Abstract: Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.

Abstract: Changes are made to a virtual network for an endpoint based on the authenticated user identity of the endpoint. The system includes a server and a controller associated with a network fabric to which the endpoint is connected. The network fabric includes network elements to carry network traffic for the endpoint. The server authenticates the endpoint associated with a network address and determines a user identity of the endpoint based on the authentication. The server determines a first virtual network associated with the user identity. The controller receives a notification from the server that the network traffic for the endpoint associated with the network address is to be routed over the first virtual network. The controller updates routing information to associate the network address with the first virtual network and sends the updated routing information to the network elements of the network fabric.

Abstract: Presented herein are hybrid approaches to multi-destination traffic forwarding in overlay networks that can be used to facilitate interoperability between head-end-replication-support network devices (i.e., those that only use head-end-replication) and multicast-support network devices (i.e., those that only use native multicast). By generally using existing tunnel end-points (TEPs) supported functionality for sending multi-destination traffic and enhancing the TEPs to receive multi-destination traffic with the encapsulation scheme they do not natively support, the presented methods and systems minimize the required enhancements to achieve interoperability and circumvents any hard limitations that the end-point hardware may have. The present methods and systems may be used with legacy hardware that are commissioned or deployed as well as new hardware that are configured with legacy protocols.

Abstract: In one embodiment, a method includes receiving a packet at a tunnel end point in a multi-tenant network, the packet comprising a destination, performing a lookup for the destination in a database comprising a mapping of global identifiers to local tenant identifiers for different hosting locations, each of the global identifiers uniquely identifying a tenant across all of the hosting locations, identifying a destination tunnel end point and a local tenant identifier for the destination, and inserting the destination tunnel end point and the local tenant identifier into the packet and forwarding the packet. An apparatus and logic are also disclosed herein.

Abstract: Techniques are disclosed for configuring a LISP mobility network. A management tool receives a configuration for a network fabric. The configuration specifies values for one or more attributes associated with a Locator ID Separation Protocol (LISP)-enabled network. The management tool generates one or more commands based on the specified values for the one or more attributes associated with the LISP-enabled network. The generated commands are distributed to a plurality of network devices in the network fabric. Each network device executes the one or more commands to configure the network fabric.

Abstract: In one embodiment, a method includes building an address resolution cache for a layer-3 router in a first layer-2 datacenter, where the address resolution cache includes a plurality of entries, each of the entries containing a host network address, a host hardware address, and a switch identifier for a switch serving a host, intercepting an address resolution flood within the first layer-2 datacenter that seeks address resolution for a host in a second layer-2 datacenter, and generating a response to the address resolution flood that indicates a source in the second layer-2 datacenter, where data indicating the source in the second layer-2 datacenter is accessed from the address resolution cache.

Abstract: Methods and apparatus for optimizing data center routing in the event of virtual machine (VM) mobility are provided. In one embodiment, a first gateway router, acting as an interface between an Ethernet Virtual Private Network (EVPN) domain and a Locator/ID Separation Protocol (LISP) domain, detects EVPN mobility messages advertised when a VM that has moved connects to a gateway router at a data center. The first gateway router then initiates a LISP mobility event that registers the new location of the moved VM to a LISP mapping system. In another embodiment, the first gateway router may notify a second gateway router, located at another data center from which the VM departed, to clean up the state maintained in that data center. This notification may be made via EVPN or LISP mechanisms. In response, the second gateway router may insert a new sequence into the other data center.

Abstract: Techniques are presented herein for optimizing traffic routing in overlay networks. At a first edge device located at a first site in a network, a message is received that indicates address information of a network device. The address information of the network device is stored in an address table. The address information is associated with a site identifier that identifies a second site at which the network device is located. The site identifier is mapped to an identifier associated with a second edge device that is responsible for routing traffic to network devices at the second site.

Abstract: In one embodiment, a method includes building an address resolution cache for a layer-3 router in a first layer-2 datacenter, where the address resolution cache includes a plurality of entries, each of the entries containing a host network address, a host hardware address, and a switch identifier for a switch serving a host, intercepting an address resolution flood within the first layer-2 datacenter that seeks address resolution for a host in a second layer-2 datacenter, and generating a response to the address resolution flood that indicates a source in the second layer-2 datacenter, where data indicating the source in the second layer-2 datacenter is accessed from the address resolution cache.

Abstract: In one embodiment, a method includes receiving a packet at an edge device in a first network site in communication with a second network site through a transport network, the packet comprising a destination address for a host at the second network site, verifying at the edge device a connection with the host, and inserting the destination address in a forwarding information base at the edge device upon verifying the connection with the host. An apparatus and logic are also disclosed herein.

Abstract: In one embodiment, a method includes receiving a packet from a first host at a first edge device, the packet comprising a layer 3 address of a second host in communication with a second edge device, using the layer 3 address of the second host to receive a layer 2 address and a location identifier for the second host from a database accessible from a core network, the database comprising a mapping of layer 3 host addresses to layer 2 host addresses and location identifiers, and storing a mapping of the layer 2 address to the location identifier at the first edge device for use in forwarding packets to the second host. The first edge device is in communication with the second edge device in an overlay network defined by the edge devices interconnected by the core network. An apparatus and logic are also disclosed herein.

Abstract: In one embodiment, a method includes receiving a packet at a tunnel end point in a multi-tenant network, the packet comprising a destination, performing a lookup for the destination in a database comprising a mapping of global identifiers to local tenant identifiers for different hosting locations, each of the global identifiers uniquely identifying a tenant across all of the hosting locations, identifying a destination tunnel end point and a local tenant identifier for the destination, and inserting the destination tunnel end point and the local tenant identifier into the packet and forwarding the packet. An apparatus and logic are also disclosed herein.

Abstract: Techniques are presented herein for optimizing traffic routing in overlay networks. At a first edge device located at a first site in a network, a message is received that indicates address information of a network device. The address information of the network device is stored in an address table. The address information is associated with a site identifier that identifies a second site at which the network device is located. The site identifier is mapped to an identifier associated with a second edge device that is responsible for routing traffic to network devices at the second site.

Abstract: In one embodiment, a method includes receiving a packet at an edge device in a first network site in communication with a second network site through a transport network, the packet comprising a destination address for a host at the second network site, verifying at the edge device a connection with the host, and inserting the destination address in a forwarding information base at the edge device upon verifying the connection with the host. An apparatus and logic are also disclosed herein.

Abstract: In one embodiment, a method includes receiving a packet from a first host at a first edge device, the packet comprising a layer 3 address of a second host in communication with a second edge device, using the layer 3 address of the second host to receive a layer 2 address and a location identifier for the second host from a database accessible from a core network, the database comprising a mapping of layer 3 host addresses to layer 2 host addresses and location identifiers, and storing a mapping of the layer 2 address to the location identifier at the first edge device for use in forwarding packets to the second host. The first edge device is in communication with the second edge device in an overlay network defined by the edge devices interconnected by the core network. An apparatus and logic are also disclosed herein.

Abstract: In one embodiment, an apparatus includes one or more internal interfaces in communication with one or more network devices in a first network site through a Layer 2 link, an overlay interface in communication through a Layer 3 link with a core network connected to one or more other network sites, and a table mapping addresses for network devices in the other network sites to addresses of edge devices in the same network site as the network device. The apparatus further includes a processor operable to encapsulate a packet received at one of the internal interfaces and destined for one of the network devices in the other network sites, with an IP header including a destination address of the edge device mapped to the destination network device, and forward the encapsulated packet to the core network.

Abstract: In one embodiment, a method includes building an address resolution cache for a layer-3 router in a first layer-2 datacenter, where the address resolution cache includes a plurality of entries, each of the entries containing a host network address, a host hardware address, and a switch identifier for a switch serving a host, intercepting an address resolution flood within the first layer-2 datacenter that seeks address resolution for a host in a second layer-2 datacenter, and generating a response to the address resolution flood that indicates a source in the second layer-2 datacenter, where data indicating the source in the second layer-2 datacenter is accessed from the address resolution cache.

Abstract: In one embodiment, an apparatus includes a plurality of network site interfaces in communication with two or more networks, each of the networks associated with a different Virtual Routing and Forwarding (VRF) instance, and a processor configured for mapping the VRF instances to an Interior Gateway Protocol (IGP) adjacency and transmitting VRF information on the IGP adjacency along with a VRF identifier indicating the network associated with the VRF information. A method is also disclosed.

Abstract: Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.

Abstract: In one embodiment, an apparatus includes one or more internal interfaces in communication with one or more network devices in a first network site through a Layer 2 link, an overlay interface in communication through a Layer 3 link with a core network connected to one or more other network sites, and a table mapping addresses for network devices in the other network sites to addresses of edge devices in the same network site as the network device. The apparatus further includes a processor operable to encapsulate a packet received at one of the internal interfaces and destined for one of the network devices in the other network sites, with an IP header including a destination address of the edge device mapped to the destination network device, and forward the encapsulated packet to the core network.