Abstract: Provided is a pharmaceutical composition for treating and/or preventing abnormal bone metabolism targeting a protein encoded by a gene strongly expressed in osteoclasts. Specifically provided is a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation, and the like.

Abstract: Problem to Be Solved It is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc. Solution The present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.

Abstract: An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods for making the antibody or the functional fragment, methods for treating a tumor using the antibody or the functional fragment, and polynucleotides encoding the antibody or the functional fragment.

Abstract: Provided is a pharmaceutical composition for treating and/or preventing abnormal bone metabolism targeting a protein encoded by a gene strongly expressed in osteoclasts. Specifically provided is a pharmaceutical composition containing an antibody which specifically recognizes human Siglec-15 and has an activity of inhibiting osteoclast formation, and the like.

Abstract: Problem to Be Solved It is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc. Solution The present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.

Abstract: A lens unit includes: a lens barrel; a movable section including a movable lens and configured to be moved in an optical axis direction relative to the lens barrel; a linear actuator including a drive magnet and a drive coil and configured to move the movable section in the optical axis direction by supplying a current to the drive coil; and a pair of biasing blade springs including holding portions for holding the movable section, a plurality of spring portions biasing the movable section in the optical axis direction, and attachment portions to be attached to the lens barrel. One of the biasing blade springs is formed with two spring members through which the current is supplied to the drive coil.

Abstract: A preload measuring device for a double row rolling bearing unit includes an outer bearing ring member having double rows of outer ring raceways on an inner circumferential surface, an inner bearing ring member having double rows of inner ring raceways on an outer circumferential surface, rolling elements rollably arranged between the outer ring raceways and the inner ring raceways in each of the rows such that contact angles given to the respective rows are opposite to one another, axial displacement measuring means for obtaining an axial relative displacement between the outer bearing ring member and the inner bearing ring member, inclination angle measuring means for obtaining an inclination angle between center axes of the outer bearing ring member and the inner bearing ring member, and preload calculating means for obtaining a preload applied to the rolling elements based on the inclination angle and the axial relative displacement.

Abstract: The wireless sensor adds identification information peculiar to respective sensor modules to detection data of vibration, temperature, and soon, detected by the sensor modules respectively. The wireless sensor transmits the detection data with the identification information as a signal through a communication unit by radio waves. On the other hand, the management apparatus receiving the signal classifies and files the detection data on the basis of the identification information included in the signal. Then, the monitoring system is designed to make the management apparatus manage a plurality of wireless sensors attached to movable shafts of processing machines or the like.

Abstract: A stability control apparatus, includes: a grip detector that changes an output based on a grip force applied in a direction hindering a slippage of a wheel, acting on a contact face between the wheel supported by a wheel supporting rolling bearing unit and the road surface, the wheel supporting rolling bearing unit for supporting freely rotatably the wheel to a vehicle body; and a controller that performs a control for keeping a running stability of the vehicle in response to an input of a detection signal of the grip detector.

Abstract: Revolution speeds nca, nib of rolling elements 9a, 9b are sensed by a pair of revolution speed sensors 21a, 21b. Also, a rotational speed ni of a hub 2 is sensed by a rotational speed sensor 15b. A sum “nca+ncb” or a difference “nca?nib” the revolution speeds of rolling elements 9a, 9b in double rows is calculated based on sensed signals of the revolution speed sensors 21a, 21b, and then a ratio “nca+nib/ni” or “nca?ncb/ni” of this sum or difference to the rotational speed ni is calculated. Then, the radial load or the an axial load is calculated based on the ratio “nca+ncb/ni” or “ca?nib/ni”.

Abstract: A stability control apparatus, includes: a grip detector that changes an output based on a grip force applied in a direction hindering a slippage of a wheel, acting on a contact face between the wheel supported by a wheel supporting rolling bearing unit and the road surface, the wheel supporting rolling bearing unit for supporting freely rotatably the wheel to a vehicle body; and a controller that performs a control for keeping a running stability of the vehicle in response to an input of a detection signal of the grip detector.

Abstract: The present invention provides a technique for readily changing the design of a projector. A projector comprises: an illumination optical system; a light modulation device; a projection optical system; and a base frame for mounting a plurality of optical components disposed on a light path from the optical illumination system to the projection optical system. The illumination optical system 300 comprises: a light source 20; a lens array 320; and a superimposing lens system 370. The base frame includes a positioning section for positioning the superimposing lens system 370. The superimposing lens system 370 includes at least two lenses 371 and 372. The first lens 371 is provided at a position nearest to the light source and mainly determines an F-number of the illumination optical system. The second lens 372 is provided at a position furthest from the light source and mainly determines a magnification of the illumination optical system.

Abstract: A sensor unit is supported on a stationary ring which does not rotate even when it is in use, and the rotation of the rotary ring can be detected by a rotation detecting sensor held within the sensor unit. Within the sensor unit, besides the rotation detecting sensor, there are disposed other sensors such as a temperature sensor and a vibration sensor, thereby being able to detect the rotation speed and the rotation number of the wheel supported on the rotary ring, and the other car driving conditions.

Abstract: A lens unit includes: a lens barrel; a movable section including a movable lens and configured to be moved in an optical axis direction relative to the lens barrel; a linear actuator including a drive magnet and a drive coil and configured to move the movable section in the optical axis direction by supplying a current to the drive coil; and a pair of biasing blade springs including holding portions for holding the movable section, a plurality of spring portions biasing the movable section in the optical axis direction, and attachment portions to be attached to the lens barrel. One of the biasing blade springs is formed with two spring members through which the current is supplied to the drive coil.

Abstract: In a lens driver apparatus using a linear actuator, spaces for installing a driving coil and a driving magnet are reduced to contribute to making the lens driver apparatus smaller. The present invention relates to the lens driver apparatus including a body that is to be driven and to which a lens is attached, a guide axis to guide and allow the body to be driven to move freely in a direction of the optical axis, a driving coil being flat-wound and fitted to the body to be driven, and a driving magnet being disposed opposite side of the driving coil and along a direction of movement of the body to be driven. In the lens driver apparatus according to the present invention, the driving coil and the driving magnet are shaped in curved forms so as to conform to an outer shape of the lens.

Abstract: The wireless sensor adds identification information peculiar to respective sensor modules to detection data of vibration, temperature, and soon, detected by the sensor modules respectively. The wireless sensor transmits the detection data with the identification information as a signal through a communication unit by radio waves. On the other hand, the management apparatus receiving the signal classifies and files the detection data on the basis of the identification information included in the signal. Then, the monitoring system is designed to make the management apparatus manage a plurality of wireless sensors attached to movable shafts of processing machines or the like.

Abstract: A rolling bearing apparatus with sensor includes a sensor unit retaining a plurality of types of sensors for detecting the status of a rolling bearing, in a single holder. The plurality of types of sensors are at least two types of sensors of a rotation speed sensor, a temperature sensor, and an acceleration sensor.

Abstract: The wireless sensor adds identification information peculiar to respective sensor modules to detection data of vibration, temperature, and so on, detected by the sensor modules respectively. The wireless sensor transmits the detection data with the identification information as a signal through a communication unit by radio waves. On the other hand, the management apparatus receiving the signal classifies and files the detection data on the basis of the identification information included in the signal. Then, the monitoring system is designed to make the management apparatus manage a plurality of wireless sensors attached to movable shafts of processing machines or the like.

Abstract: Revolution speeds nca, nib of rolling elements 9a, 9b are sensed by a pair of revolution speed sensors 21a, 21b. Also, a rotational speed ni of a hub 2 is sensed by a rotational speed sensor 15b. A sum “nca+ncb” or a difference “nca?nib” the revolution speeds of rolling elements 9a, 9b in double rows is calculated based on sensed signals of the revolution speed sensors 21a, 21b, and then a ratio “nca+nib/ni” or “nca?ncb/ni” of this sum or difference to the rotational speed ni is calculated. Then, the radial load or the an axial load is calculated based on the ratio “nca+ncb/ni” or “ca?nib/ni”.

Abstract: A rolling bearing apparatus with sensor includes a sensor unit retaining a plurality of types of sensors for detecting the status of a rolling bearing, in a single holder. The plurality of types of sensors are at least two types of sensors of a rotation speed sensor, a temperature sensor, and an acceleration sensor.