Patents by Inventor Vasantha Nagarajan

Vasantha Nagarajan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fermentive production of four carbon alcohols
    Patent number: 8889385
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 18, 2014
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Gail K. Donaldson, Andrew C. Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
  • FERMENTIVE PRODUCTION OF FOUR CARBON ALCOHOLS
    Publication number: 20140335582
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Gail K. DONALDSON, Andrew C. Eliot, Dennis Flint, Michael Charles Grady, Mehmedalija Jahic, Lori Ann Maggio-Hall, Vasantha Nagarajan, Ranjan Patnaik
  • Fermentive production of four carbon alcohols
    Patent number: 8828704
    Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein. Specifically disclosed herein are the use of coenzyme B12-independent butanediol dehydratases that catalyzes the substrate to product conversion of 2,3-butanediol to 2-butanone in the process of producing 2-butanol and 2-butanone.
    Type: Grant
    Filed: April 29, 2008
    Date of Patent: September 9, 2014
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Gail K. Donaldson, Andrew C. Eliot, Lori Ann Maggio-Hall, Vasantha Nagarajan, Charles E. Nakamura, Jean-Francois Tomb
  • Fermentive production of four carbon alcohols
    Patent number: 8735114
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: May 27, 2014
    Assignee: Butamax (TM) Advanced Biofuels LLC
    Inventors: Gail K Donaldson, Andrew C Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
  • BUTANOL TOLERANCE IN MICROORGANISMS
    Publication number: 20140096439
    Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of fermentation products from a pyruvate utilizing pathway. Yeast host cells provided herein comprise reduced pyruvate decarboxylase activity and modified adenylate cyclase activity. In embodiments, yeast host cells provided herein comprise resistance to butanol and increased biomass production.
    Type: Application
    Filed: October 3, 2013
    Publication date: April 10, 2014
    Inventors: MICHAEL G. BRAMUCCI, VASANTHA NAGARAJAN
  • Fermentive Production of Four Carbon Alcohols
    Publication number: 20140051151
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 20, 2014
    Applicant: Butamax(TM) Advanced Biofuels LLC
    Inventors: Gail K. DONALDSON, Andrew C. Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
  • Strain comprising increased expression of a CFA coding region for butanol production
    Patent number: 8518678
    Abstract: Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of cyclopropane fatty acid synthase in the presence of the enzyme substrate that is either endogenous to the cell or fed to the cell, increased butanol tolerance. Bacterial strains with increased cyclopropane fatty acid synthase and having a butanol biosynthetic pathway are useful for production of butanol.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: August 27, 2013
    Assignee: Butamax(TM) Advanced Biofuels LLC
    Inventors: Dennis Flint, Robert A. Larossa, Vasantha Nagarajan, Tina K. Van Dyk, Rick W. Ye
  • Fermentive Production of Four Carbon Alcohols
    Publication number: 20130171706
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Application
    Filed: June 29, 2012
    Publication date: July 4, 2013
    Applicant: BUTAMAX ADVANCED BIOFUELS LLC
    Inventors: Gail K. Donaldson, Andrew C. Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
  • Method for the production of 1-butanol
    Patent number: 8426173
    Abstract: A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: April 23, 2013
    Assignee: Butamax (TM) Advanced Biofuels LLC
    Inventors: Michael G. Bramucci, Dennis Flint, Edward S. Miller, Jr., Vasantha Nagarajan, Natalia Sedkova, Manjari Singh, Tina K. Van Dyk
  • Method for the production of 2-butanol
    Patent number: 8426174
    Abstract: A method for the production of 2-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: April 23, 2013
    Assignee: Butamax(TM) Advanced Biofuels LLC
    Inventors: Michael G. Bramucci, Dennis Flint, Edward S. Miller, Jr., Vasantha Nagarajan, Natalia Sedkova, Manjari Singh, Tina K. Van Dyk
  • Production of four carbon alcohols using improved strain
    Patent number: 8372612
    Abstract: Using screening of transposon random insertion mutants, genes involved in accumulation of (p)ppGpp were found to be involved in bacterial cell response to butanol. Reduced production of proteins with enzymatic activity for (p)ppGpp biosynthesis confers increased butanol tolerance. Bacterial strains with reduced (p)ppGpp accumulation and having a butanol or 2-butanone biosynthetic pathway are useful for production of butanol or 2-butanone.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: February 12, 2013
    Assignee: Butamax(TM) Advanced Biofuels LLC
    Inventors: Robert A. Larossa, Dana R. Smulski, Vasantha Nagarajan
  • Fermentive production of four carbon alcohols
    Patent number: 8283144
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: October 9, 2012
    Assignee: Butamax(TM) Advanced Biofuels LLC
    Inventors: Gail K. Donaldson, Andrew C. Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
  • Fermentive production of four carbon alcohols
    Patent number: 8273558
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: September 25, 2012
    Assignee: Butamax(TM) Advanced Biofuels LLC
    Inventors: Gail K. Donaldson, Andrew C. Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
  • FERMENTIVE PRODUCTION OF FOUR CARBON ALCOHOLS
    Publication number: 20120196341
    Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.
    Type: Application
    Filed: October 26, 2011
    Publication date: August 2, 2012
    Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLC
    Inventors: Gail K. Donaldson, Andrew C. Eliot, Vasantha Nagarajan, Charles E. Nakamura, Lixuan Lisa Huang
  • Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
    Patent number: 8206970
    Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: June 26, 2012
    Assignee: Butamax(TM) Advanced Biofuels LLC
    Inventors: Andrew C. Eliot, Vasantha Nagarajan, Lixuan Lisa Huang
  • YEAST PRODUCTION CULTURE FOR THE PRODUCTION OF BUTANOL
    Publication number: 20120149080
    Abstract: High cell density cultures of yeast were found to have higher tolerance for butanol in the medium. The high cell density yeast cultures had greater survival and higher glucose utilization than cultures with low cell densities. Production of butanol using yeast in high cell density cultures is thus beneficial for improving butanol production.
    Type: Application
    Filed: June 16, 2011
    Publication date: June 14, 2012
    Applicant: Butamax(TM) Advanced Biofuels LLC
    Inventors: VASANTHA NAGARAJAN, Michael G. Bramucci
  • Fermentive production of four carbon alcohols
    Patent number: 8178328
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: May 15, 2012
    Assignee: Butamax(TM) Advanced Biofuels LLC
    Inventors: Gail K. Donaldson, Andrew C. Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
  • FERMENTIVE PRODUCTION OF FOUR CARBON ALCOHOLS
    Publication number: 20110313206
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Application
    Filed: December 13, 2010
    Publication date: December 22, 2011
    Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLC
    Inventors: GAIL K. DONALDSON, ANDREW C. ELIOT, DENNIS FLINT, LORI ANN MAGGIO-HALL, VASANTHA NAGARAJAN
  • FERMENTIVE PRODUCTION OF FOUR CARBON ALCOHOLS
    Publication number: 20110301388
    Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.
    Type: Application
    Filed: August 8, 2011
    Publication date: December 8, 2011
    Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLC
    Inventors: GAIL K. DONALDSON, Andrew C. Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
  • FERMENTIVE PRODUCTION OF ISOBUTANOL USING HIGHLY EFFECTIVE KETOL-ACID REDUCTOISOMERASE ENZYMES
    Publication number: 20110244536
    Abstract: Ketol-acid reductoisomerase enzymes have been identified that provide high effectiveness in vivo as a step in an isobutanol biosynthetic pathway in bacteria and in yeast. These KARIs are members of a clade identified through molecular phylogenetic analysis called the SLSL Clade.
    Type: Application
    Filed: September 29, 2010
    Publication date: October 6, 2011
    Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLC
    Inventors: Vasantha Nagarajan, Brian James Paul, Wonchul Suh, Jean-Francois Tomb, Rick W. Ye