Abstract: A method is described for using an E-domain peptide for the induction of apoptosis in a cancer cells. In particular, the invention relates to methods for using a-type E-domain peptide from trout IGF and/or a b-type E-domain peptide from human IGF for the induction of apoptosis in a broad spectrum of cancer cells. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more cancer cells alone or in a pharmaceutically acceptable composition.

Abstract: A method is described for using an E-domain peptide for the induction of apoptosis in a cancer cells. In particular, the invention relates to methods for using a-type E-domain peptide from trout IGF and/or a b-type E-domain peptide from human IGF for the induction of apoptosis in a broad spectrum of cancer cells. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more cancer cells alone or in a pharmaceutically acceptable composition.

Abstract: Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.

Abstract: A method is described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I for enhancing the proliferation of fibroblasts and closure of wound. The peptide species can be homologous of trout Ea4-peptide, human Eb-peptide of pro-IGF-I or a fusion protein comprising the Ea4- or Eb-peptide of pro-IGF-I. It can be administered any wound in a pharmaceutically acceptable composition alone or in combination with other compounds.

Abstract: Compositions and methods are described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I to inhibit hematopoiesis and to induce differentiation of neuroblastoma cells and neuronal stem cells.

Abstract: Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.

Abstract: A method is described for using an a-type or b-type E domain of the human or trout IGF peptide for the inhibition of proliferation and invasiveness of a broad spectrum of malignant cells and for the inhibition of angiogenesis. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more malignant cells in a pharmaceutically acceptable composition, or alternatively, can be administered to one or more malignant cells by transforming the cells with exogenous nucleic acid that results in the expression of the E domain of IGF-1 in the cell.

Abstract: A method is described for using an a-type or b-type E domain of the human or trout IGF peptide for the inhibition of proliferation and invasiveness of a broad spectrum of malignant cells and for the inhibition of angiogenesis. The peptide species can be a homologue of the E-domain of IGF-1 or a fusion protein comprising the E-domain of IGF-1. It can be administered to one or more malignant cells in a pharmaceutically acceptable composition, or alternatively, can be administered to one or more malignant cells by transforming the cells with exogenous nucleic acid that results in the expression of the E domain of IGF-1 in the cell.

Abstract: Compositions of pro-IFG-I E-peptides for the treatment and amelioration of tumor-producing diseases, and methods for their utilization.

Abstract: Methods of increasing mitosis in cells; of increasing cell attachment in culture; of enhancing wound healing; and of inhibiting proliferation of malignant cells, are described, comprising administering an E domain peptide from insulin-like growth factor I (IGF-I) of a trout, or administering an E domain peptide homolog, an E domain peptide fusion protein, or a nucleic acid encoding an E domain peptide, an E domain peptide homolog or an E domain peptide fusion protein.

Abstract: A method for introducing foreign nucleic acid sequences into marine mollusks. A pantropic retroviral vector containing a foreign gene sequence is introduced into fertilized mollusk embryos by electroporation. The gene sequence becomes integrated into the host DNA and encodes a functional protein product. This method has implications in the introduction of disease-resistance and growth-accelerating genes into mollusks.

Abstract: DNA sequences encoding rainbow trout IGF-I and IGF-II, vectors for the expression of these sequences, and cells transformed with vectors containing these sequences are disclosed. Also disclosed are the recombinant protein and peptides produced from these sequences, antibodies and kits for the detection of IGF-I and IGF-II in fish, and methods for stimulating growth of fish using rainbow trout IGF-I and IGF-II recombinant protein or vectors encoding these proteins.

Abstract: A coil arrangement for testing magnetically operative devices comprising means for mounting a magnetically operative device to be tested by an external magnetic field; first and second coil means disposed symmetrically with respect to the place of the device, the coil means functioning to produce an external magnetic field for testing the device; characterized in that the first coil means is embedded within a metallic electrically conductive body for confining the magnetic field lines to a predetermined region.

Abstract: A magnetic bubble domain circuit which permits the information in two separate propagation paths to crossover each other without deleterious effects. The crossover junction includes at least two definable propagation paths, a merge device for joining the paths, and an active transfer junction between the two paths. The information on the two paths is arranged to become interleaved or intermixed at the merge and to be separated at the active transfer switch arrangements are made for crossing over a plurality of propagation paths by using information properly timed or spaced, or, in the alternative, using a multiple junction arrangement.

Abstract: There is shown and described a magnetic bubble domain device organization using certain propagation elements which have expanded size relative to the remainder of the propagation elements in order to improve device or system operation.

Abstract: There is shown and described a magnetic bubble domain decoder organization which is especially adaptable to a single port configuration. A plurality of separate storage loops are utilized to store data in the form of magnetic bubble domains. An input/output section is provided for supplying data to the storage loops. A crossover junction circuit permits information to be propagated along a single input/output loop into and out of the storage loops. Input and output decoder circuits are provided in each storage loop to control the data which is stored therein. Control circuits such as tranfer switches, universal switches, retarding networks and the like are arranged to control the movement of magnetic bubble domains in the storage loops. By operation of the various control circuits, interwoven data in the storage loops can be selectively separated and retrieved at the input/output section.

Abstract: A magnetic bubble domain circuit component for selectively, substantially concurrently, exchanging bubble domains from adjacent propagation paths. The exchange switch defined herein is an active (i.e. a control current is required) switch. The improved design of the exchange switch permits bubble domain exchanges in a minimum time and distance in a magnetic bubble domain circuit.

Abstract: There is disclosed an apparatus and method for constructing integrated buffered devices for use with magnetic bubble domain memories. A small storage loop acts as the buffer memory and is interfaced with the main storage loops through a new circuit component. The new circuit component performs the function of transferring a bubble from one track, holds the bubble for a prescribed number of cycles, and then transfers the bubble to another track. Thus, any arbitrarily located bubble within the storage loop can be transferred to any arbitrary location in the buffer loop.

Abstract: There is provided an improved switching arrangement for controlling the interaction of magnetic bubble domain propagation loops in order to provide a large, serial storage loop which is fault tolerant and has improved operating characteristics. The switch provides on-chip correction capability and, as well, enhanced switching capability to render defective loops or propagation path portions separable in a positive manner.