Abstract: The present disclosure provides a switching device for shower system and a shower system including same. The switching device for shower system includes a shell main body, a valve, a handle kit, and a sealing cover. The shell main body is internally provided with a partition, the partition is provided with a plurality of water passing holes, and a side of the partition is provided with a plurality of water chambers. The valve is located inside the shell main body, and a first end of the valve abuts on a side of the partition and communicates with the water passing holes. The handle kit is connected to a second end of the valve. The sealing cover is configured to block the water chambers at an outer end.

Abstract: A polar navigation window period assessment system based on three-dimensional visualization simulation of ship-ice interaction is provided in the present application, including a virtual reality interactive operation module for interacting with virtual reality scenes based on a virtual reality (VR) handle and a VR helmet; a three-dimensional virtual visualization integration module for observing the virtual reality scenes from a global perspective; a three-dimensional simulation module of the Arctic route environment for simulating a route environment scene; an Arctic navigation virtual scene module for establishing a navigation virtual scene; an Arctic navigation window period assessment module for assessing navigation window periods of the ship on different routes; a system storing and outputting module for storing interactive operation information, virtual reality scene information and window period assessment result information, and outputting them in form of curve diagrams and data tables.

Abstract: A multi-source self-adaptive low-stress additive manufacturing apparatus including a multi-axis manipulator additive manufacturing system, a high-energy sound beam regulation system, a substrate and a self-adaptive additive manufacturing workbench. The multi-axis manipulator additive manufacturing system includes multi-axis manipulator(s), welding torch(es), manipulator controller(s) and a guide rail, where base(s) of the multi-axis manipulator(s) is connected with the guide rail, the welding torch(es) is held by distal end(s) of the multi-axis manipulator(s), the multi-axis manipulator(s) is controlled by the manipulator controller(s) to move the welding torch(es) to conduct low-stress additive manufacturing on the workpiece to be additive manufactured.

Abstract: The present disclosure provides computer-aided diagnosis systems and methods. The method may include obtaining multiple medical images of one or more bones; for at least one of the multiple medical images, detecting one or more bone fracture regions of the one or more bones in the medical image; causing a management list to be displayed for managing the one or more bones; receiving an instruction related to selecting at least one of the one or more bones, the instruction being generated through the management list; and upon receiving the instruction, causing the following to be displayed: at least one of one or more reconstructed bone images related to the at least one selected bone; or a marker of the one or more detected bone fracture regions related to the at least one selected bone.

Abstract: Provided are a cell strain for producing a biosimilar drug of Ustekinumab and a production method therefor. Specifically, provided is a Chinese hamster ovary cell S cell strain. The cell strain expresses a full human monoclonal antibody directed against the P40 subunit shared by human IL-12 and human IL-23. The fully human monoclonal antibody directed against the P40 subunit shared by human IL-12 and human IL-23 is a biosimilar drug of Ustekinumab, which not only exhibits high consistency with Ustekinumab in pre-clinical research, but also passes pharmacokinetic bioequivalence and safety similarity evaluation in clinical research. The biosimilar drug of Ustekinumab is the first one that has entered clinical trials in China, is the only one that has completed the I stage clinical trial, and is also one of the biosimilar drugs of Ustekinumab, which has the fastest progress in new drug application in the world.

Abstract: A variety of applications can include apparatus having a fin field-effect transistor with a gate wrapping around fins to maintain good channel control and planar source and drain regions to reduce Miller capacitance and contact resistance. The reduced parasitic capacitance and resistance can be translated into higher performance and lower power. A fin field-effect transistor can include a bulk semiconductor region having a planar source region structured as a first top portion of the bulk semiconductor region and a planar drain region structured as a second top portion of the bulk semiconductor region, with one or more semiconductor fins contacting the planar source region and the planar drain region with a gate wrapped around the one or more semiconductor fins.

Abstract: A floating solar system, comprising a floating base having, a buoyance and a lower base frame coupled to the buoyance, a center frame coupled to the lower base frame, an anchor coupled to the lower base frame, a plurality of solar panels affixed to the lower base frame and the center frame to provide electrical power, a lightning rod coupled to the center frame and a lightning rod cap coupled to the lightning rod.

Abstract: Embodiment herein relate to logic gates. An example of a logic gate includes a semiconductor material, source regions having a first width, drain regions having a second width that is different than the first width, transistor gates, and electrical contacts coupled to the source regions and the drain regions.

Abstract: Disclosed are a method and a system for modularized modeling of equipment entities in simulation field based on meta-model, where meta-modeling is combined with modularized modeling, and equipment simulation entities are divided into different model modules in terms of their physical attributes, behavior attributes, and task reliability attributes; a complete set of metadata is designed to characterize each dimensional attribute of the entity, and a meta-model representation protocol based on extensible markup language (XML) description is used to loosely couple the modeling of each module; after the simulation experiment is designed, the modules are bound for entity instantiation.

Abstract: A switching device for shower system includes a housing; a valve core main body, wherein the valve core main body includes a first valve core and a second valve core, a first end of the first valve core is provided with a plurality of water passing holes in different positions, and a second end of the first valve core is slidably connected to the second valve core; a push rod, wherein the push rod is located inside the valve core main body, and an end of the push rod is inserted into the second valve core; and a switching assembly, wherein a first end of the switching assembly is slidably connected to the housing and a second end of the switching assembly is connected to the second valve core, when the switching assembly is pressed, the push rod is pushed to switch the water passing holes in different positions.

Abstract: Disclosed in the invention is a lithium battery production process, which comprises: through sequentially implemented processes of pre-compounding, winding for lamination, cutting, reclaiming material, continuously processing and assembling finished products, each electrode and separator are laminated, processed and formed, and finally assembled into a battery prefabricated product. The lithium battery production process is simple and efficient to implement, and it may realize continuous production of lithium battery products, thereby greatly improving battery production efficiency, and correspondingly simplifying the entire process flow to reduce the labor intensity of the staff. Also disclosed is a lithium battery production equipment for the above lithium battery production process.

Abstract: A method of estimating a speed of an object in real-time includes acquiring from an acceleration sensor mounted on the object a first original acceleration signal indicative of an acceleration of the object in a direction parallel to a travelling direction of the object, filtering the first original acceleration signal to remove noise to produce a first filtered acceleration signal, down-sampling the first filtered acceleration signal to obtain a first optimized acceleration signal, and calculating an estimated speed value of the object along the direction parallel to the travelling direction of the object based on the first optimized acceleration signal.

Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

Abstract: The present disclosure provides a structure for aligning handle and mounting base of faucet and a widespread faucet including same. The structure for aligning handle and mounting base of a faucet includes: a water access main body, a cartridge, a mounting base, a handle, a first connecting element, and a second connecting element. A water inlet end of the cartridge is mounted in the water access main body. The mounting base is arranged around the water access main body and is provided with a first mounting hole. The handle is mounted on the cartridge and is provided with a second mounting hole. The first connecting element is inserted in the second mounting hole to fix the handle with a top end of the cartridge. The second connecting element is inserted in the first mounting hole to fix the mounting base with the water access main body.

Abstract: A semiconductor device includes a semiconductor body having a base region incorporating a field stop zone where the base region and the field stop zone are both formed using an epitaxial process. Furthermore, the epitaxial layer field stop zone is formed with an enhanced doping profile to realize improved soft-switching performance for the semiconductor device. In some embodiments, the enhanced doping profile includes multiple doped regions with peak doping levels where a first doped region adjacent to a first side of the field stop zone has a first peak doping level that is not higher than a last peak doping level of a last doped region adjacent to the base region. The epitaxial layer field stop zone of the present invention enables complex field stop zone doping profiles to be used to obtain the desired soft-switching characteristics in the semiconductor device.

Abstract: Transistor device and method of making thereof comprising a substrate heavily doped with a first conductivity type and an epitaxial layer lightly doped with the first conductivity type on top of the substrate. A body region doped with a second conductivity type is formed in the epitaxial layer wherein the second conductivity type is opposite the first conductivity type and a source region doped with the first conductivity type is formed in the body region of the epitaxial layer. An integrated planar-trench gate having a planar gate portion is formed on the surface of the epitaxial layer that is contiguous with a gate trench portion formed in the epitaxial layer.

Abstract: This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.