Abstract: Provided are proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.

Abstract: The present disclosure provides an antibody, or an antigen binding fragment or variant thereof, which binds to CD27 and exhibits at least one of the following properties: specifically binds to CD27 with a KD of 10?8 M or less; activates and/or increases CD27 mediated NF-?B activity; stimulates CD4+ and/or CD8+ T cell proliferation; binds to human CD27 expressed on a cell surface; stimulates secretion of IFN-? by CD4+ and/or CD8+ T cells. The present disclosure also provides a method for preparing and using said antibody.

Abstract: A composition including an immunoconjugate and a chemotherapeutic agent. The immunoconjugate includes 1) one or more interleukins, and 2) an Fc domain consisting of a first Fc subunit and a second Fc subunit. The first Fc subunit associates with the second Fc subunit to form a dimer. The one or more interleukins are fused to the Fc domain and the chemotherapeutic agent includes a fluorouracil and/or an oxaliplatin.

Abstract: Compositions comprise statistically random heteropolymers complexed with active proteins, and are formulated and used in stimuli-responsive materials and nanoreactors composed of proteins and synthetic materials.

Abstract: The present application provides a method of treating tumor, comprising: administrating a dose of 15 mg/kg to 35 mg/kg of a HER2 bispecific antibody, which comprises a first and a second light chain, a first and a second heavy chain, and variable region of the light chain comprises an amino acid sequence as set forth in any one of SEQ ID NO: 1-6.

Abstract: The present disclosure provides a dimer formed by two polypeptide chains, with each of the two polypeptide chains comprising an antibody Fc subunit, wherein the dimer comprises two or more immunoglobulin single variable domains (ISVDs), at least one of the ISVDs is specific for PD-L1, and at least one of the ISVDs is specific for CTLA4.

Abstract: The present application provides a medicinal product comprising: an the HER2 inhibitor or a CDK inhibitor, wherein said CDK inhibitor inhibits CDK4 and/or CDK6. The present application also provides an the HER2 inhibitor for the use of treating tumor in combination with a CDK inhibitor, as well as their use in the preparation of a medicament for treating tumor. The combination in present will significantly enhance tumor inhibiting.

Abstract: Compositions comprise statistically random heteropolymers complexed with active proteins, and are formulated and used in stimuli-responsive materials and nanoreactors composed of proteins and synthetic materials.

Abstract: Examples described herein relate to a driver that is to: determine a configuration of a packet processing pipeline of a network interface device to perform an instruction set written in a domain specific language (DSL) for the packet processing pipeline based on emulation or analysis of a parser of the packet processing pipeline and provide the configuration to the packet processing pipeline of the network interface device to specify operations of the packet processing pipeline of the network interface device.

Abstract: Compositions comprise synergistic enzyme mixtures, and related methods, to realize near-complete depolymerization in biodegradable polymer/additive blends.

Abstract: The invention relates to the field of biomedicine, and an anti-pertussis toxin (PT) single domain antibody and derivative protein thereof are disclosed. Specifically, a pertussis toxin-binding protein and use thereof are disclosed.

Abstract: The present disclosure provides an article. In an embodiment, the article includes a substrate and a coating on the substrate. The coating includes a composition. The composition includes a plurality of nanoparticles, each nanoparticle having a ligand linked to a surface of each nanoparticle. The composition includes a plurality of block copolymers. Each block copolymer includes a linking block and a nonlinking block. The linking block is a random copolymer composed of at least two different monomers. At least one of the monomers is a linking comonomer. The linking comonomer is directly linked to the ligand to form a first microdomain consisting of the linking block, the nanoparticles, and the ligand. The composition further includes a second microdomain consisting of the nonlinking block.

Abstract: In a virtual extensible local area network (VXLAN) packet encapsulation and policy execution method, a communications device determines an application identifier for identifying an application type of an Ethernet frame, and places the application identifier in a VXLAN header. Another device may directly execute a corresponding policy based on the application identifier in the VXLAN header and without analyzing a packet.

Abstract: The present disclosure provides a use of a dimer in the preparation of a medicament for treating a tumor in a subject in need thereof, and the dimer formed by two polypeptide chains, with each of the two polypeptide chains comprising an antibody Fc subunit, wherein the dimer comprises two or more immunoglobulin single variable domains (ISVDs), at least one of the ISVDs is specific for PD-L1, and at least one of the ISVDs is specific for CTLA4. The present disclosure also provides a method for treating a tumor in a subject in need thereof, wherein the subject is resistant to the therapy of an immune checkpoint inhibitor.

Abstract: The present disclosure provides a use of an immune checkpoint inhibitor in combination with a Her2 inhibitor in the preparation of a medicament for treating tumor in a subject in need thereof, and also provides a pharmaceutical composition comprising an effective amount of said immune checkpoint inhibitor and an effective amount of said Her2 inhibitor, and optionally a pharmaceutically acceptable excipient, as well as a use of the pharmaceutical composition in the preparation of a medicament for treating tumor in a subject in need thereof.