Abstract: A controller (600) for a radiotherapy device (320) is provided; the radiotherapy device (320) being configured to provide therapeutic radiation to a patient (308) via a source (300) of therapeutic radiation, wherein the radiotherapy device (320) comprises a first rotatable member (304), the rotation of which can alter a physical attribute of the therapeutic radiation provided, and a patient support member (310), which is linearly moveable in at least one of a longitudinal direction and a lateral direction. The controller (600) comprises a first rotatable actuator (608) for controlling a movement of the first rotatable member (304) and a second actuator (620) for controlling a movement of the patient support member (310).

Abstract: Provided is a display panel. The display panel comprises an array substrate and a color filter substrate, wherein the color filter substrate comprises a second substrate and a black matrix pattern, wherein the black matrix pattern comprises a body, via hole shielding parts, and compensation shielding parts, the via hole shielding parts being disposed within first domains of part of plurality of sub-pixel regions, the compensation shielding parts being disposed within second domains that are adjacent in first direction to the first domains where the via hole shielding parts are disposed, and at most one of the via hole shielding part and the compensation shielding part being disposed in one sub-pixel region.

Abstract: The present application discloses a shift-register circuit including a shift-register unit and a shutdown-discharge sub-circuit. The shift-register unit is coupled to a clock port, a first reference voltage port, a second reference voltage port, and an output port and configured to set a voltage level at a pull-up node to control a clock signal from the clock port being outputted to the output port to drive a display panel during a display period. The shutdown discharge sub-circuit is configured to at least simultaneously receive at least one shutdown signal at a first voltage level from a shutdown-discharge control port and a second signal at the first voltage level from the second reference voltage port to start a shutdown period to discharge at least one of the pull-up node and the output port.

Abstract: Provided are a shift register, a driving method thereof, and a gate driving circuit. The shift register includes an input sub-circuit, a first reset sub-circuit, an output sub-circuit, a pull-down sub-circuit, a pull-down control sub-circuit, and a second reset sub-circuit. The input sub-circuit provides a signal of the first voltage source to the pull-up node and the first node under the control of the signal input terminal; the first reset sub-circuit provides a signal of the second voltage source to the pull-up node and the first node under the control of the reset terminal; the output sub-circuit outputs the signal of the clock signal terminal to the signal output terminal according to the level of the pull-up node.

Abstract: A selection circuit, a method for controlling the selection circuit, and a multiplexing circuit are provided. The selection circuit includes N control circuits and M booster circuits. Control terminals of M control circuits among the N control circuits are coupled to output terminals of the M booster circuits, respectively, and first input terminals of the M booster circuits are coupled to receive M control signals among N control signals, respectively. Second input terminals of the M booster circuits are coupled to receive M boost signals respectively, and each booster circuit is configured to provide the received control signal to an output terminal of the booster circuit and increase a potential at the output terminal of the booster circuit by using the received boost signal.

Abstract: There is provided a display panel including: a light guide structure layer having a light exiting side and configured to enable internal light to be emitted from a preset position; a display structure layer on the light exiting side and including a light adjusting structure, a black matrix and a reflection matrix positioned on a side, away from the light guide structure layer, of the light adjusting structure, the light adjusting structure is configured to control light emitted from the preset position to enter an area where the black matrix is positioned and/or an area where the reflection matrix is positioned; a light absorption structure layer on a side of the light adjusting structure away from the black matrix and configured to absorb light reflected by the black matrix and allow light reflected by the reflection matrix to pass through. A display device is further provided.

Abstract: A shift register includes: an input circuit configured to, under control of an input signal transmitted by an input signal terminal, transmit the input signal to a pull-up node; a first control circuit configured to, under control of a first voltage signal transmitted by a first voltage signal terminal, transmit the first voltage signal to a first pull-down node, and under control of a voltage of the pull-up node, transmit a second voltage signal received at a second voltage signal terminal to the first pull-down node; and an output circuit configured to transmit a clock signal received at a clock signal terminal to a first output signal terminal under the control of the voltage of the pull-up node. The first control circuit is further configured to, receive the input signal, and transmit the second voltage signal to the first pull-down node under the control of the input signal.

Abstract: Disclosed are an antibody-drug conjugate (ADC), an intermediate thereof, a preparation method therefor and an application thereof. The present invention provides an ADC. A structural general formula thereof is Ab-(L3-L2-L1-D)m. The ADC has better biological activity, stability, and uniformity, has reduced toxic and side effects, and has a faster release rate of enzyme cutting in tumor cells. The use of the novel ADC can achieve a wide application of a cytotoxic drug particularly camptothecin in the field of ADCs in treating tumor patients resistant to microtubule ADC.

Abstract: An application of an antibody conjugate in the preparation of a drug for treating CD30 positive tumors, which is characterized in that: the antibody conjugate is F0002-ADC; the general formula of the structural thereof is Ab-Lm-Yn; and the CD30-positive tumors are CD30-positive tumors that express a multidrug resistance gene 1. In addition, a pharmaceutical combination and a pharmaceutical composition containing the antibody conjugate, which may be applied to the preparation of a drug used for treating CD30-positive tumors.

Abstract: A shift register unit circuit includes an input sub-circuit, a pull-up sub-circuit, a pull-down control sub-circuit, a pull-down sub-circuit, and a voltage regulating sub-circuit. The input sub-circuit receives an input signal from a signal input terminal to control a potential of a pull-up node. The pull-up sub-circuit outputs a gate driving signal to an output terminal under control of the potential of the pull-up node and a signal from a first signal terminal. The pull-down control sub-circuit conducts a pull-down node with a first node under control of a signal from the second signal terminal. The pull-down sub-circuit conducts the pull-up node with the first node and the turn-down signal terminal with the output terminal under control of a potential of the pull-down node. The voltage regulating sub-circuit conducts the first node with the turn-down signal terminal under control of a potential of the first node.

Abstract: The present disclosure provides a target detection method, target detection system and non-volatile storage medium. The target detection method includes: acquiring an image to be detected and anchor parameters of preset type number, wherein the anchor parameters are parameters of an anchor set on the image to be detected, and each type of anchor parameters include an anchor scale and an anchor aspect ratio; inputting the image to be detected and the anchor parameters into a target detection model; and carrying out target detection on the image to be detected on the basis of the anchor parameters by the target detection model to obtain a detection result, the detection result including a category and/or a position of a target object included in the image to be detected.

Abstract: A shift register circuit includes a pull-up control sub-circuit, a pull-up sub-circuit and a shutdown auxiliary sub-circuit. The pull-up control sub-circuit is configured to transmit a voltage from the signal input terminal to the pull-up node under the control of the voltage from the signal input terminal. The shut-down auxiliary sub-circuit is configured to pull down a voltage of the pull-up node to a voltage of the discharge voltage terminal under the control of a voltage from the pull-up node. The pull-up sub-circuit is configured to transmit a voltage from the clock signal terminal to the first signal output terminal under the control of a voltage from the pull-up node. The first signal output terminal is configured to be connected to a gate line.

Abstract: An anti-B7-H3 antibody, a preparation method therefor, a conjugate and an application thereof. The anti-B7-H3 antibody comprises a complementarity determining region: one or more of heavy chain CDR1, heavy chain CDR2, and heavy chain CDR3, and/or one or more of light chain CDR1, light chain CDR2, and light chain CDR3. A sequence of the complementarity determining region is as described in the specification. The anti-B7-H3 antibody is a fully human antibody, has a unique antigen binding epitope, and can specifically bind B7-H3 antigen on tumor cells. Moreover, the antibody can rapidly internalize into cells after binding to tumor cells, and can be used for ADC drug development to obtain better anti-tumor activity and efficacy to achieve the purpose of treating cancers.

Abstract: The present disclosure provides a method for performing a non-revisiting coverage task by a manipulator with a least number of lift-offs, and relates to the technical field of manipulator path planning. By explicitly considering lift-offs of an end-effector from a surface of an object due to kinematic constraints when the manipulator performs a task of covering the surface of the object, this method transforms a problem of coverage path design into a problem of sub-cell decomposition and solves the problem to obtain an approach for the manipulator to cover a sub-cell. The method of the present disclosure minimizes the number of lift-offs of the end-effector from the surface of the object when the manipulator performs the coverage task.

Abstract: A shift register unit, a driving method thereof, a gate driving circuit, and a display device. The shift register unit comprises an input circuit, a control circuit, a reset circuit, an output circuit and a first capacitor, where the input circuit provides a signal from an input signal terminal to a first node; the control circuit controls signals from the first node and a second node; the reset circuit provides a signal from a reference signal terminal to the first node; the output circuit provides a signal from a clock signal terminal to a signal output terminal, and provides the signal from the reference signal terminal to the signal output terminal; and the first capacitor is coupled between the clock signal terminal and the second node.

Abstract: A display substrate and a preparation method therefor, a display panel and a display device. The display substrate includes a plurality of pixel regions arranged in an array. The display substrate includes: a base; pixel electrodes provided on the base and located in the pixel regions; separation columns provided on the base and located between two adjacent pixel regions in the row direction, side surfaces of the separation columns having hydrophobic characteristics; and an alignment film provided on the pixel electrodes and located in the pixel regions, where edges of two opposite sides of the alignment film in the row direction are in contact with a side surface of the separation columns, and a surface of the alignment film on a side facing away from the base has a shape of gradually protruding from both sides toward the middle in the row direction.

Abstract: In some embodiments, a method receives a message that identifies an asset being viewed on a video service at a timestamp. The message is associated with a profile identifier and a plurality of messages are received for the profile identifier while using the video service. The method determines a channel identifier for a channel in which the asset is offered during the timestamp and determines whether a channel change occurred based on the channel identifier and a prior channel identifier determined from a prior message in the plurality of messages. When the channel change has occurred, the method stores the channel identifier and timestamp for the profile identifier in a data structure, wherein a list of channels is generated by querying the data structure to determine a set of channel identifiers and timestamps for the profile identifier.

Abstract: Provided in the embodiments are a transfer structure and a manufacturing method thereof, and a transfer device and a manufacturing method thereof. The transfer structure includes: a first electrode, a piezoelectric layer, a second electrode and an adhesive layer stacked on a substrate in sequence, wherein the first electrode and the second electrode are insulated from each other. The transfer structure further includes: a position-limiting layer, wherein the position-limiting layer includes a cavity; the piezoelectric layer and at least part of the adhesive layer are located in the cavity of the position-limiting layer; and in the direction perpendicular to the substrate, the distance between the surface, away from the substrate, of the position-limiting layer and the substrate is greater than the distance between the surface, away from the substrate, of the adhesive layer and the substrate.

Abstract: A display substrate and a preparation method therefor, a display panel and a display device. The display substrate includes a plurality of pixel regions arranged in an array. The display substrate includes: a base; pixel electrodes provided on the base and located in the pixel regions; separation columns provided on the base and located between two adjacent pixel regions in the row direction, side surfaces of the separation columns having hydrophobic characteristics; and an alignment film provided on the pixel electrodes and located in the pixel regions, where edges of two opposite sides of the alignment film in the row direction are in contact with a side surface of the separation columns, and a surface of the alignment film on a side facing away from the base has a shape of gradually protruding from both sides toward the middle in the row direction.

Abstract: As feature sizes of semiconductor chips shrink there is a need for tighter overlay between layers in a lithography process. This means more advanced and larger overlay corrections may be necessary to ensure that die are properly manufactured into chips, especially in reconstituted substrates where the die can shift in the process of creating the substrate. Systems and methods for correcting these overlay errors in a lithographic process are provided. Additional rotation (theta) and projected image size (mag) corrections can be made to correct overlay errors present in reconstituted substrates by adjusting the stage and the reticle. Furthermore, these adjustments can be made allowing site-by-site or zone-by-zone corrections instead of a one-time adjustment of the reticle chuck as has been done in the past. These corrections can alleviate some of the issues associated with fan-out wafer-level packaging (FOWLP) and fan-out panel-level packaging (FOPLP).