Abstract: Implementations described herein provide a storage system including a cache, such as a solid-state cache or other relatively higher speed memory cache, and a disc array or relatively higher capacity mass data store. As the storage system receives write requests from a host device, the data of the write requests is initially written to the cache. Eventually, such data is committed to the mass data store in a flushing process. A flushing manager selects data blocks from the cache to flush to the mass data store. The flushing manager selects a sequence of data blocks that are contiguously stored on the mass data store such as to increase performance for I/O operations in the mass data store. The flushing manager utilizes a data structure, such as a binary search tree, to identify the contiguous data blocks to flush.

Abstract: A method for generating a microstructure that includes microcellular bubbles, in a material that includes molecules of a thermoplastic polymer, comprises: determining a size-index for the material that represents an average size of the thermoplastic polymer molecules included in the material, and in response to the determined size-index, setting a parameter of a process to generate a microstructure in the material that includes microcellular bubbles. The process to generate a microstructure in the material includes: 1) infusing into the material, during a first period, a gas that does not react with the material, 2) making the gas-infused material thermodynamically unstable.

Abstract: A method includes maintaining a VLR validation database accessible by an SS7 STP and receiving, by the STP, a MAP SAI request message. The method also includes determining that the MAP SAI request message includes a VLR identifier not recorded in the VLR validation database accessible by the STP and recording the VLR identifier in the VLR validation database. The method further includes receiving a first MAP LU request message and detecting a VLR identifier in the first MAP LU request message and determining that the VLR identifier read from the first MAP LU request message does not match the VLR identifier recorded for a subscriber in the VLR validation database. In response to determining that the VLR identifier does not match the VLR identifier recorded for the subscriber in the VLR validation database, the first MAP LU request message is rejected.

Abstract: A method includes classifying low-resolution pixels of a low-resolution satellite image of a geographic area to form an initial classification map and selecting at least one physically-consistent classification map of the low-resolution pixels based on the initial classification map. A water level associated with at least one of the physically-consistent classification maps is then used to identify a set of high-resolution pixels representing a perimeter of water in the geographic area.

Abstract: The present disclosure provides a computer implemented method. The method includes using a computer processor to perform the operations of constructing a nucleic acid mutation interaction network based upon nucleic acid pair-level interactions of a genetic sample scored under at least one disease model. The method further includes performing a thresholding and binarization process on the nucleic acid pair interactions to derive an interaction network. The method further includes testing pairs of pathways of the interaction network for either between pathway model (BPM) or within pathway model (WPM) enrichment of nucleic acid-nucleic acid mutation pair interaction. The method additionally includes outputting nucleic acid-nucleic acid mutation pair interaction data.

Abstract: A method for authenticating a mobility management entity (MME) for outbound roaming subscribers includes maintaining a Diameter authentication information request (AIR)/update location request (ULR) mapping database at a Diameter edge agent (DEA). A Diameter AIR message is received at the DEA. The DEA determines that the AIR message includes a visited public land mobile network identifier (VPLMN ID) not of record in the database. The DEA records the VPLMN ID in the database. A Diameter ULR message is received at the DEA, and a VPLMN ID is read from the ULR message. The DEA determines that the VPLMN ID read from the ULR message does not match the VPLMN ID recorded for the subscriber in the database. In response to determining that the VPLMN ID does not match the VPLMN ID recorded for the subscriber in the database, the DEA rejects the ULR message.

Abstract: According to the present disclosure, a method for synthesizing a free-standing flexible electrode is provided. The method includes the steps of mixing a solution comprising vanadium powder, molybdenum powder and hydrogen peroxide to form a mixture comprising nanofibers represented by the formula of V0.07Mo0.93O3nH2O, filtering the mixture to form an electrode comprising the nanofibers, treating the electrode with an acidic solution, contacting the acid-treated electrode with a solution comprising monomers of a conductive polymer, and polymerizing the monomers in a medium comprising an oxidizing agent to form the conductive polymer. According to the present disclosure, there is also a free-standing flexible electrode comprising nanofibers comprised of molybdenum, vanadium and a conductive polymer, wherein the electrode is represented by a formula of X—V0.07Mo0.93O3n-H2O. In this formula, X is the conductive polymer and n is independently 1 or 2.

Abstract: A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein.

Abstract: The present disclosure relates to processes for the preparation of sofosbuvir or of its pharmaceutically acceptable salts. The present disclosure also provides intermediates useful in the synthesis of sofosbuvir.

Abstract: The invention disclosed herein relates to relates to foamed thermoplastic material objects and articles of manufacture having an internal layered cellular structure, as well as to methods of making the same. In one embodiment, the invention is directed to a multi-layer foamed polymeric article of manufacture, comprising: a non-laminated multi-layer thermoplastic material sheet, wherein the multi-layer thermoplastic material sheet has first and second discrete outer layers sandwiching a plurality of discrete inner foamed layers, and wherein the two outer layers and plurality discrete inner foamed layers are integral with one another. The thermoplastic material may be a semi-crystalline polymer such as, for example, PET (polyethylene terephthalate), PEEK (polyetheretherketone), PEN (polyethylene naphthalate), PBT (polybutylene terephthalate), PMMA (polymethyl methacrylate), PLA (polylactide), polyhydroxy acid (PHA), thermoplastic urethane (TPU), or blends thereof.

Abstract: The present embodiments relate to methods for the prevention and treatment of inflammatory conditions such as alcoholic liver disease (ALD). More specifically the present embodiments relate to the prevention and treatment of ALD through the administration of an Retinoic Acid Receptor (RAR) agonist. Some embodiments relate to use of tazarotene in the prevention and treatment of alcohol-induced liver injury, alcohol-related liver disease, fatty liver disease, hepatic steatosis, alcoholic hepatitis or alcoholic cirrhosis.

Abstract: According to the present disclosure, a method for synthesizing a free-standing flexible electrode is provided. The method includes the steps of mixing a solution comprising vanadium powder, molybdenum powder and hydrogen peroxide to form a mixture comprising nanofibers represented by the formula of V0.07Mo0.93O3nH2O, filtering the mixture to form an electrode comprising the nanofibers, treating the electrode with an acidic solution, contacting the acid-treated electrode with a solution comprising monomers of a conductive polymer, and polymerizing the monomers in a medium comprising an oxidizing agent to form the conductive polymer. According to the present disclosure, there is also a free-standing flexible electrode comprising nanofibers comprised of molybdenum, vanadium and a conductive polymer, wherein the electrode is represented by a formula of X—V 0.07Mo0.93O3n-H2O. In this formula, X is the conductive polymer and n is independently 1 or 2.

Abstract: A process for the resolution of racemic 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine using novel chiral salts is disclosed. An L-phenylalanine p-toluene-sulfonamide salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine and a di-p-toluoyl-L-tartaric acid salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine are also provided.

Abstract: A method improves automated water body extent determinations using satellite sensor values and includes a processor receiving a time-sequence of land cover labels for a plurality of geographic areas represented by pixels in the satellite sensor values. The processor alternates between ordering the geographic areas based on a water level estimates at each time point in the time sequence such that the order of the geographic areas reflects an estimate of the relative elevations of the geographic areas and updating the water level estimates based on the land cover labels for the geographic areas. A final ordering of the geographic areas and a final water level estimate are used to correct the time-sequence of land cover labels.

Abstract: The present embodiments relate to methods for the prevention and treatment of inflammatory conditions such as alcoholic liver disease (ALD). More specifically the present embodiments relate to the prevention and treatment of ALD through the administration of an Retinoic Acid Receptor (RAR) agonist. Some embodiments relate to use of tazarotene in the prevention and treatment of alcohol-induced liver injury, alcohol-related liver disease, fatty liver disease, hepatic steatosis, alcoholic hepatitis or alcoholic cirrhosis.

Abstract: The present disclosure describes devices capable of continually and controllably passing a polymer film or fiber through a pressurized vessel, while maintaining a desired pressure inside the vessel. In certain embodiments, the devices of the present disclosure include dynamic seals capable of limiting the gas flow from the pressurized vessel to lower pressure environments.

Abstract: An improved process for the preparation of empagliflozin is disclosed. Novel intermediates of formulas (13) and (14) for the preparation of empagliflozin are also disclosed, wherein R1 and R2 are independently hydrogen or hydroxyl protecting groups.

Abstract: In one aspect, A computerized method of a gateway distributing routes learned through routing protocols (RP) into a Border Gateway Protocol (BGP) includes the step of providing a first gateway that receives a route over a routing protocol. The method includes the step of with the first gateway, redistributing the route to one or more peer routers as a BGP route based on one or more specified criteria. The method includes the step of setting a gateway precedence based on the redistribution of the route to the one or more peer routers as the BGP route. The method includes the step of, based on the gateway precedence, setting a second gateway to automatically redistribute the route with different priorities to influence steering of traffic to a preferred gateway.

Abstract: A system includes an aerial image database containing sensor data representing an aerial image of the earth surface, the sensor data comprising a feature vector for each pixel in the aerial image. A processor applies a plurality of classifiers to each feature vector to produce a plurality of classifier scores for each feature vector. The processor then determines a plurality of cluster probabilities for each feature vector, each cluster probability for a feature vector indicating a probability of the feature vector given a respective cluster of feature vectors. The processor uses the cluster probabilities for the feature vectors to form a respective weight for each of the plurality of classifiers. The processor combines the weights and the classifier scores to form an ensemble score for each pixel, the ensemble score indicating which of two possible land cover types is present on a portion of the earth surface represented by the pixel.

Abstract: Methods, systems, and devices are described for establishing a virtual communication link including at least a first and second physical link between two devices. A single virtual packet queue of a device may receive one or more data packets to be transmitted via the virtual communication link. The single virtual packet queue may attach a virtual sequence number to each of the one or more data packets and send the one or more data packets to one or more of the first or the second physical link according to the assigned virtual sequence numbers. The one or more packets may then be communicated via the first and/or second physical links according to link specific sequence numbers, such as medium access control (MAC) sequence numbers, assigned to the one or more data packets by the first and/or second physical links.