Patents by Inventor Thijs Kaper

Thijs Kaper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS COMPRISING CELLULASE VARIANTS WITH REDUCED AFFINITY TO NON-CELLULOSIC MATERIALS
    Publication number: 20120276595
    Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.
    Type: Application
    Filed: July 6, 2012
    Publication date: November 1, 2012
    Applicant: DANISCO US INC.
    Inventors: Luis G. Cascao-Pereira, Thijs Kaper, Bradley R. Kelemen, Amy D. Liu
  • Compositions and methods comprising cellulase variants with reduced affinity to non-cellulosic materials
    Patent number: 8236542
    Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: August 7, 2012
    Assignee: Danisco US Inc.
    Inventors: Luis G. Cascao-Pereira, Thijs Kaper, Bradley R Kelemen, Amy D. Liu
  • CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF
    Publication number: 20120135500
    Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.
    Type: Application
    Filed: June 3, 2010
    Publication date: May 31, 2012
    Applicant: Danisco US Inc.
    Inventors: Wolfgang Aehle, Richard R. Bott, Benjamin Bower, Jonathan Caspi, David A. Estell, Frits Goedegebuur, Ronaldus W.J. Hommes, Thijs Kaper, Bradley Kelemen, Slavko Kralj, Johan Van Lieshout, Igor Nikolaev, Sander Van Stigt Thans, Louise Wallace, Gudrun Vogtentanz, Mats Sandgren
  • METHODS OF USING RET NANOSENSORS
    Publication number: 20120028265
    Abstract: The present invention provides methods for detecting and monitoring metabolite concentrations, which comprise detection and measurement of Fluorescence Resonance Energy Transfer upon ligand binding. The methods of the present invention are useful for real time monitoring of changes in metabolite levels in living cell cultures.
    Type: Application
    Filed: August 8, 2008
    Publication date: February 2, 2012
    Inventors: Thijs Kaper, Loren L. Looger, Wolf B. Frommer
  • TRP/HIS exchange and kynurenin induced TRP transport
    Patent number: 8071744
    Abstract: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: December 6, 2011
    Assignees: Carnegie Institution of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thijs Kaper, Michael Platten, Lawrence Steinman, Wolf Frommer
  • TRP/HIS EXCHANGE AND KYNURENIN INDUCED TRP TRANSPORT
    Publication number: 20110223657
    Abstract: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
    Type: Application
    Filed: April 28, 2011
    Publication date: September 15, 2011
    Inventors: Thijs Kaper, Michael Platten, Lawrence Steinman, Wolf Frommer
  • Trp/his exchange and kynurenine induced Trp transport
    Patent number: 7935494
    Abstract: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: May 3, 2011
    Assignees: Carnegie Institution of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Thijs Kaper, Michael Platten, Lawrence Steinman, Wolf Frommer
  • Compositions and Methods Comprising Cellulase Variants with Reduced Affinity to Non-Cellulosic Materials
    Publication number: 20100041104
    Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.
    Type: Application
    Filed: June 3, 2009
    Publication date: February 18, 2010
    Applicant: Danisco US Inc.
    Inventors: Luis G. Cascao-Pereira, Thijs Kaper, Bradley R. Kelemen, Amy D. Liu
  • Multimetric Biosensors and Methods of Using Same
    Publication number: 20080311047
    Abstract: Multimeric tryptophan biosensors are disclosed, which comprise tryptophan-binding domains conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon tryptophan binding. Such biosensors are useful for real time monitoring of tryptophan metabolism in living cells.
    Type: Application
    Filed: November 16, 2006
    Publication date: December 18, 2008
    Inventors: Thijs Kaper, Wolf B. Frommer
  • TRP/HIS Exchange and Kynurenine Induced TRP Transport
    Publication number: 20080227140
    Abstract: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
    Type: Application
    Filed: February 29, 2008
    Publication date: September 18, 2008
    Inventors: Thijs Kaper, Michael Platten, Lawrence Steinman, Wolf Frommer