Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

Abstract: A medical device for wound closure, including an elongate body with a plurality of portions and a perforated region disposed therebetween. The medical device may also include an alignment member. The wound plug may also have a first position for insertion, the portions being mechanically coupled to each other, and a second position where one or more of the portions are spatially separated.

Abstract: The present disclosure provides filaments and/or surgical sutures which include an inner core, an outer sheath and a plurality of barbs on a surface thereof. The filaments and/or surgical sutures further include at least one adhesive precursor material which transitions from a non-adherent material to an adhesive material to attach a portion of the filament and/or suture to the surrounding area, such as tissue and/or other portions of the filament.

Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

Abstract: A surgical instrument is provided including a handle portion and a body portion extending distally from the handle portion and defining a longitudinal axis. The surgical instrument also includes an end effector assembly disposed at a distal end of the body portion, the end effector assembly including an electromagnetic manipulator in cooperation with an ultraviolet (UV) light source for performing tacking of an implant. In an alternative embodiment, the end effector assembly includes an electromagnetic manipulator in cooperation with at least one tack for performing tacking of an implant. The implant may be a mesh having a ferromagnetic coating activated by the electromagnetic manipulator. The tissue may have a UV coating activated by UV light applied by the UV light source.

Abstract: A medical device for wound closure, including an elongate body with a plurality of portions and a perforated region disposed therebetween. The medical device may also include an alignment member. The wound plug may also have a first position for insertion, the portions being mechanically coupled to each other, and a second position where one or more of the portions are spatially separated.

Abstract: The present disclosure relates to multi-component hydrogels. The hydrogels may include a natural component having nucleophilic functional groups as well as an electrophilic component. In embodiments, at least one of the components may be branched, having drugs, antibodies, enzymes, and the like incorporated therein, which may react with at least one of the other components of the hydrogel. Hydrogels of the present disclosure may be used to deliver bioactive agents and/or cells to a patient.

Abstract: A closure device for port site closure is provided. The closure device includes an end effector having a top surface and a bottom surface. A stem extends upwardly from a midsection of the top surface of the end effector. The stem has a free end, a distal end, and a middle portion therebetween. An attachment member extends from the distal end of the stem and is fixedly attached to the top surface of the end effector. The attachment member has a width smaller than a width of the distal end. At least one notch is defined by a gap between the distal end of the stem and the top surface of the end effector.

Abstract: The present disclosure provides medical devices possessing reactants thereon, which further promote adherence of the device to tissue in vivo and/or release of bioactive agents from the device.

Abstract: An applicator for use in tissue repair is provided. The applicator includes a base configured to dispense a material and an applicator tip operably connected to the base. The applicator tip includes a body having a distal end configured to engage a tissue defect and a mold disposed about the body configured to engage tissue about the tissue defect. The mold is configured to be selectively positioned about the distal end of the body between at least a first position and a second position to deposit material to form at least a first layer and a second layer. Also provided are applicator tips, methods and kits for tissue repair.

Abstract: Compositions provided by contacting a biotin-containing component and an avidin-containing component are useful as drug delivery devices. Bioactive agents may be covalently bound to the biotin-containing component, the avidin-containing component, or both, mixed therewith, or combinations of the foregoing.

Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

Abstract: The present disclosure relates to implantable medical devices including swellable tissue gripping elements and methods of forming such devices. The implantable medical device may comprise a biocompatible substrate having a surface comprising at least one swellable grip member. The implantable medical device may take on the form of a surgical mesh, patch, buttress, or pledget and the swellable member may comprise spikes and/or spiked naps. The implantable medical device may also contain a bioactive agent.

Abstract: A medical device includes an elongated body including an outer surface having a plurality of barbs extending therefrom and an inner surface defining a lumen therethrough. The elongated body includes at least one channel extending through the inner surface and the outer surface, the channel defined between an inner surface of one of the plurality of barbs and a cut outer surface of the elongated body. A wound treatment material is disposed within the lumen of the elongated body. The barb is configured to move between a first position to close the channel and retain the wound treatment material within the lumen and a second position to open the channel and permit the release of the wound treatment material therethrough.

Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.

Abstract: Biocompatible wound closure devices including an elongate body and a plug member are useful for wound repair.

Abstract: An osteochondral plug includes a first scaffold and a second scaffold. The first scaffold may be a solid scaffold containing one or more pendant reactive functional groups. The second scaffold capable of reacting with the one or more pendant reactive functional groups of the first scaffold.

Abstract: A surgical implant includes a porous substrate including a first surface and a second surface, and a plurality of ferromagnetic darts extending from at least one of the first and second surfaces. The surgical implant may be used in combination with an electromagnet that is configured to attract the plurality of darts for fixing the surgical implant to tissue.

Abstract: Biocompatible wound closure devices including an elongate body and a plug member are useful for wound repair. A wound closure device includes an elongate body defining a longitudinal axis and having a proximal end and a distal end, and a plug member having a tissue facing surface and including a first shaped section and a second shaped section, each of the first and second shaped sections having an abutment surface. The first and second shaped sections are movable about a hinge between a collapsed position in which the abutment surfaces extend away from the longitudinal axis of the elongate body and a deployed position in which the abutment surfaces abut and are substantially aligned with the longitudinal axis of the elongate body, the abutment surfaces controlling a deployed angle of the tissue facing surface of the plug member with respect to the elongate body.