Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Described are substrate containers that are useful for holding or transporting substrates such as semiconductor wafers and microelectronic devices, in a clean environment, as well as methods of using the substrate containers.

Abstract: System and method provide wireless distributed lighting control systems implementing a secure peer-to-peer, self-organizing and self-healing mesh network of actuators and system inputs. The system and method can be designed specifically for indoor and outdoor lighting where actuators include in-fixture, on-fixture and circuit control modules with ON/OFF and full range dimming capabilities, and system inputs include occupancy/vacancy sensors, daylight sensors and switches. A unique messaging protocol facilitates wireless and wired communication between actuators and system inputs, and provides web-based commissioning and monitoring of the lighting control system using a wireless access point accessible from a local network or Internet which can provide an intuitive and easy to use Graphical User Interface (GUI).

Abstract: A building system including one or more memory devices configured to store instructions that, when executed on one or more processors, cause the one or more processors to collect building device data of a building device, the building device data comprising a plurality of data samples of a data point and generate a time correlated data stream for the data point, the time correlated data stream comprising values of the plurality of data samples of the data point. The instructions cause the one or more processors to generate a time correlated reliability data stream for the data point, the time correlated reliability data stream comprising a plurality of reliability values indicating reliability of the values of the plurality of data samples of the data point.

Abstract: A joist assembly system that is structured for dynamic retrieval of components, dynamic and precise positioning and location of retrieved components, assembly of the components to form a joist, and delivery of the assembled joist. The joist assembly system has a plurality of material handling systems, a plurality of welding systems, and a rigging table system. The material handling systems are structured to load and position the components such as chords and webs onto the rigging table. The rigging table in turn supports the chords or webs. Subsequently, the plurality of welding systems weld the webs to the chords to form the joist.

Abstract: A motor vehicle transmission (1) has a drive input shaft (15), a drive output shaft (16) and a first planetary gearset (P1), and a second planetary gearset (P2), where the drive input shaft (15) is provided for coupling to a drive machine. In addition, a first shifting element (A) and a second shifting element (B) are provided, at least functionally. Also disclosed are a drive unit (5), a motor vehicle drivetrain, a hybrid or electric vehicle, and a method for operating a motor vehicle transmission.

Abstract: A motor vehicle transmission (1) has a drive input shaft (15), a drive output shaft (16), a first planetary gearset (P1), and a second planetary gearset (P2). The drive input shaft (15) is provided for coupling to a drive machine. In addition, a first shifting element (A) and a second shifting element (B) are provided, at least functionally. Also disclosed is a drive unit (5), a motor vehicle drivetrain, a hybrid or electric vehicle, and a method for operating a motor vehicle transmission.

Abstract: According to one aspect, provision is made of a system-on-chip comprising a master device, a slave device, a clock configured to clock the operation of the slave device, a clock controller configured to activate or deactivate the clock and/or a power-on controller configured to power on/off the slave device, a control system configured to detect that the clock is deactivated and/or that the slave device is powered off when the master device emits an access request to the slave device, the master device being configured for activating the clock when the control system detects that this clock is deactivated and/or powering on the slave device when the control system detects that the slave device is powered off, then emitting a new access request to the slave device.

Abstract: A collar is provided that can be used to either drive posts into the ground or remove posts from the ground. The collar includes a first portion defining a post opening adapted for coupling about a post, and a second portion coupled to the first portion. The second portion includes a receiver adapted for receiving a tool for use in driving the post into the ground when the first portion is coupled about the post. The first portion defines an obtuse angle with respect to the second portion. The collar is configured to be positioned in a first orientation about a post when used to drive the post into the ground, and a second orientation, rotated approximately 180 degrees relative to the first orientation, when used to remove a post from the ground.

Abstract: Provided herein are uses of chimeric antigen receptors (CARs) for treating a cancer (such as B cell related cancer, e.g., multiple myeloma).

Abstract: According to examples, an apparatus may include a fluidic chamber, in which fluid is to be temporarily held. The apparatus may also include a heating component to generate heat to form a drive bubble in the fluid held in the fluidic chamber and a cavitation plate may be provided between the fluidic chamber and the heating component. The cavitation plate may be in communication with the fluidic chamber and may physically separate the fluidic chamber from the heating component to protect the heating component. In addition, a controller may determine a condition in the fluidic chamber based on an electrical signal received from the cavitation plate.

Abstract: The virtual queue system includes a virtual queue controller comprising a processor and a memory, wherein the memory stores instructions executable by the processor and is configured to receive a request, the request being associated with an individual guest, for a position in a virtual queue of an attraction, assign the individual guest to the position in the virtual queue in response to the request, receive ride schedule data for the attraction comprising information about a change in status of individual rides of the attraction, and determine a wait time for the individual guest for the attraction based at least on the position of the individual guest in the virtual queue, the ride schedule data, and historical guest throughput at the attraction. The virtual queue system is further configured to output a signal to a guest-associated device indicating the wait time for the attraction.

Abstract: A tubular depth filter element has three or more concentric zones. Each zone is made of an essentially continuous melt blown filament. The filament of an outer zone preferably has a larger diameter than the filaments of other zones. The outer zone overlaps with at least 85%, and preferably all, of another zone. Optionally, one or more additional filaments may traverse through all of zones. The depth filter element is made by spraying filaments onto a rotating mandrel to form a filament mass in contact with a conical press roller. The filaments are sprayed from three or more nozzles which are spaced apart along the length of the mandrel. One of the filaments is formed in a spray pattern that is angled towards an adjacent spray pattern so as to overlap with at least 50 or 85%, and preferably all, of the adjacent spray pattern.

Abstract: An example of an apparatus is provided. The apparatus includes a printhead to dispense drops of print fluid on a media. The drops are to travel along a drop path through air from the printhead. In addition, the apparatus includes a light source to emit light across the drop path. The apparatus also includes a detector to detect an intensity of the light received from the light source. The drop path is to intersect an optical path from the light source to the detector. Furthermore, the apparatus includes a coating disposed on the optical path between the drop path and the detector. The coating is to absorb a threshold amount of the light.

Abstract: A rollable apparatus includes a housing being annular in shape, a heating element mounted about the exterior of the housing, a vibration-inducing motor mounted in the interior of the housing and attached thereto, and a set of batteries mounted in the interior of the housing. The set of batteries is provided for powering the heating element to control the temperature of the housing and for powering the vibration motor to induce oscillatory motion in the housing. The apparatus also includes a set of user controls mounted so as to be accessible at the exterior of the housing, a front cover removably mounted so as to form a portion of the exterior of the housing at one end thereof, and a skin of pliable cushioning material covering the housing.

Abstract: Plates are described for securement to an intervertebral implant, and for fixation to a vertebral body so as to stabilize the implant during the surgical procedure, and in particular as the patient is repositioned during the surgical procedure, for instance from from a lateral decubitus position to a prone position. The plate includes a securement member that is movable between an unlocked configuration whereby the securement member is positioned for insertion into the implant, and a locked configuration that couples the securement member to the intervertebral implant. The securement member is further movable to a secured position that secures the plate to the intervertebral implant as to to define a rigid construct.

Abstract: One example of a fluidic die includes a power supply node, a plurality of fluidic actuators, a plurality of discharge circuits, and a single discharge enable signal path. The plurality of fluidic actuators are electrically coupled to the power supply node. The plurality of discharge circuits are electrically coupled to the power supply node. The single discharge enable signal path is electrically coupled to each discharge circuit of the plurality of discharge circuits to enable each discharge circuit of the plurality of discharge circuits in parallel.