Abstract: A content aware and style aware neural network based data augmentation model generates augmented data sets to train neural network based handwriting recognition models to recognize individuals' handwriting. In embodiments, the augmented data sets are generated so as to be artificial, and to lack personal or confidential information. In embodiments, the data augmentation model generates content reference sets of individual characters generated in different fonts, and style reference sets of pluralities of characters of a particular style, for example, an individual's handwriting.

Abstract: Provided is an immunoconjugate useful in inhibiting tumor growth, and a composition and/or protein mixture comprising the immunoconjugate. Also provided are methods for the production of the immunoconjugate, as well as pharmaceutical uses of the immunoconjugate in inhibiting tumor growth, including but not limited to treatment of cancers.

Abstract: It relates to a cosmetic composition in the form of a transparent or semi-transparent gel, comprising (a) an oil phase; (b) a surfactant portion comprising a first non-ionic surfactant and a second non-ionic surfactant; (c) an aqueous phase; and (d) at least one C2-C6 polyol; wherein the first nonionic surfactant comprises at least one alkyl polyglucoside and the second nonionic surfactant comprises at least one having the following general formula (I) or (II): R(X)nOR? (I) wherein, R represents a linear or branched C8-C30 alkyl group or C8-C30 alkenyl group; X represents —OCH2CH2— or —OCH2—CHCH3—; n represents an integer from 2 to 100; and R? represents H, or a linear or branched C8-C30 alkyl group or C8-C30 alkenyl group; (II) wherein, the sum of x+y+z represents an integer from 2 to 100; and R1, R2, and R3, are the same or different and are each independently represents OH, or a linear or branched C8-C30 fatty acid ester group, with the proviso that at least one of R1, R2 and R3 is not OH.

Abstract: An isolated antigen-binding protein, having one or more of the following properties: 1) capable of binding to human and monkey-derived GITR proteins at a KD value of 7×10?12 or below, wherein the KD value is measured by BLI method; 2) capable of stimulating immune cell proliferation; 3) capable of stimulating immune cells to secrete IFN-?, wherein the secretion is measured in T cell viability assay; 4) capable of inhibiting tumor growth and/or tumor cell proliferation; 5) capable of activating GITR signaling pathway; 6) capable of inhibiting the binding of GITR to GITRL.

Abstract: Nanoscopic dispersion of trace enzymes and random heteropolymers in plastics provides to fully functional plastics with eco-friendly microplastic elimination and programmable degradation.

Abstract: Disclosed is a monoclonal antibody or an antigen binding fragment thereof which targets tissue factor pathway inhibitor (TFPI), and a medical use thereof.

Abstract: Disclosed are a method for treating a tumor using a CTLA4-binding protein and a use thereof, wherein the CTLA4-binding protein specifically binds to CTLA4 and does not compete with a ligand of CTLA4 for binding to CTLA4. The CTLA4-binding protein described in the present application can effectively inhibit tumor growth.

Abstract: Provided is a dual-neighborhood wear angle automatic detection method, including constructing a proximal neighborhood and establishing grayscale differences between a pixel in a center area and pixels having first directions in the proximal neighborhood; calculating, based on the grayscale differences, deviation degrees of all pixels in the center area in the first directions; calculating a similar direction value based on the deviation degrees; constructing a distal neighborhood and focus pixels having second directions in the distal neighborhood; calculating grayscale differences between the pixel and the focus pixels; calculating deviation degrees of all pixels in the center area, in the second directions based on the grayscale differences between the pixel and the focus pixels; calculating a direction value of a wear angle based on the deviation degrees in the second directions; and calculating the wear angle based on the direction value of the wear angle.

Abstract: The present application provides a bispecific antibody or an antibody mixture with common light chains and a preparation method therefor. the present application also provides a nucleic acid molecule encoding the antibody or the mixture, a recombinant vector and a recombinant cell comprising the nucleic acid molecule, as well as a detection and quantitation method for the antibody or the mixture.

Abstract: Proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.

Abstract: The present invention relates to the field of medical biology, and discloses a high-resolution crystal structure of a complex of PD-L1-blocking heavy-chain single-domain antibody KN035 binding with PD-L1, and the use of the crystal structure. The invention also relates to novel PD-L1 binding polypeptides or compounds developed based on the crystal structure and uses thereof.

Abstract: The present disclosure provides proteinaceous complexes, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous complexes, methods for producing the proteinaceous complexes, and uses thereof.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: A method and system to generate training data for a deep learning model in memory instead of loading pre-generated data from disk storage. A corpus may be stored as lines of text. The lines of text can be manipulated in the memory of a central processing unit (CPU) of a computing system, using asynchronous multi-processing, in parallel with a training process being conducted on the system's graphics processing unit (GPU). With such an approach, for a given line of text, it is possible to take advantage of different fonts and different types of image augmentation without having to put the images in disk storage for subsequent retrieval. Consequently, the same line of text can be used to generate different training images for use in different epochs, providing more variability in training data (no training sample is trained on more than once). A single training corpus may yield many different training data sets.

Abstract: Aspects of the present disclosure relate to a bird bath. In one configuration, a frame as a plurality lighting elements therein. A stand is provided for supporting the frame. The bath may include a control component for controlling the lighting elements and a photovoltaic cell for providing power to the lighting elements. In another aspect, the frame may include a plurality of spiral frame members. In yet another aspect, the spiral members have a channel pathway and the lighting elements are disposed in the channel pathway. In yet another aspect, the frame may includes a plurality of radial members. In yet another aspect, the radial members have a channel pathway and the lighting elements are disposed in the channel pathway.