Abstract: A wideband vibration suppression device utilizing properties of a sonic black hole, comprising: a vibration absorber (101) comprising a uniform portion (1011) of a fixed thickness and a conical portion (1012) integrally connected to the uniform portion (1011), the conical portion (1012) extending from the junction in such a manner that the thickness thereof gradually decreases from the thickness (d1) of the uniform portion (1011) to a predetermined thickness (d2); and a damping layer (102) attached to the conical portion (1012) of the vibration absorber (101).

Abstract: This disclosure relates to antibody-drug conjugates (ADCs) comprising an anti-Trop-2 antibody. Provided herein are compositions comprising such ADCs, as well as methods of making and using the same.

Abstract: Provided is a GII.4 norovirus virus-like particle or active fragment thereof, and use thereof, the virus-like particle comprising or being composed of an amino acid sequence shown as SEQ ID NO: 4. Further, provided is a composition or a kit comprising the GII.4 norovirus virus-like particle, and use thereof. The objective of covering multiple genotypes is achieved by using a single antigen of the invention, the process difficulty of the preparation for a pharmaceutical composition or a vaccine can be reduced, and the production cost is decreased. Also, provided is a norovirus immune composition or a kit comprising GII.2, GII.4, GII.6, and GII.17 norovirus virus-like particles or active fragments thereof, and use thereof.

Abstract: Various embodiments of the teachings herein include methods for implementing communication conversion between a server-client system and a publish-subscribe (pub-sub) system. An example may include: receiving a message from the pub-sub system, wherein a topic of the message includes information related to a target service in the server-client system to which the message is to be sent, and a payload of the message includes identification information of a consumer in the pub-sub system, wherein the consumer is to receive a response message from the server-client system; parsing the message to determine a host and a service provider that provide the target service, and the consumer who is to receive the response message; sending a request message for the target service to the service provider on the determined host; receiving the response message; adding the identification information to the response message; and sending it to the pub-sub system.

Abstract: A method for generating a digital identity is provided, including: extracting a first preset number of short tandem repeat STRs and relevant information of each STR from whole genome data; generating a single STR digital code corresponding to each STR according to the relevant information of each STR, to obtain a plurality of single STR digital codes; performing sequence transformation on each single STR digital code with a preset rule, and generating a target STR digital code according to the single STR digital code after the sequence transformation; generating summary information of the target STR digital code, and determining the summary information as summary information of the STR to which the target STR digital code belongs; and determining the summary information of the STR as the generated digital identity.

Abstract: Embodiments of the disclosed technologies receive a first-party trained model and a first-party data set from a first-party system into a protected environment, receive a first third-party data set into the protected environment, and, in a data clean room, joining the first-party data set and the first third-party data set to create a joint data set for the particular segment, tuning a first-party trained model with the joint data set to create a third-party tuned model, sending model parameter data learned in the data clean room as a result of the tuning to an aggregator node, receiving a globally tuned version of the first-party trained model from the aggregator node, applying the globally tuned version of the first-party trained model to a second third-party data set to produce a scored third-party data set, and providing the scored third-party data set to a content distribution service of the first-party system.

Abstract: A presence of cement may be identified based on a downhole tool that may emit neutrons into a wellbore having at least one cement casing. The neutrons may interact with the particular material via inelastic scattering, inelastic neutron reactions, capture of neutrons and/or neutron activation through one of these reactions and cause a material to emit an energy spectrum of gamma rays, and wherein the downhole tool is configured to detect an energy spectrum of the gamma rays that is specific to at least one of a plurality of elements and associated a region within the wellbore. An amount of elements, such as calcium and silicon, may be determined from the gamma ray spectra that may indicate a present of cement within the wellbore.

Abstract: Systems and methods for positive dispense verification. In one aspect, a system has a plurality of light emitters. The light from the emitters is directed toward a plurality of light detectors across a proximately horizontal plane. The liquid dispense device is positioned above the horizontal plane of light emission from the plurality of light emitters to the plurality of light detectors such that the dispensed liquid will travel through the horizontal plane defined by the emitted light and onto the container being inoculated. Each of the plurality of detectors is coupled to an amplifier. The amplifier generates a signal in response to an interrupt in the transmission of light from the light emitters to the light detectors when the light path is disrupted by the dispense of liquid confirming the liquid was dispensed onto the container.

Abstract: The invention relates to the technical field of automobile door frame structures and window sealing systems. The invention includes a door body, on which a window frame is arranged, and sliding grooves. A glass body flush with the door body, and one side of the glass body has a concave surface and a convex surface on the other side. At least one side of the glass body is provided with a guide piece, and the guide piece is slidably installed in the sliding groove. An arc-shaped limiting member is arranged on the guide piece. A bump limiter is arranged on the side of the guide piece. Since the bump limiter is a solid structure and the inner side of the arc-shaped limiting member is hollowed out, the bump limiter can resist greater pressure than the arc-shaped limiting member during the glass lifting process, preventing dislocation between the door and the glass to ensure good sealing between the door body and the glass body during long-term use.

Abstract: The present disclosure relates to the field of biotechnologies. Specifically disclosed are an interferon signaling pathway-related gene panel and an in vitro diagnostic product thereof, and the use of the same in assessing the recurrence risk of breast cancer and/or providing guidance for breast cancer treatment with interferon.

Abstract: Various embodiments of the teachings herein include methods for implementing communication conversion between a server-client system and a publish-subscribe (pub-sub) system. An example may include: receiving a message from the pub-sub system, wherein a topic of the message includes information related to a target service in the server-client system to which the message is to be sent, and a payload of the message includes identification information of a consumer in the pub-sub system, wherein the consumer is to receive a response message from the server-client system; parsing the message to determine a host and a service provider that provide the target service, and the consumer who is to receive the response message; sending a request message for the target service to the service provider on the determined host; receiving the response message; adding the identification information to the response message; and sending it to the pub-sub system.

Abstract: A method for switching transmission methods in a multiple input multiple output (MIMO) system may include: receiving scenario identification related data from a user equipment (UE) in a current transmission method; determining a target transmission method of the UE from at least two predefined transmission methods based on the scenario identification related data; and switching the current transmission method of the UE to the target transmission method.

Abstract: Embodiments of the disclosed technologies receive, for a first machine learning task, a first set of raw features arranged according to a first schema, and, for a second machine learning task, a second set of raw features arranged according to a second schema different than the first schema. A multi-task raw feature set is created by storing, in a data store arranged according to a common schema, the first and second sets of raw features. A common feature that is common to both the first and second sets of raw features is identified. A multi-task transformed feature set and a model bundle are created. The multi-task transformed feature set is separated into first and second sets of transformed features. The first and second sets of transformed features and the model bundle can be used to create a trained multi-task machine learning model.

Abstract: In accordance with an embodiment, described herein are systems and methods for providing direct access to a sharded database. A shard director provides access by software client applications to database shards. A connection pool (e.g., a Universal Connection Pool, UCP) and database driver (e.g., a Java Database Connectivity, JDBC, component) can be configured to allow a client application to provide a shard key, either during connection checkout or at a later time; recognize shard keys specified by the client application; and enable connection by the client application to a particular shard or chunk. The approach enables efficient re-use of connection resources, and faster access to appropriate shards.

Abstract: A pharmaceutical composition comprising: i) a herpes gE protein, an active fragment of the protein, a variant of the protein, or a mixture of at least two of them; ii) an immunostimulatory composition comprising a saponin and a CpG oligodeoxynucleotide, or consisting of an adjuvant comprising a saponin and a CpG oligodeoxynucleotide. Use of the pharmaceutical composition in the preparation of a medicament for preventing and/or treating a varicella-zoster virus infection and/or a varicella-zoster virus mediated disease. The pharmaceutical composition achieves an unexpected technical effect and can mediate a stronger immune response.

Abstract: The present invention belongs to the field of biopharmaceutics and in particular relates to a pharmaceutical composition. The pharmaceutical composition comprises a hepatitis B surface antigen, a hepatitis B core antigen, and an immunostimulatory composition, wherein the immunostimulatory composition comprises a saponin and a CpG oligodeoxynucleotide, or consists of an adjuvant comprising a saponin and a CpG oligodeoxynucleotide.

Abstract: A bridge structure dynamic response of a bridge structure under the action of heavy duty vehicle load is obtained through sensors arranged on the bridge structure; according to vertical vibration acceleration ao and vertical deflection yo of the bridge at a center of gravity o of the heavy duty vehicle and speed of the heavy duty vehicle Uvehicle, a response of a table top of a vibration table is reconstructed, and interaction force of the vehicle-bridge coupling model is obtained; a nonlinear finite element model of the bridge structure is established, and the vehicle-bridge interaction force is taken as external force, and the dynamic response of the bridge structure is taken as a structural response, and modification of the finite element model of the bridge structure is completed through a nonlinear parameter identification method. The invention is mainly used for updating a bridge model.

Abstract: Techniques are described herein for predicting disk drive failure using a machine learning model. The framework involves receiving disk drive sensor attributes as training data, preprocessing the training data to select a set of enhanced feature sequences, and using the enhanced feature sequences to train a machine learning model to predict disk drive failures from disk drive sensor monitoring data. Prior to the training phase, the RNN LSTM model is tuned using a set of predefined hyper-parameters. The preprocessing, which is performed during the training and evaluation phase as well as later during the prediction phase, involves using predefined values for a set of parameters to generate the set of enhanced sequences from raw sensor reading. The enhanced feature sequences are generated to maintain a desired healthy/failed disk ratio, and only use samples leading up to a last-valid-time sample in order to honor a pre-specified heads-up-period alert requirement.

Abstract: Provided is an immunostimulatory composition, comprising a saponin and a CpG oligodeoxynucleotide, or consisting of an adjuvant comprising a saponin and a CpG oligodeoxynucleotide, wherein the sequence of the CpG oligodeoxynucleotide has two or more copies of 5?-TTCGTT-3? motif or 5?-TCGTCGTCG-3? motif. Also provided is use of the immunostimulatory composition in the preparation of a medication for treating diseases.

Abstract: Systems and methods for positive dispense verification. In one aspect, a system has a plurality of light emitters. The light from the emitters is directed toward a plurality of light detectors across a proximately horizontal plane. The liquid dispense device is positioned above the horizontal plane of light emission from the plurality of light emitters to the plurality of light detectors such that the dispensed liquid will travel through the horizontal plane defined by the emitted light and onto the container being inoculated. Each of the plurality of detectors is coupled to an amplifier. The amplifier generates a signal in response to an interrupt in the transmission of light from the light emitters to the light detectors when the light path is disrupted by the dispense of liquid confirming the liquid was dispensed onto the container.