimensional lattice pattern, a signal processing unit (103) that generates first event data including position information about one or more pixels that detect a change in luminance, an adjustment unit (320) that adjusts an amount of data of the first event data to generate second event data, and an output unit (109) that outputs the second event data to an outside, wherein the adjustment unit includes a plurality of paths that adjusts the amount of data of the first event data by respective different methods to generate the second event data, and wherein the output unit outputs at least one of the second event data output from the plurality of respective paths to the outside.

Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: RQ-POLY-Xr-TLR7/8 AG)q??Formula I or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist.

Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.

Abstract: To reliably and efficiently detect an event. An imaging device includes: a plurality of photoelectric conversion elements each of which is configured to photoelectrically convert incident light to generate an electric signal; a plurality of detectors each of which is configured to output a detection signal in a case where an absolute value of an amount of change in the electric signal generated by each of the plurality of photoelectric conversion elements exceeds a predetermined threshold value; and a threshold value adjustment unit configured to adjust the threshold value on the basis of a detection situation of the respective detection signals from the plurality of detectors.

Abstract: There is provided a signal processing device, a signal processing method, and a detection sensor that enable detection of flicker information from an output indicating a luminance change. The signal processing device includes: a count unit that counts a first count number, which is a count number of pixels in which a first luminance change in a positive direction is detected, and a second count number, which is a count number of pixels in which a second luminance change in a negative direction is detected, in an image output from alight receiving unit at a predetermined frame rate and indicating a luminance change; a coefficient generation unit that generates a coefficient corresponding to a time at which the luminance change is detected; and an integrating unit that integrates a multiplication result of the count number of the pixels and the coefficient. The present technology can be applied to, for example, an event detection sensor or the like.

Abstract: Provided are methods and compositions directed to the treatment of an individual having cancer by (i) administering to the individual an adoptive cellular immunotherapy composition comprising CAR T cells and (ii) administering to the individual an interleukin-15 receptor agonist, such as, for example, a long-acting interleukin-15 receptor agonist.

Abstract: There is no possibility of the occurrence of an unnecessary event.

Abstract: A temperature detector (201) of an input unit (200) acquires a temperature of the input unit (200). A temperature detector (301) of an output unit (300) acquires a temperature of the output unit (300). When the temperature of the input unit (200) or the output unit (300) satisfies a preset condition, an input/output manager (101) of the CPU unit (100) controls passage/blockage of a signal from the detector (901) to the input unit (200) or a signal from the output unit (300) to a control target device (902) in accordance with preset content of signal input/output restriction.

Abstract: The instant disclosure provides a combination treatment, composition and kit comprising (a) a long-acting IL-15 receptor agonist and (b) one or more antibodies (mAb) targeting a tumor antigen, related methods of preparation and use, for example, in the treatment of conditions responsive to therapy effective to provide, for example, sustained immune activation and/or anti-tumor activity.

Abstract: A game device for playing a game includes a first display, a computing device, and a storage medium containing program instructions stored therein, execution of which by the computing device causes the game device to provide the functions of: obtaining item information including a game character which is used by the user in the video game, from a user item, receiving an input of an operation for the video game from the user, displaying a notification image for notifying the user of a timing of a first operation on the first display, while displaying a first animation that includes a plurality of frames, and in response to the reception of a first operation by the operation input unit during the displaying of the first animation, stopping displaying the rest of frames of the first animation after a timing at which the first operation is received.

Abstract: A temperature detector (201) of an input unit (200) acquires a temperature of the input unit (200). A temperature detector (301) of an output unit (300) acquires a temperature of the output unit (300). When the temperature of the input unit (200) or the output unit (300) satisfies a preset condition, an input/output manager (101) of the CPU unit (100) controls passage/blockage of a signal from the detector (901) to the input unit (200) or a signal from the output unit (300) to a control target device (902) in accordance with preset content of signal input/output restriction.

Abstract: Provided are multi-arm polymer conjugates of Toll-Like Receptor (“TLR”) agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and —NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2R?-activating amount of a long-acting, IL-2R?-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.

Abstract: A workpiece for a fuel injection component is made of a steel having compositions, by mass %, of C: 0.08 to 0.16%, Si: 0.10 to 0.30%, Mn: 1.00 to 2.00%, S: 0.005 to 0.030%, Cu: 0.01 to 0.30%, Ni: 0.40 to 1.50%, Cr: 0.50 to 1.50%, Mo: 0.30 to 0.70%, V: 0.10 to 0.40%, s-Al: 0.001 to 0.100%, and Fe and unavoidable impurities as remaining components. After heating the workpiece to a temperature of 950° C. or more and 1350° C. or less, the workpiece is subjected to a hot forging, and thereafter cooled at an average cooling rate of 0.1° C./sec. or more in a temperature range from 800° C. to 500° C., and at the average cooling rate of 0.02° C./sec. or more and 10° C./sec. or less in the subsequent temperature range from 500° C. to 300° C. to set an area ratio of a bainite structure after hot forging to 85% or more.

Abstract: A slag volume evaluation method for a molten metal surface includes calculating an approximation curve indicating a correspondence between a thickness of slag and a density parameter in advance by measuring thicknesses of a plurality of pieces of the slag which float on a surface of a molten metal in a container and differ from each other in thickness, and calculating a value of the density parameter which is correlated to a density in a pixel region corresponding to the plurality of pieces of the slag in a captured image of a molten metal surface in the container; and calculating a volume of the slag by calculating and integrating the thickness of the slag for each of pixels constituting the captured image obtained by capturing an image of the molten metal surface which is an evaluation target, according to a value of the density parameter of each of the pixels and the approximation curve.

Abstract: The present invention provides an age hardening type bainitic microalloyed steel having a composition which includes, in terms of mass %: 0.06-0.35% of C; 0.01-2.00% of Si; 0.10-3.00% of Mn; 0.001-0.200% of S; 0.001-2.00% of Cu; 0.40-3.00% of Ni; 0.10-3.00% of Cr; 0.10-1.00% of Mo; 0.10-1.00% of V; and 0.001-0.100% of s-Al, with the remainder being Fe and unavoidable impurities, and which satisfies a value of the following expression (1) to be 20 or larger and a value of the following expression (2) to be 0.82 or larger: 3×[C]+10×[Mn]+2×[Cu]+2×[Ni]+12×[Cr]+9×[Mo]+2×[V]??expression (1); 1.66×[C]+0.18×[Si]+0.27×[Mn]+0.09×[Ni]+0.32×[Cr]+0.34×[Mo]+0.44×[V]??expression (2), in which each [ ] in the expression (1) and the expression (2) indicates a content of the element shown therein in terms of mass %.

Abstract: A game device for playing a game includes a first display having a first display area, and being configured to display images for the game in the first display area, the first display area including an operation area on which a user item of a user is movably placeable, a computing device, and a storage medium containing program instructions stored therein, execution of which by the computing device causes the game device to provide the functions of: obtaining item information from the user item, the item information including a game character that is used by the user in the game, executing the game using the item information, and controlling displaying of the first display, by causing an associated image that is associated with the user item that has been movably placed on the operation area to display in the first display area.

Abstract: The present technology relates to a distance measuring apparatus, a distance measuring method, and a program that enable accurate measurement of the distance to a target.

Abstract: A slag volume evaluation method for a molten metal surface includes calculating an approximation curve indicating a correspondence between a thickness of slag and a density parameter in advance by measuring thicknesses of a plurality of pieces of the slag which float on a surface of a molten metal in a container and differ from each other in thickness, and calculating a value of the density parameter which is correlated to a density in a pixel region corresponding to the plurality of pieces of the slag in a captured image of a molten metal surface in the container; and calculating a volume of the slag by calculating and integrating the thickness of the slag for each of pixels constituting the captured image obtained by capturing an image of the molten metal surface which is an evaluation target, according to a value of the density parameter of each of the pixels and the approximation curve.