Abstract: The present invention relates to a disposable absorbent article comprising a chassis having a front waist region, a back waist region, and a crotch region between the front and back waist regions, said chassis having two opposing longitudinal edges and two perpendicularly placed end edges, said chassis further comprising: a. a liquid permeable topsheet spanning at least the crotch region; b. a backsheet spanning at least the crotch region; c. an absorbent core disposed between said topsheet and backsheet; and d. a elastic member disposed along at least one opposing longitudinal edge in either the front waist or back waist region of said chassis wherein said member comprises an unapertured, skinless elastomeric layer wherein said layer exhibits an Energy Recovery Value of at least about 0.

Abstract: A stretchable laminate, a process of making a stretchable laminate and a disposable absorbent article that includes a stretchable laminate are disclosed. The stretchable laminate includes a nonwoven web and a web of elastomeric material. The nonwoven web includes two layers of spunbond multi-component fibers and one layer of meltblown fibers. The multi-component fibers include a first polymer and a second polymer having different melt temperatures. Thermo-bonds are formed at least partially through the nonwoven web. Some of the thermo-bonds can be elongated in the cross-machine direction of the nonwoven web.

Abstract: A stretchable laminate, a process of making a stretchable laminate and a disposable absorbent article that includes a stretchable laminate are disclosed. The stretchable laminate includes a nonwoven web and a web of elastomeric material. The nonwoven web includes two layers of spunbond fibers and one layer of meltblown fibers. Some of the meltblown fibers are present in the interstices formed by the spunbond fibers of one of the layers. As a result of activation of the stretchable laminate, the nonwoven web has a Residual Maximum Peak Force of at least 0.3 N/cm.

Abstract: A stretchable laminate, a process of making a stretchable laminate and a disposable absorbent article that includes a stretchable laminate are disclosed. The stretchable laminate includes a nonwoven web and a web of elastomeric material. The nonwoven web includes two layers of spunbond fibers and one layer of meltblown fibers. Some of the meltblown fibers are present in the interstices formed by the spunbond fibers of one of the layers.

Abstract: The present invention relates to a disposable absorbent article comprising a chassis having a front waist region, a back waist region, and a crotch region between the front and back waist regions, said chassis having two opposing longitudinal edges and two perpendicularly placed end edges, said chassis further comprising: a. a liquid permeable topsheet spanning at least the crotch region; b. a backsheet spanning at least the crotch region; c. an absorbent core disposed between said topsheet and backsheet; and d. a elastic member disposed along at least one opposing longitudinal edge in either the front waist or back waist region of said chassis wherein said member comprises an unapertured, skinless elastomeric layer wherein said layer exhibits an Energy Recovery Value of at least about 0.77.

Abstract: The present invention relates to a process for isolating (?S,?R)-6-bromo-?-[2-(dimethylamino)ethyl]-2-methoxy-?-1-naphthalenyl-?-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-?-[2-(dimethylamino)ethyl]-2-methoxy-?-1-naphthalenyl-?-phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1?,2?-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1?,2?-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.

Abstract: The present invention relates to a process for isolating (?S,?R)-6-bromo-?-[2-(dimethylamino)ethyl]-2-methoxy-?-1-naphthalenyl-?-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-?-[2-(dimethylamino)ethyl]-2-methoxy-?-1-naphthalenyl-?-phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1?,2?-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1?,2?-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.

Abstract: The present invention is directed to novel processes for the preparation of paricalcitol to novel intermediates used in these processes, and to processes for preparation of the novel intermediates.

Abstract: The present invention provides novel polymorphic and pseudopolymorphic forms of Trandolaprilat, including crystalline Trandolaprilat Form A, crystalline Trandolaprilat Form B, crystalline Trandolaprilat Form C, crystalline Trandolaprilat Form D, crystalline Trandolaprilat Form E, and mixtures thereof. The invention also provides novel methods for producing Trandolaprilat, pharmaceutically acceptable salts of Trandolaprilat, and polymorphic and pseudopolymorphic forms of Trandolaprilat, pharmaceutical compositions including one or more novel Trandolaprilat compounds and methods for treating high blood pressure and/or cardiac insufficiency using one or more novel Trandolaprilat compounds.

Abstract: A stretchable laminate, a process of making a stretchable laminate and a disposable absorbent article that includes a stretchable laminate are disclosed. The stretchable laminate includes a nonwoven web and a web of elastomeric material. The nonwoven web includes two layers of spunbond fibers and one layer of meltblown fibers. Some of the meltblown fibers are present in the interstices formed by the spunbond fibers of one of the layers.

Abstract: A stretchable laminate, a process of making a stretchable laminate and a disposable absorbent article that includes a stretchable laminate are disclosed. The stretchable laminate includes a nonwoven web and a web of elastomeric material. The nonwoven web includes three layers of spunbond fibers and two layers of meltblown fibers. The side of the nonwoven web that includes two layers of spunbond fibers is attached to the elastomeric material.

Abstract: A stretchable laminate, a process of making a stretchable laminate and a disposable absorbent article that includes a stretchable laminate are disclosed. The stretchable laminate includes a nonwoven web and a web of elastomeric material. The nonwoven web includes two layers of spunbond multi-component fibers and one layer of meltblown fibers. The multi-component fibers include a first polymer and a second polymer having different melt temperatures. Thermo-bonds are formed at least partially through the nonwoven web. Some of the thermo-bonds can be elongated in the cross-machine direction of the nonwoven web.

Abstract: A stretchable laminate, a process of making a stretchable laminate and a disposable absorbent article that includes a stretchable laminate are disclosed. The stretchable laminate includes a nonwoven web and a web of elastomeric material. The nonwoven web includes two layers of spunbond fibers and one layer of meltblown fibers. Some of the meltblown fibers are present in the interstices formed by the spunbond fibers of one of the layers. As a result of activation of the stretchable laminate, the nonwoven web has a Residual Maximum Peak Force of at least 0.3 N/cm.

Abstract: The present invention provides a novel polymorphic form of olopatadine hydrochloride ([(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride), a selective histamine H1-receptor antagonist that is used for the treatment of ocular symptoms of seasonal allergic conjunctivitis. The present invention also provides novel methods for producing olopatadine on a large scale, and in a manner that is cost effective, provides a low level of impurities and eliminates the need to use the costly and dangerous base, butyllithium, which is used in prior art reactions for making olopatadine. The present invention further provides novel processes for carrying out a large scale production of 3-dimethylaminopropyltriphenylphosphonium bromide and its corresponding hydrobromide salt, which are employed in the production of olopatadine, and pharmaceutically acceptable salts of olopatadine.

Abstract: A process of making racemic [2S*[R*[R*[R*]]]] and [2R*[S*[S*[S*]]]]-(±)?,??-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] of the compound of the formula (I) and its pure [2S*[R*[R*[R*]]]]- and [2R*[S*[S*[S*]]]]-enantiomer compounds and pharmaceutically acceptable salts thereof.

Abstract: A process of making racemic [2S*[R*[R*[R*]]]] and [2R*[S*[S*[S*]]]]-(±)?,??-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] of the compound of the formula (I) and its pure [2S*[R*[R*[R*]]]]- and [2R*[S*[S*[S*]]]]-enantiomer compounds and pharmaceutically acceptable salts thereof.

Abstract: A machine tool is described, in particular a grinding machine, with a tool storage device. The tool storage device contains an outer magazine wheel (34) and an inner magazine wheel (58), which are independently concentrically rotatable in a controlled manner. The outer magazine wheel (34) preferably holds grinding tools (56), while the inner magazine wheel (58) preferably holds grinding wheel protectors (68). The grinding tool (56) and the grinding wheel protector (68) are removed from the tool storage device and are returned to the latter by the tool spindle (30). The grinding tools (56) and grinding wheel protectors (68) can be exchanged independently in arbitrary combinations and possibly also simultaneously.

Abstract: The present invention relates to a process for isolating (?S,?R)-6-bromo-?-[2-(dimethylamino)ethyl]-2-methoxy-?-1-naphthalenyl-?-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-?-[2-(dimethylamino)ethyl]-2-methoxy-?-1-naphthalenyl-?-phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1?,2?-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1?,2?-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.

Abstract: The invention relates to three novel forms of entacapone. These are peripheral and selective COMT inhibitors which in combination with levodopa and decarboxylase inhibitors can be used to treating Parkinson's syndrome. Said novel forms arise by crystallization of entacapone in respectively determined conditions. In certain cases, entacapone can be used as a raw product, in a special case it can be used in situ as the product of Knoevenagel condensation of 3,4-dihydroxy-5-nitro-benzaldehyde and N,N-diethyl-2-cyanoacetamide. Also disclosed are improvements of said condensation in relation to the catalyst and the production of the two components thereof.

Abstract: A depth stop device for a screw driving tool includes an adjusting ring (30), a connection sleeve (22) for rotatably mounting the adjusting ring (30) on the nose member (6) of the screw driving tool housing (4), a substantially sleeve-shaped depth stop (36) displaceable in an axial direction relative the connection sleeve (22) by rotation of the adjusting ring (30), and at least partially elastic locking element (40) engageable in the axial direction with both the adjusting ring (30) and the connection sleeve (22), the locking element being also adapted to secure the adjusting ring (30) on the connection sleeve (22) in a rotational direction (D).