Abstract: It is an object of the present invention to provide a biosensor, which is not significantly affected by the baseline fluctuation and suppresses nonspecific adsorption. The present invention provides a biosensor, which comprises a metal surface or metal film coated with a hydrophobic polymer, and has two or more types of different surfaces in a region coated with a hydrophobic polymer.

Abstract: An image processing apparatus receives n-bit image data, carries out an ?-bit bit extension, and outputs (n+?)-bit image data, where n and ? are positive integers. The apparatus also performs an epsilon filtering operation that uses the additional gray levels provided by the bit extension to smooth out false edges caused by the bit extension without smoothing out real edges. The output image preserves both the smoothness of regions of gradual change and the sharpness of abrupt changes in the input image.

Abstract: It is an object of the present invention to provide a detection surface used for biosensors, in which non-specific adsorption is suppressed and the generation of pinholes is also suppressed. The present invention provides a biosensor, which comprises a substrate coated with a hydrophobic polymer having an alkyl group substituted with a fluorine atom.

Abstract: An object of the present invention is to provide a biosensor which exhibits good reproducibility of the amount of an immobilized physiologically active substance by suppressing plane deterioration (separation of a metal film from a resin) which occurs at the formation of a thin metal film layer on a resin surface. The present invention provides a biosensor which is produced by performing plasma irradiation on a light-reflecting surface of an optical block which is obtained by molding a resin and has at least 3 surfaces including a light incident surface, the light-reflecting surface and a light-emerging surface; forming a first metal layer; and then forming a second metal layer on the side of the first metal layer which is opposite to the light-reflecting surface.

Abstract: It is an object of the present invention to provide a biosensor with an improved recovery yield of a test substance interacting with a physiologically active substance. The present invention provides a biosensor having a flow channel formed on a substrate, which is composed of a detection surface for detecting the interaction of a physiologically active substance with a test substance and a non-detection surface that does not detect said interaction, wherein the detection surface and non-detection surface are modified in such a way that the physiologically active substance can be immobilized thereon.

Abstract: It is an object of the present invention to provide a substrate for sensors and a container, wherein the adhesiveness of the substrate to a thin film is improved, a physiologically active substance can be immobilized without the peeling of the thin film from a plastic substrate, and non-specific adsorption during the analysis of interaction among biomolecules is small. The present invention provides a substrate for sensors, which has a thin film layer on a plastic substrate, wherein the plastic substrate has been treated with an organic primer before formation of the thin film.

Abstract: It is an object of the present invention to provide a biosensor used to easily produce a hydrogel capable of immobilizing a physically active substance, using safe materials; and a method for producing the same. The present invention provides a biosensor which comprises a substrate having a metal layer on the surface thereof, wherein an acetoacetyl group-containing hydrophilic polymer is bound to said metal layer directly or via an intermediate layer.

Abstract: One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on its surface, wherein a hydrophilic polymer having a reactive functional group capable of reacting with a hydroxyl group or an amino group of a physiologically active substance is bound to the metal layer directly or indirectly via an intermediate layer.

Abstract: An object of the invention is to reduce the negative drift of the baseline signal when measuring a specific binding reaction between a physiologically active substance and a test substance by using a surface plasmon resonance measurement device. The present invention provides a biosensor comprising a substrate on the surface of which a physiologically active substance is immobilized via noncovalent bond, which is used for a method for detecting or measuring a substance that interacts with the physiologically active substance, with the use of a fluid channel system comprising a cell formed on the substrate, in a state where the flow of the liquid has been stopped after the liquid contained in said flow channel system has been exchanged.

Abstract: It is an object of the present invention to provide a biosensor wherein a reference unit and a measurement unit can be prepared by performing only a single operation for immobilizing a physiologically active substance and wherein unnecessary electric charge does not remain in the reference unit. The present invention provides a biosensor which comprises a substrate composed of a metal surface or metal film coated with a hydrophilic polymer compound, and which has a surface for retaining a physiologically active substance and a surface that does not retain a physiologically active substance on a single plane of the substrate.

Abstract: It is an object of the present invention to provide a detection surface used for biosensors, in which non-specific adsorption is suppressed and the generation of pinholes is also suppressed. The present invention provides a biosensor, which comprises a substrate coated with a hydrophobic polymer having an alkyl group substituted with a fluorine atom.

Abstract: An object of the present invention is to provide a biosensor wherein at least two types of surfaces are patterned without impairing the sensor surface and non-specific adsorption is thereby suppressed. The present invention provides a biosensor comprising a substrate coated with a hydrophobic compound having a photoactive group, or a substrate which is coated with a hydrophobic polymer and is further modified with a compound having a photoactive group.

Abstract: It is an object of the present invention to provide a technique of converting carboxylic acid into an active ester with no generation of air bubbles and a technique of stabilizing the obtained active ester. The present invention provides a biosensor wherein a carboxyl group existing on the surface of a substrate thereof is activated with any one compound selected from an uronium salt, a phosphonium salt or a triazine derivative which are defined in the present application, so as to form a carboxylic acid amide group.

Abstract: It is an object of the present invention to provide a detection surface used for biosensors, which has an improved efficiency of immobilizing a physiologically active substance. The present invention provides a biosensor having a substrate, to the surface of which a compound represented by the following formula (A) is bound: wherein X represents a group capable of binding to the surface of a biosensor or a functional group existing on the surface of the biosensor; Y represents a group capable of binding to a physiologically active substance or a compound binding to the physiologically active substance; Z represents a group having an electric charge; each of L1, L2, and L3 independently represents a divalent linking group; L4 represents a trivalent group; and each of m, n, and p independently represents an integer of 0 or greater.

Abstract: It is an object of the present invention to provide a biosensor, which is not significantly affected by the baseline fluctuation and suppresses nonspecific adsorption. The present invention provides a biosensor, which comprises a metal surface or metal film coated with a hydrophobic polymer, and has two or more types of different surfaces in a region coated with a hydrophobic polymer.

Abstract: It is an object of the present invention to provide a detection surface used for a biosensor wherein nonspecific adsorption is repressed. The present invention provides a biosensor comprising a substrate coated with a hydrophobic polymer.

Abstract: A silver halide photographic light-sensitive material having layers containing a swellable inorganic stratifying compound on both sides of a support and having at least one silver halide emulsion layer on at least one of the layers. There is provided a silver halide photographic light-sensitive material showing good dimensional stability.

Abstract: A therally processed image forming material less causative of adhesion during storage in a form of commercial product is provided. The thermally processed image forming material has on only one side of a support an image forming layer, in which the outermost layer on the same side with the image forming layer contains a binder different from that contained in the outermost layer on the opposite side of the support.

Abstract: A thermographic recording element having at least one image forming layer contains an organic silver salt, a reducing agent, and optionally, a photosensitive silver halide. The element further contains a substituted alkene derivative of specific structure and preferably a specific hydrazine derivative. The element can be processed in a fully dry basis to produce images having high Dmax and gradation and free of black pepper.

Abstract: A silver halide photographic light-sensitive material having layers containing a swellable inorganic stratifying compound on both sides of a support and having at least one silver halide emulsion layer on at least one of the layers. There is provided a silver halide photographic light-sensitive material showing good dimensional stability.