Abstract: An example of an apparatus is provided. The apparatus includes a database management system. In addition, the apparatus includes a first database maintained within the database management system. Furthermore, the apparatus includes an aggregator to identify a targeted data record in the first database based on a predetermined commissionable event. The targeted data record stores a metric associated with the predetermined commissionable event. The apparatus further includes a normalization engine to normalize the targeted data record to create a standardized data record. Also, the apparatus includes a second database maintained within the database management system to store the standardized data record. The second database is accessible to a sales agent based on granted permissions. In addition, the apparatus includes a communications interface to transmit the standardized data record and a command to an external service. The external service is to execute the command to process the standardized data record.

Abstract: Systems and methods for synchronizing operation of control circuits in quantum circuit assemblies are disclosed. An example assembly for controlling operation of a qubit device includes a plurality of control circuits and an event synchronization arrangement. The plurality of control circuits may include a first and a second control circuits, configured to perform, respectively, first and second actions to control operation of the qubit device. The event synchronization arrangement may be used to control operation of the plurality of control circuits to provide to the second control circuit an indication that the first control circuit performed the first action, and to configure the second control circuit to perform the second action in response to receiving the indication that the first control circuit performed the first action. Assemblies disclosed herein provide improved control over qubits, good scalability in the number of qubits included in the device, and/or design flexibility.

Abstract: The present invention relates to the treatment of subjects having CD20-positive cell proliferative disorders (e.g., B cell proliferative disorders, such as non-Hodgkin's lymphomas). More specifically, the invention pertains to the treatment of subjects having a CD20-positive cell proliferative disorder (e.g., B cell proliferative disorder) by administering a combination of an anti-CD20/anti-CD3 bispecific antibody and an anti-CD79b antibody drug conjugate.

Abstract: The present invention relates to methods of treating a B-cell proliferative disorder by administering an anti-CD20/anti-CD3 bispecific antibody, and methods for reduction of adverse effects in response to the administration of the anti-CD20/anti-CD3 bispecific antibody. The present invention further relates to combination treatment methods of treating a B-cell proliferative disorder.

Abstract: A system includes N location indicators and a mobile scanning device. The N location indicators are configured to be arranged throughout a store that includes a plurality of stocked items for picking according to one or more electronic customer orders. Each of the N location indicators is configured to transmit a different location signal. The mobile scanning device includes a display. The mobile scanning device is configured to wirelessly receive an electronic customer order comprising a plurality of ordered items indicating which of the stocked items are to be picked, detect at least one of the N location signals, and arrange at least some of the plurality of ordered items on the display based on which of the at least one of the N location signals is detected.

Abstract: In general, the invention relates to a method for servicing query requests in a distributed system. The method includes generating a data flow graph for a data model using a plurality of metadata documents, where each of the metadata documents is associated with a consistency zone, and servicing a query request using the data flow graph and data associated with the data model.

Abstract: An order filling system includes a computing system and a mobile scanning device. The computing system is configured to generate an item adjacency map based on a plurality of scan times associated with a plurality of stocked items for picking from a store according to one or more electronic customer orders. The item adjacency map indicates which of the stocked items are adjacent to one another. Additionally, the computing system is configured to receive an electronic customer order including a plurality of ordered items indicating which of the stocked items are to be picked and wirelessly transmit the electronic customer order. The mobile scanning device includes a display. The mobile scanning device is configured to receive the transmitted electronic customer order and arrange at least some of the plurality of ordered items on the display based on the item adjacency map.

Abstract: In general, the invention relates to a method for servicing query requests in distributed systems. The method includes making a first determination by a query node that it is associated with a dataspace, making a second determination that data associated with a first input sub-region is not present on the query node, where the first input sub-region is associated with the dataspace. Based on the first determination and the second determination, the method includes obtaining data for the entire dataspace from persistent storage, associating at least a portion of the obtained data with the first input sub-region to obtain a populated first input sub-region, and servicing a query request using the populated first input sub-region.

Abstract: One embodiment provides a method for providing simplified user management within a software application, the method including: receiving, within a user management interface of the software application, input from an editing user to perform an action corresponding to a user within the software application, wherein the action comprises modifying the user within the software application; validating, within the software application, the editing user is authorized to perform the action within the software application, wherein the validating includes determining the editing user is an existing user within the software application and determining the user is associated with the editing user; and performing, responsive to validating the editing user is authorized to perform the action, the action with respect to the user in the software application. Other aspects are described and claimed.

Abstract: A node includes storage that stores a portion of high accessibility data corresponding to a shard that is divided into revisions. The portion of the high accessibility data is managed based on an activity state model including a writing state, a resolving state, a metadata update state, and a reading state. The node further includes a repository manager that obtains a cross-shard read request for the high accessibility data; makes a determination that the portion of the high accessibility data is not in the reading state; in response to the determination, adds the cross-shard read request to a delayed action queue at the revision of a last delayed action in the delayed action queue; and after processing the last delayed action in the delayed action queue and while in the resolving state: converts the cross-shard read request to a read request; and processes the read request.

Abstract: A system includes location indicators, a central computing system, and a mobile scanning device. The location indicators transmit location signals and are arranged in a store that includes stocked items. The central computing system stores an item association table that maps location values to the stocked items. The location values indicate locations of the stocked items in the store. The mobile scanning device receives ordered items from the central computing system, detects location signal(s), and determines a first location value based on the detected location signal(s). The mobile scanning device arranges the ordered items on a display based on the first location value, scans a first ordered item, and transmits data to the central computing system indicating that the first ordered item is associated with the first location value. The central computing system updates the item association table based on the data.

Abstract: A node includes storage that stores a portion of high accessibility data that is divided into revisions and managed based on an activity state model. The node also includes a repository manager that keys read requests of the data access requests for the high accessibility data to a revision of the revisions of the portion of the high accessibility data based on an activity state associated with the portion of the high accessibility data when the read requests are obtained to obtain keyed read requests; keys write requests for the high accessibility data to future revisions of the revisions of the high accessibility data when the write requests are obtained to obtain keyed write requests; adds the keyed read requests to a read queue; adds the keyed write requests to a delayed action queue; and processes the read queue and the delayed action queue to service the requests.

Abstract: A system includes N location indicators and a mobile scanning device. The N location indicators are configured to be arranged throughout a store that includes a plurality of stocked items for picking according to one or more electronic customer orders. Each of the N location indicators is configured to transmit a different location signal. The mobile scanning device includes a display. The mobile scanning device is configured to wirelessly receive an electronic customer order comprising a plurality of ordered items indicating which of the stocked items are to be picked, detect at least one of the N location signals, and arrange at least some of the plurality of ordered items on the display based on which of the at least one of the N location signals is detected.

Abstract: Disclosed herein are quantum dot devices, as well as related computing devices and methods. For example, in some embodiments, a quantum dot device may include: a quantum well stack including a quantum well layer; and a plurality of gates above the quantum well stack, wherein the gates are arranged in a ladder arrangement including two rails having at least N gates each and at least one active rung, and a number of active rungs in the ladder arrangement is less than N.

Abstract: In general, in one aspect, the invention relates to a method for servicing query requests in distributed systems. The method includes making a first determination, by a query node and in response to a query request, that a user data sub-region associated with a query request, obtaining, in response to the first determination and using a population table, a revisions map, where the revisions map specifies a version of the user data sub-region, and servicing the query request using the revisions map and data associated with the version of the user data sub-region.

Abstract: In general, in one aspect, the invention relates to a method for servicing query requests in distributed systems. The method includes making a first determination, by a query node and in response to a query request, that a user data sub-region associated with a query request, obtaining, in response to the first determination and using a population table, a revisions map, where the revisions map specifies a version of the user data sub-region, and servicing the query request using the revisions map and data associated with the version of the user data sub-region.

Abstract: Systems and methods for determining molecular structures based on atomic-orbital-based features are described. Atomic-orbital-based features can be utilized in combination with machine-learning methods to predict accurate properties, such as quantum mechanical energy, of molecular systems.

Abstract: A method for identifying T-cells that are antigen-specific for at least one neoantigen that is likely to be presented by class II MHC alleles on surfaces of tumor cells of a subject. Peptide sequences of tumor neoantigens are obtained by sequencing the tumor cells of the subject. The peptide sequences are input into a machine-learned presentation model to generate presentation likelihoods for the tumor neoantigens, each presentation likelihood representing the likelihood that a neoantigen is presented by the class II MHC alleles on the surfaces of the tumor cells of the subject. A subset of the neoantigens is selected based on the presentation likelihoods. T-cells that are antigen-specific for at least one of the neoantigens in the subset are identified. These T-cells can be expanded for use in T-cell therapy. TCRs of these identified T-cells can also be sequenced and cloned into new T-cells for use in T-cell therapy.

Abstract: A method for identifying neoantigens that are likely to be presented on a surface of tumor cells of a subject. Peptide sequences of tumor neoantigens are obtained by sequencing the tumor cells of the subject. The peptide sequence of each of the neoantigens is associated with one or more k-mer blocks of a plurality of k-mer blocks of the nucleotide sequencing data of the subject; The peptide sequences and the associated k-mer blocks are input into a machine-learned presentation model to generate presentation likelihoods for the tumor neoantigens, each presentation likelihood representing the likelihood that a neoantigen is presented by an MHC allele on the surfaces of the tumor cells of the subject. A subset of the neoantigens is selected based on the presentation likelihoods.