Abstract: A method for inserting an endoscope into the colon of a patient includes providing a generally rigid insert having proximal and distal ends and having a curved channel passing therethrough with a lateral opening at the distal end. The insert is inserted into the patient's rectum so that the distal end is in proximity to the sigmoid flexure of the colon. The endoscope is then passed through the channel and into the sigmoid colon.

Abstract: The present invention provides a combination therapy using eflomithine (DFMO) and PCV (matulane, lomustine and vincristine) in the treatment of anaplastic gliomas. In contrast to the results seen with glioblastoma multiforme, anaplastic gliomas responded better to the combination of DFMO and PCV than to either the PCV combination or DFMO alone, extending patient survival by approximately two years.

Abstract: A work-hardened poppet exhaust valve for internal combustion engines is obtained from a solutioned work-hardenable austenitic stainless steel coil or bar stock in which chromium is present in the range of 13%-25% by weight, nickel is present in the range of 4%-16% by weight, manganese is present in the range of 0.25%-8% by weight, copper is present in the range of 0.5%-7% by weight, the interstitial elements carbon plus nitrogen are present in a total amount less than 0.45% by nitrogen are present in a total amount less than 0.45% by weight, and at least one refractory metal selected from the group consisting of molybdenum, niobium, vanadium, tungsten and tantalum is present in the range of 1%-5% by weight. The coil or bar stock is extruded to a poppet valve preform configuration at a temperature in the range of room temperature to 1,000° F., and at a true strain of more than 0.8. The parameters of extrusion provide said work-hardened poppet valve with a stem hardness more than Rc=25.

Abstract: The present invention involves a method of treating cancer using a mutant adenovirus that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming the cells with a wild type retinoblastoma pathway.

Abstract: An endoscopic apparatus including an internal unit, adapted to be advanced into a gastrointestinal tract of a patient so as to enable inspection of the tract, an anchor unit, adapted to be held in a position outside the gastrointestinal tract and a flexible sleeve, having a proximal end fixed to the anchor and a distal end fixed to the internal unit, wherein at least a portion of the sleeve between the proximal end distal ends is held initially in a compact state at the internal unit and is arranged to feed out from the internal unit as the internal unit is advanced into the gastrointestinal tract. A method for endoscopic examination is also disclosed.

Abstract: The present invention provides a combination therapy using eflomithine (DFMO) and PCV (matulane, lomustine and vincristine) in the treatment of anaplastic gliomas. In contrast to the results seen with glioblastoma multiforme, anaplastic gliomas responded better to the combination of DFMO and PCV than to either the PCV combination or DFMO alone, extending patient survival by approximately two years.

Abstract: A video endoscope includes a generally rigid, elongate insertion member, having distal and proximal ends, and a video camera head fixed at the distal end of the insertion member. A sheath fits over and covers the insertion member, the sheath having a distal portion covering the video camera head, at least a section of which distal portion is substantially transparent.

Abstract: Endoscopic apparatus which advances within a lumen (40) includes a probe (20) having distal and proximal ends and a flexible sleeve (26) coupled proximally to the probe. The sleeve is inflated in order to propel the probe within the lumen. The probe typically includes an imaging device (28), which captures images inside the lumen.

Abstract: A video endoscope includes a generally rigid; elongate insertion member having distal and proximal ends, and a video camera head fixed at the distal end of the insertion member. A sheath fits over and covers the insertion member, the sheath having a distal portion covering the video camera head, at least a section of which distal portion is substantially transparent. The distal portion of the sheath further including a narrowed tip comprising two or more leaves which are closed during insertion through the anus and open apart after insertion to expose the transparent section of the distal portion of the sheath.

Abstract: Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine kinases, for example pp60.sup.c-src. Methods are further provided for the use of these inhibitors in situations where the inhibition of a protein tyrosine kinase is indicated, for example, in the treatment of certain diseases in mammals, including humans.

Abstract: A method of making work-hardened poppet exhaust valves for internal combustion engines comprises the steps of: providing a solutioned work-hardenable austenitic stainless steel coil or bar stock in which chromium is present in the range of 13%-25% by weight, nickel is present in the range of 4%-16% by weight, manganese is present in the range of 0.25%-8% by weight, copper is present in the range of 0.5%-7% by weight, the interstitial elements carbon plus nitrogen are present in a total amount less than 0.45% by weight, and at least one refractory metal selected from the group consisting of molybdenum, niobium, vanadium, tungsten and tantalum is present in the range of 1%-5% by weight; extruding the coil stock to a poppet valve preform configuration at a speed in the range of 60 to 100 strokes per minute and at a temperature in the range of room temperature to 1,000.degree. F.