Abstract: A method for manufacturing a flexible surface element with at least one thermoplastic, thermosetting and/or elastomeric wear layer is provided. The method includes introducing expandable hollow microspheres into the wear layer and/or a functional layer, applying at least one pressure-resistant layer detachably to the wear layer, and subsequently heating at least one section of the surface element to be treated by a thermal energy supply to a temperature within an expansion temperature range of the hollow microspheres, so that at least the hollow microspheres contained in the section to be treated are at least partially expanded and/or further expanded. Expansion of the hollow microspheres is limited by pressure-resistant properties of the pressure-resistant layer. The method further includes removing the pressure-resistant layer from the wear layer at least sectionally.

Abstract: The present invention provides a basal cell culture medium and a feed medium with novel amino acid ratios and/or iron choline citrate as iron carrier that result in improved performance of mammalian cell culture processes, such as CHO cultivation and protein production processes, in particular in increased product titer (e.g. of monoclonal antibodies). Also provided are methods for culturing mammalian cells and producing a protein of interest using said basal cell culture medium and optionally feed medium. The invention also provides for a medium platform that comprises (i) the basal cell culture medium and (ii) the feed medium.

Abstract: A ball retriever assembly for retrieving and storing balls includes a hopper body defining a hollow storage space therein and at least one attachment configured for removable coupling to the hopper body. Each of the attachments includes a retrieval structure configured for unidirectional passage of one of the balls through the corresponding one of the attachments. A lid is configured for removable coupling to the hopper body as well as each of the attachments. The lid is adjustable between a ball retrieval configuration wherein the lid encloses an end of the hollow storage space and a ball removal configuration wherein the lid forms a stand for maintaining an upright and open configuration of the hopper body. The different attachments configured for removable coupling to the hopper body allow for the unidirectional passage of different ranges of outer ball diameters.

Abstract: The present invention provides a basal cell culture medium and a feed medium with novel amino acid ratios and/or iron choline citrate as iron carrier that result in improved performance of mammalian cell culture processes, such as CHO cultivation and protein production processes, in particular in increased product titer (e.g. of monoclonal antibodies). Also provided are methods for culturing mammalian cells and producing a protein of interest using said basal cell culture medium and optionally feed medium. The invention also provides for a medium platform that comprises (i) the basal cell culture medium and (ii) the feed medium.

Abstract: Inventory data is stored, wherein the inventory data represents for each of a plurality of broadcast stations a corresponding inventory of audio advertising spots available from that broadcast station to be filled by an advertising placement system. An advertising campaign data representing a set of advertising objectives of an advertising campaign is received. The inventory data is used to iteratively select advertising spots to be associated with the advertising campaign, based at least in part on a respective computed fitness of match between each selected advertising spot and said advertising objectives.

Abstract: A selection of a broadcast media ad network and a set of parameters including one or both of a goal and a constraint associated with an advertising campaign is received. Based at least in part on said selection and said set of parameters an advertising proposal, the advertising proposal is determined including an identification of a set of broadcasters associated with the selected broadcast media ad network and for each a corresponding advertising plan portion of the advertising proposal. Information representing the advertising proposal is caused to be displayed at a node from which said selection and set of parameters were received.

Abstract: A new RFP specification is received for a new broadcast ad campaign. A placement is determined for a new broadcast ad in a suitable position within an ad network inventory based at least in part on the new RFP specification. A transfer of an existing placement for an existing broadcast ad campaign out of the suitable position to a newer position based at least in part on an existing RFP specification is determined.

Abstract: The present invention relates to a prefabricated microparticle for performing detection, preferably a digital detection and/or quantitation of an analyte. Furthermore, it also relates to a detection and/or quantitation of multiple analytes by prefabricated microparticles. It also relates to a collection of such prefabricated microparticles and to the use of such microparticle(s) and/or of such collection. Furthermore, the present invention also relates to a method of performing a detection and/or quantitation of an analyte in a sample wherein a microparticle or collection of microparticles are used. In one embodiment, in the collection of microparticles, individual microparticles are tailored for the detection of specific analytes and can be distinguished from each other by a specific label indicating the respective analyte for which the individual microparticle is specific.

Abstract: The present invention relates to a prefabricated microparticle for performing detection, preferably a digital detection and/or quantitation of an analyte. Furthermore, it also relates to a detection and/or quantitation of multiple analytes by prefabricated microparticles. It also relates to a collection of such prefabricated microparticles and to the use of such microparticle(s) and/or of such collection. Furthermore, the present invention also relates to a method of performing a detection and/or quantitation of an analyte in a sample wherein a microparticle or collection of microparticles are used. In one embodiment, in the collection of microparticles, individual microparticles are tailored for the detection of specific analytes and can be distinguished from each other by a specific label indicating the respective analyte for which the individual microparticle is specific.

Abstract: The present invention relates to a sensor body for binding and/or enriching and analyte. Furthermore, the present invention relates to a method of binding an analyte to a sensor body. Furthermore, the present invention also relates to a method of enriching and/or washing an analyte bound to a sensor body and to a method of detecting an analyte in a sample. Moreover, the present invention relates to a device for binding and/or enriching and/or detecting an analyte in a sample.

Abstract: The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.

Abstract: A selection of a broadcast media ad network and a set of parameters including one or both of a goal and a constraint associated with an advertising campaign is received. Based at least in part on said selection and said set of parameters an advertising proposal, the advertising proposal is determined including an identification of a set of broadcasters associated with the selected broadcast media ad network and for each a corresponding advertising plan portion of the advertising proposal. Information representing the advertising proposal is caused to be displayed at a node from which said selection and set of parameters were received.

Abstract: Inventory data is stored, wherein the inventory data represents for each of a plurality of broadcast stations a corresponding inventory of audio advertising spots available from that broadcast station to be filled by an advertising placement system. An advertising campaign data representing a set of advertising objectives of an advertising campaign is received. The inventory data is used to iteratively select advertising spots to be associated with the advertising campaign, based at least in part on a respective computed fitness of match between each selected advertising spot and said advertising objectives.

Abstract: A new RFP specification is received for a new broadcast ad campaign. A placement is determined for a new broadcast ad in a suitable position within an ad network inventory based at least in part on the new RFP specification. A transfer of an existing placement for an existing broadcast ad campaign out of the suitable position to a newer position based at least in part on an existing RFP specification is determined.

Abstract: A selection of a broadcast media ad network and a set of parameters including one or both of a goal and a constraint associated with an advertising campaign is received. Based at least in part on said selection and said set of parameters an advertising proposal, the advertising proposal is determined including an identification of a set of broadcasters associated with the selected broadcast media ad network and for each a corresponding advertising plan portion of the advertising proposal. Information representing the advertising proposal is caused to be displayed at a node from which said selection and set of parameters were received.

Abstract: Inventory data is stored, wherein the inventory data represents for each of a plurality of broadcast stations a corresponding inventory of audio advertising spots available from that broadcast station to be filled by an advertising placement system. An advertising campaign data representing a set of advertising objectives of an advertising campaign is received. The inventory data is used to iteratively select advertising spots to be associated with the advertising campaign, based at least in part on a respective computed fitness of match between each selected advertising spot and said advertising objectives.

Abstract: The present invention relates to a microcapsule for detecting and/or quantitating an analyte in a sample. Furthermore, the invention relates to a method of detecting and/quantitating an analyte in a sample using said microcapsule. Moreover, the present invention relates to a method of preparing microcapsules for detecting and/ or quantitating an analyte in a sample.

Abstract: Inventory data representing for each of a plurality of broadcast stations a corresponding inventory of audio advertising spots available from that broadcast station to be filled by an advertising exchange system is stored. One or more sets of advertising campaign data, each representing a set of advertising objectives of an advertising campaign, is received via a demand side interface. The inventory data is received via a supply side interface. The inventory data is used to determine for each advertising campaign a corresponding set of advertising spots to be associated with that advertising campaign.

Abstract: A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.

Abstract: A new RFP specification is received for a new broadcast ad campaign. A placement is determined for a new broadcast ad in a suitable position within an ad network inventory based at least in part on the new RFP specification. A transfer of an existing placement for an existing broadcast ad campaign out of the suitable position to a newer position based at least in part on an existing RFP specification is determined.