Abstract: The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells, utilizing a fully-enclosed cell engineering system.

Abstract: An internal combustion rotary engine comprising a housing, at least one sun wheel centered about the central axis and positioned within one of at least one cylindrical compartment of the housing, and including a sun wheel circumference and at least one semicylindrical receptable defined along the sun wheel circumference, at least one lobe extending from an inner cylindrical surface of the compartment, and at least one planet wheel received in the at least one semicylindrical receptable of the sun wheel. The at least one planet wheel may be configured to engage the inner cylindrical surface of the cylindrical compartment and include at least one indentation configured to be received by the at least one lobe when the at least one planet wheel rotates along the inner cylindrical surface. Air intake and compression as well as combustion and exhaust may be performed within the same or different compartments of the at least one cylindrical compartment.

Abstract: Systems, apparatuses and methods may provide for technology that allocates a portion of operational power in a source device to an external sink device in response to a connection of the external sink device to the source device, detects a low power state with respect to the external sink device, and decreases the portion of operational power allocated to the external sink device in response to the low power state.

Abstract: A data processing device for detecting motion in a sequence of frames each comprising one or more blocks of pixels, includes a sampling unit configured to determine image characteristics at a set of sample points of a block, a feature generation unit configured to form a current feature for the block, the current feature having a plurality of values derived from the sample points, and motion detection logic configured to generate a motion output for a block by comparing the current feature for the block to a learned feature representing historical feature values for the block.

Abstract: A computer-implemented method for generating a rotation-invariant feature descriptor for a location in an image for use in performing descriptor matching in analysing the image, extracts samples according to a descriptor pattern for the location in the image; uses the extracted samples to determine a measure of rotation for the location in the image, the measure of rotation describing an angle between an orientation of the image and a characteristic direction of the image at the location; generating a feature descriptor for the location in the image by determining a set of samples characterising the location in dependence on the determined measure of rotation and the extracted samples; and processes the determined set of samples to generate the feature descriptor for the location in the image.

Abstract: An automated carousel and system configured for translationally moving a plurality of biological production units in unison along a vertical frame while maintaining a precise alignment of each of the biological production units relative to gravity, and simultaneously providing independent dynamic adjustment of the axial orientation of each of the plurality of biological production units relative to gravity. The automated carousel may be adapted for use with a variety of biological production units supporting cell culture and/or tissue engineering systems in various clinical and laboratory settings and provides for ergonomic use thereof.

Abstract: The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells, utilizing a fully-enclosed cell engineering system.

Abstract: A method of feature matching in images captured from camera viewpoints uses the epipolar geometry of the viewpoints to define a geometrically-constrained region in a second image corresponding to a first feature in a first image; comparing the local descriptor of the first feature with local descriptors of features in the second image to determine respective measures of similarity; identifying, from the features located in the geometrically-constrained region, (i) a geometric best match and (ii) a geometric next-best match to the first feature; identifying a global best match to the first feature; performing a first comparison of the measures of similarity for the geometric best match and the global best match; performing a second comparison of the measures of similarity for the geometric best match and the geometric next-best match; and, if thresholds are met, selecting the geometric best match feature in the second image.

Abstract: An automated carousel and system configured for translationally moving a plurality of biological production units in unison along a vertical frame while maintaining a precise alignment of each of the biological production units relative to gravity, and simultaneously providing independent dynamic adjustment of the axial orientation of each of the plurality of biological production units relative to gravity. The automated carousel may be adapted for use with a variety of biological production units supporting cell culture and/or tissue engineering systems in various clinical and laboratory settings and provides for ergonomic use thereof.

Abstract: Apparatus for binning an input value into an array of bins, each bin representing a range of input values and the bins collectively representing a histogram of input values, the apparatus comprising: an input for receiving the input value; a memory for storing the array; and a binning controller configured to: derive a plurality of bin values from the input value according to a binning distribution located about the input value, the binning distribution spanning a range of input values and each bin value having a respective input value dependent on the position of the bin value in the binning distribution; and allocate the plurality of bin values to a plurality of bins in the array, each bin value being allocated to a bin selected according to the respective input value of the bin value.

Abstract: A data processing device for detecting motion in a sequence of frames each comprising one or more blocks of pixels, includes a sampling unit configured to determine image characteristics at a set of sample points of a block, a feature generation unit configured to form a current feature for the block, the current feature having a plurality of values derived from the sample points, and motion detection logic configured to generate a motion output for a block by comparing the current feature for the block to a learned feature representing historical feature values for the block.

Abstract: Methods and systems for implementing a traditional computer vision algorithm as a neural network. The method includes: receiving a definition of the traditional computer vision algorithm that identifies a sequence of one or more traditional computer vision algorithm operations; mapping each of the one or more traditional computer vision algorithm operations to a set of one or more neural network primitives that is mathematically equivalent to that traditional computer vision algorithm operation; linking the one or more network primitives mapped to each traditional computer vision algorithm operation according to the sequence to form a neural network representing the traditional computer vision algorithm; and configuring hardware logic capable of implementing a neural network to implement the neural network that represents the traditional computer vision algorithm.

Abstract: An automated cell culture and tissue engineering system comprising defined and separate environmental zones provide for increased control and maintenance of the internal environment of the system such that the temperature, air flow and gases surrounding the bioreactor module form one zone that is maintained separately to a second zone formed surrounding the reagent fluid reservoir. The system further comprises means for elimination and/or management of condensation within the second zone of the system.

Abstract: Apparatus for binning an input value into an array of bins, each bin representing a range of input values and the bins collectively representing a histogram of input values, the apparatus comprising: an input for receiving the input value; a memory for storing the array; and a binning controller configured to: derive a plurality of bin values from the input value according to a binning distribution located about the input value, the binning distribution spanning a range of input values and each bin value having a respective input value dependent on the position of the bin value in the binning distribution; and allocate the plurality of bin values to a plurality of bins in the array, each bin value being allocated to a bin selected according to the respective input value of the bin value.

Abstract: Systems, methods, devices, and other techniques for managing a computing resource shared by a set of online entities. A system can receive a request from a first online entity to reserve capacity of the computing resource. The system determines a relative priority of the first online entity and identifies a reservation zone that corresponds to the relative priority of the first online entity. The system determines whether to satisfy the request based on comparing (i) an amount of the requested capacity of the computing resource and (ii) an amount of the portion of unused capacity of the computing resource designated by the reservation zone that online entities having relative priorities at or below the relative priority of the first online entity are permitted to reserve.

Abstract: The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation.

Abstract: The present disclosure provides a cell harvesting method for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology.

Abstract: An automated cell culture and tissue engineering system comprising defined and separate environmental zones provide for increased control and maintenance of the internal environment of the system such that the temperature, air flow and gases surrounding the bioreactor module form one zone that is maintained separately to a second zone formed surrounding the reagent fluid reservoir. The system further comprises means for elimination and/or management of condensation within the second zone of the system.

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Abstract: A method of image retargeting is provided. The method includes obtaining a source image, obtaining a target size for a retargeted image based on the source image, generating a two-dimensional importance map for the source image, generating, based on the two-dimensional importance map and the target size, a warping mesh having a distortion metric below a threshold value, determining whether a size of the warping mesh corresponds to the target size, and based on the size of the warping mesh being determined to correspond to the target size, rendering the retargeted image by applying the warping mesh to the source image.