Abstract: A drill adapter for a power screwdriver and including a locking device for releasably securing the drill adapter (28) on the support region (66) of the screwdriver (4) and having a push-on sleeve (30) supportable on the support region (66) and at least one engagement member (52) for releasably securing the push-on sleeve (30) on the support region, and an element for actuating the drive clutch (10) of the screwdriver (4) via the tool spindle (12) and projecting into a receiving space (38), which is partially limited by the push-on sleeve (30) and is open at one side, and having an axial stop (46) for engaging the tool spindle (12), with the at least one engagement member (52) projecting, in its locking position, beyond an inner surface (70) of the push-on sleeve (30) for establishing an axial formlocking connection between the push-on sleeve (30) and the support region (66) of the screwdriver (4) and which provides for actuation of the drive clutch (10) with actuating element.

Abstract: A machine tool is described, in particular a grinding machine, with a tool storage device. The tool storage device contains an outer magazine wheel (34) and an inner magazine wheel (58), which are independently concentrically rotatable in a controlled manner. The outer magazine wheel (34) preferably holds grinding tools (56), while the inner magazine wheel (58) preferably holds grinding wheel protectors (68). The grinding tool (56) and the grinding wheel protector (68) are removed from the tool storage device and are returned to the latter by the tool spindle (30). The grinding tools (56) and grinding wheel protectors (68) can be exchanged independently in arbitrary combinations and possibly also simultaneously.

Abstract: The present invention provides novel polymorphic and pseudopolymorphic forms of Trandolaprilat, including crystalline Trandolaprilat Form A, crystalline Trandolaprilat Form B, crystalline Trandolaprilat Form C, crystalline Trandolaprilat Form D, crystalline Trandolaprilat Form E, and mixtures thereof. The invention also provides novel methods for producing Trandolaprilat, pharmaceutically acceptable salts of Trandolaprilat, and polymorphic and pseudopolymorphic forms of Trandolaprilat, pharmaceutical compositions including one or more novel Trandolaprilat compounds and methods for treating high blood pressure and/or cardiac insufficiency using one or more novel Trandolaprilat compounds.

Abstract: The present invention provides a novel polymorphic form of olopatadine hydrochloride ([(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride), a selective histamine H1-receptor antagonist that is used for the treatment of ocular symptoms of seasonal allergic conjunctivitis. The present invention also provides novel methods for producing olopatadine on a large scale, and in a manner that is cost effective, provides a low level of impurities and eliminates the need to use the costly and dangerous base, butyllithium, which is used in prior art reactions for making olopatadine. The present invention further provides novel processes for carrying out a large scale production of 3-dimethylaminopropyltriphenylphosphonium bromide and its corresponding hydrobromide salt, which are employed in the production of olopatadine, and pharmaceutically acceptable salts of olopatadine.

Abstract: A machine tool for machining workpieces (22), comprising three NC-controlled linear axes orthogonal to each other, namely a horizontal X-axis, a horizontal Y-axis and a vertical Z-axis, with a machine base (10), which comprises two vertically upwardly directed side beds (12) that are spaced from each other in the X-axis, with a bridge (28) displaceably guided in the Y-axis on top of the side beds (12), with a Z-slide disposed at the &enter of the bridge (28) in relation to the side beds (12), which slide can be displaced in the Z-axis and carries a tool spindle (46), with an X-guide element (14) disposed on the machine base (10), with a wbrkpiece holder element (16, 18, 20) displaceable on the X-guide unit, and with a tool holder disposed on the tool spindle (46).

Abstract: A depth stop device for a screw driving tool includes an adjusting ring (30), a connection sleeve (22) for rotatably mounting the adjusting ring (30) on the nose member (6) of the screw driving tool housing (4), a substantially sleeve-shaped depth stop (36) displaceable in an axial direction relative the connection sleeve (22) by rotation of the adjusting ring (30), and at least partially elastic locking element (40) engageable in the axial direction with both the adjusting ring (30) and the connection sleeve (22), the locking element being also adapted to secure the adjusting ring (30) on the connection sleeve (22) in a rotational direction (D).

Abstract: A process of making racemic [2S*[R*[R*[R*]]]] and [2R*[S*[S*[S*]]]]-(±)?,??-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] of the compound of the formula (I) and its pure [2S*[R*[R*[R*]]]]- and [2R*[S*[S*[S*]]]]-enantiomer compounds and pharmaceutically acceptable salts thereof.

Abstract: A holding device for fastening elements which is securable to screw-driving power tool and includes at least two clamping members (20) which abut a stem (74) of the fastening element in a release position of the clamping members and which are displaceable upon an application of a force thereto into their release position, with the clamping members (20) having at least one contact region which forms, at least in the support position of the clamping members (20), a front stop of the holding device (10) in a drive-in direction (22) of the power tool (2).

Abstract: A method for preparing optionally substituted {N-[1-(S)-carbalkoxy-3-phenylpropyl]-S-alanyl-2S,3aR,7aS-octahydroindole-2-carboxylic acid} and pharmaceutically acceptable salts thereof, wherein a racemic mixture of optionally substituted trans-octahydroindole-2-carboxylic acid is reacted with the N-carboxyanhydride of {N-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-L-alanine}, which is optionally substituted on the phenyl ring, in a suitable inert solvent, and subsequently the resulting optionally substituted {N-[1-S-carbalkoxy-3-phenylpropyl]-S-alanyl-2S,3aR,7aS-octahydroindole-2-carboxylic acid}, preferably trandolapril, is isolated, and polymorphic forms A and B of trandolapril.

Abstract: A depth stop device (14) for use with a hand-held screw driving tool (2) includes an axial element (32) for driving a screw bit (34) and a sleeve element (20) having a longitudinal bore (30) in which the axial element (32) is at least partially received and an exit opening (36) extending sidewise from the longitudinal bore (30). The exit opening (36) is limited by a deflection surface (40) which is stretched over an intersection plane (SE) and has a geometrical center (M) that forms an origin of a spatial system of coordinates. The intersection plane (SE) forms with a tangential axis (T) of the spatial coordinate system that extends perpendicular to both the longitudinal (L) and radial (R) axis of the coordinate system, an acute angle (?).

Abstract: A hand-held power tool including a housing (1) having a handle (7), and a holding device (3) having a catch element (9) with a free end (9a) for suspending the power tool, with the free end (9a) having a main axis (K) intersecting a normal live (N) that extends transverse to the tool plane which is defined by the plane of the handle and the operational direction of the tool, and passes through the center of gravity (S) of the tool.

Abstract: A depth stop device (14) for use with a hand-held screw driving tool (2) includes an axial element (32) for driving a screw bit (34) and a sleeve element (20) having a longitudinal bore (30) in which the axial element (32) is at least partially received and an exit opening (36) extending sidewise from the longitudinal bore (30). The exit opening (36) is limited by a deflection surface (40) which is stretched over an intersection plane (SE) and has a geometrical center (M) that forms an origin of a spatial system of coordinates. The intersection plane (SE) forms with a tangential axis (T) of the spatial coordinate system that extends perpendicular to both the longitudinal (L) and radial (R) axis of the coordinate system, an acute angle (?).

Abstract: The screwdriving power tool includes a hollow spindle (8) rotatably supported in the tool housing (4) and driven by a motor (26), a clutch (30) that rotatably connects and disconnects the hollow spindle (8) with and from the motor (26), respectively, in engagement and disengagement positions of the clutch (30), a screwing-in spindle (6) connected with a chuck (10) for a working tool (12) and connected with the hollow spindle (8) for a joint rotation therewith and for an axial displacement relative thereto, and a percussion mechanism (14) for applying a pulsed axial force to the screwing-in spindle (6), with the clutch (30) being brought into its engagement position by the screwing-in spindle (6) by being displaced against a biasing force of the clutch springs (40, 44), and being locked in its engagement position.

Abstract: A drill adapter for a power screwdriver and including a locking device for releasably securing the drill adapter (28) on the support region (66) of the screwdriver (4) and having a push-on sleeve (30) supportable on the support region (66) and at least one engagement member (52) for releasably securing the push-on sleeve (30) on the support region, and an element for actuating the drive clutch (10) of the screwdriver (4) via the tool spindle (12) and projecting into a receiving space (38), which is partially limited by the push-on sleeve (30) and is open at one side, and having an axial stop (46) for engaging the tool spindle (12), with the at least one engagement member (52) projecting, in its locking position, beyond an inner surface (70) of the push-on sleeve (30) for establishing an axial formlocking connection between the push-on sleeve (30) and the support region (66) of the screwdriver (4) and which provides for actuation of the drive clutch (10) with actuating element.

Abstract: A device switch (2) for a hand-held tool, particularly for a screw drill or drilling machine, having a control device (50) which is arranged in a switch housing (4), a trigger (6) which is movably supported at the switch housing (4), the rotational speed of a driving motor (52) of the hand-held tool being controlled by the control device (50) depending on the position of the trigger (6) relative to the switch housing (4), and a pressure increasing arrangement (10) with a contacting area (14) on a contacting element (12) which makes pressing contact with a contact region (26) of a mechanical resistance element (24) in a trigger pressure position of the trigger (6) between a zero load position and a full load position, the displacement resistance of the trigger (6) being increased by this mechanical resistance element (24). The contact region (26) is arranged outside the switch housing (4).

Abstract: A hand-held power tool including a housing (1) having a handle (7), and a holding device (3) having a catch element (9) with a free end (9a) for suspending the power tool, with the free end (9a) having a main axis (K) intersecting a normal live (N) that extends transverse to the tool plane which is defined by the plane of the handle and the operational direction of the tool, and passes through the center of gravity (S) of the tool.

Abstract: A device switch (2) for a hand-held tool, particularly for a screw drill or drilling machine, having a control device (50) which is arranged in a switch housing (4), a trigger (6) which is movably supported at the switch housing (4), the rotational speed of a driving motor (52) of the hand-held tool being controlled by the control device (50) depending on the position of the trigger (6) relative to the switch housing (4), and a pressure increasing arrangement (10) with a contacting area (14) on a contacting element (12) which makes pressing contact with a contact region (26) of a mechanical resistance element (24) in a trigger pressure position of the trigger (6) between a zero load position and a full load position, the displacement resistance of the trigger (6) being increased by this mechanical resistance element (24). The contact region (26) is arranged outside the switch housing (4).

Abstract: A holding device for fastening elements which is securable to screw-driving power tool and includes at least two clamping members (20) which abut a stem (74) of the fastening element in a release position of the clamping members and which are displaceable upon an application of a force thereto into their release position, with the clamping members (20) having at least one contact region which forms, at least in the support position of the clamping members (20), a front stop of the holding device (10) in a drive-in direction (22) of the power tool (2).

Abstract: A screw driving tool comprises a housing (1), a drive (2), a drive spindle (3), a torque coupling (4) between the drive (2) and the drive spindle (3), as well as an adjustment mechanism disposed between the free end of the drive spindle (3) and the torque coupling (4), the adjustment mechanism is used for adjusting the torque transmitted using the torque coupling (4). The adjustment mechanism has at least one prestressable spring element (5) cooperating with the torque coupling; a compression sleeve (6) that is displaceable parallel to the axis of the drive spindle (3) and cooperating with the spring element (5); a control sleeve (7) arranged coaxially with the compression sleeve (6) and cooperating with the compression sleeve (6); a rotatable adjustment sleeve (8), and a plurality of rotationally mounted planet wheels (10) cooperating in a form locked manner with the control sleeve (7) and inner teeth (9) of the adjustment sleeve (8).

Abstract: The present invention relates to methods of screening compounds that modulate mucus secretion. The invention also includes compositions, products and kits for use in performing the above methods, as well as the compounds identified by said methods, and their uses. The invention is particularly adapted for (high throughput) screening of various compounds in parallel.