Abstract: A modulator of PDE1A and/or PDE1C can be used as a medicament, in particular in the prevention or treatment of synucleinopathies, such as multiple system atrophy, dementia with Lewy bodies, Parkinson's disease, pure autonomic failure, rapid eye movement sleep behavior disorder, inherited synucleinopathies caused by mutations or multiplications of the SNCA gene, or synucleinopathies caused by mutations in other genes including, but not limited to, GBA, LRRK2 and PARK2.

Abstract: A method for registering a device with a connected computing facility includes registering the device with the computing facility by using a first encryption method, defining, in the computing facility, a user-specific and device-specific second encryption method based on device identification data and user identification data, and communicating the second encryption method from the computing facility to the device for future communication. A communication system and an energy supply network are also provided.

Abstract: A voice interaction development tool is described. Initially, user input associating voice interaction data with a visual object is received via a user interface. The voice interaction data, for example, may include voice commands and corresponding output content. Subsequently, a request is received from a voice assistant platform, due to initiation via a voice command to the voice assistant platform. In real-time (e.g., as the user speaks the voice command) a visual object corresponding to the spoken voice command is graphically indicated, e.g., a flow diagram element corresponding to the voice command is emphasized. In real-time as output content corresponding to the voice command is output by a voice assistant device, the user interface provides a graphical indication of the visual object associated with the output content. In this way, the described system provides graphical feedback for testing voice interactions being developed.

Abstract: A method operates a technical or non-technical system. At least one information element of a first type which relates to the system and is dependent on the respective system state of the system is transmitted according to the method from at least one first facility of the system to at least one second facility. The second facility uses at least one information element of a second type which originates neither from the first facility nor from a different facility of the system, i.e. it comes from a source other than the system, to estimate the system state, checks, on the basis of the estimated system state, whether the received information matches the estimated system state to a predefined extent, and, in the event of a match to the predefined extent, regards the information as trusted, and otherwise generates a warning signal indicating a possible data attack.

Abstract: A system is provided including an implantable device configured to be implanted subcutaneously within a patient, a clinician monitoring and control device, an optional patient mobile device, a remote server and/or at least one data analyst device used by a data analyst. The implantable device may communicate with any or all of the monitoring and control device, the mobile device and/or the remote server through the charging device or by establishing a direct wireless connection with each such device. The data analyst device may establish a direct connection with the remote server and also may establish a connection with the monitoring and control device and the mobile device. By analyzing and reviewing the data generated by the implantable device, the data analyst may diagnose a medical condition or indicate a heightened risk of a condition.

Abstract: A method for providing a personal identification code of a security module, includes a personal identification code assigned to the security module and a server is provided which a user of the security module can access after an authentication. In the method, triggered by a request from the user at the server, an authentication code is transmitted to a terminal of the user by means of a first message. An authentication code input by the user is received at the server, whereupon it is verified whether the input authentication code matches the authentication code transmitted to the terminal, wherein, in the case of a match, the personal identification code is transmitted to the terminal of the user by means of a second message.

Abstract: Assembled voice interaction techniques are leveraged in a digital medium environment. During a voice interaction with a voice assistant platform, user portions and voice assistant portions of a voice interaction with a voice assistant platform are received and stored in a sequential order. The user portions of the voice interaction, for example, may correspond to audio data or text data indicative of speech included as part of a request to the voice assistant platform. In contrast, the voice assistant portions of the voice interaction may correspond to output content returned by the voice assistant platform for output as part of a response to the request. An assembled voice interaction file is assembled by interleaving the stored user portions of the voice interaction with the stored voice assistant portions of the voice interaction based on the sequential order.

Abstract: A system in which a device may automatically provision another device with credentials, at the behest of a cloud-based service, based in part on the physical proximity of the device to be provisioned. The provisioning device and the device to be provisioned may use a radio access technology (RAT) with a limited radio range. Account information associated with the device to be provisioned is known to the cloud-based service, which authenticates the device to be provisioned via the device with credentials.

Abstract: A system is provided including an implantable device configured to be implanted subcutaneously within a patient, a clinician monitoring and control device, an optional patient mobile device, a remote server and/or at least one data analyst device used by a data analyst. The implantable device may communicate with any or all of the monitoring and control device, the mobile device and/or the remote server through the charging device or by establishing a direct wireless connection with each such device. The data analyst device may establish a direct connection with the remote server and also may establish a connection with the monitoring and control device and the mobile device. By analyzing and reviewing the data generated by the implantable device, the data analyst may diagnose a medical condition or indicate a heightened risk of a condition.

Abstract: Cleaning device for cleaning a transparent cover of a camera, in particular a lens of the camera, comprising at least one cleaning agent feed line and at least two cleaning agent spraying elements.

Abstract: A voice interaction tool for voice-assisted application prototypes is described. A visual page of an application prototype is displayed in a design interface. The design interface is controlled to provide an interaction interface to receive a trigger and an associated action for the visual page of the application prototype. The trigger may correspond to one of a voice command, a user gesture, or a time delay, and the action may correspond to one of a speech response, a page transition to an additional visual page of the application prototype, or playback of a media file. User input is received to provide the trigger and the action, and associated interaction data is generated to include the trigger, the action, and the visual page of the application prototype. The associated interaction data is stored to enable testing of the trigger and the action during a testing phase of the application prototype.

Abstract: Voice command matching during testing of voice-assisted application prototypes for languages with non-phonetic alphabets is described. A visual page of an application prototype is displayed during a testing phase of the application prototype. A speech-to-text service converts a non-phonetic voice command spoken in a language with a non-phonetic alphabet, captured by at least one microphone during the testing phase of the application prototype, into a non-phonetic text string in the non-phonetic alphabet of the voice command. A phonetic language translator translates the non-phonetic text string of the voice command into a phonetic text string in a phonetic alphabet of the voice command. A comparison module compares the phonetic text string of the voice command to phonetic text strings in the phonetic alphabet of stored voice commands associated with the application prototype to identify a matching voice command. A performance module performs an action associated with the matching voice command.

Abstract: A telecontrol arrangement observes and/or controls an installation. The telecontrol arrangement is set up to communicate with field devices of the installation and with a control center arrangement. In order to specify a comparatively flexible telecontrol arrangement which can be adapted to change intended purposes with a smaller amount of effort, provision is made for the telecontrol arrangement to be formed in a data processing cloud.

Abstract: A fluid management system for moving bodily fluid accumulated due to ascites, pleural effusion or pericardial effusion is provided including an implantable pump coupled to an inflow catheter, an outflow catheter, and optionally an anti-clog catheter. The fluid management system facilitates removal of fluid from a body region, such as the peritoneum, pleural cavity or pericardial sac, where drainage is desired to another body region, such as the urinary bladder or the peritoneal cavity. The system includes clog resistant mechanisms such as clog resistant catheters and/or programmed routines for cycling fluid through inlet catheters in predetermined time intervals and/or responsive to sensed conditions to minimize the risk that inlet catheters become clogged due to, for example, tissue ingrowth and/or solid objects within accumulated fluid.

Abstract: The present disclosure provides genomic arrangements of the chromosome 3q13 region that are associated with prostate cancer, such as rearrangements between the ZBTB20 and LSAMP genes, including gene fusions between the ZBTB20 gene and the LSAMP gene and deletions spanning both genes. The ZBTB20/LSAMP genomic rearrangement serves as a biomarker for prostate cancer and can be used to stratify prostate cancer based on ethnicity or the severity or aggressiveness of prostate cancer and/or identify a patient for prostate cancer treatment. Another aspect involves discovering that deletions of the PTEN gene are observed predominately in prostate cancer from subjects of Caucasian descent. Also provided are kits for diagnosing and prognosing prostate cancer.

Abstract: A system includes an implantable device including a pump to pump the fluid from the peritoneum to the bladder via respective catheters, control circuitry, battery and transceiver; a charging and communication system configured to periodically charge the battery and communicate with the implantable device to retrieve data reflective of the patient's health; and monitoring and control software, suitable for use with conventional personal computers, for configuring and controlling operation of the implantable device and charging and communication system. The monitoring and control software allows a treating physician to remotely adjust the volume, time, and frequency with which fluid is pumped from the peritoneal cavity to the bladder based on the data reflective of the patient's health.

Abstract: A method and corresponding device are provided for determining a flow speed in a fluid conduit. The fluid conduit is provided with first, second and third ultrasonic transducers, wherein respective connection lines between transducers extend outside of a symmetry axis of the fluid conduit. First and second measuring signals are applied to the first ultrasonic transducer and received at the second and the third ultrasonic transducer, respectively. The measuring signals comprise a respective reversed signal portion with respect to time of a response signal. Respective first and second response signals are measured and the flow speed is derived from at least one of the first and second response signals.

Abstract: Assembled voice interaction techniques are leveraged in a digital medium environment. During a voice interaction with a voice assistant platform, user portions and voice assistant portions of a voice interaction with a voice assistant platform are received and stored in a sequential order. The user portions of the voice interaction, for example, may correspond to audio data or text data indicative of speech included as part of a request to the voice assistant platform. In contrast, the voice assistant portions of the voice interaction may correspond to output content returned by the voice assistant platform for output as part of a response to the request. An assembled voice interaction file is assembled by interleaving the stored user portions of the voice interaction with the stored voice assistant portions of the voice interaction based on the sequential order.

Abstract: A method for determining a flow speed of a liquid in a fluid conduit is provided. During a signal-generating phase, an impulse signal is applied to a first ultrasonic transducer. A response signal is then received at a second ultrasonic transducer. A measuring signal is later derived from the response signal, wherein the derivation comprises reversing a signal portion with respect to time. During a measurement phase, a liquid moves with respect to the fluid conduit. The measuring signal is then applied to one of the two transducers and a response signal of the measuring signal is measured at the other transducer. A flow speed is derived from the response signal of the measuring signal.

Abstract: A voice interaction development tool is described. Initially, user input associating voice interaction data with a visual object is received via a user interface. The voice interaction data, for example, may include voice commands and corresponding output content. Subsequently, a request is received from a voice assistant platform, due to initiation via a voice command to the voice assistant platform. In real-time (e.g., as the user speaks the voice command) a visual object corresponding to the spoken voice command is graphically indicated, e.g., a flow diagram element corresponding to the voice command is emphasized. In real-time as output content corresponding to the voice command is output by a voice assistant device, the user interface provides a graphical indication of the visual object associated with the output content. In this way, the described system provides graphical feedback for testing voice interactions being developed.