Abstract: Imatinib can be used in the treatment of stroke in a new dosage regime, where Imatinib is administered to the patient at a dose of 650 mg/day or higher for at least 3 consecutive days, and preferably administered in a starting dose of 1000 mg/day or higher on day 1, and at a dose in the interval of 650 mg/day to 1000 mg/day on the subsequent days. A method for the treatment of stroke, a pharmaceutical composition and a kit of parts is/are also disclosed.

Abstract: A method of reducing an effect of stroke in a subject, the method comprising administering to the subject a compound that inhibits VEGF-B signaling

Abstract: Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-? antagonist.

Abstract: In an outlet flow control arrangement (1) arrangeable to control a flow of material through an outlet (2) with a predetermined diameter arranged at an end of a pressurized processing container (3), the outlet flow control arrangement (1) comprises an adaptor unit (4) configured so that a cross-section of a flow into the adaptor unit (4) is reduced as compared to a cross-section of the outlet (2), to enable the adaptor unit (4) to control and center a flow of processed material out of the processing container (3) and through the outlet (2) into a discharge pipe (5).

Abstract: The present disclosure provides a method of treating diabetic nephropathy in a subject suffering from diabetic nephropathy, the method comprising administering to the subject a compound that inhibits VEGF-B signalling.

Abstract: Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-? antagonist.

Abstract: The present disclosure provides a method of treating diabetic nephropathy in a subject suffering from diabetic nephropathy, the method comprising administering to the subject a compound that inhibits VEGF-B signalling.

Abstract: Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-? antagonist.

Abstract: In an outlet flow control arrangement (1) arrangeable to control a flow of material through an outlet (2) with a predetermined diameter arranged at an end of a pressurized processing container (3), the outlet flow control arrangement (1) comprises an adaptor unit (4) configured so that a cross-section of a flow into the adaptor unit (4) is reduced as compared to a cross-section of the outlet (2), to enable the adaptor unit (4) to control and center a flow of processed material out of the processing container (3) and through the outlet (2) into a discharge pipe (5).

Abstract: The present disclosure provides a method of treating diabetic nephropathy in a subject suffering from diabetic nephropathy, the method comprising administering to the subject a compound that inhibits VEGF-B signalling.

Abstract: Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-? antagonist.

Abstract: The present disclosure provides a method of treating wound healing in a subject, the method comprising administering to the subject a compound that inhibits VEGF-B signalling.

Abstract: A steering column arrangement for a motor vehicle. The arrangement comprises a main bracket which is to be attached to the motor vehicle, and a steering column with a steering shaft. The steering column is rotatable in relation to the main bracket between a driving position and a parking position. The arrangement also comprises a driving adjustment bracket which is rotatable in relation to the main bracket and in relation to the steering column. The steering column is lockable in different positions in the driving position, and may be locked in the parking position.

Abstract: The present disclosure provides methods of treating diabetic conditions, restoring insulin sensitivity and/or improving regulation of glycemia using an antagonist of VEGF-B, particularly in combination with other anti-diabetic agents such as insulin secretagogues. Compositions are also provided comprising one or more VEGF-B antagonists, particularly in combination with other anti-diabetic agents such as insulin secretagogues. In particular embodiments, the VEGF-B antagonist is an anti-VEGF-B antibody. In further particular embodiments, the other anti-diabetic agent or insulin secretagogue is a DPP-4 inhibitor or a GLP-1R agonist.

Abstract: The present invention provides materials and methods for modulating FATP expression and/or activity in vivo. The materials and methods have numerous diagnostic, prophylactic, and therapeutic applications for various diseases and conditions that are influenced by FATPs, or characterized by excessive or inadequate FATP expression or activity.

Abstract: A steering column arrangement (2) for a motor vehicle (1) and a motor vehicle is described. The arrangement (2) comprises a main bracket (3) which is to be attached to the motor vehicle (1), a steering column (4) with a steering shaft (5). The steering column (4) is rotatable in relation to the main bracket (3) between a driving position and a parking position. The arrangement also comprises a driving adjustment bracket (9) which is rotatable in relation to the main bracket (3) and in relation to the steering column (4). The arrangement comprises a driving adjustment locking system by means of which the steering column (4) is lockable in different positions in the driving position, and locking means with which the steering column (4) may be locked in the parking position.

Abstract: A user interface of a wireless user terminal provides a forecast of a future rate discount that may apply at a future time and/or at a possible future location of the wireless user terminal. The forecast may be displayed as a map and/or as textual or graphical information, and may be provided in response to a user request, in response to receipt of a message from the wireless network and/or automatically at a given time. Related systems, methods and devices are described.

Abstract: Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-? antagonist.

Abstract: Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway. The inventive method and composition is particularly suitable for conjunctive therapy of ischemic stroke using tPA and an anti-PDGF-C antagonist or an anti-PDGFR-? antagonist.