Patents by Inventor Toshio Imai
Toshio Imai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8056746Abstract: There is provided a synthetic resin bottle in which an amorphous carbon film having good appearance without forming the brown mottled pattern on the surface thereof is deposited. The present invention provides a bottle having a mouth portion, a shoulder portion, a body portion and a bottom portion in which an amorphous carbon film is deposited on the inner surfaces of the mouth portion, the shoulder portion, the body portion and the bottom portion by supplying C2H2 gas. When the height position of the shoulder portion in the direction toward the mouth portion along the bottle axis from the position at which the inner diameter of the shoulder portion is maximal is within the area whose height is not more than 70% the total height of the shoulder portion along the bottle axis, the amorphous carbon film on the shoulder portion within the above range of height position is formed so that the thickness thereof is not less than 0.9 times but not more than 1.Type: GrantFiled: August 20, 2007Date of Patent: November 15, 2011Assignee: Yoshino Kogyosho Co., Ltd.Inventor: Toshio Imai
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Patent number: 8017344Abstract: The inventors discovered that the adhesion molecule CAR, known to be localized in intracellular adhesion sites, functioned as an adhesion molecule for activated lymphocytes. Further, the inventors identified CARL, a novel CAR ligand expressed in lymphocytes, and clarified that the ligand was expressed selectively in Th1 cells. In addition, they found that anti-CAR antibodies could inhibit the adhesion of activated lymphocytes to CAR molecules. Thus, the present invention provides methods for detecting Th1 cells using CAR or anti-CARL antibodies, and methods of screening for inhibitors suppressing the adhesion of Th1 cells using the binding between CAR and CARL as an index. Furthermore, the present invention relates to methods of screening for inhibitors of the binding between CAR and CARL, antibodies that inhibit the binding between CAR and CARL, and therapeutic compositions comprising these antibodies.Type: GrantFiled: April 28, 2005Date of Patent: September 13, 2011Assignee: Eisai R&D Management Co., Ltd.Inventors: Keiko Yamaguchi, Toshio Imai, Kenzo Muramoto
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Patent number: 7992736Abstract: There is provided a synthetic resin bottle in which an amorphous carbon film having good appearance without forming the brown mottled pattern on the surface thereof is deposited. The present invention provides a bottle having a mouth portion, a shoulder portion, a body portion and a bottom portion in which an amorphous carbon film is deposited on the inner surfaces of the mouth portion, the shoulder portion, the body portion and the bottom portion by supplying C2H2 gas. When the height position of the shoulder portion in the direction toward the mouth portion along the bottle axis from the position at which the inner diameter of the shoulder portion is maximal is within the area whose height is not more than 70% the total height of the shoulder portion along the bottle axis, the amorphous carbon film on the shoulder portion within the above range of height position is formed so that the thickness thereof is not less than 0.9 times but not more than 1.Type: GrantFiled: August 20, 2007Date of Patent: August 9, 2011Assignee: Yoshino Kogyosho Co., Ltd.Inventor: Toshio Imai
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Patent number: 7989722Abstract: Disclosed is an illuminated switch device capable of effectively preventing light leakage between different light sources, thereby obtaining a good lighting quality, while reducing the overall size of the switch device. The illuminated switch device includes: a casing that has an open upper end and a partition wall provided therein and is formed on a bottom plate member having light sources and a push switch mounted thereon; and an operating body that has a light-shielding wall provided on the rear surface of an upper plate, is arranged so as to close the open end, and can be pressed. First and second illuminated regions to which light components are emitted from first and second light sources are provided on the upper plate. A protruding portion is formed at a leading end portion of a light-shielding wall, and a concave groove is provided at a leading end portion of a partition wall. The leading end portions are opposite to each other such that they can approach or separate from each other.Type: GrantFiled: October 6, 2008Date of Patent: August 2, 2011Assignee: Alps Electric Co., Ltd.Inventors: Anthony McCurdy, Takayoshi Hoshi, Toshio Imai
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Patent number: 7959997Abstract: This invention is intended to improve the heat resistance of PET bottles from a material aspect. A technical problem of this invention is to find a polyester resin which is suitable for heat and pressure resistant plastic bottles and which does not eat into productivity and is available at a low cost. The object of this invention is to provide a heat and pressure resistant plastic bottle that can be manufactured at a low cost and has pressure resistance at a high temperature and high impact strength. The means of fulfilling this object is a polyester resin comprising a major part of ethylene terephthalate units and containing at least one of minor copolymerizable components selected from a group consisting of isophthalic acid, cyclohexane dimethanol, and diethylene glycol, wherein three minor copolymerizable components have total content less than 3 mol. %.Type: GrantFiled: September 6, 2006Date of Patent: June 14, 2011Assignee: Yoshino Kogyosho Co., Ltd.Inventors: Makoto Takada, Toshio Imai
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Patent number: 7824676Abstract: A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.Type: GrantFiled: September 15, 2006Date of Patent: November 2, 2010Assignee: Eisai R&D Management Co., Ltd.Inventors: Miyuki Nishimura, Mayumi Asano, Yuichi Ono, Koji Morimoto, Masakazu Takeuchi, Yoko Inoue, Toshio Imai, Yoshimi Takai
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Patent number: 7790279Abstract: A constructional board has a coat formed on the surface, and is characterized in that carbodihydrazide are included on the surface of the coat and a coat layer containing colloidal silica as a main component is formed.Type: GrantFiled: January 8, 2008Date of Patent: September 7, 2010Assignee: Nichiha CorporationInventors: Hiroshi Tonomura, Toshio Imai
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Publication number: 20090277864Abstract: There is provided a synthetic resin bottle in which an amorphous carbon film having good appearance without forming the brown mottled pattern on the surface thereof is deposited. The present invention provides a bottle 1 having a mouth portion 2, a shoulder portion 3, a body portion 4 and a bottom portion 5 in which an amorphous carbon film 7 is deposited on the inner surfaces f1-f5 of the mouth portion 2, the shoulder portion 3, the body portion 4 and the bottom portion 5 by supplying C2H2 gas. When the height position ?1 of the shoulder portion 3 in the direction toward the mouth portion 2 along the bottle axis O from the position X2 at which the inner diameter of the shoulder portion 3 is maximal is within the area whose height is not more than 70% the total height 1 of the shoulder portion 3 along the bottle axis O, the amorphous carbon film 7 on the shoulder portion 3 within the above range of height position is formed so that the thickness thereof is not less than 0.9 times but not more than 1.Type: ApplicationFiled: August 20, 2007Publication date: November 12, 2009Applicant: YOSHINO KOGYOSHO CO., LTD.Inventor: Toshio Imai
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Publication number: 20090181025Abstract: An object of the present invention is to provide a T cell adhesion molecule that is expressed on a dendritic cell. According to the present invention, there is provided a protein comprising the amino acid sequence of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10 or SEQ ID NO: 12.Type: ApplicationFiled: September 29, 2006Publication date: July 16, 2009Inventors: Hideaki Ogasawara, Keiko Mizuno, Yoshihisa Arita, Miyuki Nishimura, Toshio Imai
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Publication number: 20090142604Abstract: A building material and a method for coating a substrate for the building material with a coating film having a variety of functions relating to an environment such as mildew resistance, deodorization, antibacterial activity and air purification in addition to the anti-staining effect by having an excellent hydrophilicity. The method for coating the substrate for a building material comprises the steps of; coating a coating material comprising a hydrophilic polymer and a photocatalyst on the substrate, and drying the coating material to form a coating film containing the photocatalyst, wherein the hydrophilic polymer is at least one selected from the group consisting of methyl silicate, liquid glass, colloidal silica, poly(meth)acrylate, and polytetrafluoroethylene graft-polymerized with sulfonic acid, and the photocatalyst is at least one selected from the group consisting of titanium oxide coated with zeolite, titanium oxide coated silica and titanium oxide coated with apatite.Type: ApplicationFiled: November 21, 2008Publication date: June 4, 2009Applicant: NICHIHA CORPORATIONInventors: Toshio Imai, Toshifumi Takahashi, Yoshinori Hibino
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Patent number: 7534485Abstract: Provided is a functional building board having an antimicrobial function, which retains anti-algal and antifungal agents for a long period of time in a coat on an external wall material by using several kinds of antimicrobial composite materials, and is provided with stain-proofing function to wash away stains on the external wall material, and in which the design is not largely restricted by the color of the anti-algal or antifungal paint or by the state of the coat and the design is not influenced by the coating step in the final step. The building board according to the present invention has a coat formed on the surface, and is characterized in that antimicrobial composite materials are included on the surface of the coat and a coat layer containing colloidal silica as a main component is formed, said antimicrobial composite materials being characterized in that they control generation of algae and fungi and said building board being a fiber reinforced cement board.Type: GrantFiled: September 18, 2007Date of Patent: May 19, 2009Assignee: Nichiha CorporationInventors: Takahiro Yamaguchi, Toshio Imai
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Publication number: 20090114515Abstract: Disclosed is an illuminated switch device capable of effectively preventing light leakage between different light sources, thereby obtaining a good lighting quality, while reducing the overall size of the switch device. The illuminated switch device includes: a casing that has an open upper end and a partition wall provided therein and is formed on a bottom plate member having light sources and a push switch mounted thereon; and an operating body that has a light-shielding wall provided on the rear surface of an upper plate, is arranged so as to close the open end, and can be pressed. First and second illuminated regions to which light components are emitted from first and second light sources are provided on the upper plate. A protruding portion is formed at a leading end portion of a light-shielding wall, and a concave groove is provided at a leading end portion of a partition wall. The leading end portions are opposite to each other such that they can approach or separate from each other.Type: ApplicationFiled: October 6, 2008Publication date: May 7, 2009Inventors: Anthony McCurdy, Takayoshi Hoshi, Toshio Imai
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Patent number: 7491041Abstract: The invention reduces power consumption and makes a rotor with ease. As illustrated in FIG. 2, a multistage roots pump (1) in the invention includes upstream rotors (R1a, R1b, R2a, R2b) having multiple teeth, supported by a pair of revolving shafts (A1, A2); and downstream rotors (R3a, R3b-R5a, R5b) having an identical number of teeth (31) with the upstream rotors, supported by revolving shafts (A1, A2). The discharge area formed by the outer periphery of the downstream rotors (R3a, R3b-R5a, R5b) and the inner periphewy of the pump chambers (P1-P5) is smaller than that of the upstream rotors (R1a, R1b, R2a, R2b).Type: GrantFiled: August 24, 2006Date of Patent: February 17, 2009Assignee: Kashiyama Industries, Ltd.Inventors: Toshio Imai, Hideaki Itou, Masayuki Misaizu
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Publication number: 20080274318Abstract: This invention is intended to improve the heat resistance of PET bottles from a material aspect. A technical problem of this invention is to find a polyester resin which is suitable for heat and pressure resistant plastic bottles and which does not eat into productivity and is available at a low cost. The object of this invention is to provide a heat and pressure resistant plastic bottle that can be manufactured at a low cost and has pressure resistance at a high temperature and high impact strength. The means of fulfilling this object is a polyester resin comprising a major part of ethylene terephthalate units and containing at least one of minor copolymerizable components selected from a group consisting of isophthalic acid, cyclohexane dimethanol, and diethylene glycol, wherein three minor copolymerizable components have total content less than 3 mol. %.Type: ApplicationFiled: September 6, 2006Publication date: November 6, 2008Applicant: YOSHINO KOGYOSHO CO., LTD.Inventors: Makoto Takada, Toshio Imai
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Patent number: 7434949Abstract: An illumination device includes a control knob having a display portion, a tubular case combined with a back side of the control knob, a light guide plate attached to seal an upper opening of the tubular case, and LEDs disposed at a lower opening of the tubular case. Light emitted from the LEDs is applied to the display portion through the light guide plate. A plurality of retaining projections and a plurality of push-up projections are provided on an inner surface of the tubular case adjacent to the upper opening. An upper surface of an outer edge of the light guide plate is retained by lower ends of the retaining projections, and a lower surface of the outer edge is pushed up by upper ends of the push-up projections so that the light guide plate is held inside the tubular case while being bent upwardly.Type: GrantFiled: February 27, 2007Date of Patent: October 14, 2008Assignee: Alps Electric Co. ,Ltd.Inventor: Toshio Imai
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Publication number: 20080248502Abstract: The inventors discovered that the adhesion molecule CAR, known to be localized in intracellular adhesion sites, functioned as an adhesion molecule for activated lymphocytes. Further, the inventors identified CARL, a novel CAR ligand expressed in lymphocytes, and clarified that the ligand was expressed selectively in Th1 cells. In addition, they found that anti-CAR antibodies could inhibit the adhesion of activated lymphocytes to CAR molecules. Thus, the present invention provides methods for detecting Th1 cells using CAR or anti-CARL antibodies, and methods of screening for inhibitors suppressing the adhesion of Th1 cells using the binding between CAR and CARL as an index. Furthermore, the present invention relates to methods of screening for inhibitors of the binding between CAR and CARL, antibodies that inhibit the binding between CAR and CARL, and therapeutic compositions comprising these antibodies.Type: ApplicationFiled: April 28, 2005Publication date: October 9, 2008Applicant: EISAI R&D MANAGEMENT CO., LTD.Inventors: Keiko Yamaguchi, Toshio Imai, Kenzo Muramoto
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Publication number: 20080233160Abstract: Provided is a functional building board having an antimicrobial function, which retains anti-algal and antifungal agents for a long period of time in a coat on an external wall material by using several kinds of antimicrobial composite materials, and is provided with stain-proofing function to wash away stains on the external wall material, and in which the design is not largely restricted by the color of the anti-algal or antifungal paint or by the state of the coat and the design is not influenced by the coating step in the final step. The building board according to the present invention has a coat formed on the surface, and is characterized in that antimicrobial composite materials are included on the surface of the coat and a coat layer containing colloidal silica as a main component is formed, said antimicrobial composite materials being characterized in that they control generation of algae and fungi and said building board being a fiber reinforced cement board.Type: ApplicationFiled: September 18, 2007Publication date: September 25, 2008Inventors: Takahiro Yamaguchi, Toshio Imai
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Publication number: 20080199437Abstract: The present invention relates to polynucleotide probes and antibodies for detecting Lrp4/Corin dopaminergic neuron progenitor cell markers, which enable the efficient separation of dopaminergic neuron progenitor cells; and methods for selecting the progenitor cells by the use thereof.Type: ApplicationFiled: July 22, 2005Publication date: August 21, 2008Applicant: EISAI CO., LTD.Inventors: Yoshimasa Sakamoto, Yuichi Ono, Toshio Imai, Yasuko Nakagawa
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Publication number: 20080187738Abstract: A constructional board has a coat formed on the surface, and is characterized in that carbodihydrazide are included on the surface of the coat and a coat layer containing colloidal silica as a main component is formed,Type: ApplicationFiled: January 8, 2008Publication date: August 7, 2008Applicant: NICHIHA CORPORATIONInventors: Hiroshi Tonomura, Toshio Imai
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Patent number: 7390490Abstract: There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotoxic activity of killer lymphocytes by suppressing an interaction between CX3CR1 and fractalkine.Type: GrantFiled: September 13, 2005Date of Patent: June 24, 2008Assignee: Eisai Co., Ltd.Inventors: Toshio Imai, Miyuki Nishimura, Kenzo Muramoto, Yoshikazu Kuboi