Patents by Inventor Tomomi Murakami

Tomomi Murakami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9671348
    Abstract: The present invention provides a method for measuring a component to be measured in a sample, comprising converting the component to be measured in the sample into hydrogen peroxide and measuring the formed hydrogen peroxide in the presence of an ?-keto acid using an oxidative-coloring chromogen. The present invention also provides a method for suppressing the influence of a peroxide on a method of converting a component to be measured in a sample into hydrogen peroxide and measuring the formed hydrogen peroxide using an oxidative-coloring chromogen, the suppression method comprising using an ?-keto acid. The measuring method and the suppression method of the present invention using an ?-keto acid suppress the influence of a peroxide to give an accurate measurement of the component to be measured in the sample.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: June 6, 2017
    Assignee: KYOWA MEDEX CO., LTD.
    Inventor: Tomomi Murakami
  • Patent number: 9493433
    Abstract: Described is a method for preserving an aqueous solution comprising a leuco chromogen, comprising adding at least one compound selected from the group consisting of polyoxyethylene alkylamine and polyoxyethylene alkenylamine to the aqueous solution containing a leuco chromogen, and a method for stabilizing a leuco chromogen, comprising allowing the leuco chromogen to coexist in an aqueous solution comprising at least one compound selected from the group consisting of polyoxyethylene alkylamine and polyoxyethylene alkenylamine.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: November 15, 2016
    Assignee: KYOWA MEDEX CO., LTD.
    Inventors: Haruyo Soya, Tomomi Murakami, Haruki Tsunoda, Yu Ohsugi, Ayako Yoda, Masashi Matsushita
  • Patent number: 9360432
    Abstract: The present invention provides a method for a simple and accurate measurement of triglycerides in low-density lipoprotein in a sample comprising performing the following steps sequentially: (i) a step of generating free glycerol by allowing lipoprotein lipase to act on a sample, in an aqueous medium comprising the sample and a specific surfactant such as polyoxyethylene polyoxyalkylene polycyclic phenyl ether; (ii) a step of removing free glycerol present in the reaction solution of the above step (i); (iii) a step of generating free glycerol by allowing lipoprotein lipase to act on the reaction solution from which free glycerol has been removed in step (ii), in the presence of a specific surfactant such as polyoxyethylene polyoxyalkylene alkyl ether; and (iv) a step of measuring free glycerol generated in step (iii), and a kit used for the method.
    Type: Grant
    Filed: October 31, 2006
    Date of Patent: June 7, 2016
    Assignee: KYOWA MEDEX CO., LTD.
    Inventors: Yuki Katayama, Kazuhito Miyauchi, Shizuyo Takada, Tomomi Murakami
  • Patent number: 9090931
    Abstract: It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising: reacting glycated hemoglobin in the hemoglobin-containing sample with a proteolytic enzyme in the presence of at least one salt selected from the group consisting of a pyridinium salt, a phosphonium salt, an imidazolium salt, and an isoquinolinium salt; reacting the obtained reaction product with fructosyl peptide oxidase; and measuring the generated hydrogen peroxide. The present invention provides a method for accurately measuring glycated hemoglobin in a hemoglobin-containing sample.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: July 28, 2015
    Assignee: KYOWA MEDEX CO., LTD
    Inventors: Haruyo Soya, Tomomi Murakami, Haruki Tsunoda, Yu Ohsugi, Ayako Yoda, Masashi Matsushita
  • Patent number: 8685663
    Abstract: A method for measuring cholesterol in low-density lipoprotein contained in a sample, which comprises reacting a sample with (i) a combination of cholesterol ester hydrolase and cholesterol oxidase or (ii) a combination of cholesterol ester hydrolase, an oxidized coenzyme and cholesterol dehydrogenase in the presence of: [a] a polyoxyethylene-polyoxyalkylene alkylaryl ether; [b] one or more surfactants selected from the group consisting of a polyoxyethylene-polyoxyalkylene copolymer, a polyoxyethylene alkenyl ether, a polyoxyethylene branched alkyl ether, and a polyoxyethylene-polyoxyalkylene branched alkyl ether; [c] one or more surfactants selected from the group consisting of a primary amine, a secondary amine, a tertiary amine, and a quaternary ammonium; and [d] a polyanion, and measuring a substance formed or consumed in the reaction.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: April 1, 2014
    Assignee: Kyowa Medex Co., Ltd.
    Inventors: Tomomi Murakami, Tomoko Aratake, Shingo Mishima, Hideyuki Kuwata
  • Publication number: 20130288283
    Abstract: The present invention provides a method for measuring a component to be measured in a sample, comprising converting the component to be measured in the sample into hydrogen peroxide and measuring the formed hydrogen peroxide in the presence of an ?-keto acid using an oxidative-coloring chromogen. The present invention also provides a method for suppressing the influence of a peroxide on a method of converting a component to be measured in a sample into hydrogen peroxide and measuring the formed hydrogen peroxide using an oxidative-coloring chromogen, the suppression method comprising using an ?-keto acid. The measuring method and the suppression method of the present invention using an ?-keto acid suppress the influence of a peroxide to give an accurate measurement of the component to be measured in the sample.
    Type: Application
    Filed: December 12, 2011
    Publication date: October 31, 2013
    Applicant: KYOWA MEDEX CO., LTD.
    Inventor: Tomomi Murakami
  • Publication number: 20130171676
    Abstract: It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising reacting the hemoglobin-containing sample with a proteolytic enzyme in the presence of a surfactant, and then reacting the obtained reaction product with fructosyl peptide oxidase, wherein at least one of the former reaction and the latter reaction is performed in the presence of an isothiazolinone derivative; and measuring the generated hydrogen peroxide. The present invention provides a method for accurately and highly sensitively measuring glycated hemoglobin in a hemoglobin-containing sample without being influenced by hemoglobin.
    Type: Application
    Filed: August 9, 2011
    Publication date: July 4, 2013
    Applicant: Kyowa Medex Co., Ltd.
    Inventors: Tomomi Murakami, Haruyo Soya, Yu Ohsugi, Ayako Yoda, Haruki Tsunoda, Masashi Matsushita
  • Publication number: 20130123491
    Abstract: It is to provide a method for preserving an aqueous solution comprising a leuco chromogen, comprising adding at least one compound selected from the group consisting of polyoxyethylene alkylamine and polyoxyethylene alkenylamine to the aqueous solution containing a leuco chromogen, and a method for stabilizing a leuco chromogen, comprising allowing the leuco chromogen to coexist in an aqueous solution comprising at least one compound selected from the group consisting of polyoxyethylene alkylamine and polyoxyethylene alkenylamine. The present invention provides a method for preserving an aqueous solution comprising a leuco chromogen for stably preserving the leuco chromogen in an aqueous solution and a method for stabilizing a leuco chromogen.
    Type: Application
    Filed: August 9, 2011
    Publication date: May 16, 2013
    Applicant: KYOWA MEDEX CO., LTD.
    Inventors: Haruyo Soya, Tomomi Murakami, Haruki Tsunoda, Yu Ohsugi, Ayako Yoda, Masashi Matsushita
  • Publication number: 20130115646
    Abstract: It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising: reacting glycated hemoglobin in the hemoglobin-containing sample with a proteolytic enzyme in the presence of at least one salt selected from the group consisting of a pyridinium salt, a phosphonium salt, an imidazolium salt, and an isoquinolinium salt; reacting the obtained reaction product with fructosyl peptide oxidase; and measuring the generated hydrogen peroxide. The present invention provides a method for accurately measuring glycated hemoglobin in a hemoglobin-containing sample.
    Type: Application
    Filed: August 9, 2011
    Publication date: May 9, 2013
    Applicant: KYOWA MEDEX CO., LTD.
    Inventors: Haruyo Soya, Tomomi Murakami, Haruki Tsunoda, Yu Ohsugi, Ayako Yoda, Masashi Matsushita
  • Publication number: 20110223626
    Abstract: A method for measuring cholesterol in low-density lipoprotein contained in a sample, which comprises reacting a sample with (i) a combination of cholesterol ester hydrolase and cholesterol oxidase or (ii) a combination of cholesterol ester hydrolase, an oxidized coenzyme and cholesterol dehydrogenase in the presence of: [a] a polyoxyethylene-polyoxyalkylene alkylaryl ether; [b] one or more surfactants selected from the group consisting of a polyoxyethylene-polyoxyalkylene copolymer, a polyoxyethylene alkenyl ether, a polyoxyethylene branched alkyl ether, and a polyoxyethylene-polyoxyalkylene branched alkyl ether; [c] one or more surfactants selected from the group consisting of a primary amine, a secondary amine, a tertiary amine, and a quaternary ammonium; and [d] a polyanion, and measuring a substance formed or consumed in the reaction.
    Type: Application
    Filed: November 13, 2009
    Publication date: September 15, 2011
    Applicant: KYOWA MEDEX CO., LTD.
    Inventors: Tomomi Murakami, Tomoko Aratake, Shingo Mishima, Hideyuki Kuwata
  • Publication number: 20090226944
    Abstract: The present invention provides a method for a simple and accurate measurement of triglycerides in low-density lipoprotein in a sample comprising performing the following steps sequentially: (i) a step of generating free glycerol by allowing lipoprotein lipase to act on a sample, in an aqueous medium comprising the sample and a specific surfactant such as polyoxyethylene polyoxyalkylene polycyclic phenyl ether; (ii) a step of removing free glycerol present in the reaction solution of the above step (i); (iii) a step of generating free glycerol by allowing lipoprotein lipase to act on the reaction solution from which free glycerol has been removed in step (ii), in the presence of a specific surfactant such as polyoxyethylene polyoxyalkylene alkyl ether; and (iv) a step of measuring free glycerol generated in step (iii), and a kit used for the method.
    Type: Application
    Filed: October 31, 2006
    Publication date: September 10, 2009
    Applicant: KYOWA MEDEX CO., LTD.
    Inventors: Yuki Katayama, Kazuhito Miyauchi, Shizuyo Takada, Tomomi Murakami
  • Publication number: 20080312435
    Abstract: An imine compound represented by the formula: wherein A represents a heterocyclic group; R1, R2, an R3 each represent a hydrogen atom, a halogen atom, a C1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom(s), a C3-10 cycloalkyl group, a C1-6 haloalkyl group, a C1-10 alkoxy group, etc.; R4 represents an optionally substituted C1-10 alkyl, C2-6 alkenyl, or aryl group; R5 represents a hydrogen atom, a C1-10 alkoxy group, a C1-6 haloalkyl group, an optionally substituted C1-10 alkyl or C2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents —CO—, —CO—CO—, —CO—NH—, —CS—NH—, or —SO2—, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.
    Type: Application
    Filed: October 31, 2005
    Publication date: December 18, 2008
    Applicant: TAISHO PHARMACEUTICAL CO., LTD.
    Inventors: Shiuji Saito, Hiroshi Ohta, Tomoko Ishizaki, Mitsukane Yoshinaga, Makoto Tatsuzuki, Yuji Yokobori, Yasumitsu Tomishima, Aki Morita, Yoshihisa Toda, Kimiko Tokugawa, Ayaka Kaku, Tomomi Murakami, Hiromitsu Yoshimura, Shingo Sekine, Takao Yoshimizu
  • Patent number: 7400556
    Abstract: An electronic timepiece with a solar cell includes a timepiece movement, a timepiece case for housing the timepiece movement, a casing ring for housing and holding the timepiece movement in the timepiece case, a solar cell and a dial. The solar cell is disposed almost vertically to a solar cell positioning portion provided in the casing ring, and the solar cell has a slender strip shape formed on a flexible substrate. Consequently, the solar cell is not disposed in the timepiece movement, and it is only necessary to change the casing ring as an external component even when a panel cover diameter is changed. Further, a solar cell can be coiled to match the size of the casing ring when it is incorporated in the casing ring, so that a common solar cell can be used despite a change in the panel cover diameter of the timepiece.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: July 15, 2008
    Assignee: Citizen Watch Co., Ltd.
    Inventors: Takashi Osa, Tomomi Murakami, Hitoshi Fujita
  • Publication number: 20060153011
    Abstract: According to the present invention, in an electronic timepiece with a solar cell comprising a timepiece movement, a timepiece case for housing the timepiece movement, a casing ring for housing and holding the timepiece movement in the timepiece case, a solar cell and a dial, the solar cell is disposed almost vertically to a solar cell positioning portion provided in the casing ring, and the solar cell has a slender strip shape formed on a flexible substrate. Consequently, a solar cell need not be disposed in a timepiece movement, and it is only necessary to change a casing ring as an external component even when a panel cover diameter is changed, allowing a common use of a timepiece movement. Further, a solar cell can be coiled to match the size of a casing ring when it is incorporated in the casing ring, therefore a common solar cell can be used despite a change in the panel cover diameter of the timepiece.
    Type: Application
    Filed: December 12, 2003
    Publication date: July 13, 2006
    Applicant: Citizen Watch Co., LTD
    Inventors: Takashi Osa, Tomomi Murakami, Hitoshi Fujita
  • Publication number: 20060050618
    Abstract: In the present invention, a light permeable dial trim ring is arranged on the inner side of a solar cell, and a part of a solar cell photovoltaic area and a part of the dial trim ring which covers the solar cell photovoltaic area are arranged to be lower than a dial upper surface height. Further, a dial thickness of the dial inner side is set larger than a thickness of a dial peripheral edge on which the light permeable dial trim ring is mounted while assuring a light leading portion for a light which enters the dial trim ring. Alternatively, a flange portion which fixes a glass to a watch case is arranged outside the light permeable dial trim ring and the solar cell, the dial trim ring is arranged directly below the glass, and a blind portion is provided above the dial trim ring or the solar cell. As a result, a gap between the glass lower surface and the dial upper surface can be reduced, thereby eliminating a “hollow-eyed” design.
    Type: Application
    Filed: December 16, 2003
    Publication date: March 9, 2006
    Inventors: Takashi Osa, Tomomi Murakami
  • Publication number: 20050042703
    Abstract: The present invention relates to a method for conveniently quantitating TGs contained in various lipoproteins. A method for quantitating trigyceride (TG) in a particular lipoprotein which comprises eliminating free glycerol from a sample containing free glycerol and TG in the particular lipoprotein, then allowing the resulting sample to react with lipoprotein lipase and an enzyme system which generates hydrogen peroxide from free glycerol, and quantitating the generated hydrogen peroxide, is provided.
    Type: Application
    Filed: September 29, 2004
    Publication date: February 24, 2005
    Applicant: KYOWA MEDEX CO., LTD.
    Inventors: Kazuhito Miyauchi, Shizuyo Takada, Tomomi Murakami, Akira Miike
  • Patent number: 6811994
    Abstract: The present invention relates to a method for conveniently quantitating TGs contained in various lipoproteins. A method for quantitating trigyceride (TG) in a particular lipoprotein which comprises eliminating free glycerol from a sample containing free glycerol and TG in the particular lipoprotein, then allowing the resulting sample to react with lipoprotein lipase and an enzyme system which generates hydrogen peroxide from free glycerol, and quantitating the generated hydrogen peroxide, is provided.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: November 2, 2004
    Assignee: Kyowa Medex Co., Ltd.
    Inventors: Kazuhito Miyauchi, Shizuyo Takada, Tomomi Murakami, Akira Miike
  • Patent number: 6580665
    Abstract: An electronic timepiece is formed of a power generating device for generating power, a control device for driving on receipt of a power supply from the power generating device, a display device for displaying a time by an operation of the control device, a detecting device for detecting a state of the power generating device, and a deciding device for deciding whether or not the power generating device generates power based on a detection signal sent from the detecting device. The control device controls such that a power generating state of the power generating device is displayed on the display device based on a decision of the deciding device. It is possible to reduce power consumption by stopping hands if required.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: June 17, 2003
    Assignee: Citizen Watch Co., Ltd.
    Inventors: Yasuo Kamiyama, Tomomi Murakami, Masao Mafune, Yoichi Nagata
  • Patent number: 6518493
    Abstract: In a display device for an electronic apparatus, a circular polarizing plate constituted by a linear polarizing plate 42 and a ¼&lgr; plate 43 is provided between a solar display board 41 and a middle frame 46 for fixing a module 45 having a solar cell 44 to an outer case. As a result, a boundary line between the middle frame 46 and the solar cell 44, a gate track generated through injection molding of the middle frame 46, and further more, a solar cell element dividing line of the solar cell 44 cannot be seen. Consequently, a variation in design of the solar display board 41 can be increased. Moreover, the color of the solar display board 41 is deepened so that a feeling of high quality can be obtained as goods, and the provision of the middle frame can provide various external shapes of a watch in respect of the design.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: February 11, 2003
    Assignee: Citizen Watch Co., Ltd.
    Inventors: Tomomi Murakami, Shin-ichi Sakamaki, Yoshiya Tanaka, Katsuyuki Yamaguchi
  • Patent number: 6516252
    Abstract: A method for acquiring a satellite using satellite prediction values has a behavior analysis step for analyzing a behavior unique to a satellite orbit, a search range calculation step for calculating a search range based on the analysis, and a search step for searching ranges in accordance with the predicted values.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: February 4, 2003
    Assignee: Mitsubishi Denki Kabushiki Kaisha
    Inventors: Michihiko Suzuki, Toru Okanuma, Tomomi Murakami, Yurika Hirano, Takako Kouti